Newsletter_04-2024_EN

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Revolutionary cell therapy:Restarting immune system switchesoff autoimmune diseasesOne single infusion with CAR-T cellsreplaces immune-suppressive medicinesIn March 2021, doctors from FAU treated a young woman with asevere autoimmune disease with chimeric antigen receptor (CAR)T-cells, the first time a treatment of this kind has been attemptedanywhere in the world. Today, nearly 3 years later, they were able topublish a pilot study in the New England Journal of Medicine demonstratingthat CAR T-cell therapy can make various autoimmunediseases disappear completely for a long period of time, waiving theneed for a further drug-based therapy.“We believe that we have succeeded in finding the reset buttonthat works like with a computer to reboot the system and restartthe immune system without errors,” explains Prof. Dr. Georg Schett(director of Department of Medicine 3 – Rheumatology and Immunology)who conducted the study together with Prof. Dr. AndreasMackensen (director of Department of Medicine 5 – Hematologyand Oncology). The team pressed this “reset button” with 15 patientswith severe forms of autoimmune diseases, such as “red wolf disease”(systemic lupus erythematosus), systemic sclerosis (also knownas scleroderma) and the autoimmune disease triggering inflammationof the muscles known as myositis. One single infusion of cellsknown as CAR T-cells from the patient’s own body manipulated outsidethe body led to a resolution of chronic inflammation in organssuch as the heart, lungs and kidneys, in the joints and in the skin,allowing patients to stop using immune-suppressive drugs such ascortisone altogether for several years.Treatment with CAR T-cells was made possible by using a specialcleanroom in Department of Medicine 5 at Uniklinikum Erlangen.In this laboratory, the patients’ own immune cells are transformedinto therapeutic weapons (CAR T-cells). PD Dr. Michael Aignerand his team from the GMP laboratory monitor the manufacturingprocess of these living medicines and the quality of the cells beforethey are returned to the patient. The CAR T-cells very effectivelyattack pathogenic B-lymphocytes in the bone marrow, in the lymphglands and in all other organs. Completely eliminating B-cells finallyleads to the disease being cured, as has now been demonstratedvery impressively with the publication in the New England Journalof Medicine.“It is particularly interesting that the B-cells return at some pointafter treatment, but the disease does not,” explain Dr. Jule Taubmannand Dr. Fabian Müller, who are part of the interdisciplinary team caringfor patients after treatment. The new B-cells in the patients arenaive “innocent” cells similar to those in a child, and no longer triggerdisease.Further information:These findings are a breakthrough in immunomedicine. It is alreadypossible for the CAR T-cell therapy to be used on further patientswith severe forms of systemic lupus erythematosus, systemic sclerosisand myositis as part of the CASTLE study conducted at UniklinikumErlangen. Anyone affected by one of these diseases can write toCar-T-Cell.UKER@uk-erlangen.de.Friedrich-Alexander-Universität Erlangen-NürnbergD 91054 ErlangenSeven of the patients with autoimmune diseases who were successfully treated with CAR-T cells as part of the study. (Image: SIMOarts/Simone Kessler)www.reinraum.de | www.cleanroom-online.com NEWSLETTER | Edition EN 04-2024page 20/35
Das zentrale Event der Reinraum- und ProzessbrancheBuchen Sie jetzt mit dem Code rronline2024 Ihr kostenlosesBesucher-Ticket oder sichern Sie sich mit dem PREMIUM-Ticket50 % Rabatt* auf den Zugang zu allen Videos der Fach- undSchulungsvorträge der LOUNGES 2024 in Karlsruhe!*bei Buchung und Zahlungseingang bis 15. April 2024www.cleanroom-processes.deDie Plattform der Reinraum- und Prozesstechnikbranchewww.reinraum.de | www.cleanroom-online.comNEWSLETTER | Edition EN 04-2024page 21/35
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