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<strong>IMS</strong> COM PANY PRO FILES TAKEDA<br />
<strong>Company</strong>/Organization Date Area of<br />
Collaboration<br />
ARIUS Research 2006 FunctionFIRST<br />
technology platform<br />
Paradigm Therapeutics<br />
(UK)<br />
2005 Drug discovery (CNS<br />
disorders)<br />
Terms of Agreement<br />
ARIUS Research signed a three-year<br />
collaborative agreement with Takeda to<br />
discover treatments for human disease<br />
using ARIUS’s FunctionFIRST technology<br />
platform. Under the terms of agreement<br />
Takeda will pay an upfront technology<br />
access fee of $2 million ($1 million each in<br />
cash and equity investment, respectively)<br />
as well as research funding for three<br />
years. Confirmed ongoing by Takeda in<br />
2008.<br />
3-year deal to access novel proprietary<br />
therapeutic targets identified by Paradigm<br />
for selected CNS disorders. Takeda will<br />
pay up-front fees and milestones totaling<br />
up to $18m for each product and then<br />
sales royalties.<br />
Flamel Technologies 2004 New formulations TAP licensed the worldwide rights for<br />
Flamel’s Micropump controlled-release<br />
technology for the oral administration of<br />
lansoprazole. TAP will pay costs of further<br />
development, testing, regulatory approval,<br />
and marketing of the new formulation.<br />
HTG 2004 New drug candidates HTG will use its multiplexed ArrayPlate<br />
technology to screen samples provided by<br />
Takeda and gather critical information on<br />
the interplay of genes in biological<br />
systems. HTG will deliver high-quality,<br />
multiplexed gene expression test results to<br />
assist Takeda to identify promising new<br />
drug candidates. Financial terms were not<br />
disclosed. In 2006 Array BioPharma<br />
advanced two lead compounds into<br />
preclinical studies, triggering milestone<br />
payments from Takeda.<br />
© 2009 <strong>IMS</strong> Health In cor po rated or its af fil i ates Page 101