PeloBiotech

www.pelobiotech.com
Adult Stem Cells
Adult stem cells, also known as somatic or multipotent stem cells, are a unique class of undifferentiated cells found within
various tissues and organs of the human body. Unlike embryonic stem cells, which can differentiate into any cell type,
adult stem cells are more restricted in their potential but still possess the ability to develop into a range of specialized cell
types within the specific tissue or organ where they reside as shown in the figure above. However, these cells play a vital
role in tissue maintenance. As you can see in the figure they form cells that repair, and aid in regeneration throughout an
individual's life, making them a valuable resource for regenerative medicine and research aimed at understanding and
treating various medical conditions. We offer the following cells:
• Hematopoietic CD34+ stem cells and Mononuclear cells to isolate CD34 or CD113 cells
• Available from both males and females, complete with donor clinical status.
• Sourced from peripheral blood, cord blood and bone marrow.
CD34 is a crucial marker for various progenitor cells, particularly hematopoietic stem cells (HSC) and hematopoietic
progenitor cells (Sidney et al., 2014). It plays a significant role in hematopoiesis, as evidenced by its presence in progenitor
cells during hematopoiesis, and its potential to give rise to hematopoietic, endothelial cells, and smooth muscle cells
(Kapoor et al., 2019; Bai et al., 2009). CD34 has been linked to cellular homing patterns to the bone marrow and adhesion
of cells to stromal microenvironments or sites of inflammation (Kopher et al., 2010). Furthermore, CD34(+) stem cells
have been found to play an important role during liver development and regeneration (Park et al., 2015). Additionally,
CD34 has been associated with the regulation and compartmentalization of stem cells, promoting their adhesive
interactions with the stromal microenvironment of the bone marrow (Healy et al., 1995). It has also been identified as a
marker for hematopoietic stem cells and non-hematopoietic progenitors, including vascular endothelial progenitors and
embryonic fibroblasts, multipotent mesenchymal stromal cells, interstitial dendritic cells, and epithelial progenitors
(Soliman, 2021). Moreover, CD34 has been utilized as an important marker for labeling hematopoietic stem cells,
demonstrating its significance in stem cell research and applications (Ye et al., 2004).
Mesenchymal/Stromal Stem cells
Mesenchymal stromal cells (MSCs), often called mesenchymal stem cells, are adult stem cells found in bone marrow,
adipose, Wharton jelly and other tissues. Notable characteristics include:
• Differentiation into various cell types, such as bone, cartilage, and fat cells.
• Immune system modulation, making them valuable for treating autoimmune diseases, inflammatory conditions,
and tissue damage.
• Regenerative properties that promote tissue repair.
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