ijapr - international journal of advances in pharmaceutical research

M.S Latha et al. / International Journal of Advances in Pharmaceutical Research
CONCLUSION
The results presented in this study indicate that the
HCC induced by N-nitrosodiethylamine was
effectively inhibited by the treatment with MEWF at
a dose of 200 mg/kg, b.w. When compared to
standard drug silymarin treated group, the MEWF
treated group showed better efficacy towards NDEA
induced hepatocellular carcinoma. In rats treated with
MEWF alone no significant change was observed.
The pretreatment with MEWF on pathological
conditions in chronic hepatic disorder such as HCC
showed remarkable protection; provide a new
approach to study the active principle responsible for
chemoprevention in tumor models. However further
work is required for the fractionation of MEWF and
identification of the active compound which is
underway.
Conflict of interest statement
We declare that we have no conflict of interest.
Acknowledgments
Financial assistance from Mahatma Gandhi
University as Junior Research Fellowship to Nitha
Anand is thankfully acknowledged. Authors also
thankful to Dr. P.J Wills, Scientist, MIMS research
foundation, Calicut., Ms. Jyothi Lekshmi M,
Research scholar, SBS, M. G. University, Kottayam
and Ms. Reshmi Radhakrishnan, project staff, SBS,
M.G University, Kottayam for their help in this work.
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