PeloBiotech

www.pelobiotech.com
Pancreas
We extract beta cells and diseased cells from diabetic
patients from the pancreas. Additionally, we isolate
endothelial cells, epithelial cells, fibroblasts, and PDX
cancer cells from different pancreatic regions and various
species. The uses of beta cells in research are extensive
and diverse. Studies have focused on understanding the
factors influencing beta cell turnover, proliferation, and
functional state, particularly in the context of diabetes and
regenerative therapy.
Research has explored the essential role of Nkx6.1 in
maintaining the functional state of pancreatic beta cells,
adaptive changes in beta cell turnover during pregnancy,
the relationship between beta-cell mass and obesity/type 2
diabetes, and the gene regulatory network required for
establishing and maintaining pancreatic beta cell identity.
Additionally, the beta cell workload hypothesis has been
revisited in the context of type 2 diabetes, and
mathematical modeling has been used to estimate the long lifespan and low turnover of human islet beta cells.
Studies have investigated the proliferation of sorted human and rat beta cells, targeted insulin-producing beta cells for
regenerative therapy, and explored the potential for beta cell regeneration in aging pancreatic beta cells. Single-cell RNA
sequencing has revealed a role for reactive oxygen species and peroxiredoxins in fatty acid-induced rat beta-cell
proliferation, and reciprocal modulation of adult beta cell maturity by activin A and follistatin has been studied. Moreover,
research has focused on beta cell regeneration after immunological destruction in a mouse model, explored the potential
for making better beta cells, and investigated agents inducing both alpha and beta cell proliferation without affecting
differentiation or viability. Additionally, efforts have been made to expand human beta cells, and heterogeneities of normal
and stimulated pancreatic beta cells have been examined. These studies collectively contribute to a comprehensive
understanding of beta cell biology and its implications for diabetes and regenerative medicine.
Lungs and Oral cavity
Apart from isolated and iPS derived alveolar and
bronchial epithelial cells, fibroblasts, smooth muscle
cells, macrophages, endothelial cells PDX cancer cells,
mesenchymal stem cells from different regions of the
heart and various species. The uses of iPS-derived
alveolar and bronchial epithelial cells, fibroblasts,
smooth muscle cells, macrophages, endothelial cells,
PDX cancer cells, and mesenchymal stem cells from
different regions of the heart and various species are
diverse and impactful in biomedical research. Patientderived
xenograft (PDX) models have been extensively
used in cancer research to simulate human tumor
biology in vivo, aiding in the development of anticancer
drugs and providing a better representation of tumor
heterogeneity and the tumor microenvironment.
Mesenchymal stem cells (MSCs) have shown promise in the treatment of chronic lung diseases and ischemic heart
disease, with studies demonstrating their potential for myocardial survival and repair, as well as their ability to
differentiate into endothelial cells, vascular smooth muscle cells, or cardiac-like myocytes when transplanted into the
ischemic heart. Smooth muscle cells have been studied for their contractile properties and their association with neuroglial
cells and interstitial cells of Cajal in intestinal tissue engineering. Additionally, endothelial and smooth muscle cells have
been isolated and characterized from coronary vessels, providing insights into their contractile phenotype and potential
applications in vascular research.
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