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Adolor / Pfizer: Making Opioids More Tolerant 40 Pharmaprojects PharmaprojectsR&D R&D Pipeline Pipeline News News Feed Feed Adolor Adolorand and Pfizer Pfizer join join forces forces on on novel novel pain pain compounds compounds 7 Dec Dec 2007 2007 Pfizer Pfizer has has signed signed a deal deal with with Adolor Adolorsecuring securing exclusive exclusive worldwide worldwide rights rights to to two two novel novel compounds compounds for for pain. pain. The The deal deal grants grants Pfizer Pfizer access access to to Adolor's Adolor'sADL-5859 ADL-5859 and and ADL- ADL- 5747, 5747, both both proprietary proprietary delta delta opioid opioidreceptor receptor agonists agonists with with potential potential application application in in a wide wide range range of of inflammatory, inflammatory, neuropathic neuropathic and and acute acute pain pain conditions. conditions. There There are are three three known known opioid opioidreceptors receptors --mu, mu, kappa kappa and and delta. delta. All All current current opioid opioid analgesics analgesics exert exert their their effect effect mainly mainly on on the the mu mu variant, variant, with with no no presently-approved presently-approved compounds compounds ADL-5859 targeted targeted specifically and specifically ADL-5747, at at the the kappa kappa both or or delta delta proprietary types. types. Preclinical Preclinical delta work work suggests opioid suggests that that delta-specific delta-specific receptor agonists agonists may may exhibit exhibit with superior superior potential analgesic analgesic application properties properties to to mu in mu agonists a agonists wide whilst whilst avoiding avoiding some some of of their their common common and and undesirable undesirable side-effects. side-effects. range of inflammatory, neuropathic and acute pain ADL-5859 ADL-5859 is is the the most most advanced advanced compound, compound, currently currently in in Phase Phase IIa IIatrials trials in in inflammatory inflammatory conditions. pain, pain, with with more more Phase Phase II II trials trials planned planned for for 2008. 2008. An An IND IND for for ADL-5747 ADL-5747 is is pending pending and and Adolor Adoloris is planning planning to to initiate initiate clinical clinical development development in in the the first first quarter quarter of of 2008. 2008. © Defined Health, 2009 Pain Insight Briefing
Like All Things CNS, It’s Not So Easy 41 F I N A L T R A N S C R I P T Dec. 18. 2008 / 8:30AM, ADLR - Adolor Corporation Investor Update Call Just completed two Phase IIa trials on ADL5859 to explore safety and efficacy in two distinct models of pain: diabetic peripheral neuropathy as a model of neuropathic pain; and rheumatoid arthritis as a model of chronic inflammatory pain. Neither showed statistical significance on efficacy measures, but were safe and well tolerated. The company is now evaluating the current formulation and considering an increase in exposure and decrease in variability before initiating additional studies in patients. For ADL5747, our second Delta Agonist, we recently have completed enrollment in a multiple ascending dose Phase I trial in 32 healthy volunteers. To date, we have not observed any dose-limiting toxicity or clinically significant adverse events. Pfizer and we intend to initiate a proof of concept trial of 5747 in osteoarthritis during the third quarter of 2009 and in neuropathic pain in the fourth quarter of 2009. To close the Delta section of this call, it is our interpretation that the results of these preliminary Phase IIa trials of ADL5859 were inconclusive as to efficacy. Pfizer and we continue to believe that Delta Agonists represent an exciting new class of drugs to treat pain and are in agreement that both ADL5859 and ADL5747 merit continued clinical development. © Defined Health, 2009 Pain Insight Briefing
- Page 1 and 2: Game Changing Plays in the Pain Mar
- Page 3 and 4: Our Disclaimer 3 The information in
- Page 5 and 6: Everyone Hurts “Pain is whatever
- Page 7 and 8: It’s A Big Market with a Few Domi
- Page 9 and 10: $ Millions But Few “Big Pharma-Si
- Page 11 and 12: Pain Historically: Drug Delivery ha
- Page 13 and 14: It’s Getting Tougher Labopharm La
- Page 15 and 16: The Risk : Reward Profile for Novel
- Page 17 and 18: Current Standard of Care for Pain
- Page 19 and 20: Leaving Plenty of Unmet Need to Be
- Page 21 and 22: In the Meantime, Let’s Teach Old
- Page 23 and 24: A Better NSAID: NicOx • Naproxcin
- Page 25 and 26: A Better NSAID: NicOx 25 Company pr
- Page 27 and 28: A Better NSAID: Pozen / AstraZeneca
- Page 29 and 30: The First-to-Market Topical NSAIDs
- Page 31 and 32: Even So, Flector is Expected To Be
- Page 33 and 34: Now We Have a Patch and a Gel Volta
- Page 35 and 36: The Need is Clear 35 © Defined Hea
- Page 37 and 38: Progenics / Wyeth: Making Opioids M
- Page 39: Adolor / Pfizer: Making Opioids Mor
- Page 43 and 44: A New, and Better Opioid from J&J /
- Page 45 and 46: A New, and Better Opioid from J&J /
- Page 47 and 48: Opioid Abuse Deterrence 47 © Defin
- Page 49 and 50: King Pharmaceuticals: Making Big Be
- Page 51 and 52: But Also Significant Hurdles • Te
- Page 53 and 54: The Technologies are Not the Proble
- Page 55 and 56: The Real Issue is Risk Management
- Page 57 and 58: Fentanyl: Again, REMS is the Big Re
- Page 59 and 60: Lessons from Fentora 59 What the FD
- Page 61 and 62: For Some Mechanisms, the US Regulat
- Page 63 and 64: FAAH Pipeline 63 Compound SSR 10101
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- Page 67 and 68: Addressing the Big Problem 67 >50%
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- Page 73 and 74: TRPV1 • The transient receptor po
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- Page 85 and 86: Good Phase III Data, An Accepted ND
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Adolor / Pfizer: Making Opioids More Tolerant<br />
40<br />
Pharmaprojects PharmaprojectsR&D R&D Pipeline Pipeline News News Feed Feed<br />
Adolor Adolorand and Pfizer Pfizer join join forces forces on on novel novel pain pain compounds<br />
compounds<br />
7 Dec Dec 2007 2007<br />
Pfizer Pfizer has has signed signed a deal deal with with Adolor Adolorsecuring securing exclusive exclusive worldwide worldwide rights rights to to two two novel novel<br />
compounds compounds for for pain. pain. The The deal deal grants grants Pfizer Pfizer access access to to Adolor's Adolor'sADL-5859 ADL-5859 and and ADL- ADL-<br />
5747, 5747, both both proprietary proprietary delta delta opioid opioidreceptor receptor agonists agonists with with potential potential application application<br />
in in a wide wide range range of of inflammatory, inflammatory, neuropathic neuropathic and and acute acute pain pain conditions. conditions.<br />
T<strong>here</strong> T<strong>here</strong> are are three three known known opioid opioidreceptors receptors --mu, mu, kappa kappa and and delta. delta. All All current current opioid opioid<br />
analgesics analgesics exert exert <strong>the</strong>ir <strong>the</strong>ir effect effect mainly mainly on on <strong>the</strong> <strong>the</strong> mu mu variant, variant, with with no no presently-approved<br />
presently-approved<br />
compounds compounds ADL-5859 targeted targeted specifically and specifically ADL-5747, at at <strong>the</strong> <strong>the</strong> kappa kappa both or or delta delta proprietary types. types. Preclinical Preclinical delta work work suggests opioid suggests<br />
that that delta-specific delta-specific receptor agonists agonists may may exhibit exhibit with superior superior potential analgesic analgesic application properties properties to to mu in mu agonists a agonists wide<br />
whilst whilst avoiding avoiding some some of of <strong>the</strong>ir <strong>the</strong>ir common common and and undesirable undesirable side-effects.<br />
side-effects.<br />
range of inflammatory, neuropathic and acute pain<br />
ADL-5859 ADL-5859 is is <strong>the</strong> <strong>the</strong> most most advanced advanced compound, compound, currently currently in in Phase Phase IIa IIatrials trials in in<br />
inflammatory inflammatory conditions.<br />
pain, pain, with with more more Phase Phase II II trials trials planned planned for for 2008. 2008. An An IND IND for for ADL-5747 ADL-5747 is is<br />
pending pending and and Adolor Adoloris is planning planning to to initiate initiate clinical clinical development development in in <strong>the</strong> <strong>the</strong> first first quarter quarter of of<br />
2008. 2008.<br />
© Defined Health, 2009<br />
Pain Insight Briefing
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