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Pain Historically: Drug Delivery has “Delivered” 10 Drug Delivery-Based Pain Products Have Greatly Surpassed Expectations • OXYCONTIN • MS-CONTIN • DURAGESIC • ACTIQ • ORALET • AVINZA • KADIAN • STADOL • LIDODERM © Defined Health, 2009 Pain Insight Briefing The initial sales forecast for Oxycontin was $350 M (Wall Street Journal, May 2002) … now a billion+ dollar franchise.
Pain Historically: Drug Delivery has “Delivered” 11 Drug Delivery-Based Pain Products Have Greatly Surpassed Expectations • The epidemiology of pain is uncertain at best • Off-label use is always greater than anticipated • Nature of a symptom-driven market welcomes the next new thing • Healthy price hikes THE BAR Development Risk Regulatory Risk Market Risk © Defined Health, 2009 Pain Insight Briefing
- Page 1 and 2: Game Changing Plays in the Pain Mar
- Page 3 and 4: Our Disclaimer 3 The information in
- Page 5 and 6: Everyone Hurts “Pain is whatever
- Page 7 and 8: It’s A Big Market with a Few Domi
- Page 9: $ Millions But Few “Big Pharma-Si
- Page 13 and 14: It’s Getting Tougher Labopharm La
- Page 15 and 16: The Risk : Reward Profile for Novel
- Page 17 and 18: Current Standard of Care for Pain
- Page 19 and 20: Leaving Plenty of Unmet Need to Be
- Page 21 and 22: In the Meantime, Let’s Teach Old
- Page 23 and 24: A Better NSAID: NicOx • Naproxcin
- Page 25 and 26: A Better NSAID: NicOx 25 Company pr
- Page 27 and 28: A Better NSAID: Pozen / AstraZeneca
- Page 29 and 30: The First-to-Market Topical NSAIDs
- Page 31 and 32: Even So, Flector is Expected To Be
- Page 33 and 34: Now We Have a Patch and a Gel Volta
- Page 35 and 36: The Need is Clear 35 © Defined Hea
- Page 37 and 38: Progenics / Wyeth: Making Opioids M
- Page 39 and 40: Adolor / Pfizer: Making Opioids Mor
- Page 41 and 42: Like All Things CNS, It’s Not So
- Page 43 and 44: A New, and Better Opioid from J&J /
- Page 45 and 46: A New, and Better Opioid from J&J /
- Page 47 and 48: Opioid Abuse Deterrence 47 © Defin
- Page 49 and 50: King Pharmaceuticals: Making Big Be
- Page 51 and 52: But Also Significant Hurdles • Te
- Page 53 and 54: The Technologies are Not the Proble
- Page 55 and 56: The Real Issue is Risk Management
- Page 57 and 58: Fentanyl: Again, REMS is the Big Re
- Page 59 and 60: Lessons from Fentora 59 What the FD
Pain Historically: Drug Delivery has “Delivered”<br />
10<br />
Drug Delivery-Based Pain Products Have Greatly Surpassed Expectations<br />
• OXYCONTIN<br />
• MS-CONTIN<br />
• DURAGESIC<br />
• ACTIQ<br />
• ORALET<br />
• AVINZA<br />
• KADIAN<br />
• STADOL<br />
• LIDODERM<br />
© Defined Health, 2009<br />
Pain Insight Briefing<br />
The initial sales forecast for<br />
Oxycontin was $350 M (Wall<br />
Street Journal, May 2002) …<br />
now a billion+ dollar franchise.
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