PeloBiotech

www.pelobiotech.com
HUVECs have been used in the cultivation of cardiovascular grafts to study fibrinolytic parameters. The versatility of
HUVECs is evident in their application in various fields such as medicine, biology, and endothelial dysfunction research.
HUVECs have also been employed in the investigation of signaling pathways, including the lactate/NFkB/IL-8 pathway,
which plays a crucial role in tumor metabolism and angiogenesis. HUVECs have been utilized to study the interaction
between TRPV4 and KCa2.3 in the context of hypertension treatment.
The significance of HUVECs in research is further emphasized by their use in the study of autophagy, apoptosis, and
oxidative stress, as well as their role in modeling atherosclerosis and investigating protective mechanisms against injury.
GFP-tagged with liposomes and viruses HUVECs offer real-time visualization of subcellular structures, facilitating studies
on cellular dynamics and interactions. Conditionally immortalized umbilical cord MSCs are valuable for regenerative
medicine research, exploring their potential in tissue engineering and cell-based therapies.
Breast
We isolate epithelial cells, fibroblasts, endothelial cells, breast cancer cells from tumors, as well as patient-derived
xenograft (PDX) cells, and breast cancer-associated fibroblasts from breast tissue. These samples are sourced from
various species. The use of epithelial cells, fibroblasts, endothelial cells, breast cancer cells from tumors, patient-derived
xenograft (PDX) cells, and breast cancer-associated fibroblasts from breast tissue are diverse and significant in various
research and clinical applications. Epithelial cells have been utilized in the separation of breast cancer cells from peripherally
circulating blood, particularly through the use of antibodies fixed in microchannels, which enables the isolation of breast
cancer cells at an early stage of tumor growth and metastasis.
Fibroblasts have been employed in regenerative medicine due to their potential to provide appropriate cross-talk and
extracellular matrix (ECM) production to maintain tissue homeostasis and enable repair. Additionally, fibroblasts have
been used in the treatment of skin disorders, such as recessive dystrophic epidermolysis bullosa, and have been applied
as a biological dressing in wound beds. Furthermore, fibroblasts have been studied for their paracrine anti-fibrotic effects
on young and senescent human dermal fibroblasts, indicating their potential in wound repair and regeneration.
Breast cancer cells from tumors have been utilized in various studies, including the investigation of cancer-associated
fibroblasts (CAFs) inducing epithelial–mesenchymal transition (EMT) of breast cancer cells through paracrine TGF-β
signaling, and the promotion of breast cancer cell malignancy via CXCL5 secretion in the tumor microenvironment.
Additionally, patient-derived tumor cells, combined with three-dimensional culture technology, have been used to form
breast cancer organoids that resemble the in vivo tumor structure. Furthermore, patient-derived xenograft (PDX) cells
have been employed in studying the progression of breast cancer through the regulation of epithelial and stromal cell
signaling in the TGF-β pathway. Breast cancer-associated fibroblasts from breast tissue have been studied for their role in
promoting breast tumorigenesis through the secretion of hepatocyte growth factor and the expansion of cancer-stem like
cells. Additionally, engineered human breast tissue models have been used to show that ATR-deficient breast stromal
fibroblasts enhance the growth of breast cancer cells.
Ovaries
We isolate epithelial cells, fibroblasts, endothelial cells, smooth muscle cells, and ovarian cancer cells from tumors, in
addition to patient-derived xenograft (PDX) cells and ovarian cancer-associated fibroblasts from ovarian tissue. These
samples are sourced from various species. Epithelial cells are crucial for studying tissue development and differentiation,
while fibroblasts play a pivotal role in extracellular matrix synthesis and tissue remodeling. Endothelial cells contribute to
angiogenesis and vascular biology, and smooth muscle cells are integral in understanding vascular and muscular
physiology. Isolating ovarian cancer cells from tumors facilitates studies on cancer progression and potential therapeutic
targets. PDX cells, derived from patient tumors and engrafted into immunocompromised mice, serve as powerful models
for preclinical drug testing, allowing researchers to assess treatment efficacy and tumor response in a more clinically
relevant context. Ovarian cancer-associated fibroblasts derived from ovarian tissues contribute to the understanding of
tumor microenvironment interactions.
Testes and prostate
We extract epithelial cells, fibroblasts, endothelial cells, smooth muscle cells, and prostate cancer cells from tumors, in
addition to patient-derived xenograft (PDX) cells and prostate cancer-associated fibroblasts from prostate tissue. These
samples are sourced from various species. Additionally, total RNA from the prostate and testes is also available. Epithelial
cells are vital for studying tissue structure and function, often applied in investigations related to epithelial biology, wound
healing, and drug response.
Fibroblasts have been employed in the regulation of biomechanical properties of human microvascular endothelial cells,
indicating their significance in cancer cell interactions and the tumor microenvironment. Fibroblasts have been studied for
their potential role in the regulation of the immune and epithelial barrier responses in the prostate. Endothelial cells play
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