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Concerning, but Transient Adverse Events<br />
• Headache, upper respiratory tract infection, pares<strong>the</strong>sias, hypoes<strong>the</strong>sias, and<br />
arthralgia or joint pain, were <strong>the</strong> most frequently reported adverse events for patients<br />
treated with tanezumab.<br />
• In terms of withdrawals due to adverse events, only arthralgia or worsening diabetes<br />
led to <strong>the</strong> withdrawal in more than one patient across <strong>the</strong> treatment arms.<br />
• Seven patients experienced a<br />
serious adverse event in this<br />
study.<br />
– Chest pain (placebo)<br />
– Cellulitis, appendicitis<br />
(10µg/kg)<br />
– Breast cancer, bacterial<br />
arthritis (50µg/kg)<br />
– Syncope, lumbar spine<br />
stenosis (200µg/kg)<br />
Pfizer Analyst and Investor Meeting Oct. 28, 2008<br />
89<br />
© Defined Health, 2009<br />
Pain Insight Briefing