PeloBiotech

www.pelobiotech.com
lymphangiogenesis in a lymphatic organotypic co-culture model, providing valuable insights into the mechanisms
underlying lymphatic vessel formation in the context of tumor microenvironment. Endothelial cells from the lymphatic
system have been extensively studied for their role in lymphangiogenesis and the development of the lymphatic
vasculature.
Studies have demonstrated that Prox1 is a master control gene in the program specifying lymphatic endothelial cell fate,
highlighting its essential role in the induction of the lymphatic endothelial cell phenotype. The expression of podoplanin
in stromal fibroblasts has been associated with high lymphatic vessel density in triple-negative, basal marker-expressing,
and high-grade breast carcinomas, indicating its potential as a marker for lymphatic endothelial cells and
lymphangiogenesis. The differential response of lymphatic endothelial cells to angiopoietin-1 and angiopoietin-2 has
been investigated, providing insights into the molecular regulation of lymphangiogenesis and the distinct functions of
angiopoietins in lymphatic vessel development.
Skeletal system
We offer a variety of synovial cells, chondrocytes, osteoblasts, endothelial cells from various vessels, and tenocytes
sourced from different animal species, with cell RNA from adults and fetuses all of which are extracted from various
bones. Synovial cells have been studied for their modulatory effect on cell phenotype and metabolic behavior in
osteoarthritic patients, providing insights into the inflammatory and metabolomic profile of synovial fluid and its impact
on synovial cell behavior. Additionally, the inflammatory response of synovial fibroblasts has been investigated, shedding
light on the regulation of synovial cell growth by polypeptide growth factors. Chondrocytes have been extensively utilized
in the study of cartilage regeneration and the development of high-quality cartilage. Studies have focused on the potential
of aged human articular chondrocytes for cartilage regeneration, aiming to reverse chondrocyte aging and enhance
cartilage regeneration. Furthermore, the role of microRNA-224 in suppressing osteoblast differentiation by inhibiting
SMAD4 has been investigated, providing insights into the molecular mechanisms underlying osteoblast differentiation
and function.
Osteoblasts have been studied for their role in bone formation and bone-related diseases, with a focus on the regulation
of osteoblast proliferation and differentiation. The knockout of the BK channel in osteoblasts has been investigated to
determine its impact on osteoblast function and bone formation. The proliferative actions of parathyroid hormonerelated
protein (PTHrP) in chondrocytes have been studied, highlighting the role of the cyclin-dependent kinase inhibitor
p57Kip2 in mediating PTHrP-induced proliferation in chondrocytes.
Circulatory system
We provide a diverse array of cells from different animal species, isolated from various arteries and veins. Our offerings
include endothelial cells, MSCs, fibroblasts, peripheral blood cells with a variety of markers, NK cells, monocytes, and
blood cells. Additionally, we offer MSCs with GFP and RFP tags, as well as smooth muscle cells, with available cell RNA.
Mesenchymal stem cells (MSCs) have been extensively studied and utilized in various research and clinical applications
due to their regenerative and immunomodulatory properties. MSCs have been identified and isolated from different
sources, including the umbilical cord, bone marrow, adipose tissue, and other tissues. These cells have shown potential
for use in tissue engineering, regenerative medicine, and immunotherapy. The expression of specific surface markers and
the characterization of MSCs from various sources have been the focus of numerous studies, aiming to understand their
properties and potential applications.
Peripheral blood cells with a variety of markers have been extensively studied for their role in the immune response and
as a source of hematopoietic stem cells. These cells have been used in the study of immune cell populations, including T
cells, B cells, and natural killer (NK) cells. The expression of specific markers on peripheral blood cells has been investigated
to understand their functions and to develop targeted therapies for various diseases. NK cells, a type of cytotoxic
lymphocyte, have been studied for their role in the immune response against infected or malignant cells. These cells have
been investigated for their potential use in cancer immunotherapy and as a treatment for viral infections. The expression
of specific markers on NK cells has been studied to understand their activation and cytotoxic functions.
Monocytes, which are a type of white blood cell, have been extensively studied for their role in the immune response
and as precursors to macrophages and dendritic cells. These cells have been investigated for their potential use in
immunotherapy and as a source of antigen-presenting cells. The expression of specific markers on monocytes has been
studied to understand their differentiation and immune functions.
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