PeloBiotech

www.pelobiotech.com
Blood-Brain-Barrier (BBB) system
Realistic. Dynamic. Cell-Based Assays
SynVivo offers a physiological, cell-based microchip platform that provides a morphologically and biologically realistic
microenvironment allowing real-time study of cellular behavior, drug delivery and drug discovery.
A Microfluidic Cell-based Assay Platform imprinted with real microvasculature morphology...
…cultured with cells and studied under physiological flow to provide a more realistic in vitro assay.
How it works...
Use Microvascular Networks to replicate in vivo cell/particle adhesion
and cell-cell or cell-particle interactions in an in vitro setting.
Investigate effects of flow and morphology for drug development and
cellular research. Obtain shear-adhesion maps and bifurcation vs.
branch adhesion in single experiment.
By incorporating natural tissue regions within the network topology,
the co-culture networks allow study of cell and drug behavior at and
across the interface between the vessel lumen and tissue space. The
co-culture network constructs are available with several options for
channel size, tissue region scaffolding, barrier design and 3D tumor
models. Intended to mimic the formation of and transport across tight
and gap junctions such as the blood-brain barrier (BBB) and other
endothelial/tissue interfaces, the idealized co-culture constructs are
available with several options for channel size, tissue chamber size
and scaffolding, and barrier design.
The Most Realistic In vitro Blood-Brain Barrier Model
SynVivo’s Blood-Brain-Barrier (BBB) system recreates the in vivo microenvironment by emulating a histological slice of
brain tissue cells in communication with endothelial cells across the BBB. SynVivo-BBB avoids limitations of traditional BBB
models such as lack of physiological shear stress and real-time visualization capability. The SynVivo-BBB system serves as
an exceptionally versatile platform, offering comprehensive investigation capabilities across various domains. This
innovative system enables in-depth exploration of tight junction proteins, transporter proteins, drug permeability,
inflammation, cell migration, omic changes, neurotoxicity, and neuro-oncology within the intricate framework of the
blood-brain barrier (BBB). Its adaptability extends to diverse application areas, making it an invaluable tool for basic
research, drug delivery optimization, drug discovery acceleration, and ADME/Tox assessment. Researchers benefit from a
realistic environment to unravel BBB dynamics and phenomena, optimize drug delivery strategies, expedite drug discovery
processes, and assess critical drug characteristics. The SynVivo-BBB system stands at the forefront of scientific
advancements, fostering a deeper understanding of biological processes and contributing to breakthroughs in research and
pharmaceutical development.
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