Scientific Program Committee

Scientific Program Committee Scientific Program Committee

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Monday February 4 Sessions Session 5 CROI 2008 i Monday, 8:30-9 am; Auditorium Session 5–Plenary CME Morbidity and Mortality in the HAART Era 8 Andrew Phillips Royal Free and Univ Coll Med Sch, Univ Coll London, UK Objectives: This session is directed to clinicians and scientists interested in gaining greater appreciation of the extent of continued morbidity and mortality occurring during the HAART era, the surprisingly broad spectrum of clinical disease that might be influenced by HIV infection, and measures that might be needed to further reduce morbidity and mortality. It is assumed participants in this session are familiar with basic concepts of HIV progression, such as CD4 count decline and the link between CD4 count level and risk of AIDS, and the effects of HAART in suppressing viral load and raising the CD4 count, leading to a reduction in AIDS risk. Participants are further assumed to be broadly familiar with current guidelines for treating individuals with HIV infection in developed countries. At the completion of the session, participants should have greater knowledge of the 3 areas outlined above. j Monday, 9-9:30 am; Auditorium Session 6–Plenary CME Searching the Genome for Determinants of Response to HIV 9 David Goldstein Duke Univ, Durham, NC, US Objectives: This session is directed to clinicians and scientists interested in how genome-wide association is being applied to study HIV host genetics, and what has been found with this approach. It is assumed that participants are familiar with basic genetics, but not with the details of statistical genomics. At the completion of the session, participants will be knowledgeable about how genome-wide association studies work, how they are being applied in HIV genetics, and what new studies are being carried out as part of the CHAVI program. 4 15th Conference on Retroviruses and Opportunistic Infections k Monday, 10 -11:45 am; Room 302-304 CME Session 7–Oral Abstracts Epidemiology of SIV/HIV Infection and AIDS-related Malignancies Moderators: Marie-Laure Chaix, Hosp Necker, Paris, France Harold Jaffe, Univ of Oxford, UK 10:00 10 Geographic Distribution of SIV gor in Wild-living Gorillas from Cameroon Cecile Neel* 1,2 , F Van Heuverswyn 1 , E Mpoudi Ngole 2 , Y Li 3 , B Keele 3 , F Liegeois 1 , C Butel 1 , E Delaporte 1 , B Hahn 3 , and M Peeters 1 1 UMR145, Inst for Res and Devt, Univ of Montpellier 1, France; 2 PRESICA, Yaounde, Cameroon; and 3 Univ of Alabama at Birmingham, US 10:15 11 Diagnosis and Monitoring of HIV-1 Group O Infections in Cameroon Aurelia Vessiere* 1 , D Rousset 1 , M Leoz 2 , A Depatureaux 2 , F Simon 3 , and JC Plantier 2 1 Ctr Pasteur of Cameroon, Yaounde; 2 Hosp Charles Nicolle, Rouen, France; and 3 Hosp St Louis, Paris, France 10:30 12 New and Old Complex Recombinant HIV-1 Strains Entering in France among Patients with Primary Infection in 2004 to 2006: The French ANRS CO06 Primo Cohort Study P Frange1 , J Galimand1 , M Peeters2 , C Goujard3 , C Deveau4 , V Avettand - Fenoel1 , F Souala5 , L Meyer4 , C Rouzioux1 , and Marie-Laure Chaix* 1 1 2 Ctr Hosp Univ Necker, Paris, France; Inst for Res and Devt, Montpellier, France; 3Ctr Hosp Univ Bicetre, Le Kremlin-Bicetre, France; 4INSERM, Le Kremlin Bicetre, France; and 5Ctr Hosp Univ Pontchaillou, Rennes, France 10:45 13 Recent Phylodynamics of the HIV Epidemic among MSM in the UK Gareth Hughes* 1 , A Leigh Brown1 , A Rambaut1 , S Lycett1 , F Lewis2 , E Fearnhill3 , and UK Collaborative Group on HIV Drug Resistance 1 2 Univ of Edinburgh, Scotland; Scottish Agricultural Coll, Inverness, UK; and 3Med Res Council Clinical Trials Unit, London, UK 11:00 14 Changes Over Time in the Risk of Death following HIV Seroconversion Compared with Mortality in the General Population Kholoud Porter* 1 , O Hamouda2 , M Sannes3 , F Boufassa4 , A Johnson5 , S Walker1 , and CASCADE Collaboration 1 2 Med Res Council Clinical Trials Unit, London, UK; Robert Koch Inst, Germany; 3Ulleval Univ Hosp, Oslo, Norway; 4INSERM, Paris, France; and 5Univ Coll London, UK 11:15 15 Immunodeficiency and Risk of AIDS-defining and Non- AIDS-defining Cancers: ANRS CO3 Aquitaine Cohort, 1998 to 2006 M Bruyand1,2 , R Thiebaut1,2,3,4 , S Lawson-Ayayi1,2 , P Joly3,4 , A Sasco5 , JL Pellegrin2,4 , D Neau2,4 , P Morlat1,2,4 , G Chene1,2,4 , Fabrice Bonnet* 1,2,4 , and Groupe d’Epidémiologie Clinique du SIDA en Aquitaine (GECSA) 1 2 INSERM U593 and CIC-EC7, Bordeaux, France; Ctr Hosp Univ Bordeaux, France; 3INSERM U875, Bordeaux, France; 4Univ Victor Segalen, Bordeaux, France; and 5INSERM U897, Bordeaux, France 11:30 16 Insufficient Virus Suppression during HAART Is a Strong Predictor for the Development of AIDS-related Lymphoma: German CLINSURV Cohort Alexander Zoufaly* 1 , HJ Stellbrink2 , M an der Heiden3 , C Kollan3 , J van Lunzen1 , O Hamouda3 , and CLINSURV Study Group 1 2 Univ Med Ctr Hamburg-Eppendorf, Germany; IPM Study Ctr, Hamburg, Germany; and 3Robert Koch Inst, Berlin, Germany

Monday<br />

February 4 Sessions<br />

Session 5 CROI 2008<br />

i Monday, 8:30-9 am; Auditorium<br />

Session 5–Plenary CME<br />

Morbidity and Mortality in the HAART Era<br />

8<br />

Andrew Phillips<br />

Royal Free and Univ Coll Med Sch, Univ Coll London, UK<br />

Objectives: This session is directed to clinicians and scientists interested in<br />

gaining greater appreciation of the extent of continued morbidity and mortality<br />

occurring during the HAART era, the surprisingly broad spectrum of clinical<br />

disease that might be influenced by HIV infection, and measures that might be<br />

needed to further reduce morbidity and mortality. It is assumed participants in<br />

this session are familiar with basic concepts of HIV progression, such as CD4<br />

count decline and the link between CD4 count level and risk of AIDS, and the<br />

effects of HAART in suppressing viral load and raising the CD4 count, leading<br />

to a reduction in AIDS risk. Participants are further assumed to be broadly<br />

familiar with current guidelines for treating individuals with HIV infection<br />

in developed countries. At the completion of the session, participants should<br />

have greater knowledge of the 3 areas outlined above.<br />

j Monday, 9-9:30 am; Auditorium<br />

Session 6–Plenary CME<br />

Searching the Genome for Determinants<br />

of Response to HIV<br />

9<br />

David Goldstein<br />

Duke Univ, Durham, NC, US<br />

Objectives: This session is directed to clinicians and scientists interested in<br />

how genome-wide association is being applied to study HIV host genetics,<br />

and what has been found with this approach. It is assumed that participants are<br />

familiar with basic genetics, but not with the details of statistical genomics. At<br />

the completion of the session, participants will be knowledgeable about how<br />

genome-wide association studies work, how they are being applied in HIV<br />

genetics, and what new studies are being carried out as part of the CHAVI<br />

program.<br />

4 15th Conference on Retroviruses and Opportunistic Infections<br />

k Monday, 10 -11:45 am; Room 302-304<br />

CME<br />

Session 7–Oral Abstracts<br />

Epidemiology of SIV/HIV Infection and<br />

AIDS-related Malignancies<br />

Moderators:<br />

Marie-Laure Chaix, Hosp Necker, Paris, France<br />

Harold Jaffe, Univ of Oxford, UK<br />

10:00 10 Geographic Distribution of SIV gor in Wild-living<br />

Gorillas from Cameroon<br />

Cecile Neel* 1,2 , F Van Heuverswyn 1 , E Mpoudi Ngole 2 , Y Li 3 ,<br />

B Keele 3 , F Liegeois 1 , C Butel 1 , E Delaporte 1 , B Hahn 3 , and<br />

M Peeters 1<br />

1 UMR145, Inst for Res and Devt, Univ of Montpellier 1, France;<br />

2 PRESICA, Yaounde, Cameroon; and 3 Univ of Alabama at<br />

Birmingham, US<br />

10:15 11 Diagnosis and Monitoring of HIV-1 Group O Infections<br />

in Cameroon<br />

Aurelia Vessiere* 1 , D Rousset 1 , M Leoz 2 , A Depatureaux 2 ,<br />

F Simon 3 , and JC Plantier 2<br />

1 Ctr Pasteur of Cameroon, Yaounde; 2 Hosp Charles Nicolle, Rouen,<br />

France; and 3 Hosp St Louis, Paris, France<br />

10:30 12 New and Old Complex Recombinant HIV-1 Strains<br />

Entering in France among Patients with Primary<br />

Infection in 2004 to 2006: The French ANRS CO06<br />

Primo Cohort Study<br />

P Frange1 , J Galimand1 , M Peeters2 , C Goujard3 , C Deveau4 ,<br />

V Avettand - Fenoel1 , F Souala5 , L Meyer4 , C Rouzioux1 , and<br />

Marie-Laure Chaix* 1<br />

1 2 Ctr Hosp Univ Necker, Paris, France; Inst for Res and Devt,<br />

Montpellier, France; 3Ctr Hosp Univ Bicetre, Le Kremlin-Bicetre,<br />

France; 4INSERM, Le Kremlin Bicetre, France; and 5Ctr Hosp Univ<br />

Pontchaillou, Rennes, France<br />

10:45 13 Recent Phylodynamics of the HIV Epidemic among<br />

MSM in the UK<br />

Gareth Hughes* 1 , A Leigh Brown1 , A Rambaut1 , S Lycett1 , F Lewis2 ,<br />

E Fearnhill3 , and UK Collaborative Group on HIV Drug Resistance<br />

1 2 Univ of Edinburgh, Scotland; Scottish Agricultural Coll, Inverness,<br />

UK; and 3Med Res Council Clinical Trials Unit, London, UK<br />

11:00 14 Changes Over Time in the Risk of Death following<br />

HIV Seroconversion Compared with Mortality in the<br />

General Population<br />

Kholoud Porter* 1 , O Hamouda2 , M Sannes3 , F Boufassa4 ,<br />

A Johnson5 , S Walker1 , and CASCADE Collaboration<br />

1 2 Med Res Council Clinical Trials Unit, London, UK; Robert Koch<br />

Inst, Germany; 3Ulleval Univ Hosp, Oslo, Norway; 4INSERM, Paris,<br />

France; and 5Univ Coll London, UK<br />

11:15 15 Immunodeficiency and Risk of AIDS-defining and Non-<br />

AIDS-defining Cancers: ANRS CO3 Aquitaine Cohort,<br />

1998 to 2006<br />

M Bruyand1,2 , R Thiebaut1,2,3,4 , S Lawson-Ayayi1,2 , P Joly3,4 ,<br />

A Sasco5 , JL Pellegrin2,4 , D Neau2,4 , P Morlat1,2,4 , G Chene1,2,4 ,<br />

Fabrice Bonnet* 1,2,4 , and Groupe d’Epidémiologie Clinique du SIDA<br />

en Aquitaine (GECSA)<br />

1 2 INSERM U593 and CIC-EC7, Bordeaux, France; Ctr Hosp Univ<br />

Bordeaux, France; 3INSERM U875, Bordeaux, France; 4Univ Victor<br />

Segalen, Bordeaux, France; and 5INSERM U897, Bordeaux, France<br />

11:30 16 Insufficient Virus Suppression during HAART Is a<br />

Strong Predictor for the Development of AIDS-related<br />

Lymphoma: German CLINSURV Cohort<br />

Alexander Zoufaly* 1 , HJ Stellbrink2 , M an der Heiden3 ,<br />

C Kollan3 , J van Lunzen1 , O Hamouda3 , and CLINSURV Study Group<br />

1 2 Univ Med Ctr Hamburg-Eppendorf, Germany; IPM Study Ctr,<br />

Hamburg, Germany; and 3Robert Koch Inst, Berlin, Germany

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