PeloBiotech

www.pelobiotech.com
4. Detailed Donor Information:
We offer in-depth donor information, including gender, age, ethnicity, BMI, cause of death, smoking and
alcohol history, HLA typing, serology data, and past medical records, allowing you to choose cells that align
with your specific research requirements.
5. Versatility in Testing:
Our hepatocytes are not only plateable but also 3D tested, offering versatility for various research applications,
from monolayer cultures to complex 3D experiments. Please contact us for detailed information about 3D cell
culture to find out how we can help you better.
Explore the intricate and vital role of hepatocytes in the human body's metabolism of xenobiotics and
drugs by reading our article on our News section on website for in-depth information. Just scan the QR
code for direct access.
Scan the QR code to see our full cell list.
Fibroblasts contribute to studies on liver fibrosis and tissue repair, shedding light on the cellular dynamics in hepatic
wound healing. Kupffer cells, as liver-resident macrophages, are key players in immune response studies, inflammation,
and liver pathophysiology. Stellate cells, involved in liver fibrosis, are integral for investigations into hepatic stellate cell
activation and its impact on liver health.
Hematopoietic stem cells extracted from the liver provide a unique perspective on hematopoiesis and immune cell
development. Non-parenchymal cells, comprising various liver cell types, enable comprehensive studies encompassing
liver microenvironment, cell-to-cell interactions, and organ-specific responses to therapeutic interventions.
Stellate cells, also known as hepatic stellate cells, play a significant role in liver fibrosis, and their activation is a key event
in the development of fibrosis. They are involved in the resolution of liver injury and are the primary storage site for
retinoids in the liver. Additionally, stellate cells have been shown to express desmin, suggesting their contribution to the
stellate cell population. Furthermore, stellate cells have been implicated in the regulation of liver fibrosis and have been
shown to produce increased levels of inflammatory mediators, contributing to the fibrogenic program of liver cells. They
are also involved in the turnover of extracellular matrix, and their activation is a major pathogenic determinant of liver
fibrosis. Moreover, stellate cells have been shown to be coupled to one another by gap junctions, indicating their role in
intercellular communication. Additionally, stellate cells have been studied in the context of liver regeneration, and their
inhibition has been shown to reduce renal fibrosis.
Kupffer cells, which are liver-resident macrophages, play a crucial role in liver homeostasis, inflammation, and immune
regulation. They have been implicated in the pathogenesis of wound healing and fibrosis in the liver. Kupffer cells have
been shown to be involved in the regulation of stellate cell activation and susceptibility to fibrotic liver disease.
Sinusoidal microvascular endothelial cells, which line the hepatic sinusoids, have been studied for their involvement in
liver fibrogenesis and the resolution of liver injury. They have been shown to be regulated by vitamin A and retinoic acid
signaling, which are essential for their development and liver morphogenesis. Endothelin antagonism has been studied in
the context of hepatic fibrosis, implicating endothelial cells in the pathogenesis of wound healing and fibrosis.
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