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New MOA Challenges<br />
68<br />
An increased understanding of <strong>the</strong> neurobiology of pain has not yet<br />
translated into breakthroughs in pain <strong>the</strong>rapies. Why?<br />
• Development Risk<br />
– Animal models are not disease models, but are useful for<br />
PK/PD.<br />
– Correlations from animals to clinic only exist for precedented<br />
targets.<br />
– Biggest clinical risk is in exposure, limited by safety/tolerability.<br />
– Access to correct compartment (CNS) is next most important<br />
consideration.<br />
NeuroDiscovery/NeuroSolutions <strong>presentation</strong>s, Arrowhead Pain Conference 2008; Stephenson, D.T.<br />
and Arneric, S.P. The Journal of Pain, Vol 9, No 7, 2008: p 567-579<br />
© Defined Health, 2009<br />
Pain Insight Briefing
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