Scientific Program Committee

Scientific Program Committee Scientific Program Committee

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CROI 2008 Session 12 c Monday, 2-3 pm; Room 311 CME Session 11–Poster Discussion (see Session 65 on Wednesday for corresponding Poster Abstracts) Lymphocyte Depletion in the Gut Discussants: Cristian Apetrei, Tulane Natl Primate Res Ctr, Covington , LA, US Martin Markowitz, Aaron Diamond AIDS Res Ctr, The Rockefeller Univ, New York, NY, US 372 HIV Pathogenesis: Viral Blitzkrieg or 10 Years’ War? Cristian Apetrei* 1 , R Gautam1 , T Gaufin1 , R Ribeiro2 , M Pattison1 , M Barnes1 , C Monjure1 , A Perelson2 , G Silvestri3 , and I Pandrea1 1 2 Tulane Natl Primate Res Ctr, Covington, LA, US; Los Alamos Natl Lab, NM, US; and 3Univ of Pennsylvania, Philadelphia, US 373 Collagen Deposition Limits Immune Reconstitution in the Gut J Estes 1 , J Brenchley 2 , A Khoruts 3 , J Barthold 3 , C Reilly 3 , G Beilman 3 , D Douek 2 , A Haase 3 , and Timothy Schacker* 3 1 NCI-Frederick, MD, US; 2 Vaccine Res Ctr, NIAID, NIH, Bethesda, MD, US; and 3 Univ of Minnesota, Minneapolis, US 374 Disruption of Intestinal Epithelial Integrity and Increased Microbial Translocation and Systemic Dissemination in HIV and SIV Infections Are Linked to Impaired IL-17expressing Mucosal T Cell Responses Satya Dandekar*, M Rafatellu, M Macal, S Sankaran, D Verhoeven, M George, R Santos, and A Baumler Univ of California, Davis, US 375a Differential Mucosal Pathogenesis of SIV Infection in Progressing and Long-term Nonprogressing Rhesus Macaques Binhua Ling*, M Mohan, T Ooms, A Lackner, P Marx, and R Veazey Tulane Natl Primate Res Ctr, Covington, LA, US 375b Disturbed Gut Microbiota in HAART-naïve HIV + Adults: Effect of Intervention with a Specific Prebiotic Oligosaccharide Mixture Kaouther Ben Amor* 1 , G Rizzardini 2 , C Torti 3 , T Quirino 4 , M Moroni 2 , J Knol 1 , D Bray 5 , A Vriesema 1 , M Clerici 6 , and A Gori 7 1 Numico Res, Wageningen, The Netherlands; 2 Hosp Luigi Sacco, Milan, Italy; 3 Univ of Brescia, Italy; 4 Hosp Busto Arsizio, Italy; 5 ImmunoClin, Paris, France; 6 Univ of Milan, Italy; and 7 Hosp San Gerardo, Univ of Milan-Bicocca, Monza, Italy 376 Functional Analysis of Intestinal Epithelial Cells Isolated by Laser Dissection from SIV-infected Rhesus Macaques in vivo Michael George*, S Sankaran, I Grishina, and S Dandekar Univ of California, Davis, US 377 Microbial Translocation Is a Determinant of Persisting T Cell Hyperactivation in HIV-infected Patients Failing to Recover CD4 following Long-term HAART Giusi Maria Bellistri* 1 , V Pegorer 1 , C Tincati 1 , L Meroni 2 , A Gori 3 , A d’Arminio Monforte 1 , and G Marchetti 1 1 San Paolo Hosp, Univ of Milan, Italy; 2 Luigi Sacco Hosp, Univ of Milan, Italy; and 3 San Gerardo Hosp, Monza, Italy c Monday, 2-3 pm; Room 312 CME Session 12–Poster Discussion (see Session 88 on Tuesday for corresponding Poster Abstracts) New Approaches to HIV Testing Discussants: Susan Buchbinder, San Francisco Dept of Publ Hlth, CA, US Carlos Del Rio, Emory Univ Ctr for AIDS Res, Atlanta, GA, US 531 Partner Counseling and Referral Outcomes after Acute HIV Identification in North Carolina Sandra McCoy* 1 , J Kuruc 1 , C Gay 1 , C Hurt 1 , J Anderson 1 , C Pilcher 2 , J Barnhart 3 , J Eron 1 , P Leone 1,3 , and the North Carolina STAT Team 1 Univ of North Carolina at Chapel Hill, US; 2 Univ of California, San Francisco, US; and 3 North Carolina Dept of Hlth and Human Svcs, Raleigh, US 532 Acceptance of Routine HIV Testing in Medical Inpatients in Nigeria: Implications for a New HIV Testing Approach in Sub-Saharan Africa Olusegun Busari* 1 , M Nakayima 2 , O Busari 1 , G Oligbu 1 , A Adeyemi 3 , L Onigbogi 4 , and HIV Study Group 1 Federal Med Ctr, Ido-Ekiti, Nigeria; 2 AIDS Support Org, Masaka, Uganda; 3 Hlthmatch Intl, Lagos, Nigeria; and 4 Univ Coll Hosp, Ibadan, Nigeria 533 Interim Findings from a Multi-site Evaluation of HIV Testing in Emergency Departments James Heffelfinger* 1 , R Rothman 2 , H Pollack 3 , J Brown 4 , M Lyons 5 , G Almond 6 , P Sullivan 1 , S Barera 7 , and G Williams Torres 7 1 CDC, Atlanta, GA, US; 2 Johns Hopkins Univ, Baltimore, MD, US; 3 Sch of Social Svc Admin, Ctr for Hlth Admin Studies, Univ of Chicago, IL, US; 4 George Washington Univ, Washington, DC, US; 5 Univ of Cincinnati Coll of Med, OH, US; 6 Metropolitan Hosp Ctr, New York, NY, US; and 7 Hlth Res and Ed Trust, Chicago, IL, US 534 Revisiting Expectations from Rapid HIV Test and Confirmation in the Emergency Department Rochelle Walensky* 1,2,3 , C Arbelaez 2 , W Reichmann 2 , R Walls 2 , J Katz 2,4 , and E Losina 1,2,5 1 Massachusetts Gen Hosp, Boston, US; 2 Brigham and Women’s Hosp, Boston, MA, US; 3 Harvard Med Sch, Boston, MA, US; 4 Harvard Sch of Publ Hlth, Boston, MA, US; and 5 Boston Univ Sch of Publ Hlth, MA, US 535a Patient Perspectives and Testing Uptake with Abbreviated versus Standard Pre-test HIV Counseling in the Prenatal Setting: A Randomized-Controlled, Non-inferiority Trial Deborah Cohan* 1,2 , E Gomez1,2 , and E Charlebois1 1 2 Univ of California, San Francisco, US and San Francisco Gen Hosp, CA, US 535b Using Multiple Rapid HIV Tests at the Point of Care: Implications for Clinicians Receiving Referrals Kevin Delaney* 1 , T Knoble2 , J Rurangirwa3 , A Scribner4 , E Hopkins5 , B Boyett1 , D White4 , J Haukoos5 , T Dowling2 , and J King3 1 2 CDC, Atlanta, GA, US; HIV Prevention Prgm, City and County of San Francisco, CA, US; 3Los Angeles County Dept of Hlth, CA, US; 4Highland Hosp, Alameda County Hlth Ctr, Oakland, CA, US; and 5Denver Hlth Med Ctr, CO, US Program 7 Monday February 4 Sessions

CROI 2008 Session 12<br />

c Monday, 2-3 pm; Room 311<br />

CME<br />

Session 11–Poster Discussion<br />

(see Session 65 on Wednesday for corresponding Poster Abstracts)<br />

Lymphocyte Depletion in the Gut<br />

Discussants:<br />

Cristian Apetrei, Tulane Natl Primate Res Ctr, Covington , LA, US<br />

Martin Markowitz, Aaron Diamond AIDS Res Ctr, The Rockefeller Univ, New York,<br />

NY, US<br />

372 HIV Pathogenesis: Viral Blitzkrieg or 10 Years’ War?<br />

Cristian Apetrei* 1 , R Gautam1 , T Gaufin1 , R Ribeiro2 , M Pattison1 ,<br />

M Barnes1 , C Monjure1 , A Perelson2 , G Silvestri3 , and I Pandrea1 1 2 Tulane Natl Primate Res Ctr, Covington, LA, US; Los Alamos Natl Lab,<br />

NM, US; and 3Univ of Pennsylvania, Philadelphia, US<br />

373 Collagen Deposition Limits Immune Reconstitution in the Gut<br />

J Estes 1 , J Brenchley 2 , A Khoruts 3 , J Barthold 3 , C Reilly 3 , G Beilman 3 ,<br />

D Douek 2 , A Haase 3 , and Timothy Schacker* 3<br />

1 NCI-Frederick, MD, US; 2 Vaccine Res Ctr, NIAID, NIH, Bethesda, MD,<br />

US; and 3 Univ of Minnesota, Minneapolis, US<br />

374 Disruption of Intestinal Epithelial Integrity and Increased<br />

Microbial Translocation and Systemic Dissemination in<br />

HIV and SIV Infections Are Linked to Impaired IL-17expressing<br />

Mucosal T Cell Responses<br />

Satya Dandekar*, M Rafatellu, M Macal, S Sankaran, D Verhoeven,<br />

M George, R Santos, and A Baumler<br />

Univ of California, Davis, US<br />

375a Differential Mucosal Pathogenesis of SIV Infection in<br />

Progressing and Long-term Nonprogressing Rhesus<br />

Macaques<br />

Binhua Ling*, M Mohan, T Ooms, A Lackner, P Marx, and R Veazey<br />

Tulane Natl Primate Res Ctr, Covington, LA, US<br />

375b Disturbed Gut Microbiota in HAART-naïve HIV + Adults:<br />

Effect of Intervention with a Specific Prebiotic Oligosaccharide<br />

Mixture<br />

Kaouther Ben Amor* 1 , G Rizzardini 2 , C Torti 3 , T Quirino 4 , M Moroni 2 ,<br />

J Knol 1 , D Bray 5 , A Vriesema 1 , M Clerici 6 , and A Gori 7<br />

1 Numico Res, Wageningen, The Netherlands; 2 Hosp Luigi Sacco, Milan,<br />

Italy; 3 Univ of Brescia, Italy; 4 Hosp Busto Arsizio, Italy; 5 ImmunoClin,<br />

Paris, France; 6 Univ of Milan, Italy; and 7 Hosp San Gerardo, Univ of<br />

Milan-Bicocca, Monza, Italy<br />

376 Functional Analysis of Intestinal Epithelial Cells Isolated by<br />

Laser Dissection from SIV-infected Rhesus Macaques in vivo<br />

Michael George*, S Sankaran, I Grishina, and S Dandekar<br />

Univ of California, Davis, US<br />

377 Microbial Translocation Is a Determinant of Persisting T Cell<br />

Hyperactivation in HIV-infected Patients Failing to Recover<br />

CD4 following Long-term HAART<br />

Giusi Maria Bellistri* 1 , V Pegorer 1 , C Tincati 1 , L Meroni 2 , A Gori 3 ,<br />

A d’Arminio Monforte 1 , and G Marchetti 1<br />

1 San Paolo Hosp, Univ of Milan, Italy; 2 Luigi Sacco Hosp, Univ of Milan,<br />

Italy; and 3 San Gerardo Hosp, Monza, Italy<br />

c Monday, 2-3 pm; Room 312<br />

CME<br />

Session 12–Poster Discussion<br />

(see Session 88 on Tuesday for corresponding Poster Abstracts)<br />

New Approaches to HIV Testing<br />

Discussants:<br />

Susan Buchbinder, San Francisco Dept of Publ Hlth, CA, US<br />

Carlos Del Rio, Emory Univ Ctr for AIDS Res, Atlanta, GA, US<br />

531 Partner Counseling and Referral Outcomes after Acute HIV<br />

Identification in North Carolina<br />

Sandra McCoy* 1 , J Kuruc 1 , C Gay 1 , C Hurt 1 , J Anderson 1 , C Pilcher 2 ,<br />

J Barnhart 3 , J Eron 1 , P Leone 1,3 , and the North Carolina STAT Team<br />

1 Univ of North Carolina at Chapel Hill, US; 2 Univ of California, San<br />

Francisco, US; and 3 North Carolina Dept of Hlth and Human Svcs,<br />

Raleigh, US<br />

532 Acceptance of Routine HIV Testing in Medical Inpatients in<br />

Nigeria: Implications for a New HIV Testing Approach in<br />

Sub-Saharan Africa<br />

Olusegun Busari* 1 , M Nakayima 2 , O Busari 1 , G Oligbu 1 , A Adeyemi 3 ,<br />

L Onigbogi 4 , and HIV Study Group<br />

1 Federal Med Ctr, Ido-Ekiti, Nigeria; 2 AIDS Support Org, Masaka,<br />

Uganda; 3 Hlthmatch Intl, Lagos, Nigeria; and 4 Univ Coll Hosp, Ibadan,<br />

Nigeria<br />

533 Interim Findings from a Multi-site Evaluation of HIV<br />

Testing in Emergency Departments<br />

James Heffelfinger* 1 , R Rothman 2 , H Pollack 3 , J Brown 4 , M Lyons 5 ,<br />

G Almond 6 , P Sullivan 1 , S Barera 7 , and G Williams Torres 7<br />

1 CDC, Atlanta, GA, US; 2 Johns Hopkins Univ, Baltimore, MD, US; 3 Sch<br />

of Social Svc Admin, Ctr for Hlth Admin Studies, Univ of Chicago, IL,<br />

US; 4 George Washington Univ, Washington, DC, US; 5 Univ of Cincinnati<br />

Coll of Med, OH, US; 6 Metropolitan Hosp Ctr, New York, NY, US; and<br />

7 Hlth Res and Ed Trust, Chicago, IL, US<br />

534 Revisiting Expectations from Rapid HIV Test and<br />

Confirmation in the Emergency Department<br />

Rochelle Walensky* 1,2,3 , C Arbelaez 2 , W Reichmann 2 , R Walls 2 , J Katz 2,4 , and<br />

E Losina 1,2,5<br />

1 Massachusetts Gen Hosp, Boston, US; 2 Brigham and Women’s Hosp,<br />

Boston, MA, US; 3 Harvard Med Sch, Boston, MA, US; 4 Harvard Sch of<br />

Publ Hlth, Boston, MA, US; and 5 Boston Univ Sch of Publ Hlth, MA, US<br />

535a Patient Perspectives and Testing Uptake with Abbreviated<br />

versus Standard Pre-test HIV Counseling in the Prenatal<br />

Setting: A Randomized-Controlled, Non-inferiority Trial<br />

Deborah Cohan* 1,2 , E Gomez1,2 , and E Charlebois1 1 2 Univ of California, San Francisco, US and San Francisco Gen Hosp,<br />

CA, US<br />

535b Using Multiple Rapid HIV Tests at the Point of Care:<br />

Implications for Clinicians Receiving Referrals<br />

Kevin Delaney* 1 , T Knoble2 , J Rurangirwa3 , A Scribner4 , E Hopkins5 ,<br />

B Boyett1 , D White4 , J Haukoos5 , T Dowling2 , and J King3 1 2 CDC, Atlanta, GA, US; HIV Prevention Prgm, City and County of San<br />

Francisco, CA, US; 3Los Angeles County Dept of Hlth, CA, US; 4Highland Hosp, Alameda County Hlth Ctr, Oakland, CA, US; and 5Denver Hlth<br />

Med Ctr, CO, US<br />

<strong>Program</strong> 7<br />

Monday<br />

February 4 Sessions

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