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www.pelobiotech.com Essential Extras • Antibodies • Dyes • Proteins • TR-FRET Reagents o Europium chelates • Reagents • Tools • Sample Preparation Tools • Safety tools 62
www.pelobiotech.com Antibodies Antibodies are glycoproteins produced by plasma cells in response to foreign antigens that illicit an innate immune response. Due to recombination of the genes the variety of antibody responses is vast but highly specific, monoclonal antibodies are produced by clonally expanded by lymphocytes against a specific antigen and these have similar antigen binding site region binding affinity for their targets and identical downstream effects. These antibodies are often used in biochemical analysis, radioimmunotherapy, detection of various viruses and diseases. We offer various antibodies for detection of immune cells, proteins, epigenetic modifications, viruses, stemness and diseases. Amyloidosis is one such disease which is difficult to diagnose due to the heterogeneity of the amyloid proteins. The gold standard for amyloidosis diagnosis is tissue biopsy followed by Congo red staining and confirmation through characteristic apple-green birefringence under polarized light microscopy. However, biopsies may not always be feasible or accessible, and sampling errors can occur due to the focal nature of amyloid deposition. Additionally, immunohistochemistry, immunofluorescence, and electron microscopy can aid in subtype identification. However, these techniques have limitations in detecting small or oligomeric forms of amyloid fibrils. Currently amYmed is the only company that offers antibodies designed for detecting amyloidosis. The immunohistochemical classification of amyloid using the amY-kit antibodies is a key offering from amYmed. Their antibody panel consists of 10 tubes with 16 antibodies, covering 98% of the most common amyloidosis. The accuracy of their classification method has been validated through extensive studies, blind comparative analyses, and collaborations with other institutes. Comparisons with mass spectrometry have further confirmed the reliability and quality of their approach. The advantages of immunohistochemical classification include its precision, simplicity, speed, and affordability. By utilizing this technique, healthcare professionals can quickly identify the correct amyloid type, even in the early stages of the disease, allowing for timely intervention and management. If you would like to know more about Amyloidosis then please take a look at our article on our website here. You can also check out articles by a leading researcher in the field of amyloidosis here. 63
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