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3D Hydrogel-based<br />
Organotypic Hydrogels - TissueSpec® Matrix Hydrogel<br />
TissueSpec ® Hydrogel Kits are acellular matrix products derived from a<br />
variety of porcine organs and tissues. Versatile<br />
in format, hydrogel matrix kits offer the matrix components present in<br />
natural tissues and recreates a physiological substrate for 3D cell culture.<br />
TissueSpec® Hydrogel Kits have been shown to enhance cell attachment,<br />
growth, and function in stem cell research. These<br />
kits are designed for easy application in cell culture and provide structural,<br />
mechanical, and compositional cues of the native tissue<br />
microenvironment.<br />
TissueSpec ® Liver Hydrogel contains liver specific matrix components.<br />
• Compatible with standard cell culture programs<br />
• Lot to lot Consistency<br />
• Easy to Use<br />
Hydrogel can be applied as a thin gel. Liver cells migrate into<br />
hydrogel, enabling migration and invasion assays.<br />
Low-density lipoprotein uptake<br />
TissueSpec® Liver Hydrogel. liver cells show higher expression of LDL<br />
receptor and secretion of fibrinogen. pics: Xylyx Bio<br />
For optimal results: Combine Microvascular Endothelial Cell Growth Medium Kit enhanced (PB-MH 100-4099) with<br />
PELOBiotech-Cells. Ask for our human and animal cell list.<br />
Natural Hydrogels – Collagen & Fibronectin<br />
MatriMix<br />
The first MatriMix product, MatriMix (511), is composed of fibrillar collagen, recombinant human laminin-511 E8<br />
fragment, and hyaluronic acid. The types of collagen, isoforms of laminin, and the concentration of each component have<br />
been customized to provide the optimal extracellular environment for your target cells. Gelation takes advantage of<br />
collagen's ability to form fibers at a physiological temperature and solvent environment.<br />
52<br />
Figure 1 Cells derived from<br />
tissues during mouse<br />
development were cultured<br />
in 3D using MatriMix. Cell<br />
organization occurred by day<br />
7 of culture.