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FAAH Pipeline<br />
KDS-4103, acquired by Schering-<br />
Plough when <strong>the</strong>y purchased<br />
Organon, has shown potent analgesic<br />
activity in models of neuropathic pain<br />
when administered orally and has<br />
proved efficacious following systemic<br />
administration in models of<br />
inflammatory pain and inflammation.<br />
However, high oral doses of this<br />
compound (10–50 mg per kg) are<br />
required to inhibit neuropathic pain,<br />
w<strong>here</strong>as lower intraperitoneal doses<br />
are not effective against this type of<br />
pain.<br />
65<br />
Nature Reviews Drug Discovery 7, 438-455 (May 2008)<br />
Compound<br />
SSR 101010<br />
SSR411298<br />
KDS 4103<br />
ORG 231295<br />
OL-135<br />
FAAH Inhibitor<br />
JNJ 2883315<br />
JNJ 1661010<br />
RN-A<br />
RN-B<br />
FAAH Inhibitor<br />
Adis R&D Insight<br />
© Defined Health, 2009<br />
Pain Insight Briefing<br />
Developer<br />
sanofi-aventis<br />
sanofi-aventis<br />
Schering-Plough<br />
Schering-Plough<br />
Adolor Corporation<br />
Vernalis<br />
Johnson & Johnson<br />
Johnson & Johnson<br />
Evotec AG<br />
Evotec AG<br />
Infinity/Purdue/Mundipharma<br />
Phase<br />
I<br />
I<br />
Preclinical<br />
Preclinical<br />
Preclinical<br />
Preclinical<br />
Preclinical<br />
Preclinical<br />
Preclinical<br />
Preclinical<br />
Preclinical<br />
Indications<br />
Anxiety disorders, depression<br />
Anxiety disorders, depression<br />
Anxiety, depression, and pain<br />
Anxiety, depression, and pain<br />
Inflammatory pain<br />
Neuropathic pain<br />
Neuropathic pain<br />
Neuropathic pain<br />
Chronic pain<br />
Chronic pain<br />
Neuropathic pain
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