PeloBiotech
Create successful ePaper yourself
Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.
www.pelobiotech.com<br />
SEEDEZ TM<br />
What is SEEDEZ TM ?<br />
Our partner Lena Biosciences offers a robust 3D cell culture system for routine, predictive testing in vitro. SEEDEZ TM is a<br />
three-dimensional cell culture scaffold made of randomly oriented, inert glass microfibers. The diameter of microfibers is<br />
carefully optimized for long-term cell growth and repeat-dose drug testing. The microfibers are arranged in such a way that<br />
creates tiny pores for nutrients, gases, and metabolites to pass through the scaffold allowing normal cell functions.<br />
With a simple workflow and consistent composition, SEEDEZ TM can be used with all cell types. SEEDEZ TM enables the cells<br />
to utilize their cadherin (cell-to-cell connections) and integrin (cell-to-ECM) receptors which are vital for biomimetic<br />
functions of the engineered tissue.<br />
Unlike soft hydrogel-based scaffolds SEEDEZ TM does not peel off the culture dish or get drawn into the pipette tip. When<br />
compared to less porous and more rigid scaffolds, cells permeate SEEDEZ TM readily.<br />
How it works!<br />
At a glance:<br />
• Supports most cell types<br />
• Supports most ECMs<br />
• Consistent 3D cell distribution<br />
• Consistent cultures<br />
• Long-term culture (2 months+)<br />
• In-well assaying<br />
• Assay multiplexing<br />
• Fluorescence imaging<br />
• Easy to transfer from dish-to-dish<br />
• Cells can be recovered<br />
• Custom diameters upon request<br />
Applications:<br />
• Culture complex 3D cell culture and co-culture models long-term;<br />
• Small molecule drug testing (drug metabolism, toxicity etc.);<br />
• Testing on-target efficacy/ off-target toxicity of antibody-drugconjugates<br />
& multi-specific antibodies.<br />
SEEDEZ TM<br />
So easy to use!<br />
Just unwrap product, add cell suspension in appropriate medium at optimized seeding density and place in incubator to<br />
culture cells in 3D<br />
Is SEEDEZ TM compatible with other assays?<br />
3D tissues grown in SEEDEZ TM can be studied using a variety of standard molecular and cellular techniques. Cells can be<br />
harvested by using passaging solutions (e.g. trypsin or Accutase. DNA/RNA and proteins can be isolated direct out of the<br />
scaffolds.<br />
49
Change language