PeloBiotech

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You can also check out our Heart slices for toxicology, arrythmia related work which is more translationally relevant. You
can read more about the use of heart slices for research in this article here.
Brain
Apart from isolated and iPS derived astrocytes, Schwann cell like cells, microglia, oligodendrocytes, sensory neurons,
cortical neurons, dopamergic neurons we also isolate endothelial
cells, glioblastomas, pericytes, neuron precursor cells from different
regions of the heart and from various species. Isolated and induced
pluripotent stem (iPS) cell-derived neural cell types, such as
astrocytes, Schwann cell-like cells, microglia, oligodendrocytes,
sensory neurons, cortical neurons, and dopaminergic neurons, serve
as invaluable tools across a spectrum of studies and applications.
Astrocytes, Schwann cell-like cells, microglia, and oligodendrocytes
play crucial roles in various aspects of neuroscience research.
Astrocytes, for instance, are involved in the regulation of cerebral blood
flow, maintenance of synaptic environments, and modulation of
synapse formation and synaptic transmission. They are also implicated in the glymphatic system's ability to eliminate waste
in the brain and are essential for the maintenance of brain homeostasis and neuronal protection. Furthermore, astrocytes
are involved in regulating neuronal synaptogenesis, maintaining blood-brain barrier integrity, and recycling
neurotransmitters. Additionally, they have been shown to mediate analogous memory in a multi-layer neuron-astrocyte
network, and targeting astrocytic function may protect against brain injury induced by blood-brain barrier disruption.
Schwann cell-like cells have been studied for their morphological, transcriptional, and functional differences from mouse
astrocytes, and they play key roles in supporting the central nervous system structure, regulating synaptic functions, and
maintaining brain homeostasis. Microglia, on the other hand, have been found to regulate synapses, neuronal circuits, and
behavior, and they are thought to play a pivotal role in coupling neural activity and cerebral blood flow. Oligodendrocytes,
which are responsible for producing myelin in the central nervous system, have been implicated in the regulation of neuronal
excitability, synaptic transmission, plasticity, and in higher cognitive functions, including the initiation, maintenance, and
consolidation of memories.
Additionally, isolated endothelial cells, glioblastomas, pericytes, and neuron precursor cells from various brain regions
offer insights into angiogenesis, brain tumors, blood-brain barrier function, and neurogenesis, respectively. These diverse
neural cell types facilitate a broad range of studies, including disease modeling, drug screening, neurotoxicity testing, and
elucidating fundamental mechanisms underlying neurological and neurodegenerative disorders.
We also offer brain tissue slices Brain slices, including brain and root ganglionic slices, are valuable tools in neuroscience
research due to their ability to provide a controlled and accessible model for studying various aspects of neuroscience.
Brain slices have been widely used to study neuronal differentiation, cell differentiation, and synaptic transmission. They
have also been utilized to model neurodegenerative proteinopathies and to enhance the quality of acute slice preparations,
particularly for electrophysiology studies.
Brain slices have been instrumental in profiling sequential sections with multiplex staining, which benefits research in life
sciences. Furthermore, brain slice preparations have been validated for enhancing neuronal preservation and overall brain
slice viability, making them essential for studying metabolic changes and facilitating experimentation on age-related
disorders. Moreover, root ganglionic slices, such as dorsal root ganglion neurons, have been used to study neuronal
connectivity, synaptic transmission, and plasticity, as well as to perform whole-cell patch-clamp recordings, allowing
precise measurement of cellular and synaptic properties.
The dorsal root ganglion has been identified as a novel neuromodulatory target for evoking strong and reproducible
motor responses in chronic motor complete spinal cord injury. Studies have been conducted on the trigeminal ganglion
morphology in human fetuses, and the trigeminal ganglion has been studied for its potential in treating trigeminal
neuralgia.
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