Scientific Program Committee

Tuesday
February 5 Sessions
Session 21 CROI 2008
k Tuesday, 10-11:30 am; Ballroom A
CME
Session 21–Oral Abstracts
HIV in Women and Children
Moderators:
Linda-Gail Bekker, Desmond Tutu HIV Ctr, Univ of Cape Town, South Africa
Addy Kekitiinwa, Mulago Hosp, Kampala, Uganda
10:00 73 Alternatives to Prolonged Breastfeeding and Incidence
of Pregnancies among HIV-infected Women: The
ANRS 1201-1202 Ditrame Plus Cohort in Abidjan, Côte
d’Ivoire, 2001 to 2005
I Viho1 , R Becquet2,3 , D Ekouevi1,2 , H Brou1 , A Yao1 , F Dabis2,3 ,
C Amani-Bosse1 , A Desgree-du-Lou4 , M Timite-Konan5 ,
Valeriane Leroy* 2,3 , and ANRS 1201-1202 DITRAME PLUS Study
Group
1Natl Agency for AIDS Res Ditrame Plus Project, PACCI
Collaboration, Abidjan, Côte d’Ivoire; 2INSERM U593, Bordeaux,
France; 3Inst for Publ Hlth, Epi and Devt, Univ Victor Segalen,
Bordeaux, France; 4Inst for Res and Devt, UMR 151, Nogent-sur-
Marne, France; and 5Ctr Hosp Univ of Yopougon, Abidjan, Côte
d’Ivoire
10:15 74 Incidence and Determinants of Pregnancy among
Women Receiving ART in Rural Uganda
Jaco Homsy* 1,2 , R Bunnell2 , D Moore2,3 , R King2 , S Malamba2 ,
R Nakityo2 , D Glidden1 , C Likicho2 , J Tappero2 , and J Mermin2 1Inst for Global Hlth, Univ of California, San Francisco, US;
2 3 Global AIDS Prgm, CDC Uganda, Entebbe; and BC Ctr for
Excellence in HIV/AIDS, Vancouver, Canada
10:30 75 Immune Reconstitution Inflammatory Syndrome in
HIV-infected Infants and Young Children Initiating
ART
1 2 3 4 3 Kelly Smith* , L Kuhn , A Coovadia , T Meyers , B Marais ,
G Barry3 , and E Abrams2 1Columbia Univ Coll of Physicians and Surgeons, New York,
NY, US; 2Columbia Univ Mailman Sch of Publ Hlth, New York,
NY, US; 3Coronation Women and Children’s Hosp, Univ of the
Witwatersrand, Johannesburg, South Africa; and 4Chris Hani
Baragwanath Hosp, Univ of the Witwatersrand, Johannesburg,
South Africa
10:45 76 Clinical and Immunological Characteristics of Very
Young Infants with HIV Infection: Children with HIV
Early Antiretroviral Study
Heather Jaspan* 1 , L Myer2 , A Violari3 , S Madhi4 , J Steyn3 ,
R van Niekerk3 , W Stevens3 , and M Cotton1 1Faculty of Hlth Sci, Univ of Stellenbosch, Cape Town, South Africa;
2 3 Univ of Cape Town, South Africa; Univ of the Witwatersrand,
Johannesburg, South Africa; and 4Chris Hani Baragwanath Hosp,
Johannesburg, South Africa
11:00 77LB Randomized, Controlled Trial of 3 Approaches to
Management of HIV-infected Infants
Andrew Prendergast* 1 , F Chonco2 , G Tudor-Williams3 , W Mphatswe2 ,
A Cengimbo2 , C Thobakgale2 , K Dong4 , H Coovadia2 , B Walker4 , and
P Goulder1 1 2 Univ of Oxford, UK; Univ of KwaZulu Natal, Durban, South
Africa; 3Imperial Coll, London, UK; and 4Partners AIDS Res Ctr,
Boston, MA, US
11:15 78LB Safety and Efficacy of Darunavir Co-administered
with Low-dose Ritonavir in Treatment-experienced
Children and Adolescents at Week 24
R Bologna1 , S Rugina2 , P Cahn3 , P Flynn4 , S Blanche5 ,
B Van Baelen6 , R De Greef6 , L Lavreys6 , T Van De Casteele6 , and
Sabrina Spinosa-Guzman* 6
1Hosp de Pediatria “JP Garrahan”, Buenos Aires, Argentina;
2 3 Spitalul Clinic de Boli Infectioase, Constanta, Romania; Fndn
Huesped, Buenos Aires, Argentina; 4St Jude Children’s Res Hosp,
Memphis, TN, US; 5Hosp Necker-Enfants Malades, Paris, France;
and 6Tibotec, Inc, Mechelen, Belgium
12 15th Conference on Retroviruses and Opportunistic Infections
k Tuesday, 10-11:30 am; Ballroom B/C
CME
Session 22–Oral Abstracts
New Mechanisms of Resistance and Virologic
Failure
Moderators:
Bonaventura Clotet, Fndn irsiCaixa, Barcelona, Spain
Karin Metzner, Univ of Erlangen-Nuremberg, Germany
10:00 79 Mechanism by which N348I in HIV-1 Reverse
Transcriptase Confers Dual Zidovudine/Nevirapine
Resistance
Soo-Huey Yap* 1,2 , J Radzio3,4 , N Sluis-Cremer3 , and
G Tachedjian1,5 1 2 Burnet Inst, Melbourne, Australia; Monash Univ, Churchill,
Australia; 3Univ of Pittsburgh Sch of Med, PA, US; 4Univ of
Pittsburgh Grad Sch of Publ Hlth, PA, US; and 5Monash Univ,
Clayton, Australia
10:15 80 Molecular Mechanisms for 3’-Azido-3’-
Dideoxythymidine-resistance Conferred by Mutations
in the Connection and RNase H Domains of HIV-1
Reverse Transcriptase
Jessica Brehm*, N Sluis-Cremer, and J Mellors
Univ of Pittsburgh, PA, US
10:30 81 Connection Domain Mutations N348I and A360V in
HIV-1 RT Selectively Facilitate Excision of AZT by
Improving Access to Transiently Formed RNA/DNA
Hybrids
Maryam Ehteshami*, G Beilhartz, B Scarth, E Tchesnokov, and
M Gotte
McGill Univ, Montreal, Canada
10:45 82 Circumventing Drug Resistance: Using the Substrate
Envelope Hypothesis to Develop Robust Novel HIV-1
Protease Inhibitors
M Nalam1 , A Ali1 , K Reddy1 , M Altman2 , S Chellappan3 , S Anjum1 ,
T Rana1 , M Gilson3 , B Tidor2 , and Celia Schiffer* 1
1 2 Univ of Massachusetts Med Sch, Worcester, US; Massachusetts
Inst of Tech, Cambridge, US; and 3Ctr for Advanced Res in Biotech,
Univ of Maryland, Baltimore, US
11:00 83 Presence of Minor Populations of Y181C Mutants
Detected by Allele-specific PCR and Risk of Efavirenz
Failure in Treatment-naïve Patients: Results of an
ACTG 5095 Case-cohort Study
Roger Paredes* 1,2 , C Lalama3 , H Ribaudo3 , B Schackman4 ,
C Shikuma5 , W Meyer6 , F Giguel1 , K Squires7 , R Gulick4 , and
D Kuritzkes1 1Brigham and Women’s Hosp, Harvard Med Sch, Boston, MA,
US; 2Fndns irsiCaixa and Lluita contra la SIDA, Badalona, Spain;
3 4 Harvard Sch of Publ Hlth, Boston, MA, US; Weill Med Coll of
Cornell Univ, New York, NY, US; 5Univ of Hawaii, Honolulu, US;
6 7 Quest Diagnostics, Baltimore, MD, US; and Jefferson Med Coll,
Philadelphia, PA, US
11:15 84LB Emergence of HIV-1 Drug Resistance among
Breastfeeding Infants Born to HIV-infected Mothers
Taking Antiretrovirals for Prevention of Mother-to-
Child Transmission of HIV: The Kisumu Breastfeeding
Study, Kenya
Clement Zeh* 1 , P Weidle2 , L Nafisa1 , H Musuluma1 , J Okonji1 ,
E Anyango1 , P Bondo1 , R Masaba1 , M Thigpen2 , and T Thomas1 1 2 CDC Kenya, Kisumu and CDC, Atlanta, GA, US