Scientific Program Committee

CROI 2008 Session 9
k Monday, 10 am-12:15 pm; Ballroom A
CME
Session 8–Oral Abstracts
Viral Pathogenesis and Immune Surveillance
Moderators:
Amitinder Kaur, New England Primate Res Ctr, Harvard Med Sch, Southborough,
MA, US
David Watkins, Univ of Wisconsin, Madison, US
10:00 18 Patterns of CD8 + Immunodominance May Influence the
Ability of Mamu-B*08 + Macaques to Naturally Control
SIVmac239 Replication
John Loffredo* 1 , A Bean1 , D Beal1 , E Leon1 , S Piaskowski1 ,
S Musani2 , E Rakasz1 , N Wilson1 , D Allison2 , and D Watkins1 1Wisconsin Natl Primate Res Ctr, Univ of Wisconsin, Madison, US
and 2Univ of Alabama at Birmingham, US
10:15 19 CD20 + Cell Depletion Results in Abbreviated Cellmediated
Immune Responses, Higher Viral Set-points and
Shortened Survival in SIV-infected Pigtailed Macaques
Lu-Ann Pozzi*, D Pauley, S Sato, H Knight, D Walsh,
A Carville, W Johnson, S Westmoreland, and S O’Neil
New England Primate Res Ctr, Harvard Med Sch, Southborough,
MA, US
10:30 20 Humoral Immune Responses Have Little Effect on
Controlling Viremia during SIVagm Infection of African
Green Monkeys
Thaidra Gaufin* 1 , M Pattison1 , C Stoulig1 , R Gautam1 , M Barnes1 ,
C Monjure1 , M Marx1 , D Montefiori2 , C Apetrei1 , and I Pandrea1 1 2 Tulane Natl Primate Res Ctr, Covington, LA, US and Duke Univ,
Durham, NC, US
10:45 21aLB Experimentally Induced Immune Activation in Natural
Hosts of SIV Results in Significant Increases in Viral
Replication
Ivona Pandrea*, C Coleman, T Gaufin, R Gautam, M Pattison,
C Monjure, A Lackner, and C Apetrei
Tulane Natl Primate Res Ctr, Tulane Univ, Covington, LA, US
11:00 21bLB Depletion of CD8 + T Cells Does Not Change the in vivo Life
Span of Infected Cells during Pathogenic SIV Infection of
Rhesus Macaques
Nichole Klatt* 1,2 , E Shudo3 , A Ortiz1 , J Engram1 , S Gordon1,2 ,
B Lawson2 , J Else2 , J Schmitz4 , A Perelson3 , and G Silvestri1 1 2 Univ of Pennsylvania, Philadelphia, US; Yerkes Natl Primate Res
Ctr, Emory Univ, Atlanta, GA, US; 3Los Alamos Natl Lab, NM, US;
and 4Beth Israel Deaconess Med Ctr, Boston, MA, US
11:15 22 Functionality of HIV-1-specific CD8 + T Cells Is Dependent
on Antigen Load and Sequence Diversification
Hendrik Streeck* 1 , Z Brumme1 , M Anastario2 , K Cohen1 , J Jolin1 ,
G Alter1 , A Meier1 , T Allen1 , B Walker1 , and M Altfeld1 1Partners AIDS Res Ctr, Massachusetts Gen Hosp, Harvard Med
Sch, Boston, US and 2 Ctr for Disaster and Humanitarian Assistance
Med, Univ of the Hlth Sci, Bethesda, MD, US
11:30 23 Kinetics of Escape within HLA-restricted CTL Epitopes
in the First Year of HIV Infection Is Consistent with
Early Immunodominant CTL Response Patterns
Zabrina Brumme* 1 , C Brumme1 , H Streeck1 , J Carlson2,3 ,
M Markowitz4 , H Jessen5 , A Kelleher6 , M John7 , D Heckerman2 , and
B Walker1,8 1 2 Partners AIDS Res Ctr, Boston, MA, US; Microsoft Res, Redmond
WA, US; 3Univ of Washington, Seattle, US; 4Aaron Diamond AIDS
Res Ctr, The Rockefeller Univ, New York, NY, US; 5Jessen-Praxis, Berlin, Germany; 6Univ of New South Wales, Sydney, Australia;
7 8 Murdoch Univ, Perth, Australia; and Howard Hughes Med Inst,
Chevy Chase, MD, US
11:45 24 Intracellular Epitope Stability Contributes to HIV
Epitope Hierarchy and Can Be Altered to Modulate
Epitope Presentation
E Lazaro1 , P Stamegna1 , D Heckerman2 , B Walker1,3 , and
Sylvie Le Gall* 1,3
1Massachusetts Gen Hosp, Harvard Med Sch, Boston, US;
2 3 Microsoft Res, Seattle, WA, US; and Howard Hughes Med Inst,
Chevy Chase, MD, US
12:00 25 Mapping Escape Mutations Arising under HLArestricted
CTL Selection Pressure in HIV-1 Gag:
Correlations with Plasma Viral Load and CD4 Count in
Untreated Chronic Infection
Chanson Brumme* 1 , I Tao2 , S Szeto2 , Z Brumme1 , J Carlson3,4 ,
N Frahm1 , R Hogg2,5 , B Walker1,6 , D Heckerman3 , and R Harrigan2,7 1 2 Partners AIDS Res Ctr, Boston, MA, US; BC Ctr for Excellence in
HIV/AIDS, Vancouver, Canada; 3Microsoft Res, Redmond WA, US;
4 5 Univ of Washington, Seattle, US; Simon Fraser Univ, Burnaby,
Canada; 6Howard Hughes Med Inst, Chevy Chase, MD, US; and
7Univ of British Columbia, Vancouver, Canada
k Monday, 10 am-12 noon; Ballroom B/C
CME
Session 9–Oral Abstracts
Prevention Strategies
Moderators:
Myron Cohen, Univ of North Carolina at Chapel Hill, US
Jeanne Marrazzo, Univ of Washington, Harborview Med Ctr, Seattle, US
10:00 26 Comprehensive Pre-clinical Assessment of Microbicide
Safety Using in vitro and Murine Models
Pedro Mesquita*, S Wilson, N Cheshenko, M Keller, B Galen,
and B Herold
Albert Einstein Coll of Med, Bronx, NY, US
10:15 27LB Protective Effect of Vaginal Lactobacillus on Genital
HIV-1 RNA Concentrations: Longitudinal Data from a
US Cohort Study
Jane Hitti* 1 , K Paul1 , K Agnew1 , R Gausman1 , D Lockhart1 , S Cohn2 ,
A Luque2 , and R Coombs1 1 2 Univ of Washington, Seattle, US and Univ of Rochester, NY, US
10:30 28LB Trial of Male Circumcision: Prevention of HSV-2 in Men
and Vaginal Infections in Female Partners, Rakai, Uganda
Aaron Tobian* 1 , D Serwadda2 , T Quinn1,3 , G Kigozi4 , S Reynolds1,3 ,
F Makumbi4 , T Suntoke1 , S Watya5 , M Wawer1 , and R Gray1 1 2 Johns Hopkins Univ, Baltimore, MD, US; Makerere Univ Sch of
Publ Hlth, Kampala, Uganda; 3NIAID, NIH, Bethesda, MD, US;
4 5 Rakai Hlth Sci Prgm, Entebbe, Uganda; and Makerere Univ,
Kampala, Uganda
10:45 29 3-Year Follow-up of Sexual Behavior and HIV
Transmission Risk of Persons Taking ART in Rural
Uganda
Rebecca Bunnell* 1 , J Ekwaru1 , R King1 , S Bechange1 , D Moore2 ,
K Khana1 , W Were1 , A Coutinho3 , J Tappero1 , and J Mermin1 1 2 Global AIDS Prgm, CDC Uganda, Kampala; Univ of California,
San Francisco, US; and 3AIDS Support Org, Kampala, Uganda
11:00 30 Effect of a Novel Behavioral Intervention to Promote
Condom Use among Female Sex Workers along Lagos,
Nigeria–Cotonou, Benin International Border
Olusegun Busari*, O Busari, G Oligbu, and HIV Study Group
Federal Med Ctr, Ido-Ekiti, Nigeria
11:15 31 Serosorting, but Not Seropositioning, Is Associated
with Decreased Risk of HIV Seroconversion in the
EXPLORE Study Cohort
Susan Philip* 1 , D Donnell2 , X Yu2 , E Vittinghoff3 , and S Buchbinder1 1 2 San Francisco Dept of Publ Hlth, CA, US; Statistical Ctr for HIV/
AIDS Res and Prevention, Seattle, WA, US; and 3Univ of California,
San Francisco, US
11:30 32LB HSV-2 Suppressive Therapy for Prevention of HIV
Acquisition: Results of HPTN 039
Connie Celum* 1 , A Wald1 , J Hughes1 , J Sanchez2 , S Reid3 ,
S Delaney-Moretlwe4 , F Cowan5 , J Fuchs6 , B Koblin7 , L Corey8 , and
HPTN 039
1 2 3 Univ of Washington, Seattle, US; Impacta, Lima, Peru; Univ of
Alabama at Birmingham, Ctr for Infectious Disease Res in Zambia,
Lusaka; 4Univ of the Witwatersrand, Johannesburg, South Africa; 5Univ of California, San Francisco, US and Univ of Zimbabwe, Harare; 6San Francisco Dept of Publ Hlth, CA, US; 7New York Blood Ctr, New York,
US; and 8Fred Hutchinson Cancer Res Ctr, Seattle, WA, US
11:45 33LB Trial of Male Circumcision in HIV+ Men, Rakai,
Uganda: Effects in HIV+ Men and in Women Partners
Maria Wawer* 1 , G Kigozi2 , D Serwadda3 , F Makumbi3 , F Nalugoda2 ,
S Watya4 , D Buwembo2 , V Ssempijja2 , L Moulton1 , and R Gray1 1Johns Hopkins Univ Bloomberg Sch of Publ Hlth, Baltimore, MD,
US; 2Rakai Hlth Sci Prgm, Kalisizo, Uganda; 3Makerere Univ Sch of
Publ Hlth, Kampala, Uganda; and 4Makerere Univ Faculty of Med,
Kampala, Uganda
Program 5
Monday
February 4 Sessions