YSM Issue 97.1

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NEWS Astronomy / Social Medicine LIFE OUT OF BALANCE THE TILTED PLANET PHENOMENON BY ESTELLA WITTSTRUCK THE RIPPLE EFFECT HOW SOCIAL STRESSORS IMPACT FETAL BRAIN DEVELOPMENT BY JIYA MODY IMAGE COURTESY OF TONYNETONE VIA FLICKR IMAGE COURTESY OF ANDRE FURTADO VIA PEXELS Scientists believe that when planetary systems first form, they are in a pristine, near-resonant state. Near-resonance describes when the orbits of multiple planets meet in set ratios and the planets regularly line up during their orbits. Nearresonant planets are expected to orbit in the same direction as their star’s rotation—an orientation known as alignment. However, orbits often aren’t perfectly aligned. Malena Rice GSAS ’22, an assistant professor of astronomy at Yale, researched a group of near-resonant planets to better understand why so many planetary systems have misaligned, sideways, or backward orbits. “The fact that we have all these weird, wacky planets means we can study other kinds of systems as we’re working toward understanding how our solar system fits into a broader picture,” Rice said. Rice examined the tilts of orbits in near-resonant systems through the Stellar Obliquities in Long-period Exoplanet Systems survey, founded by Rice as a PhD student. With telescopes, Rice and an international team of collaborators recorded the properties of large planet TOI-2202 b. Despite TOI-2202 b being in a near-resonant system, its orbit was still tilted by twenty degrees, likely from interacting with other celestial bodies. The reason for this dramatic tilt is unknown, but discoveries like this help scientists get closer to the answer. While TOI-2202 b is the most tilted example to date, several other near-resonant systems demonstrate a similar slant. “A lot of planetary systems are being tilted a little bit; there’s this low-level dynamical disturbance that is regularly occurring,” Rice said. “Understanding their properties helps us to engage with how amazing the laws of the universe are on a broad scale.” ■ A groundbreaking study conducted by a team of researchers from Yale and Columbia University found that a pregnant woman’s experience of discrimination and acculturation, or assimilation to a new culture, can leave a lasting imprint on their infant’s brain, altering key emotional processing centers. The collaboration between Yale’s Multi-modal Imaging, Neuroinformatics, & Data Science Laboratory and Columbia’s Early Neuroimaging, Neuroimmune, and Neuropsychology Lab examined the experiences of Latina women in New York City’s Washington Heights neighborhood. By measuring brain activity with a technique known as functional magnetic resonance imaging, the study examined changes in functional connectivity—how parts of the brain interact with each other—in infants. The study found that negative experiences during pregnancy, including discrimination, acculturation, stress, anxiety, and depression, have distinct effects. Infants from mothers facing higher discrimination levels exhibited weaker connectivity in the amygdala (the brain’s emotional processing center) and stronger connectivity in the fusiform cortex (the facial processing site). Acculturation was associated with weaker connectivity in both areas among infants. The findings have important implications for healthcare professionals, particularly in prenatal care. Dustin Scheinost GSAS ’13, an associate professor of radiology and biomedical imaging at Yale and the senior author of the study, emphasized the importance of screening for acculturation to improve maternal and newborn outcomes. The results, he explained, underscore the need for broader societal awareness of the long-lasting physical impacts of discriminatory experiences. “How we treat each other is pretty important,” Schienost said. This study adds to the mountain of evidence showing that discrimination harms not only the person experiencing it, but also future generations—a powerful argument for working toward a more just and inclusive world. ■ 6 Yale Scientific Magazine March 2024 www.yalescientific.org

Biology / Mathematical Ecology NEWS MIMICKING TUMOR INTERACTIONS A NEW PATH TOWARD PERSONALIZED CANCER THERAPY BY NUSAIBA ISLAM SSSENSITIVE SNAKES HUNTING WITH PRECISE INFRARED SENSORS BY LYNNA THAI IMAGE COURTESY OF WEINING ZHONG VIA FLICKR IMAGE COURTESY OF GEOFF GALLICE VIA FLICKR In a world where cancer claims millions of lives every year, a pioneering study by Yale’s Krishnaswamy lab in collaboration with the University College London Cancer Institute shines a beacon of hope by introducing a novel method that personalizes cancer therapy based on a patient’s unique genetic profile. Their study employed patient-derived organoids (PDOs) and cancer-associated fibroblasts (CAFs) to replicate the tumor’s environment in the lab. PDOs are small, lab-created structures that simulate the complexity of real tumors, while CAFs are cells within tumors that aid cancer growth. By employing heavy metal labels for molecular analysis and a unique data analysis system named “Trellis,” the team tracked each cell’s drug response, identifying those resistant to chemotherapy for targeted future treatments. Alexander Tong GSAS ’20 and ’21, a former graduate student in the Krishnaswamy lab and an author of the study, emphasized the potential of this approach. “The closer we can get our models to the tumor microenvironment, the closer we can get to treating patients individually,” Tong said. This research represents a significant shift from the one-sizefits-all approach to cancer treatment, focusing instead on the specific genetic landscape of each patient’s tumor. It is a crucial step forward in combating drug resistance and boosting the effectiveness of cancer therapies. In the future, the team aims to refine its methodology by developing sophisticated algorithms to accurately predict treatment outcomes for diverse patient profiles, drug combinations, and therapeutic strategies. This computational innovation could greatly reduce the reliance on extensive data collection, leading to more efficient treatment plans and optimizing the path toward individualized cancer care. ■ In the gloomy hours of the night, a hungry pit viper finds itself in search of a meal. Despite the darkness, the snake’s ability to locate its prey is strong and precise without visual cues. How is this possible? The viper utilizes a unique sensory system—a thermal imaging pit organ where neurons embedded in a tissue at the back of the pit can detect temperature changes as small as one milli-Kelvin, exposing all of the snake’s nearby food options. In a recent study published in Proceedings of the National Academy of Sciences, Yale physicists Isabella Graf and Benjamin Machta were interested in understanding how these sensory organs could detect such small temperature changes. Using statistical physics concepts and information theory, the researchers constructed a simple mathematical model that describes the basic parameters of infrared sensing. “Our model focuses on how information in temperaturesensitive ion channels is aggregated into a collective neural response,” Graf said. “We have a mathematical equation for how these channels influence voltage dynamics in single neurons. We use rather simple dynamic equations that don’t depend on space, but just on time.” Many biological sensory systems can detect small changes, meaning that the scientists’ model may have applications outside of the pit viper study. There are numerous examples where it’s important to recognize the use of a feedback system for sensory adaptation—for instance, in bacteria like E. coli, which can sense and move towards certain chemicals in their environment. The researchers aim to answer questions of how collective sensory organs can detect what individual senses can’t catch on their own—a striking example of biological innovation. ■ www.yalescientific.org March 2024 Yale Scientific Magazine 7

NEWS<br />

Astronomy / Social Medicine<br />

LIFE OUT OF<br />

BALANCE<br />

THE TILTED PLANET<br />

PHENOMENON<br />

BY ESTELLA WITTSTRUCK<br />

THE RIPPLE<br />

EFFECT<br />

HOW SOCIAL STRESSORS<br />

IMPACT FETAL BRAIN<br />

DEVELOPMENT<br />

BY JIYA MODY<br />

IMAGE COURTESY OF TONYNETONE VIA FLICKR<br />

IMAGE COURTESY OF ANDRE FURTADO VIA PEXELS<br />

Scientists believe that when planetary systems first form,<br />

they are in a pristine, near-resonant state. Near-resonance<br />

describes when the orbits of multiple planets meet in set<br />

ratios and the planets regularly line up during their orbits. Nearresonant<br />

planets are expected to orbit in the same direction<br />

as their star’s rotation—an orientation known as alignment.<br />

However, orbits often aren’t perfectly aligned. Malena Rice<br />

GSAS ’22, an assistant professor of astronomy at Yale, researched<br />

a group of near-resonant planets to better understand why so<br />

many planetary systems have misaligned, sideways, or backward<br />

orbits. “The fact that we have all these weird, wacky planets<br />

means we can study other kinds of systems as we’re working<br />

toward understanding how our solar system fits into a broader<br />

picture,” Rice said.<br />

Rice examined the tilts of orbits in near-resonant systems<br />

through the Stellar Obliquities in Long-period Exoplanet Systems<br />

survey, founded by Rice as a PhD student. With telescopes,<br />

Rice and an international team of collaborators recorded the<br />

properties of large planet TOI-2202 b. Despite TOI-2202 b being<br />

in a near-resonant system, its orbit was still tilted by twenty<br />

degrees, likely from interacting with other celestial bodies. The<br />

reason for this dramatic tilt is unknown, but discoveries like this<br />

help scientists get closer to the answer. While TOI-2202 b is the<br />

most tilted example to date, several other near-resonant systems<br />

demonstrate a similar slant. “A lot of planetary systems are being<br />

tilted a little bit; there’s this low-level dynamical disturbance<br />

that is regularly occurring,” Rice said. “Understanding their<br />

properties helps us to engage with how amazing the laws of the<br />

universe are on a broad scale.” ■<br />

A<br />

groundbreaking study conducted by a team of researchers<br />

from Yale and Columbia University found that a pregnant<br />

woman’s experience of discrimination and acculturation,<br />

or assimilation to a new culture, can leave a lasting imprint on their<br />

infant’s brain, altering key emotional processing centers.<br />

The collaboration between Yale’s Multi-modal Imaging,<br />

Neuroinformatics, & Data Science Laboratory and Columbia’s Early<br />

Neuroimaging, Neuroimmune, and Neuropsychology Lab examined<br />

the experiences of Latina women in New York City’s Washington<br />

Heights neighborhood. By measuring brain activity with a technique<br />

known as functional magnetic resonance imaging, the study examined<br />

changes in functional connectivity—how parts of the brain interact with<br />

each other—in infants. The study found that negative experiences during<br />

pregnancy, including discrimination, acculturation, stress, anxiety, and<br />

depression, have distinct effects. Infants from mothers facing higher<br />

discrimination levels exhibited weaker connectivity in the amygdala (the<br />

brain’s emotional processing center) and stronger connectivity in the<br />

fusiform cortex (the facial processing site). Acculturation was associated<br />

with weaker connectivity in both areas among infants.<br />

The findings have important implications for healthcare<br />

professionals, particularly in prenatal care. Dustin Scheinost GSAS<br />

’13, an associate professor of radiology and biomedical imaging at<br />

Yale and the senior author of the study, emphasized the importance<br />

of screening for acculturation to improve maternal and newborn<br />

outcomes. The results, he explained, underscore the need for<br />

broader societal awareness of the long-lasting physical impacts of<br />

discriminatory experiences. “How we treat each other is pretty<br />

important,” Schienost said. This study adds to the mountain of<br />

evidence showing that discrimination harms not only the person<br />

experiencing it, but also future generations—a powerful argument<br />

for working toward a more just and inclusive world. ■<br />

6 Yale Scientific Magazine March 2024 www.yalescientific.org

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