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Like All Things CNS, It’s Not So Easy<br />
42<br />
F I N A L T R A N S C R I P T<br />
To close <strong>the</strong> Delta section of this call, it<br />
is our interpretation that <strong>the</strong> results of<br />
<strong>the</strong>se preliminary Phase IIa trials of<br />
Dec. 18. 2008 / 8:30AM, ADLR - Adolor Corporation Investor Update Call<br />
Just completed two Phase IIa trials on ADL5859 to explore safety and efficacy in two<br />
distinct models of pain: diabetic ADL5859 peripheral neuropathy were inconclusive as a model of neuropathic as to<br />
pain; and rheumatoid arthritis as a model of chronic inflammatory pain. Nei<strong>the</strong>r<br />
showed statistical significance efficacy. on efficacy Pfizer measures, and we but were continue safe and well to<br />
tolerated. The company is now evaluating <strong>the</strong> current formulation and considering<br />
an increase in exposure and decrease in variability before initiating additional studies<br />
in patients.<br />
believe that Delta Agonists represent an<br />
exciting new class of drugs to treat pain<br />
and are in agreement that both ADL5859<br />
For ADL5747, our second Delta Agonist, we recently have completed enrollment in a<br />
multiple ascending dose Phase and I trial ADL5747 in 32 healthy merit volunteers. continued To date, we clinical have not<br />
observed any dose-limiting toxicity development.<br />
or clinically significant adverse events. Pfizer and<br />
we intend to initiate a proof of concept trial of 5747 in osteoarthritis during <strong>the</strong> third<br />
quarter of 2009 and in neuropathic pain in <strong>the</strong> fourth quarter of 2009.<br />
To close <strong>the</strong> Delta section of this call, it is our interpretation that <strong>the</strong> results of<br />
<strong>the</strong>se preliminary Phase IIa trials of ADL5859 were inconclusive as to efficacy.<br />
Pfizer and we continue to believe that Delta Agonists represent an exciting<br />
new class of drugs to treat pain and are in agreement that both ADL5859 and<br />
ADL5747 merit continued clinical development.<br />
© Defined Health, 2009<br />
Pain Insight Briefing