Wellness Foods + Supplements 3/2023

No. 3, November/December 2023 

www.harnisch.com | ISSN 2364-8104 

Photo © : Adobe Stock/Mediteraneo 

Women's health 

Probiotics 

Dairy products 

Marine ingredients 

Vitamins 

Healthy ageing 

Energy and endurance 

Plant extracts

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Editorial 

SILKE WATKINS, Editor-in-Chief 

Are we losing touch with nature? 

Today’s generation of grandparents have not 

only spent more time experiencing nature, 

they also know more about the various plant 

and animal species and are well versed in 

the healing power of herbs and plants. Not 

that everything used to be better in the good 

old days. But when it comes to nature, that 

is actually true. Technology and digitalisation 

now take up so much space in our lives 

that there is very little room left for experiencing 

nature. 

A distinct estrangement from nature among 

children and adolescents began back at 

the end of the 1990s. 60 per cent of the 

people interviewed found it unpleasant to 

have a bug crawl over their hand. 36 per 

cent were unable to recall a beautiful experience 

of nature. Sadly, this situation has not 

improved. There is a connection between 

experiences in nature and media consumption. 

62 per cent of adolescents who rarely 

go out into the woods spend three or more 

hours in front of a screen every day. This 

figure is only 45 per cent among adolescents 

who spend time in the woods almost daily. 

Back in 1990, a survey showed that nearly 

three quarters of all children between 6 and 

13 years of age were spending time outside 

every day. This was true for less than half the 

children in 2003. 

We know that regular experiences in nature 

support children’s overall development, 

including their sense of balance, body confidence, 

maturing of the senses, social skills, 

cognitive abilities, language, imagination and 

overall health. Brain research has found that 

the presence of nature, interacting with and playing in it, is relevant for 

satisfying emotional as well as cognitive needs of people as they grow 

up. When children are denied these experiences, they have difficulty 

developing key abilities. Their emotional bonding capacity becomes 

stunted without proximity to plants and animals. The empathy, imagination 

and zest for life of the children decline. 

When parents are asked why they do not allow their children to have 

these experiences, the answer is often: Fear. Fear that the children 

may get hurt outdoors, that they may become ill through contact 

with plants and animals. Many children internalise the views of their 

parents that are passed on to them. Dangers and diseases are seen 

to be lurking everywhere. These children are however robbed of the 

opportunity to experience the meaning of life. Their vitality is taken 

from them. Cognition researchers view this as the primary cause of 

psychological illnesses. 

Estrangement from nature has significant potential to be disastrous 

for civilisation. Who is to preserve nature when there is nobody left 

with awareness that it forms part of our lives? That it provides us with 

everything we need to lead a good and healthy life? 

Schools, too, largely limit themselves to imparting information. Topics 

pertaining to nature are of course included in the curriculum, and 

students gain an awareness of nature. But that is the crux of the 

matter: While children and adolescents learn about the composition 

of animals and plants, this learning is theoretical and detached from 

life. Young people are not truly experiencing anything when they go 

to parks, but are not allowed to touch anything there and have to stay 

on designated trails. They need opportunities for contact with nature, 

to freely experience it with all their senses and to give their creativity 

free rein. Even though it may be difficult for many people today, this 

always includes an element of risk. But that’s life. 

I wish you an interesting read! 

Silke Watkins 

No. 3 November/December 2023 

3

Contents 

Health 

Convenience Food 

Food & Beverages 

Confectionary 

Cover Photo © : Adobe Stock/Mediteraneo 

Various studies increasingly indicate that nutrition during 

prenatal and early childhood development in particular can 

have a decisive and formative influence on the later development 

of obesity, type 2 diabetes mellitus and cardiovascular 

disease. This means that someone will be healthy or ill 

in old age, is laid out in the early phase of life and can be 

strongly influenced by environmental factors. For example, 

an un balanced diet can lead to changes in development as 

early as the embryonic phase and into the first years of life. 

These changes can even be passed down through generations. 

However, this also means that external factors are much more 

decisive for health than genes. The mother's eating habits 

and the child's subsequent diet in the first few years of life 

can therefore have significant consequences for the child. This 

naturally continues as the child grows older. 

(see articles on pages: 10, 12, 16, 19, 27, 42) 

Sports Nutrition 

Health Care 

Contents 

Personal Care 


06 Menobelle TM , living through the menopause comfortably 

08 Arjuna Natural’s turmeric – Frankincense botanical blend relieves menstrual pain in clinical study 

Probiotics 

10 Food probiotics, add a pinch of healthy 

Gut health 

12 “Prebiocran - The new generation of gut health solutions” 


16 How can we rethink food products and adapt them to the world we live in? 

Natural marine complex 

19 Perspectives in osteoporosis therapy: The unique contribution of salmon-based CalGo ® 

Vitamins 

22 Moringa: Multivitamin with high protein content 

Botanical extracts 

24 Botanical extracts: the natural solution to flavourists’ technical and organoleptic requirements 

Natural plant extracts 

27 Why does Pycnogenol ® offer such a wide range of health benefits? 

Energy drinks 

33 “Caffeine alone is not enough”: Reinventing the ‘energy drink’ for a modern lens 

Sweetening alternatives 

36 Date derivatives as a special sweetening alternative 

38 Ticking the boxes for sweetness and improved nutritional properties 


42 Spermidine science: unlocking the secrets to healthy ageing 


46 Equipping the body to push harder for longer 

Obituary 

50 Au Revoir Edouard 

50 Impressum 

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These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.


Photo © : Adobe Stock/Ivan Traimak 

Menobelle TM , living through the 

menopause comfortably 

Women have to address any number of specific issues throughout 

their lives, but tackling physical concerns and the desire to age 

happily and healthily are major priorities. Menopause is one of these 

issues and is associated with personal challenges and changes in 

personal roles within the family and society. Committed to improving 

women’s well-being, Robertet has developed Menobelle, a solution 

to live through the menopause comfortably. 

This upcycled ingredient containing lemon balm, bergamot and 

peony relieves the physical and mental discomforts of menopause. 

It can be easily used in food supplements or functional foods and its 

efficiency has been proven with clinical studies. 

Menopause, a key stage in women’s health 

The women’s health market continues to grow. Indeed, the annual 

growth rate of the global market is estimated at 12.4 % over the 

period 2020-2030 1 . Femtech startups worldwide have invested and 

raised a record of 2.6 billion euros, up 44% from 2020 2 . 

Menopause is a natural event in a woman’s life. For 85 % of women, 

this phenomenon is also associated to physical and emotional 

changes that can strongly affect their everyday life. 3 With an estimation 

of 9.7 billion people in 2050, and an aging population 4 , the 

number of menopausal women is set to rise. Numerous challenges 

are being launched on the market to meet women’s needs. 

Menobelle a new active for women's health 

Menobelle is an ingredient that accompanies women during menopause 

to target physical and mental changes. This natural ingredient 

is composed of a blend of synergistic Mediterranean plants, without 

hormones or phyto-oestrogens compared to some ingredients on the 

market. 

– Menobelle is composed of Melissa officilalis, a plant of Robertet 

sourcing extracted from fresh leaves. This plant improves sleep, 

mood, cognitive health, digestion and bloating. 

– Citrus bergamia, supplied thanks to a long-standing partnership 

with Robertet, also enters in the ingredient’s composition. It targets 

cardio-metabolic disorders. 

– The third plant is Paeonia lactiflora which has analgesic and antispasmodic 

properties to fight against menopausal disorders. 

Beyond the natural character of the ingredient, Menobelle matches 

with the sustainability trend, as it is upcycled. 

This ingredient offers an effective solution that women can trust. A clinical 

study was carried out on 153 pre-menopausal and menopausal 

women aged 45 to 55. With two capsules of Menobelle, two times 

a day, during two months, the ingredient had relieved menopausal 

discomforts. Indeed, Menobelle had decreased many menopausal 

symptoms: hot flushes, night sweats, need for solitude, dissatisfac- 

6 No. 3 November/December 2023


tion with work life, stomach pain, fatigue, sexual desire reduction, 

lack of energy, physical changes, irritability... The results had been 

proven from the second month. The ingredient, in the form of a beige 

to yellow powder, is not soluble in water. It can be easily used in food 

supplements or functional foods. The optimal dose is 475 mg/day. 

With its plant-based composition, it is suitable for vegans. 

The following claims can be used for the ingredient: Menobelle 

relieves menopausal discomfort, including mental and physical wellbeing. 

Robertet is aware of the problems women face throughout 

their lives, especially menopause. 

Robertet, a partner in women’s health 

Robertet, committed to improving women’s well-being, expresses its 

desire to support women at every stage of life, with the development 

of a range of ingredients whose reliability and efficacy have been 

proven by scientific studies. 

– Among these ingredients, Lipowheat targets a glowing and 

younger-looking skin. 

– Holimel ® also plays a role in skin beauty, and particularly in the skin 

photoaging protection. 

– To help reduce cellulite, Dimpless ® has been developed. 

– And Robertet doesn’t stop here: Keranat acts on the anti-hair 

loss solution to enhance hair beauty. With many ingredients 

designed to improve women’s quality of life, Robertet is deep into 

the women’s health. 

References 

1 

Women Health and Beauty Supplements Market, by Ingredient Application, Distribution 

Channel : Global Opportunity Analysis and Indutry Forecast, 2021-2030 

2 

CB Insights, La carte du marché Femtech, 2021 

3 

Robertet, Menobelle, living through the menopause comfortably 

4 

United Nations, Global Issues, Population. 

For more information, please visit 

www.robertet.com 


7


Photo © : Adobe Stock/New Africa 

Arjuna Natural’s turmeric – Frankincense botanical 

blend relieves menstrual pain in clinical study 

A novel botanical formula powered by turmeric (Curcuma 

longa L), and frankincense (Boswellia serrata) has demonstrated 

abilities to alleviate menstrual cramps in a new clinical 

study. Rhuleave-K, a breakthrough blend composed by 

the renowned nutraceutical company Arjuna Natural Pvt 

Ltd, is poised to offer a natural holistic solution to manage 

menstrual discomfort, allowing women to enjoy their daily 

activities without interruption. 

Primary dysmenorrhea is characterized by intense, and sometimes 

excruciating cramping that grips the lower abdomen and pelvic zone. 

It emerges right before and during the first couple of days of menstruation 

and lasts for about 48 to 72 hours. It can be accompanied by 

additional symptoms such as sweating, headache, nausea, vomiting 

and diarrhoea. 

The burden of menstrual pain is the single most prevalent gynaecological 

complaint that affects over half of women in their reproductive 

age regardless of age or socioeconomic status. For many, the pain is 

so debilitating that it disrupts their daily routine leading to diminished 

work productivity, missed days at work or study, reduced sleep quality 

with knock-on effects on the overall quality of life for at least several 

days each month. 

The randomized, double-blinded, placebo-controlled study led by 

Dr Divya Agarwal was published in the Journal of Clinical Medicine 

in June 2023. The study which was conducted at the Smt. Meva 

Chaudhary Hospital in Jhansi involved healthy women suffering from 

primary dysmenorrhea: painful menstruation unrelated to any uterine 

pathology. Only women reporting moderate to severe menstrual 

cramping were qualified to participate. 



In a one-day, single-dose study, the cohort of women was randomly 

split into two groups. One group was allocated 1000 mg Rhuleave-K 

in two soft gels, while the other received a placebo. The participants 

were administered their assigned treatments only when the menstrual 

pain reached a severity of 5 or greater on a 0–10 numeri cal rating 

scale (NRS). 

After dosing, the participants were evaluated every 30 minutes for 

six hours to track changes in pain intensity and pain relief. Results 

indicated a promising role of the turmeric–Boswellia formulation in 

reducing pain intensity. The mean total pain relief of the treatment 

group was found to be 12.6 times better than the placebo group with 

a statistically significant difference at every 30-minute time point. 

Moreover, the overall difference in pain intensity following six hours of 

observation was 20 times better than the placebo group. 

Rhuleave-K is a pioneering formula meticulously crafted by Arjuna 

Natural, as a botanical solution for providing pain relief. In this 

ground-breaking botanical blend, turmeric and Boswellia extracts are 

brought together in an oil base and manufactured using proprietary 

SPEEDTECH technology to elicit fast action. 

This unique blend has already showcased potent analgesic activity in 

numerous clinical trials, specifically targeting musculoskeletal pain. 

“The excellent results we witnessed in the previous studies on musculoskeletal 

pain inspired us to see if we can extend Rhuleave-K’s benefits 

to other common forms of pain,” reports Benny Antony, PhD, joint 

managing director for Arjuna Natural. “Menstrual pain is a relentless 

burden for countless women globally. Many depend on overthe-counter 

NSAIDs to get pain relief. Yet more and more women 

are turning to natural therapies as they seek a comprehensive and 

enduring solution for menstrual pain relief. Rhuleave-K has the potential 

to offer an easy and rapid natural solution to this common issue, 

our company is dedicated to empowering women to take control of 

their well-being through natural solutions.” 

“Additional clinical trials are in the pipeline to further explore 

Rhuleave-K potential role in providing fast action menstrual pain 

relief and synergistic all-round support,” concludes Antony. 

References 

“Effect of Turmeric–Boswellia–Sesame Formulation in Menstrual Cramp Pain Associated 

with Primary Dysmenorrhea—A Double-Blind, Randomized, Placebo-Controlled Study”, 

June 2023 

Authors: Divya Agarval, et al. 

doi.org/10.3390/jcm12123968 


https://arjunanatural.com/ 


9

Probiotics 

Photo © : Adobe Stock/Krakenimages 

Food probiotics, add a pinch of healthy 

Consumer awareness and demand for healthier ingredients, 

especially for probiotics in foodstuffs, is increasing as they 

are looking to improve their overall wellbeing. The role of 

probiotics to support a healthy and balanced gut microflora 

is well documented and known by the consumers; 68 % 

of consumers recognize the link between digestive health 

and overall health. Hence, functional foods and beverages 

containing specific probiotics with health benefits have been 

growing as a category around the world. 

Functional foods or beverages offer health benefits that extend 

beyond their nutritional value. In addition to nutrient-rich ingredients 

like fruits and vegetables, the category includes foods fortified with 

vitamins, minerals, fiber, and probiotics. 55 % of global consumers 

say they prefer to choose foods and beverages that provide functional 

benefits and 40 % of global consumers state they are willing to pay up 

to 10 % more for foods that provide functional benefits. 1 

FMCG GURUS affirms, in their 2022 non-alcoholic beverages 

global report, that consumers are nowadays most likely to choose 

“better-for-you” beverages that are winning over sugary juices and 

colas. Consumers are taking a proactive 

approach to health and wellbeing, as 

44 % of consumers state they are interested 

by pro ducts supporting the immune 

system, and 41 % of consumers say they are 

appealed by the claim “contains probiotics”. 

Overall, 59 % of global consumers state they 

have purchased a probiotic product in the 

last 12 months. 

The challenges of formulating 

with probiotics 

Probiotics are defined as “live microorganisms 

that, when administered in adequate 

amounts, confer a health benefit on the 

host”. The key aspects of this definition 

include that probiotic bacteria must be alive 

when administered and be able to survive in 

a sufficient amount until they reach their site 

of action – the intestinal tract. 


Probiotics 

Microencapsulated strains 

Formulating probiotics in food matrices 

comes with challenges, and it takes specific 

know-how to incorporate probiotics in food 

matrices. The efficacy of probiotics is contingent 

to their capacity to survive the many 

stressors from the manufacturer’s plant 

to the consumer’s gut. Lallemand Health 

Solutions has developed a range of protective 

technologies to ensure optimal probiotic 

survival in food matrices, and efficacy 

at their site of action. Probiocap ® technology 

is a microencapsulation procedure that 

protects probiotic strains from physical food 

processing conditions such as compression, 

thermal shocks, and high acidity, offering 

great opportunities for food applications. 

Probiocap ® technology can be applied to the 

following strains, which have been extensively 

studied in humans either alone or in 

combination: 

L. helveticus Rosell ® -52 

L. rhamnosus Rosell ® -11 

B. longum Rosell ® -175 

L. helveticus LAFTI ® L10 

Spore-forming Bacillus strains 

The spore-forming Bacillus probiotic strains 

are intrinsically resistant strains. In hostile 

conditions, Bacillus probiotics can perform 

a specific transformation, called sporulation, 

which leads to the formation of an 

endospore. When the environment becomes 

favorable, the endospore can reactivate itself 

into a vegetative cell. Due to the protective 

endospore, spore-forming probiotics 

are naturally capable of surviving thermal 

shocks, high pressure, pH variations, gastric 

acidity from digestion and long-term storage. 

Photo © : shutterstock/losangela 

Their viability and efficacy were successfully 

tested in several extreme conditions 

for many food and beverage applications. 

Bacillus probiotics withstand high pressure 

processing and pasteurization, common 

manufacturing processes to preserve beverages. 

Lallemand’s strain resistance to 

pasteurization has notably been tested in 

non-dairy milks, namely almond milk and 

soy milk and showed great survival. Moreover, 

the strain was shown to survive throughout the shelf life of several 

kombucha products, despite the low pH environment. 

Overall, Bacillus strains have been tested in many food and beverages 

applications. Lallemand Health Solutions proposes two sporeforming 

probiotic strains: Bacillus subtilis Rosell ® -179 which has identified 

mechanism of action for its beneficial effects on gut health and 

is documented with one clinical study on bile acid metabolism in overweight, 

otherwise healthy, adults. As per its latest addition, Bacillus 

coagulans Rosell ® -449 it has demonstrated gut health benefits. 

Building on over 85 years of probiotic knowledge and know-how from 

its research center, the Rosell ® Institute for Microbiome and Probiotics, 

Lallemand Heath Solutions is leveraging functionality for gut 

microbiome, and many more health purposes, by offering probiotic 

solutions for food and beverage applications such as microencapsulated 

Lactobacilli and Bifidobacterium strains and spore forming 

Bacillus bacteria. This brings added health solutions to the global food 

and beverage market, for gut, immune, mental, women’s, metabolic, 

skin, oral health, and the sports category. 

Reference 

1 

FMCG Gurus, 2022 

For more information, please contact 

foodprobiotics@lallemand.com 

foodprobiotics.lallemand.com 


11

Gut health 

“Prebiocran - The new generation 

of gut health solutions” 

It is widely recognized that diet is an essential determinant 

of health, and a predominant factor shaping the host-microbiota 

relationship. Indeed, gut microbiota contributes to the 

energy balance and produces metabolites triggering metabolic 

and inflammatory responses in response to various 

stimuli such as diet 1 . 

In a healthy state, the epithelial cells form a strong barrier protected 

by a mucus layer keeping the bacterial community at a safe distance, 

while select symbionts favor maturation of the mucosal immune 

system by interacting with the host epithelium 1 . However, a growing 

body of evidence indicates that western diet, characterized by high-fat, 

high sugar, and low fiber content, contributes to the etiology of chronic 

inflammatory diseases, and alters the gut microbiota (i. e., dysbiosis), 

with harmful consequences on the intestinal barrier and immune function. 

This notably leads to what is called a “leaky gut”, i. e., the disruption 

of the intestinal barrier, which is associated with alterations of the 

gut microbiota, reduction of the mucus layer thickness and consistency, 

impairment of the tight junction, microbiota 

encroachment, increased permeability 

allowing translocation of pathogens and associated 

molecules (i. e., endotoxemia) and 

inflammation 1,2 . 

Fortunately, some nutritional components 

like polyphenols emerge as potential dietary 

solutions associated with health benefits. 

Fruits polyphenols consumption is associated 

with reduced risk of chronic diseases, 

such as cardiovascular pathologies or metabolic 

syndrome 3–5 . These bioactive metabolites 

are poorly absorbed in the small intestine 

and reach the colon, where they modulate 

the gut microbiota and exert a prebio tic 1 

effect which is positively associated with 

metabolic and gut health 3–5 . 


Gut health 

Phenobio+ - A 5-year 

research program 

In 2018, Symrise supported the creation of 

a 5-year Industrial Partnership Chair called 

Phenobio+, together with the Institute of 

Nutrition and Functional Foods (INAF) 

and the Natural Science and Engineering 

Research Council of Canada (NSERC). The 

Chair was led by Prof. Yves Desjardins and 

aimed to investigate the potential prebiotic 

effect of fruit polyphenols, in particular from 

cranberry. This unprecedented scientific 

program produced cutting-edge research. 

The results are the outcome of talented 

student’s work guided by Prof. Yves Desjardins, 

but also other prominent researchers 

involved in the Chair (Prof. André Marette, 

Denis Roy, Alain Veilleux and Emile Levy). 

prebiotics such as fibers. In the context of the Industrial Partnership 

Chair, Symrise aimed to investigate the potential prebiotic impact of 

Prebiocran on intestinal barrier function and potential metabolic 

health benefits. A systemic approach used a clinical study, some 

animal models of metabolic disorders and cell line experiments, 

and advanced in vitro models, such as intestinal organoids and the 

M-SHIME, one the few gut models that artificially mimics the entire 

gastrointestinal tract. The results showed that Prebiocran modulates 

the gut microbiota composition and function, which is associated 

with metabolic health improvement. 

Prebiocran modulates the gut microbiota beta-diversity 

In a short-term clinical trial, 39 healthy participants daily consumed 

480 mg of Prebiocran for 4 days. A 7-day washout period preceded 

the intervention, with strict limitation of polyphenols-containing food. 

Biological samples were collected before and after the treatment and 

fecal DNA has been sequenced to study the gut microbiota evolution. 

Symrise and cranberry: a long history 

Cranberry (Vaccinium macrocarpon) is a 

fruit originating from North America, rich in 

polyphenols and traditionally used by Native 

Americans to relieve a variety of ailments. 

Symrise expertise in the processing and 

extraction of cranberry polyphenols started 

back in 2008. Thanks to its dedicated extraction 

facility located in the Quebec province 

of Canada, in the heart of the cranberry 

production area, the company has a unique 

access to local cranberry farmers and carefully 

selects the most concentrated in polyphenols 

varieties. 

Prebiocran - Symrise's polyphenolrich 

cranberry extract 

Cranberries are high in polyphenols, having 

antioxidant properties and supporting 

various health benefits of which urinary but 

also cardiometabolic health. Prebiocran is 

a natural ingredient obtained by extracting 

the phenolic compounds of cranberries. 

It has been designed to offer all the varieties 

of polyphenols present in the fruit and 

is standardized to feature no less than 30 % 

total polyphenols (Folin-Ciocalteu method). 

Prebiocran is a low-dose (480 mg) offering 

convenient on-the-go supplement formats 

that cannot be formulated with traditional 

Prebiocran treatment modulates the human microbiota in a clinical study. 

Lessard-Lord et al., unpublished. The distance-based redundancy analysis 

based on 16S RNAr gene amplicon sequencing exhibits the dissimilarity between 

the subjects. Each dot represents a unique human subject microbiota 

before (in blue) and after (in purple) 4 days of Prebiocran treatment. 

The results of this clinical trial showed that a short-term administration 

of Prebiocran was sufficient to modulate the basal human gut 

microbiota beta-diversity, and to notably induce a bloom of Bifidobacterium, 

a bacteria associated with gut health 7 (Lessard-Lord et al., 

unpublished). 

This modulation of the gut microbiota was also observed in the 

M-SHIME ® complex in vitro model. The Simulator of the Human 

Intestinal Microbial Ecosystem (SHIME ® ) is one of the few gut models 

that mimics the entire gastrointestinal tract. It is a semi-dynamic 

model with multi-stage compartment reactors, each of them respec- 


13

Gut health 

tively displaying defined conditions (pH, nutritional medium etc.) 

according to the intestinal region they represent, following a longitudinal 

axis. The M-SHIME, i. e., Mucosal-SHIME, is an extension 

of this model which also mimics the mucosal microbiome, incorporating 

mucin-covered microcosms and allowing better understanding 

of the host-microbe interaction according to the transversal axis 8,9 . 

In this study (Cattero et al., unpublished), researchers inoculated 

the M-SHIME system with the fecal material of six healthy subjects. 

After a suitable adaptation period, they administrated 480 mg Prebiocran 

for two weeks. Then, they analyzed the gut microbiota 

composition and showed that, consistent with the clinical study, 

Prebiocran significantly and gradually modulated the microbiota 

composition in all the gut compartments (lumen and mucus of the 

ascendant and transverse colons). More specifically, Prebiocran 

promoted, in both lumen and mucin compartments of the transverse 

colon, the growth of bacteria known to metabolize proanthocyanidins 

(PACs) into smaller bioactive metabolites (i. e., Eggerthella, Flavonifactor 

and Lactiplantibacillus) 10,11 , but also bacteria associated with 

gut barrier protection and health, such as Akkermansia and Faecalibacterium 

12,13 . 

Finally, these results were also confirmed by in vivo models in a 

longer term. Most of the preclinical studies were performed using 

diet-induced obesity and type 2 diabetes mouse models. Mice 

received either a control diet, a high-fat high-sugar (HFHS) diet or a 

high-fat high sugar diet supplemented with Prebiocran for 14-19 

weeks 14,15 . Interestingly, all the animal studies converged with the clinical 

and M-SHIME studies and repeatedly showed that Prebiocran 

modulates the gut microbiota 14–16 . This was often associated with the 

increase of Akkermansia genus 14 . 

Prebiocran and cranberry extract fractions support 

gut barrier function 

Alongside with these previous investigations, the researchers also 

studied the capacity of cranberry extracts to support the gut barrier 

function in several models. 

To understand underlying mechanisms and involved functions, 

in-depth investigations in the M-SHIME ® model specifically showed 

that Prebiocran not only increased some individual bacteria, but 

a consortium or a guild of bacteria. This was associated with health 

benefits, enhancing a favorable ecosystem and health relatedmetabo 

lites production such as butyrate and specific bile acids 

(Cattero and Lessard-Lord et al., unpublished). 

Also, mouse organoids were used to mimic a mini intestine, as a 

complex multicellular in vitro system. Researchers reproduced the 

model published by O’Rourke and al. 17 , which presents the main 

types of intestinal barrier cells (i.e., Paneth cells, enterocytes, Goblet 

cells and enteroendocrine cells). Results showed that a fraction of 

Prebiocran, purified in proanthocyanidins (PACs), time and dosedependently 

increases Muc2 and Klf4 gene 

expression, some key biomarkers of intestinal 

strengthening involved in Goblet cells differentiation 

and mucin production (Tinoco-Mar 

et al., unpublished). 

Moreover, additional results in the same 

previously described obesity and type 2 

diabetes mouse studies highlighted the 

capacity of Prebiocran to improve the gut 

health barrier function and metabolic health, 

supporting its prebiotic potential. Indeed, 

Anhê et al. observed a prevention of the endotoxemia 

(i. e., high level of lipopolysaccharides 

in blood circulation – also a marker of 

intestinal permeability) and several markers 

of jejunum inflammation such as increased 

Cox2, TNFα or NF-κB gene expression 14 . 

Medina-Larqué et al. also showed that Prebiocran 

prevented the deleterious effects 

of the HFHS diet on the intestinal barrier 

strength, counteracting the decrease of 

crypt depth, Goblet cells (mucin producers) 

number and mucus degradation 16 . Finally, 

in a model where mice were already obese 

after 13 weeks of HFHS diet, Prebiocran 

administration tended to restore the mucin 

amount present in feces 18 . 

Prebiocran sustains 

metabolic health 

In a classic model of Caco-2/15 intestinal 

cells, researchers evaluated the beneficial 

impact of a PACs-rich cranberry fraction 

on inflammation, oxidation, lipid, and 

glucose homeostasis. It was observed that 

this fraction from Prebiocran was effective 

in counteracting the decrease of antioxidant 

defense (SOD2) and oxidative stress (COX2) 

markers in intestinal cells. Also, the extract 

prevented the increase of several lipogenesis 

(SREBP-1C), neoglucogenesis (G6P) and 

insulin signaling (pAkt) markers. 

Finally, researchers also tested in murine 

models the potential beneficial preventive 

effects of Prebiocran on obesity-associated 

disorders, such as type 2 diabetes and 

hepatic steatosis. Anhê et al. and Daoust 

et al. notably observed that the cranberry 

extract prevented the HFHS-induced metabolic 

damages, in particular the liver weight 


Gut health 

gain and the hepatic lipid accumulation, as 

well as the hyperinsulinemia and the Homeostasis 

Model Assessment of Insulin Resistance 

(HOMA-IR) index increase 14,15 . 

Overall, the results of Symrise’s partnership 

with INAF demonstrate the role of 

Prebiocran in supporting gut and metabolic 

health at a low dose of 480 mg. 

References 

1. Régnier, M., Hul, M. V., Knauf, C. & Cani, P. D. Gut microbiome, endocrine control of gut barrier function and metabolic 

diseases. Journal of Endocrinology 248, R67–R82 (2021). 

2. Daniel, N., Lécuyer, E. & Chassaing, B. Host/microbiota interactions in health and diseases—Time for mucosal microbiology! 

Mucosal Immunology 14, 1006–1016 (2021). 

3. Fraga, C. G., Croft, K. D., Kennedy, D. O. & Tomás-Barberán, F. A. The effects of polyphenols and other bioactives on 

human health. Food Funct. 10, 514–528 (2019). 

4. Crowe-White, K. M. et al. Flavan-3-ols and Cardiometabolic Health: First Ever Dietary Bioactive Guideline. Adv Nutr 13, 

2070–2083 (2022). 

5. Vivarelli, S. et al. Polyphenols: a route from bioavailability to bioactivity addressing potential health benefits to tackle 

human chronic diseases. Arch Toxicol 97, 3–38 (2023). 

6. Gibson, G. R. et al. Expert consensus document: The International Scientific Association for Probiotics and Prebiotics 

(ISAPP) consensus statement on the definition and scope of prebiotics. Nat Rev Gastroenterol Hepatol 14, 491–502 (2017). 

7. Chen, J., Chen, X. & Ho, C. L. Recent Development of Probiotic Bifidobacteria for Treating Human Diseases. Front Bioeng 

Biotechnol 9, 770248 (2021). 

8. Molly, K., Vande Woestyne, M. & Verstraete, W. Development of a 5-step multi-chamber reactor as a simulation of the 

human intestinal microbial ecosystem. Appl Microbiol Biotechnol 39, 254–258 (1993). 

9. Van de Wiele, T., Van den Abbeele, P., Ossieur, W., Possemiers, S. & Marzorati, M. The Simulator of the Human Intestinal 

Microbial Ecosystem (SHIME ® ). in The Impact of Food Bioactives on Health: in vitro and ex vivo models (eds. Verhoeckx, K. 

et al.) (Springer, 2015). 

10. Corrêa, T. A. F., Rogero, M. M., Hassimotto, N. M. A. & Lajolo, F. M. The Two-Way Polyphenols-Microbiota Interactions and 

Their Effects on Obesity and Related Metabolic Diseases. Front Nutr 6, 188 (2019). 

11. Gaur, G. & Gänzle, M. G. Conversion of (poly)phenolic compounds in food fermentations by lactic acid bacteria: Novel 

insights into metabolic pathways and functional metabolites. Current Research in Food Science 6, 100448 (2023). 

12. Cani, P. D., Depommier, C., Derrien, M., Everard, A. & de Vos, W. M. Akkermansia muciniphila: paradigm for next-generation 

beneficial microorganisms. Nat Rev Gastroenterol Hepatol 19, 625–637 (2022). 

13. Leylabadlo, H. E. et al. The critical role of Faecalibacterium prausnitzii in human health: An overview. Microbial Pathogenesis 

149, 104344 (2020). 

14. Anhê, F. F. et al. A polyphenol-rich cranberry extract protects from diet-induced obesity, insulin resistance and intestinal 

inflammation in association with increased Akkermansia spp. population in the gut microbiota of mice. Gut 64, 872–883 

(2015). 

15. Daoust, L. et al. The postnatal window is critical for the development of sex-specific metabolic and gut microbiota 

outcomes in offspring. Gut Microbes 13, 2004070 (2021). 

16. Medina-Larqué, A.-S. et al. Cranberry polyphenols and agave agavins impact gut immune response and microbiota 

composition while improving gut barrier function, inflammation, and glucose metabolism in mice fed an obesogenic diet. 

Front Immunol 13, 871080 (2022). 

17. O’Rourke, K. P., Ackerman, S., Dow, L. E. & Lowe, S. W. Isolation, Culture, and Maintenance of Mouse Intestinal Stem 

Cells. Bio Protoc 6, e1733 (2016). 

18. Anhê, F. F. et al. A polyphenol-rich cranberry extract reverses insulin resistance and hepatic steatosis independently of 

body weight loss. Mol Metab 6, 1563–1573 (2017). 

The new 

gut health 

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backed by 

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For more information, feel free to contact 

Symrise at https://www.diana-food.com/contact 

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15


How can we rethink food products and 

adapt them to the world we live in? 

Anne Laure LEGRAND 

Yogurt-based products are enjoying growing popularity, 

thanks to the increasing interest shown by consumers in 

fermentation processes and the functional properties associated 

with this category. In response, French dairy ingredient 

supplier Epi Ingredients has contributed its expertise 

develop a yogurt powder set to become a reference in the 

market. This product reflects the company’s determination 

to meet customer demands with useful innovations offering 

numerous benefits. 

What do consumers expect today? 

Consumer demands are increasingly specific and varied. Since the 

Covid-19 crisis, interest in health is particularly strong, and a balanced 

nutritious diet is seen as essential for maintaining good health. 1 

Compositions are scrutinized for beneficial or innovative elements. 

However, the search for improved health has not come to replace the 

search for eating pleasure, only to complement it. Flavors are therefore 

still of prime importance. It is also interesting 

to note that consumers are becoming 

increasingly curious about experiencing new 

flavors. Indeed, as a sign of increased openmindedness, 

an appetite for foreign cuisine 

seems to be becoming more and more widespread 

around the world. 

Against this backdrop, new product launches 

and innovations are not uncommon since 

the pandemic. In particular, nearly 800 

products containing yogurt powder have 

been launched in Europe, including 213 in 

the last year. 2 This specific market therefore 

appears to be dynamic and could remain so 

if the demands presented above are taken 

as a roadmap for the development of new 

products. 



Yogurt: a combination of taste 

and health 

A solid nutritional composition 

The nutritional benefits of yogurt - and yogurt 

powders - are beyond question. They provide 

a significant quantity of nutrients essential to 

the body’s proper functioning. In terms of vitamins 

and minerals, it contains calcium, B vitamins, 

phosphorus, and potassium which are 

all involved in biological processes as varied 

as they are important. For example, calcium 

is essential for maintaining healthy teeth and 

bones and minerals are involved in the functions 

of the metabolism and blood pressure 

regulation. Yogurt powder is also rich in highquality 

protein. Indeed, the proteins present 

in yogurt contain essential amino acids not 

produced in the human body. 

Microorganisms: the indispensable 

ingredients in yogurt 

Yogurt is a dairy product obtained by the 

fermentation of milk by certain microorganisms. 

These microorganisms must be alive, 

active, and present in significant quantities. 

The characteristics of yogurt, such as 

its texture, flavor and nutritional value, are 

precisely those influenced by the microorganisms 

selected and the management 

of fermentation concentration, temperature 

and duration. They are therefore of the 

utmost importance. 

More specifically, these microorganisms 

are lactic acid bacteria. Lactic acid bacteria 

are a group of bacteria involved in various 

ways in the fermentation process and 

some of them are specific to yogurt e. g., 

Streptococcus thermophilus and Lactobacillus 

bulgaricus. They possess an enzyme, 

B-galactosidase, which breaks down lactose 

into simple sugar (glucose and galactose). 

This enzyme remains active throughout the 

digestive tract, making yogurt powder suitable 

for people with lactose intolerance. 

Probiotics for better health 

Let's give these bacteria another title! 

They can also be described as probiotics. 

According to the WHO definition, probiotics 

are “living microorganisms which, 

when ingested in sufficient quantities, exert 

a health benefit over and above the traditional nutritional effects”. 

This is precisely the case with yogurt and yogurt powder, which can 

contain more than 10 7 cfu/g of powder. For sure, a sufficient quantity! 

So, what are the benefits of probiotics in yogurt? There is no shortage 

of them! They contribute to well-being, nutritional support, improved 

transit and lactose digestion. 

Yogurt powder: a wide range of applications 

Yogurt powder is a dried form of yogurt. One of the main aims of drying 

is to preserve it. Yogurt powder has a longer shelf life than fresh yogurt, 

and its low moisture content means it does not need to be refrigerated. 

Yogurt powder is also very easy to use. Compared with conventional 

yogurt, its smaller volume makes it easier to transport, and the fields 

of application are wide. Yogurt powders can be used in adult and 

baby foods, to make ice creams, drinks, and bakery products, and 

in numerous innovations around the world. They can be found, for 

example, in pastry fillings and toppings, frozen desserts, seasonings, 

yogurt drinks and nutritional products. 

In some of these applications, fresh yogurt could not be used. For 

example, it is not used in chocolate and confectionery, whereas 

yogurt powder can be found in recipes for marshmallows or gums. 

Epi Ingredients’ solution: a process to preserve benefits 

and ensure quality 

Between convenience, proven health benefits and a familiar, appreciated 

taste, it is clear that yogurt powder has all the potential to appeal 

to consumers. French ingredient supplier Epi Ingredients provides a 

complete range of yogurt powders that take into account all the issues 

presented here. 

Well-preserved benefits 

These yogurt powders are produced from skimmed yogurts by a 

spray drying process, giving them a shelf life of 9 to 12 months. The 

same process is also used to manufacture milk powders. 

In setting up this process, careful attention was paid to the microorganisms 

that are essential to yogurt. Epi Ingredients’ manufacturing 

process has been fine-tuned by solid technical expertise to keep 

certain cultures alive throughout the manufacturing process, right 

up to the final product obtained. Their effect on texture and health 

is thus preserved. In addition, neither the other nutritional benefits 

nor the characteristic taste of yogurt is affected. In short, despite the 

drying process, there’s no difference with fresh yogurt. 

Superior quality, suitable for infants 

As mentioned before, the functional benefits of yogurt powders enable 

a wide range of applications: e. g., ice creams, beverages, adult nutrition, 

bakery products etc. To this list, Epi Ingredients added an application 

that requires the utmost attention: infant nutrition. 


17


Thanks to these various controls, Epi Ingredients’ yogurt powders 

are of the highest hygienic quality. They can be used in baby foods, 

providing the essential elements for their development in complete 

safety. 

Dynamic products to meet societal demand 

Ingredient supplier Epi Ingredients is committed to finding solutions 

in line with current consumer trends and expectations. The manufacture 

of yogurt powder is therefore adapted to the development of new 

products and to strict certifications. This is illustrated by the launch 

of new preparations sourced from a diverse blend of cultures as well 

as organic and acid yogurt powders. 

A new product innovation in response to current trends embracing 

cuisine from diverse cultures has recently been developed in powder 

form: kefir. Kefir is a drink from the Caucasus with a texture close 

to drinking yogurt. It can be consumed as it is or used in recipes to 

replace milk or cream. 

Epi Ingredients’ first guarantee of quality is manufacturing on an 

industrial site that produces infant formula. All yogurt powders are 

thus controlled according to strict criteria concerning infant nutrition. 

In particular, the environment of the drying towers is highly 

controlled: children’s products are monitored with the utmost vigilance, 

and microbiological tests are carried out on a regular basis. 

Not all microorganisms are harmful to humans, but those that are 

must be monitored with the strictest attention. For example, Cronobacter 

is a bacterium present in the environment that is transmitted 

mainly via food consumption and can therefore be responsible for 

human infections. Infants and young children under 5 are particularly 

vulnerable targets. Infected by Cronobacter, they can develop 

meningitis or septicemia among other things. Cronobacter is therefore 

a key concern at the forefront of anti-bacterial controls. 

The presence of microorganisms can also give rise to a bacterial 

competition mechanism. Placed in the same environment, different 

species can enter into competition: sharing the same resource or 

secreting toxins can affect their survival and reproduction. In other 

words, microorganisms regulate their own development. In yogurt, 

the lactic flora of at least 10 7 cfu/g enables this competition mechanism 

to take place, naturally limiting the development of undesirable 

microorganisms. 

Consumer awareness of food quality and the goal of eating better, 

healthier food is driving the organic market. Against this backdrop, 

Epi Ingredients has made considerable efforts to offer organic yogurt 

powders. The result? The strict requirements of organic specifications 

are met, while still retaining functional, nutritional, and organoleptic 

benefits without the need for refrigeration. 

Consumer demands also concern taste. In response, Epi Ingredients 

has developed an additive-free sour yogurt powder providing a full 

range of traditional, authentic and natural yogurt flavors. 

Epi Ingredients’ yogurt powders are thus an ideal example of a 

product designed with no compromise on eating pleasure, nutrition, 

and health benefits. Their superior quality and strict conformity with 

infant nutrition requirements make them a product you can trust. 

This is also the perfect illustration of Groupe Laïta's CSR approach 

initiated in 2015, Passion du Lait ® . Innovations are designed in 

response to societal expectations, with a focus on utility and openness 

to the world. 

These products and their applications will be presented at 

FI Europe 2023, Booth: 3.0J20. 

References 

1 

Mazars, Les Français et le système de santé, 02/2022 

2 

Mintel, 2023 


Anne Laure LEGRAND 

Product manager 

EPI INGREDIENTS 

epi.ingredients@laita.fr 

https://epi-ingredients.com/en/ 



Photo © : Hofseth Biocare 

Perspectives in osteoporosis therapy: The 

unique contribution of salmon-based CalGo ® 

Dr. Sonja John 

Osteoporosis is a widespread and 

serious health problem that affects 

millions of people. This disease leads 

to a decrease in bone density with an 

increased risk of fractures. To address 

this challenge, it is crucial to understand 

the prevention and treatment 

of osteoporosis and explore ways to 

promote bone health. 

Osteoporosis: a complex disease 

The risk of developing osteoporosis varies 

across the population. The differences 

include gender, age 1 , family predisposition, 

diet and other external factors such as 

smoking and alcohol consumption 2 . In addition, 

certain medications such as glucocorticoids 

3 can also increase the risk of osteoporosis. 

Compared to men, women have a higher 

risk of osteoporosis, due to a lack of estrogen 

during the menopause 5 . The risk of developing 

osteoporosis increases with age due to natural bone loss; therefore, 

elderly women are the most vulnerable group for osteoporosis. 

The complexity of the factors that contribute to the development of 

this disease demonstrates the importance of targeted measures for 

prevention and treatment. 

Prevention and early detection: the key to health 

The prevention of osteoporosis involves a variety of measures that are 

closely linked with diet, exercise and lifestyle. 

A diet with sufficient amounts of calcium, vitamin D and vitamin K 

plays a decisive role in the early prevention of osteoporosis 4,6 . These 

factors are responsible for achieving a high peak bone mass, meaning 

the maximum bone density achieved in early adulthood. 

In prevention, calcium carbonates and other calcium salts are most 

frequently used to improve the dietary supply of calcium 11, 12, 13 . 

Calcium carbonate has a very high calcium content compared to 

other calcium salts and was therefore often used as the main active 

component in food supplements in the past. However, the clini cal 

evidence has been questioned by some scientists. Excessive intake of 

calcium may lead to negative effects, such as an increased tendency 

to arteriosclerosis and the associated risks. 


19


Nature has given us the opportunity to utilise 

precisely this perfect mixture in the form of 

food supplements: literally bones for bones. 

The use of a natural complex of calcium, 

phosphorus, zinc and collagen has been 

shown in scientific studies to be an effective 

means of strengthening and supporting an 

already damaged bone structure. 

Fish as a secret weapon for bone 

health 

Photo © : Adobe Stock/luciano 

Another essential trace element for bone health is zinc. It is involved in 

numerous biological processes and promotes bone strength through 

the formation of osteoblasts (bone-forming cells) and inhibiting osteoclasts 

(bone-degrading cells) at the same time 15 . 

In addition to an adequate supply of minerals, collagen is of particular 

importance for bone health. Collagen is present in the bones in the 

form of collagen fibres and collagen matrix and is responsible for 

the structure and strength of bone tissue 9 . Even if osteoporosis is 

already present, collagen can support the regeneration process of 

the bone structure, as it interacts with various growth factors and thus 

promotes bone regeneration and tissue repair 10 . 

Fish, especially sea fish, is widely recognised 

for its positive health effects. Omega-3 

fatty acids and the high-quality protein in fish 

meat are often emphasised in this context. 

However, fish can contribute so much more 

to human health. By utilising the whole fish, 

a high-quality basis for food supplements can 

be obtained. In Norway, the fish skeletons 

from sustainably produced farmed salmon 

are carefully processed in accordance with 

the highest quality standards. The resulting, 

gently produced natural product consists of a 

complex of HAP, collagen type II, protein and 

zinc as well as other valuable ingredients. 

Particularly noteworthy is the marine HAP, 

which is obtained from salmon and marketed 

under the brand name CalGo ® . This natural 

complex is still relatively unknown when 

Targeted weight training is also important for the long-term strengthening 

of bone substance 8 . Protein supply also has a positive effect on 

bone health 7 . 

The combination product from nature 

A combination of active ingredients that are similar to the bone 

structure is a sensible alternative to the well-known sources of 

calcium. A closer look at the potentially preventive effects of these 

substances suggests that this combination can be used both for the 

supportive treatment of osteoporosis and for prevention, with proven 

positive effects on bone structure. 

Calcium and phosphate are present in the bones in the form of 

hydroxyapatite (HAP), a substance that plays a crucial role in maintaining 

bone health and strength. Despite the balanced Ca:P ratio, 

HAP has rarely been used in the prevention of osteoporosis. Instead, 

different combinations of calcium and phosphate are used, as these 

are necessary for the formation of hydroxyapatite in bone 13, 14 . 

Photo © : Adobe Stock/Jakub Ruthiewicz 



it comes to preventing osteoporosis and 

promoting general bone health. However, 

its properties are impressive: the absorption 

rate of CalGo ® exceeds that of conventional 

calcium carbonate by a factor of six 17 . 

Even in cases where the bone structure has 

already been damaged, the use of CalGo ® 

can help to restore stability. Recent studies 

provide convincing results and emphasise 

the benefits of this complex, readily bioavailable 

compound 16 . 

Food supplements for strong bones: The right choice can 

make the difference 

The prevention and treatment of osteoporosis requires a holistic 

approach. The right choice of supplements can have a decisive 

impact on bone health. In a world where osteoporosis is a widespread 

challenge, natural approaches such as CalGo ® open up new ways to 

promote strong and healthy bones. Osteoporosis may be complex, 

but the first line of defence can be simple and natural. Bones for 

healthy bones. 

References 

1. McGuigan, F. E., Murray, L., & Gallagher, A. (2011). Body mass index and the risk of fracture. Osteoporosis International, 22(2), 587-592. 

2. Berg, K. M., Kunins, H. V., Jackson, J. L., Nahvi, S., Chaudhry, A., Harris, K. A., ... & Arnsten, J. H. (2008). Association between alcohol consumption and 

both osteoporotic fracture and bone density. The American Journal of Medicine, 121(5), 406-418. 

3. Van Staa, T. P., Leufkens, H. G. M., Abenhaim, L., Zhang, B., & Cooper, C. (2000). Use of oral corticosteroids and risk of fractures. Journal of Bone and 

Mineral Research, 15(6), 993-1000. 

4. Weaver, C. M. (2011). Calcium requirements of physically active people. The American Journal of Clinical Nutrition, 93(3), 545S-555S. 

5. Johnell, O., & Kanis, J. A. (2006). An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporosis International, 

17(12), 1726-1733. 

6. Holick, M. F. (2007). Vitamin D deficiency. New England Journal of Medicine, 357(3), 266-281. 

7. Darling, A. L., Millward, D. J., Torgerson, D. J., Hewitt, C. E., Lanham-New, S. A., & Berry, J. L. (2009). Dietary protein and bone health: a systematic review 

and meta-analysis. The American Journal of Clinical Nutrition, 90(6), 1674-1692. 

8. Kohrt, W. M., Bloomfield, S. A., Little, K. D., Nelson, M. E., & Yingling, V. R. (2004). American College of Sports Medicine Position Stand: physical activity 

and bone health. Medicine and Science in Sports and Exercise, 36(11), 1985-1996. 

9. Saito, M., & Marumo, K. (2010). Collagen cross-links as a determinant of bone quality: a possible explanation for bone fragility in aging, osteoporosis, 

and diabetes mellitus. Osteoporosis International, 21(2), 195-214. 

10. Martino, M. M., Briquez, P. S., Güç, E., Tortelli, F., Kilarski, W. W., Metzger, S., ... & Hubbell, J. A. (2014). Growth factors engineered for super-affinity to 

the extracellular matrix enhance tissue healing. Science, 343(6173), 885-888. 

11. Reid, I. R., Bolland, M. J., & Grey, A. (2010). Effect of calcium supplementation on hip fractures. Osteoporosis International, 21(2), 291-299. 

12. Tang, B. M., Eslick, G. D., Nowson, C., Smith, C., & Bensoussan, A. (2007). Use of calcium or calcium in combination with vitamin D supplementation 

to prevent fractures and bone loss in people aged 50 years and older: a meta-analysis. The Lancet, 370(9588), 657-666. 

13. Bristow, S. M., Gamble, G. D., Stewart, A., Horne, L., House, M. E., Aati, O., ... & Reid, I. R. (2015). Acute and 3-month effects of microcrystalline 

hydroxyapatite, calcium citrate malate, and calcium carbonate on serum calcium and markers of bone turnover: a randomised controlled trial in postmenopausal 

women. Osteoporosis International, 26(1), 408-419. 

14 Martínez-Maestre, M. Á., González-Cruz, M., & Clavel, J. (2013). Efficacy of hydroxyapatite and a triticum vulgare extract in preventing and treating osteoporosis 

in wistar rats. Journal of Osteoporosis, 2013. 

15. Yamaguchi, M., Weitzmann, M. N. (2011). Zinc stimulates osteoblastogenesis and suppresses osteoclastogenesis by antagonizing NF-κB activation. 

Molecular and Cellular Biochemistry, 355(1-2), 179-186. 

16. Xu, Y., Ye, J., Zhou, D., & Su, L. (2020). Research progress on applications of calcium derived from marine organisms. Scientific reports, 10(1), 18425 

17. Currie, C., Framroze, B., Bjerknes, C., & Hermansen, E. (2022). A Randomized, Blinded, Calcium-Carbonate Controlled Cross over Study of Serum 

Calcium Levels 24 Hours after CalGotm Oral Supplementation in Post-Menopausal Women. Biomed. J. Sci. Tech. Res, 41, 32581-32585. 


Dr. Sonja John, Head of Product and 

Application Management 

MAGNESIA GmbH 


21

Vitamins 

Photo © : Adobe Stock/Homesh 

Green powder from the Moringa tree 

Moringa: Multivitamin 

with high protein content 

Horseradish tree, drumstick tree and miracle tree are names 

for the inconspicuous Moringa tree. It has the reputation 

of being one of the most nutrient-rich plants in the world. 

Almost all plant components are usable and edible: from the 

root to the flowers and seeds to the leaves. Especially the 

powder as well as the tablets made from Moringa leaves and 

the seed oil find their way onto the European market. Moringa 

products are popular because of their ingredients and their 

many uses. The Import Promotion Desk (IPD), a project of 

the German Federal Minis-try for Economic Cooperation and 

Development (BMZ), supports producers of Moringa from 

developing and emerging countries, such as Ethiopia, Madagascar 

and Sri Lanka, in bringing their products to the EU 

market. In turn, IPD connects European buyers with selected 

suppliers and opens up alternative procurement sources for 

them. 

Wonder tree and “Shiferaw” 

There are 13 different types of Moringa trees. They belong to the plant 

family of the bennut family. The best known and most widespread 

is Moringa oleifera. The species originates 

from the Indian Himalayan region and is now 

cultivated in many tropical areas, including 

Africa, South America and Southeast Asia. 

Moringa stenopetala is a wild species native 

to southern Ethiopia and northern Kenya. It 

is often called the African Moringa tree. Both 

species do not require a lot of water, are fastgrowing 

and can reach up to ten metres in 

height. 

The Moringa tree has many names: It is 

called the horseradish tree because the tree 

roots have a pungent horseradish-like aroma 

due to the content of mustard oil glycosides. 

It is also called the drumstick tree after the 

long thin Moringa pods, which resemble 

small drumsticks in appearance. Its designation 

as a cabbage tree already indicates 

that the tree plays an important role in the 

diet of the population in southern Ethiopia. In 


Vitamins 

E thio pia, the Moringa tree is also called “Shiferaw”: the tree that can 

be used for more than 1.000 diseases. Furthermore, another name 

for it is miracle tree. It has earned this honorary title not only because 

of its richness in nutrients, but also because almost all of its parts are 

used by the local population as a food or remedy. 

Crop plant from the root to the crown 

The Moringa tree is a 100 per cent useful plant – from the roots to 

the crown of the tree: the root with its horseradish-like flavour is often 

used as a condiment. The root and bark are also used medicinally for 

internal and external applications. The blossoms of the Moringa tree 

can be processed into tea or eaten fresh. An oil rich in unsaturated 

fatty acids can be pressed from the Moringa seeds. The fruits of the 

Moringa tree, the pods, can also be used in the kitchen. The tase of 

the drumstick is said to be reminiscent of asparagus. 

Moringa leaves, for example, are traded on the markets in southern 

Ethiopia as a nutrient-rich vegetable. They serve as a cabbage substitute 

in the local cuisine and can be eaten fresh or cooked. The leaves 

are also used to make Moringa powder, which is in high demand on 

the European market. 

Nutrient bomb: Moringa powder 

Moringa leaves have a very high nutrient density. They contain vitamins 

A, B and C as well as minerals such as calcium, magnesium 

and iron. In addition, the protein content is high and most of the 

known essential amino acids are found in the leaves. 

Even after the drying process, a high proportion of nutrients is retained. 

The IPD partner com-panies in Ethiopia and Madagascar rely on 

gentle natural drying to preserve the protein and mineral content of 

the Moringa leaves, thus retaining the health-promoting effects of the 

Moringa. During the careful drying process on the shelfs, the Moringa 

leaves have to be turned daily to achieve even drying, colouring and 

to retain their high quality. The leaves come from smallholders or 

from the farm itself. 

During cultivation and processing, care is taken to ensure that 

the leaves are left in their natural state. The companies in the IPD 

programme are bio-certified, thus avoiding exposure to pesticides. 

The multivitamin with high protein content is offered in powder, tea 

and tablet form. The powder tastes slightly spicy and can be used 

in many ways. It is very popular in smoothies. But it also goes well 

in salad dressings, dips and spreads. Additionally, it can be used 

for baking and cooking to enrich hearty dishes with nutrients. Those 

who do not like the spiciness of the powder can choose Moringa 

tablets. Tea can also be brewed from the leaves. Although vitamins 

are broken down by the heat, many other nutrients of the Moringa 

leaves are also retained in the tea. 

Nutrient mix for the immune system 

In Ayurvedic medicine, Moringa is used for a variety of ailments. 

Moringa is said to help with up to 300 different conditions. As a 

dietary supplement, dried Moringa leaves with their mix of nutrients 

can help to strengthen the immune system, reduce inflammation and 

stimulate blood circulation. Moringa powder and tablets are also said 

to have a beneficial effect on the cardiovascular system. Moreover, 

it is stated that the leaves have a positive effect on blood sugar and 

cholesterol levels. 

Unsaturated fatty acids: Behen oil 

In addition to Moringa powder, Moringa oil, also known as behen oil, 

is meeting increasing interest on the European markets. It is pressed 

from the ripe Moringa seeds. The cold-pressed organic virgin oil is 

mainly known as a massage oil and as an oil for skin and hair care. It 

is said to be effective against skin infections, allergies and hair loss. 

Moringa oil is also in demand as a cooking or salad oil. The sweetnutty 

tasting oil has a high content of omega-9 fatty acids, vitamin C 

and E. 

Photo © : Betigil, Ethiopia 


www.importpromotiondesk.de/en/ 


23


Photo © : shutterstock/seksan-wangjaisuk 

Botanical extracts: 

the natural solution to flavourists’ technical 

and organoleptic requirements 

Anne Manubens 

“80 % of consumers who say they are concerned about the composition 

of their food prioritise natural products free of preservatives and 

artificial colours.” 1 Far from anecdotal, this figure reflects not simply 

a trend but a reality in numerous markets: naturalness is a core 

consumer demand. And with ‘demand’ comes ‘response’ on the part 

of manufacturers, who must be able to rely on absolutely irreproachable 

raw materials and ingredients if they are to guarantee both the 

naturalness and functionality of food products. Such is Herbarom’s 

field of expertise. For almost 30 years, the company has been developing 

and offering natural botanical extracts enabling flavourists to 

respond to market demands. 

Botanical extracts: Herbarom expertise in creating value 

all along the chain 

Established at the heart of the Fragrant, Aromatic and Medicinal 

plants sector since 1994, Herbarom has forged unique know-how 

in both the sensorial and functional aspects 

of natural ingredients. Herbarom’s expertise 

draws on guaranteed sourcing and 

traceability through controlled and sometimes 

exclusive crop-growing contracts, 

thus ensuring the availability of fundamental 

botanical extracts such as essential 

oils and flavouring preparations in addition 

to the development of tailor-made extracts 

or ingredient blends meeting specific flavour 

profiles. 

An example of this advanced expertise is 

Petroselinum crispum (Mill.) Fuss parsley, 

one of Herbarom’s specialities par excellence. 

This know-how, acquired through years 

of experience in seed selection, extraction 



processes and blending, enables Herbarom 

to effectively respond to the aromatic profiles 

sought by its customers. 

Regulatory expertise: Herbarom’s 

added value for naturalness 

The growing demand for naturalness on the 

part of both manufacturers and consumers 

is therefore a reality which requires a keen 

sense of trend anticipation by the former 

in order to meet the exact demands of the 

latter. However, this sense of anticipation 

cannot be put to work effectively without 

guidance in regulatory compliance. 

For example, a flavour can only be described 

as ‘natural’ if the aromatic agents in its 

formulation are themselves natural (such 

as mint extract or essential oil of lemon, 

etc.). This guidance constitutes Herbarom’s 

added value. Trends, by nature volatile, can 

be applied to a product only in strict compliance 

with regulations, which change regularly. 

Regulatory expertise plays an inherent 

role in the composition of the end product, 

which in addition to the demand for naturalness, 

includes functional and emotional 

aspects. 

Botanical extracts: 

the source of functionality 

In developing a successful product, botani cal 

extracts offer a dual benefit by combining 

both functional and sensorial properties. 

Photo © : Pixabay 

Functionality is a fundamental trend in food and it is worth noting in 

this respect how the dividing line between food and nutraceuticals is 

blurring. Consumers are increasingly attracted to food products with 

a beneficial aspect, an encouraging sign of the growing awareness of 

the link between diet and good health. From a market perspective, 

the functional food and beverage market represented $259 billion in 

2020, and forecasts place this figure at $530 billion in 2028. 2 

In terms of naturalness, transparency, practicality and health benefits, 

functional beverages tick all the boxes with respect to consumer 

expectations, combining the response to a physiological need with 

taste pleasure and well-being. The most popular functional beverages 

among consumers are those targeting energy, immunity, detoxification 

and stress or sleep management. 

+ 

Development of 

tailor-made solutions 

FRENCH EXPERT IN 

NATURAL PLANT EXTRACTS 

FOR FLAVOURINGS AND FOOD 

Essential oils 

Liquid extracts 

Aromatic substances 

Vegetable oils 

WWW.HERBAROM-GROUPE.COM


This sensorial and organoleptic characterisation 

of ingredients is a Herbarom specificity, 

an essential skill in guiding customers’ 

choice of ingredients and helping them to 

obtain their desired flavour. 

This natural quality of food products, 

combined with functionality and emotion, 

has thus become a key factor for consumers, 

who are increasingly attentive to both 

reduced ingredient lists, in addition to the 

correlation between the ways in which raw 

materials have been grown and used and 

the quality of the end product. 3 The steady 

growth of the natural ingredient market in the 

food sector is proof of this, and these ingredients 

are used in a wide range of applications, 

including culinary flavouring and 

plant-based beverages. 

Photo © : Shutterstock 

Herbarom boasts a unique chain of expertise 

in this market, from the selection of plant 

variety and cultivation with partner farmers, 

to extraction and technical or organoleptic 

qualification. This expertise is the result of 

almost 30 years of collaboration with the 

brands, laboratories and flavourists shaping 

the products of the future. 

For more than 15 years, the Herbarom Group has also been leading 

the development and tailoring of dietary supplements, with specific 

expertise in liquid forms. The company thus plays a strategic role in 

meeting the demand for functional food by developing plant extract 

solutions to be incorporated in the formulation of beverages. 

The emotional benefits of natural botanical extracts 

In addition to their functional properties, plant extracts are also 

emotional vectors. Their taste triggers olfactory memory, the ability we 

all have to recall a past event or moment associated with a specific 

smell. The olfactory receptors in our nose capture scent molecules 

and transmit signals to our brain, which we interpret as smell sensations. 

Added to this is the notion of taste and retronasal olfaction, and 

it is this complex combination of sensations which forms the flavour 

we can taste in food or drink. 

References 

1 

Agrotech survey, representation relative to the French 

population, Part 1: Food sensitivity and expectations - 

2022. 

2 

Fortune Business Insights, global functional food and 

beverage market, 2020 

3 

Le concept et la représentation visuelle de la naturalité 

des produits alimentaires pour le consommateur français 

[Concept and visual representation of food product naturalness 

for the French consumer], Annick Tamaro, Morgane 

Innocent, Patricia Mouen, HAL Science, 2022. 


Anne Manubens, 

Group Marketing Director and Sales Director 

at Herbarom Laboratoire 

Phone +33(0)4 81160202 

www.herbarom-groupe.com 



Photo © : shutterstock/Sergio Pazzano 

Why does Pycnogenol ® offer such 

a wide range of health benefits? 

Its mechanisms of action explained 

Dr. Franziska Weichmann 

Pycnogenol ® French maritime pine bark is 

dubbed the “gold standard ingredient”, “a 

phenomenon” and a “natural all-rounder” (1, 

2). Clinical studies have shown Pycnogenol ® 

to be beneficial for heart health, cognitive 

function and respiratory health, as well as 

for eye health, skincare, women’s health and 

several other body functions (3-10). But how 

can one ingredient alone have such a wide 

range of benefits across multiple applications? 

Let’s shed some light on the holistic 

nature and efficacy of Pycnogenol ® . 

Pycnogenol ® is much more than just 

an ingredient 

First and foremost, Pycnogenol ® stands 

apart from single compounds. Pycnogenol ® 

is a naturally programmed combination with 

constant proportions of procyanidins, bioflavonoids 

and organic acids, which offer amazing natural properties. 

Pycnogenol ® French maritime pine bark extract’s unique blend of 

active compounds cannot be found in any other plant extract. Each 

of its compounds provides a different way of acting in the body. Some 

of the larger molecules get further processed in the gut into metabolites. 

Remarkably, these metabolites are also absorbed into our bloodstream, 

contributing to Pycnogenol ® overall efficacy. 

Consequently, Pycnogenol ® offers a comprehensive array of active 

compounds, distinguishing it from single-component alternatives. 

The key properties of Pycnogenol ® on the body are its powerful antioxidant 

actions (3, 4, 11-16), its natural anti-inflammatory benefits 

(17-19), its effects on the skin and tissues (8, 18, 20, 21) and its 

support to blood circulation (3, 7, 22-33). 

Collectively, these mechanisms account for the extensive range of 

applications that Pycnogenol ® holds in the realms of health and 

beauty. Ongoing research will continue to unveil further insights 

and potentially discover additional applications for the effects of 

Pycnogenol ® . 


27


15, 25, 26, 38-43). Interestingly, it was found that a metabolite of 

Pycnogenol ® can be taken up in endothelial cells and can thus exert 

its anti-inflammatory effects directly in the endothelium (24). 

Pycnogenol ® for the endothelium 

Numerous studies have consistently shown that Pycnogenol ® improves 

endothelial function, resulting in a positive impact on both blood circulation 

and microcirculation, firmly establishing its effectiveness. 

In patients with coronary artery disease, the effect of Pycnogenol ® 

on endothelial function was investigated by assessing “flow-mediated 

dilation” in the upper arm artery (3). For this method, the expansion 

of the artery in response to an increase in the shear stress associated 

with blood flow is measured. An 8-week randomized, placebocontrolled, 

crossover, double-blind study showed an improvement 

in flow-mediated dilation of 32 % in the Pycnogenol ® group, while it 

deteriorated slightly in the placebo patients. 

In another study, the flow-mediated dilation of patients with borderline 

high blood pressure, high blood lipid levels and increased blood sugar 

levels improved significantly after 8 and 12 weeks of Pycnogenol ® 

intake (27). These studies, among several others, confirm the positive 

effects of taking Pycnogenol ® on endothelial function in patients 

with cardiovascular diseases. 

Pycnogenol ® improves blood circulation 

Keeping the cardiovascular system healthy is key for maintaining good 

vitality, physical strength, mental health and for general well-being. 

Blood vessels bring oxygen and nutrients through arteries and the 

tiniest micro vessels all over our body, providing beneficial effects from 

head to toe. Pycnogenol ® exerts some of its beneficial effects as it optimizes 

blood flow by improving endothelial function. Blood flow regulation 

involves maintaining an appropriate distribution of blood throughout 

the body to meet the metabolic demands of tissues and organs. 

All blood vessels in the cardiovascular system are lined with the 

so-called endothelium. The endothelium is a single layer of cells 

lining the inner surface of blood vessels, including arteries and veins. 

This layer not only serves as a simple delimitation of the vessel wall 

but is also significantly involved in many physiological functions, like 

controlling blood pressure by vasoconstriction and-dilation, regulating 

the exchange of substances between blood and tissues, preventing 

blood clotting, and signaling during inflammation. Endothelial function 

and blood flow regulation are crucial for overall health. 

Pycnogenol ® improves microcirculation 

Healthy microcirculation is vital as it leads to a well-functioning supply 

of nutrients and oxygen to all parts of the body. In several previously 

published studies, Pycnogenol ® was shown to improve blood circulation 

in small blood vessels in the body, like the very fine micro vessels 

in the skin, fingertips and in the inner ear or the retinal capillaries in 

the eye (7, 28-31, 34-37). 

In a 3-month study on diabetic retinopathy, Pycnogenol ® supplementation 

improved the retinal blood flow by around 30 % compared to 

no change in the control patients (7). In another study with patients 

Many different studies have shown that Pycnogenol ® has a positive 

effect on blood circulation and microcirculation (7, 28-31, 34-37) by 

improving endothelial function (3, 22-27) and by lowering platelet 

aggregation without increasing bleeding time (32, 33). In addition, 

Pycnogenol ® has been shown to normalize blood pressure and to 

improve blood lipid profile as well as blood sugar values (12, 13, 



suffering from coronary heart disease, 

microcirculation on the fingertip improved 

significantly in 54 % of the patients, taking 

Pycnogenol ® and in 33 % of the placebo 

patients after 4 weeks (31). 

inflammatory conditions like knee osteoarthritis (45, 46), endometriosis 

(47, 48) or allergic rhinitis (6, 49). Pycnogenol ® was shown to 

promote joint mobility and flexibility and naturally relieve pain. 

Pycnogenol ® helps break the 

cycle of inflammation and oxidative 

stress naturally 

The anti-inflammatory and antioxidant 

pro perties of Pycnogenol ® further contribute 

to the versatile nature of Pycnogenol ® on 

body health and beauty. Inflammation and 

oxidative stress. Inflammation and oxidative 

stress are closely linked processes in the 

body. Oxidative stress can trigger inflammation, 

and inflammation, in turn, can lead to 

more oxidative stress. (44). Initially, inflammation 

is a complex protective response of 

the body to harmful stimuli and is part of 

innate immunity. However, too much inflammation 

can lead to chronic inflammation - 

the basis of various diseases such as atherosclerosis, 

arthritis or allergies. 

Pycnogenol ® is a powerful antioxidant 

Pycnogenol ® has been investigated in various clinical studies 

and shown to possess potent antioxidant properties (3, 4, 11-16). 

Pycnogenol ® , when taken orally has been shown to both increase 

plasma antioxidant capacity, expressed as oxygen radical absorbance 

capacity (13), and decrease plasma oxidative stress measured 

as plasma free radicals (50). Pycnogenol ® has further been shown to 

protect lipids from peroxidation by free radicals in elderly people and 

people with coronary artery disease (3, 4). The protective effect of 

Pycnogenol ® on DNA oxidation was shown in a randomized, doubleblind, 

placebo-controlled study of children with ADHD, by measuring 

the level of oxidized purines (11). 

Pycnogenol ® controls inflammation 

In several studies, it was shown that 

Pycnogenol ® has inflammation reducing 

properties (17-19). Consumption of 

Pycnogenol ® was shown to significantly 

limit the activation of the pro-inflammatory 

«master switch» NF-kB by 15.5 % and 

matrix metalloproteinase 9 (MMP-9) release 

by 25 %. These are two important regulators 

in the inflammation process. This positive 

effect thus helps prevent the mobilization 

of proinflammatory molecules, which 

play a destructive role in arthritis. In another 

study, Pycnogenol ® significantly prevented 

the up-regulation of the pro-inflammatory 

enzymes 5-LOX and COX-2 after only five 

days of daily intake (17). (18). In addition, 

the consumption of a single dose of 300 mg 

Pycnogenol ® was found to naturally inhibit 

generation of COX-2 enzymes during inflammation 

in humans, thus providing a significant 

contribution for lowering pain (19). 

These beneficial effects of Pycnogenol ® 

were also observed in clinical studies with 

patients, suffering from different chronic 

Pycnogenol ® strengthens the extracellular matrix in skin, 

joints and other tissues 

The extracellular matrix consists of a complex mixture of proteins, 

glycoproteins, proteoglycans, and other molecules. It plays a vital role 

in various connective tissues, functioning as a supportive framework. 

It provides mechanical support to tissues, regulates cell behavior, 

and influences tissue development and repair. Collagen and elastin 

are crucial components of the skin’s extracellular matrix. Collagen 

provides structural support and firmness to the skin, while elastin 

ensures its elasticity. Hyaluronic acid contributes to skin hydration 

by retaining moisture. These molecules collectively promote youthful,


healthy skin and can help address issues related to aging and skin 

aging processes. In addition, collagen is a significant component 

of cartilage, which covers and protects the ends of bones in joints. 

It contributes to joint stability and flexibility. Hyaluronic acid is also 

found in joint fluid and lubricates and cushions the joints, allowing 

for smooth movement. 

Pycnogenol ® improves skin hydration and elasticity 

Pycnogenol ® was shown to increase skin elasticity and reduce skin 

fatigue by stimulation of the synthesis of new collagen and hyaluronic 

acid in the skin and inhibiting the activity of enzymes that break down 

collagen and elastin (8, 18, 20, 21). Pycnogenol ® further protects 

skin proteins against enzymatic degradation by selectively binding to 

elastin and collagen (21). 

Clinical investigations of Pycnogenol ® supplementation for 12 weeks 

with female volunteers, aged 55 to 68 years revealed increased hyaluronic 

acid synthase levels within the skin by 44 %, leading to improved 

skin hydration (20). Hyaluronic acid synthase is the natural source of 

water-binding hyaluronic acid in the dermis, which moisturizes the 

skin and keeps it taut and smooth. 

Consequently, an average skin-hydration increase by 21 % in the 

group of Pycnogenol ® supplementation was found, particularly in 

women presenting with dry skin prior to Pycnogenol ® intake. In this 

study, Pycnogenol ® was also shown to improve skin elasticity by 

25 % and decrease skin fatigue by 30 %. Interestingly, the results 

were paralleled by Pycnogenol ® ’s ability to generate skin’s connective 

tissue collagen in average by 40 %. In addition to stimulating the 

synthesis of new collagen, Pycnogenol ® metabolites can inhibit the 

release and activity of destructive enzymes (metalloproteinases 1,2 

and 9), which break down dermal tissue proteins, like collagen or 

elastin (18, 21). The reduced activity of these lytic enzymes saves the 

connective tissues from degradation, representing the basis for maintaining 

an elastic, smooth and youthful looking skin. The beneficial 

effects of Pycnogenol ® on the skin have been confirmed in several 

clinical studies. 

Pycnogenol ® has beneficial effects on joint function 

Pycnogenol ® has been shown to act beneficially in patients presenting 

with joint problems (45, 51-53). In a study with 33 patients suffering 

from severe osteoarthritis, a joint cartilage damaging condition, the 

level of matrix metalloproteinases (MMP) enzymes, that are responsible 

for destroying cartilage in joints was significantly downregulated 

in the fluid around the knee joints after taking Pycnogenol ® 

(46). These results confirm previous findings that regular intake of 

Pycnogenol ® leads to a potent decrease of pro-inflammatory markers 

like NF-κB and COX-enzymes and MMPs (17-19, 21). 

In most cases, joint pain is due to damage to the articular cartilage. 

Hyaluronic acid contributes to the shock-absorbing abilities of cartilage. 

As Pycnogenol ® significantly increased 

gene expression of hyaluronic acid synthase, 

this is helpful not only for skin but also for 

articular cartilage (20). Additionally, the abilities 

of Pycnogenol ® to increase the synthesis 

of collagen and to protect collagen from 

degradation are crucial for joint health as 

collagen is an important component of articular 

cartilage. These results are backed up 

by the finding of a strong increase of the 

concentration of Pycnogenol ® ’s metabolites 

in the synovial fluid, surrounding articular 

cartilage in the joints in osteoarthritis patients 

(46, 54). In this way, the active ingredients of 

Pycnogenol ® can act directly where they are 

needed. This comprehensively explains how 

Pycnogenol ® contributes to restoring health 

in damaged joints. 

Pycnogenol ® French pine bark extract is 

one of the most widely investigated natural 

supplements worldwide with convincing data 

for various fields of application, including 

heart health, skin care, cognitive function 

and allergy control. Pycnogenol ® is a standardized 

complex mixture of many molecules 

and has shown beneficial efficacy on blood 

circulation, strong anti-inflammatory and 

antioxidant effects and impressive action on 

the integrity of tissues. 

References 

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The Most Unique & Versatile Health Supplement: 

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4. Ryan J, Croft K, Mori T, Wesnes K, Spong J, Downey 

L, et al. An examination of the effects of the antioxidant 

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5. Weyns A-S, Verlaet AAJ, Breynaert A, Naessens T, Fransen 

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7. Steigerwalt R, Belcaro G, Cesarone MR, Di Renzo A, Grossi 

MG, Ricci A, et al. Pycnogenol improves microcirculation, 

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8. Zhao H, Wu J, Wang N, Grether-Beck S, Krutmann J, 

Wei L. Oral Pycnogenol(R) Intake Benefits the Skin in 

Urban Chinese Outdoor Workers: A Randomized, Placebo- 

Controlled, Double-Blind, and Crossover Intervention 

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14. Kolacek M, Muchova J, Dvorakova M, Paduchova Z, Zitnanova I, Cierna I, et al. Effect 

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18. Grimm T, Chovanova Z, Muchova J, Sumegova K, Liptakova A, Duracková Z, et al. Inhibition 

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20. Marini A, Grether-Beck S, Jaenicke T, Weber M, Burki C, Formann P, et al. Pycnogenol(R) 

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21. Grimm T, Schäfer A, Högger P. Antioxidant activity and inhibition of matrix metalloproteinases 

by metabolites of maritime pine bark extract (pycnogenol). Free Radic Biol Med. 

2004;36(6):811-22. 

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22. Fitzpatrick DF, Bing B, Rohdewald P. Endothelium-dependent vascular effects of 

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French maritime pine bark extract, augments endothelium-dependent vasodilation in 

humans. Hypertens Res. 2007;30(9):775-80. 

24. Uhlenhut K, Högger P. Facilitated cellular uptake and suppression of inducible nitric 

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26. Zibadi S, Rohdewald PJ, Park D, Watson RR. Reduction of cardiovascular risk factors in 

subjects with type 2 diabetes by Pycnogenol supplementation. Nutr Res. 2008;28(5):315-20. 

27. Hu S BG, Cornelli U, et al Effects of Pycnogenol ® on endothelial dysfunction in borderline 

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28. Belcaro G, Cesarone MR, Errichi BM, Ledda A, Di Renzo A, Stuard S, et al. Diabetic 

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venous insufficiency and venous microangiopathy: management with compression and 

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36. Luzzi R, Belcaro G, Hu S, Dugall M, Hosoi M, Cacchio M, et al. Improvement in symptoms 

and cochlear flow with Pycnogenol in patients with Meniere’s disease and tinnitus. 

Minerva Med 2014;105:245-54. 

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flow with Pycnogenol ® in patients with tinnitus: a pilot evaluation. Panminerva Med. 

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38. Hosseini S LJ, Sepulveda RT, Rohdewald P, Watson RR. A randomized, double-blind, 

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in modifying blood pressure in mildly hypertensive patients. Nutr Res. 2001;21(9):1251-60. 

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Panminerva Med. 2010;52(2):27-32. 

40. Schäfer A, Högger P. Oligomeric procyanidins of French maritime pine bark 

extract (Pycnogenol) effectively inhibit alpha-glucosidase. Diabetes Res Clin Pract. 

2007;77(1):41-6. 

41. Koch R. Comparative study of Venostasin and Pycnogenol in chronic venous insufficiency. 

Phytother Res. 2002;16 Suppl 1:S1-5. 

42. Trebaticky B, Muchova J, Ziaran S, Bujdak P, Breza J, Durackova Z. Natural polyphenols 

improve erectile function and lipid profile in patients suffering from erectile dysfunction. 

Bratisl Med J. 2019;120(12):941 – 4. 

43. Belcaro G, Cornelli U, Luzzi R, Cesarone MR, Dugall M, Feragalli B, et al. Pycnogenol(R) 

supplementation improves health risk factors in subjects with metabolic syndrome. Phytother 

Res. 2013;27(10):1572-8. 

44. Zuo L, Prather EL, Stetskiv M, Garrison DE, Meade 

JR, Peace TI, et al. Inflammaging and Oxidative Stress in 

Human Diseases: From Molecular Mechanisms to Novel 

Treatments. International Journal of Molecular Sciences. 

2019;20(18):4472. 

45. Cisar P, Jany R, Waczulikova I, Sumegova K, Muchova 

J, Vojtassak J, et al. Effect of pine bark extract (Pycnogenol) 

on symptoms of knee osteoarthritis. Phytother Res. 

2008;22(8):1087-92. 

46. Jessberger S, Högger P, Genest F, Salter DM, Seefried 

L. Cellular pharmacodynamic effects of Pycnogenol(R) in 

patients with severe osteoarthritis: a randomized controlled 

pilot study. BMC Complement Altern Med. 2017;17(1):537. 

47. Kohama T, Herai, K., Inoue, M Effect of French Maritime 

Pine Bark Extract on endometriosis as compared with 

leuprorelin acetate. J Reprod Med. 2007;52(8):703-8. 

48. Maia H, Jr., Haddad C, Casoy J. Combining oral contraceptives 

with a natural nuclear factor-kappa B inhibitor for 

the treatment of endometriosis-related pain. Int J Womens 

Health. 2013;6:35-9. 

49. Belcaro G LR, Cesinaro di Rocco P, Cesarone MR, 

Dugall M, Feragalli B, Errichi BM, Ippolito E, Grossi MG, 

Hosoi M, Errichi S, Cornelli U, Ledda A, Gizzi G. Pycnogenol 

improvements in asthma management. Panminerva Med. 

2011;53(3):57-64. 

50. Belcaro H, Cesarone, Dugall. A controlled study shows 

daily intake of 50 mg of French Pine Bark Extract (Pycnogenol 

® ) lowers plasma reactive oxygen metabolites in 

healthy smokers. Minerva medica. 2013;104(4):439-46. 

51. Belcaro G, Cesarone MR, Errichi S, Zulli C, Errichi 

BM, Vinciguerra G, et al. Variations in C-reactive protein, 

plasma free radicals and fibrinogen values in patients 

with osteoarthritis treated with Pycnogenol. Redox Rep. 

2008;13(6):271-6. 

52. Farid R, Mirfeizi Z, Mirheidari M, Rezaieyazdi Z, 

Mansouri H, Esmaelli H, et al. Pycnogenol supplementation 

reduces pain and stiffness and improves physical function 

in adults with knee osteoarthritis. Nutrition Research. 

2007;27(11):692-7. 

53. Belcaro G, Cesarone MR, Errichi S, Zulli C, Errichi BM, 

Vinciguerra G, et al. Treatment of osteoarthritis with Pycnogenol. 

The SVOS (San Valentino Osteo-arthrosis Study). 

Evaluation of signs, symptoms, physical performance and 

vascular aspects. Phytother Res. 2008;22(4):518-23. 

54. Mülek M, Seefried L, Genest F, Högger P. Distribution of 

Constituents and Metabolites of Maritime Pine Bark Extract 

(Pycnogenol((R))) into Serum, Blood Cells, and Synovial 

Fluid of Patients with Severe Osteoarthritis: A Randomized 

Controlled Trial. Nutrients. 2017;9(5). 


Dr. Franziska Weichmann, 

Manager of Scientific Communications and 

Product Development at 

Horphag Research 

www.pycnogenol.com 


Energy drinks 

Photo © : Stocksy_txp142854ebI5o300_OriginalDelivery_837852k 

“Caffeine alone is not enough”: Reinventing 

the ‘energy drink’ for a modern lens 

Fredrik Hjelmqvist 

Modern life is demanding as many know. 

Work, education, childcare, commuting, exercise 

and even – occasionally – just having fun, 

for consumers today it can feel like they need 

an endless reservoir of energy, just to make 

it through the day. It’s unsurprising then, 

that energy drink sales are on the rise. The 

global energy drinks market is projected to 

grow at a CAGR of 8 % over the next decade, 

reaching a value of $108 billion by 2031. 1 

Energy boosting beverages are as popular as 

ever, but is caffeine content alone enough to 

excite consumers? The holistic wellness trend 

sweeping the food and beverage sector has 

made an indelible impact on shoppers’ priorities, 

blurring the lines between health, indulgence 

and functional nutrition. The consequence 

of this attitude shift for the beverage 

segment is that shoppers don’t just want 

‘energy’ drinks, but solutions to give them 

an all-round boost with cognitive and mood 

support, as well as improved alertness and 

endurance. 

Read on as we discuss the latest nutraceutical trends and ingredients 

designed to promote a healthy mood and energize the body, 

and how producers can level up their energy drink offering for the 

modern market. 

A new view on ‘energy’ 

Despite their enduring popularity, energy drinks have had somewhat 

of a bad reputation in the popular consciousness – thought of as 

‘quick fixes’ full of sugar, excessive amounts of caffeine and artificial 

ingredients. Even among university-aged young adults – the demographic 

group most likely to consume energy drinks – the potential 

side effects of these beverages are well known. 2 According to one 

study, after consuming a traditional energy drink, 42 % of students 

reported experiencing an increased heartbeat, 36 % cited jitteriness 

and 29 % spoke of anxiety or irritability. 3 Results like this have played 

a major role in shifting attitudes towards energy drinks in recent 

years, and the subsequent rise of a more natural, healthy approach 

to energy enhancement. 

Perhaps the biggest change here relates to sugar content. Excessively 

sweet foods and beverages are an increasing concern for 

consumers, and regulators alike, with the European Soft Drinks asso- 


33

Energy drinks 

It’s been said a thousand times; taste is king. No matter how revolutionary 

a beverage’s proclaimed benefits are, if it cannot deliver 

a delicious flavour and attractive sensory experience, consumers 

simply won’t come back for more. The challenge for today’s energy 

drink formulators is balancing taste against consumer expectations 

for a natural and low-sugar positioning. Here we’ve seen plantbased 

prebiotic fibres and, more recently, 

fermented sweetening options come to the 

fore as a natural solution to creating a great 

taste, without excess added sugar. 

Photo © : GettyImages-1129493647 

ciation, UNESDA, extending its 2025 sugar reduction targets by a 

further 10 % 4 , mirroring similar initiatives from food standards agencies 

around the world. In tandem with increased regulatory scrutiny, 

consumers are driving progress through their purchasing decisions. 

Close to a quarter of recent energy drink launches featured a ‘sugar 

free’ positioning 5 , while 15 % combined the claims ‘no added sugar’ 

and ‘natural energy drink’. 6 This second point brings up the equally 

crucial factor of ‘naturalness’. Research from dsm-firmenich found 

that around 80 % of beverage consumers wanted to know whether 

a product contained natural or artificial colorants, with the former 

achieving a significantly higher purchase intent. 7 When it comes to 

the look, feel and taste of energy drinks designed for a contemporary 

audience, brands clearly need to focus on blending naturalness with 

that all important low-sugar positioning. 

Attitudes are also in flux regarding the functional side of energy 

drinks. Consumers still want their caffeine fix, but a simple, shortterm 

energy boost is no longer enough for some. Digestive health 

and immune support, for example, were cited as the most appealing 

functional beverage benefits by more than 70 % of consumers in a 

recent Global Data survey 8 , while Mintel found that almost a third of 

energy drink consumers would be motivated to buy a product proven 

to promote brain health. 9 Vitamin and mineral content too is a central 

purchase driver in the energy drink segment, both in terms of classic 

inclusions like fatigue-fighting B vitamins, and familiar favourites like 

vitamin C. The energy drink market is entering a whole new era of 

dynamism, creating exciting opportunities for beverage manufacturers. 

What brands need now is the right, high-quality ingredients 

to address evolving consumer priorities around taste, colour, sugar 

content and functionality. 

The fundamentals: Taste, texture and colour 

Nature is similarly a key inspiration in 

the realm of colorants. Ingredients like 

β-Carotene – a family of carotenoid pigments 

– for instance, have been used to great 

success to bring vibrant red, orange and 

yellow hues to beverages, the natural way. 

There are even plant-derived solutions for 

improving product texture – an aspect too 

often overlooked in energy drink formulation. 

Hydrocolloids such as pectin are an invaluable 

tool for enhancing the appearance 

and mouthfeel of ready-to-drink beverages, 

imbuing drinks with a smooth texture that 

lets star flavours shine and ensures all active 

ingredients are thoroughly suspended. 

The main event: Energy boosting 

ingredients 

The clue is in the name – ‘energy’ drinks, 

even naturally positioned, multifunctional 

ones, still need to provide consumers with a 

much-needed boost. Caffeine and, to a lesser 

extent, B vitamins remain the front runners 

in this space, but producers have begun 

exploring the potential of alternative energy 

enhancers. Proteins (including collagen 

peptides) and amino-acids have been shown 

to contribute to increased satiety 10 , as well as 

sports recovery benefits like reduced muscle 

soreness 11 , while vitamin-like substances 

like Coenzyme Q-10 help support a healthy 

cardiovascular system. 12 

Building out the nutrition profile: 

Additional functional ingredients 

As mentioned above, consumers are looking 

for more than ‘empty energy’ from their 

beverage choices. From CBD to yerba mate 

extract, adaptogens to vitamins, the wide 

array of functional ingredients we’ve seen 

added to energy drinks has gone a long way 

towards shifting the segment’s ‘unhealthy’ 

reputation. The crucial point to remember 

here for drinks manufacturers is not just 

what ingredients to include, but how they are 


Energy drinks 

incorporated. Not all trending ingredients 

are easy to blend into a beverage format, 

requiring careful management of sweetening 

solutions, texturizers, energy-boosting 

inclusions and functional extras to create the 

ideal end product. It’s here where the help of 

an experienced ingredients partner can add 

real value. 

Single supplier, multiple benefits 

To stand out in the increasingly competitive 

energy drinks space, brands need more 

than just a supplier – they need a strategic 

partner. The most experienced players operating 

in food and beverage ingredients today 

offer concept development support, formulation 

expertise, regulatory and marketing 

advice and efficiency improvements, as well 

as a comprehensive portfolio of sciencebacked 

solutions. Just as caffeine alone isn’t 

enough for today’s consumers, single-ingredient 

suppliers should not be the first choice 

for beverage brands looking to cement their 

position in the energy drink market. At dsmfirmenich, 

we strive to be this ‘one-stopshop’ 

for our customers, helping them work 

smarter at speed to create the next energy 

drink sensation. 

References 

1 

Global Opportunity Analysis and Industry Forecast, 2020- 

2031, Allied Market Research 

2 

Ghozayel M, Ghaddar A, Farhat G, Nasreddine L, Kara J, 

Jomaa L. Energy drinks consumption and perceptions 

among University Students in Beirut, Lebanon: A mixed 

methods approach. PLoS One. 2020 Apr 30;15(4):e0232199. 

doi: 10.1371/journal.pone.0232199. PMID: 32353017; 

PMCID: PMC7192412. 

3 

Ibid, Ghozayel et al, Energy drinks consumption and 

perceptions among University Students in Beirut, Lebanon 

4 

UNESDA, Soft drinks industry’s sugar reduction commitments 

across Europe, https://www.unesda.eu/sugarand-calorie-reduction/#:~:text=UNESDA%20has%20 

committed%20to%20reduce,milk%20based%20and%20 

hot%20beverages 

5 

Mintel GNDP database, accessed March 2022 

6 

Future Market Insights, Soft drinks industry’s sugar reduction 

commitments across Europe, September 2022, https:// 

www.futuremarketinsights.com/reports/energy-drinksmarket?utm_source=adwords&utm_medium=ppc&utm_ 

source=adwords&utm_medium=ppc&id=5&gclid=CjwKCAjw38SoBhB6EiwA8EQVLtCoM9MUCAY62vk0dM 

8OqDcBzECHy7n9Ks5SeLddNCs0fZgGigbr5BoCKDwQAvD_ 

BwE 

7 

Global coloration study, dsm-firmenich 2021 

8 

GlobalData, 2021 Q2 global consumer survey 

9 

A year of innovation in sports and energy drinks, Mintel 2020 

10 

Moon J, Koh G. Clinical Evidence and Mechanisms of High- 

Protein Diet-Induced Weight Loss. J Obes Metab Syndr. 

2020 Sep 30;29(3):166-173. doi: 10.7570/jomes20028. 

PMID: 32699189; PMCID: PMC7539343 

11 

Kuwaba K, Kusubata M, Taga Y, Igarashi H, Nakazato 

K, Mizuno K. Dietary collagen peptides alleviate exercise-induced 

muscle soreness in healthy middle-aged 

males: a randomized double-blinded crossover clini cal 

trial. J Int Soc Sports Nutr. 2023 Dec;20(1):2206392. doi: 

10.1080/15502783.2023.2206392. PMID: 37133292; 

PMCID: PMC10158542. 

12 

Saini R. Coenzyme Q10: The essential nutrient. J Pharm 

Bioallied Sci. 2011 Jul;3(3):466-7. doi: 10.4103/0975- 

7406.84471. PMID: 21966175; PMCID: PMC3178961. 

Faster. 

Farther. 

Longer. 


https://www.dsm.com/food-beverage/ 

en_US/insights/insights/beverage/ 

a-total-solution-for-energy-drinks--nowthat-s-worth-getting-energized-about. 

html# 

Fredrik Hjelmqvist, 

Senior Vice President Beverages & More, 

dsm-firmenich 

PeptENDURE ® – Advanced 

Performance Nutrition 

• First protein proven to enhance 

endurance performance 

• > 14 % higher speed 

• Improves energy metabolism 

NEW! 

GELITA AG · Uferstr. 7 · 69412 Eberbach · Germany · www.gelita.com


Photo © : AdobeStock_MUS_GRAPHIC 

Made from dates in Tunisia 

Date derivatives as a 

special sweetening alternative 

Who doesn't know – especially at Christmas time – the 

wonderful taste of dates?! This aromatic sweetness and a 

hint of oriental delight. Very popular are Deglet Nour dates. 

What is special about this date variety is its small fruit 

and firm flesh. Almost one third of the world’s Deglet Nour 

production comes from Tunisia. Overall, Tunisia is one of the 

largest date exporters in the world. More than 200 different 

date varieties grow in Tunisia, the most widespread being the 

Deglet Nour variety. Although the focus of Tunisian agriculture 

is on the export of fresh dates, the offer of processed 

dates is also growing. Dates can be processed into a variety 

of pro ducts: Syrup, powder, paste, juice from the fruits. The 

kernels can also be used to produce oil and coffee substitutes. 

The sugar alternatives such as date paste, powder and 

syrup impress with their taste and nutritional profile. The 

PAMPAT Tunisia project, implemented by the UN Industrial 

Develop ment Organization (UNIDO) and financed by the Swiss 

State Secretariat for Economic Affairs (SECO), supports the 

marketing of date products. At this year’s Anuga in Cologne, 

PAMPAT Tunisia organised a cooking show together with the 

Tunisian export promotion agency CEPEX to demonstrate the 

taste and uses of processed dates. 

Full of nutrients 

2 nd choice dates that cannot be sold as a 

fresh product are processed into natural 

sweeteners. Date syrup, for example, also 

contains minerals and vitamins from the date 

fruit compared to ordinary sugar (sucrose). 

Deglet Nour dates are rich in potassium, 

but also contain calcium, magnesium and B 

vitamins. Another advantage: date syrup has 

significantly fewer calories than sucrose. The 

date products consist mainly of fructose and 

retain the typical date flavour. 

“We like to use alternative sweeteners in our 

recipes,” says star chef Julia Komp from 

Cologne (“Sahila”) at Anuga. “Especially if 

they contain valuable nutritional values in 

addition to the sweetness. Date syrup is also 

vegan and thus a good honey alternative. We 

appreciate date sweetness, also because it 

gives dishes an oriental touch.” 


Date syrup, paste and powder 

Date syrup is a good alternative to honey, maple syrup, agave syrup, 

sugar beet syrup etc. Date syrup tastes less sweet than sugar and 

is good for sweetening mueslis and desserts, for example. In the 

production process, dates are cooked and the date juice is extracted. 

The juice is then boiled down to syrup. 

The main product in Tunisia with a production volume of around 

10,000 tons is date paste. It is rich in dietary fibre and you can use 

it in baking. Date powder is also used as substitute for refined sugar, 

especially in baking. Date powder is made from 100 percent dates by 

cleaning, pitting, drying at 70° C, grinding and final sieving the dates. 

Healthy and vegan sweetener 

Date products are still little known, but there is great potential 

because alternative natural and healthy sweeteners are in demand. 

In addition, unlike honey, date products are also suitable for vegan 

diets. “Almost one in three dates is not suitable for marketing as 

fresh dates”, explains Nuria Ackermann, Chief Technical Advisor 

of the PAMPAT Project (UNIDO). “And this proportion of 2 nd choice 

dates will increase as global warming will reduce date quality. But 

with processed dates and the wide range of products, Tunisia has 

an opportunity to develop a new segment and add value. Through 

processing, 2 nd choice dates can increase in value by five times.” 

NFOBOX 

About PAMPAT Tunisia 

PAMPAT (Project for Market Access of Typical Agrofood 

Products) promotes the marketing of regionally produced 

Tunisian food products both in Tunisia itself and on international 

markets. The approach includes the development of 

value chains, the promotion of origin-based quality labels and 

the promotion of products, including at international trade fairs 

such as Anuga. 

PAMPAT is a project of the United Nations Industrial 

Development Organization (UNIDO) and is financed by the 

Swiss State Secretariat for Economic Affairs (SECO). It is being 

implemented in close cooperation with the Tunisian Ministry 

of Economy, Finance and Investment Promotion, the Ministry 

of Industry, Energy and Mines and the Ministry of Agriculture, 

Water Resources and Fisheries. 


www.pampat.tn/en/ 

Create excitement with 

plant-based ingredients. 

Awaken your customers’ 

senses, naturally. 

With 70 % of consumers being convinced their food choices impact 

their mood, it comes as no surprise that they indulge in ‘good mood food’. 

With plant-based recipes becoming increasingly popular in the dessert aisle, 

BENEO’s egg-free meringue is the perfect go-to option. The recipe offers 

a delicious treat without having to compromise on taste or texture. Develop 

with BENEO and let people enjoy, experience and fulfil all senses, not just 

their taste buds. 

Healthier living through tasty food that 

tickles all senses. Move towards a more 

sustainable plant-based ingredients era. 

Come and visit us at 

booth #3.1G160 

Food ingredients 

Europe 

November 28 –30, 2023 

Frankfurt, Germany 

Want to know more 

about BENEO? 

Scan here! 


www.beneo.com


When it comes to baked goods it is crucial that alternative sweetening solutions provide a similar bulk than sugar. 

Photo © : shutterstock/4 PM production 

Ticking the boxes for sweetness and 

improved nutritional properties 

Klaudia Volmer 

Products using alternative sugars or sweeteners, and their 

effects on health, are under constant re-evaluation. Recent 

criticism of artificial sweeteners brought new attention to the 

topic, and calls for a closer look at existing solutions. Here, 

BENEO’s low-glycaemic ingredients from sugar beet offer 

indulgence while aligning with a healthy diet. 

Alternatives to traditional sugar is a topic that has recently hit the 

headlines following WHO’s publication of new guidelines on nonsugar 

sweeteners. The organisation advises against the use of noncaloric 

sweeteners for weight management, seeing them as a false 

friend when it comes to losing weight. Moreover, WHO says there 

may be other potential harmful effects from long-term use, such 

as an increased risk of type 2 diabetes, cardiovascular diseases, 

and mortality in adults. 1 The widespread notion that high-intensity 

sweeteners do not influence the human body has been challenged 

before. Data from human and animal studies indicate that nonnutritive 

sweeteners seem to impair glucose tolerance which might 

be mediated by changes in the gut microbiome. 

Though further research is needed 

for a better understanding, these results 

give reason to be cautious about the use of 

certain sweeteners. Luckily, the takeaway 

message is not to abandon anything sweet 

from the recipe or opt for industrial sugar, 

but take an informed decision on sweetening 

ingredients. 

Low-glycaemic carbohydrates 

gain traction 

Industrial sugar, but also natural sugars such 

as honey, for example, lead to a sharp rise 

of blood sugar levels quickly followed by a 

sudden fall. This so-called “boost and crash 

effect” usually causes strong cravings, which 



can lead to increased calorie intake. In the 

long run, these extreme changes in blood 

sugar levels, and thus also in insulin levels, 

can put a strain on the human body and also 

increase the risk of insulin resistance. 

Benefits for seniors and athletes alike 

The mentioned health benefits that Palatinose offers are interesting 

for various consumer groups. The potential for blood glucose 

management is, for example, particularly evident for the silver generation. 

As we age, biological processes slow down and metabolic 

responses become less effective. As a consequence, insulin resistance 

and impaired glucose tolerance is more likely. 

Moreover, as people get older, they tend to gain weight, which can 

lead to further health problems. Overweight or obese people show 

an increased risk for conditions such as higher blood pressure, 

cholesterol, triglycerides and thrombosis. Impaired glucose tolerance 

increases with age, as does the development of Diabetes mellitus. 2 

These can all increase the chances of non-communicable diseases 

such as cardiovascular disease, hypertension or type-2 diabetes. 

Fig. 1: Palatinose TM has a more moderate effect 

on blood sugar levels than conventional sugar. 

Photo © : BENEO 

This is where low-glycaemic carbohydrates 

act differently. They release their glucose 

more slowly and help to keep blood sugar 

levels more balanced. Beet sugar-derived 

Palatinose belongs to this group of lowglycaemic 

carbs. It provides energy over 

longer periods of time compared to conventional 

sugar. As the only fully available and 

slowly digestible carbohydrate with a low 

glycaemic index of 32, it delivers the same 

amount of energy to the body as sucrose 

(4 kcal/g). In comparison, conventional 

sugar is metabolised quickly, and blood 

glucose levels rise sharply before dropping 

to the basal level about one hour after intake. 

Palatinose, however, takes up to two hours 

to become fully digested and causes no boost 

and crash effect. This can be explained by 

the different structure of Palatinose and 

sucrose: Although, they resemble each 

other in their molecular structure, the fructose-glucose 

connection of Palatinose 

is more stable than that of sucrose. The 

enzymes in the small intestine take about 

four to five times as long to fully break down 

Palatinose. Thus, the contained glucose 

is gradually released into the bloodstream, 

keeping insulin secretion low, which, in turn, 

promotes fat burning. 

In order to counteract such “side effects” of ageing and avoid or 

reduce weight gain in seniors – and also in younger generations – 

a low release of the hormone insulin is key. Therefore, successful 

weight management must take blood sugar levels into account. 

In practice, this means choosing foods and beverages with only 

moderate glycaemic effects. 

The higher fat-burning rate combined with a slower, more balanced 

glucose supply, makes the low-glycaemic carb Palatinose appealing 

in the field of sports nutrition too. As endurance athletes aim for higher 

fat-burning rates as a means to improve endurance and conserve 

limited glycogen stores, Palatinose can be a true asset. 

Fig. 2: Naturalness meets functionality: BENEO’s Palatinose TM and Isomalt 

are derived from sugar beet. Photo © : BENEO 

No. 3 November/December 2023


INFOBOX 

Chicory root fibres: 

Inulin and oligofructose are further low-glycaemic ingredients. 

As prebiotic fibres, they come with a special focus on digestive 

health. While their main purpose is to support the gut, they also 

show a beneficial side effect by helping to replace sugar in end 

products. Inulin is a non-digestible fibre that occurs naturally 

in many fruits and vegetables, with chicory root as an abundant 

source. As it is not broken down in the small intestine, 

it reaches the large intestine intact and serves as “food” for 

the beneficial intestinal bacteria. The subsequent fermenting 

process in the gut produces short-chain fatty acids which have 

a positive effect on the intestinal tract, helping to maintain the 

intestinal mucosa while inhibiting the presence of undesirable 

bacteria. An EU health claim confirms that inulin promotes 

digestive health. 

BENEO’s chicory root fibres Orafti ® Inulin and Oligofructose 

have texturising properties, a mild taste, well-balanced, 

round flavour and deliver half as many calories as sugar. Due 

to their good solubility, the prebiotic fibres are suitable for a 

range of solid and liquid applications. Since they do not have an 

e-number, they allow for clean label recipes too. 

By raising the fibre content, while reducing sugar, prebiotic 

fibres make products healthier. Therefore, they support nutritional 

claims as well as a better Nutri-Score rating. In beverages, 

inulin and oligofructose benefit from the latest Nutri-Score 

updates. In April 2023, the classification for drinks underwent 

a few changes in order to be more informative for consumers. 

These changes will also be valid for milk, milk-based and plantbased 

drinks that will be included in the drinks category. One 

of the major adaptations concerns the sugar content, which will 

have a greater impact on the score once the changes are implemented 

in 2024, with a transition period of two years. Here, 

reformulation of drinks with prebiotic fibres from chicory root 

will clearly be advantageous. 

Moreover, the advantages of this alternative sugar extend beyond 

actual physi cal activity, as it also supports recovery and replenishes 

glycogen levels. To provide their body with sufficient energy, 

many athletes include a bedtime drink in their diet, especially after 

demanding hours of training or competition. Even at rest, their body 

tends to burn more calories compared to the average individual. This 

need for energy can interfere with the athlete’s recovery at night-time, 

too, when there is no food intake over many hours. Palatinose and 

its balanced glucose supply help to bridge this gap. 

Furthermore, there is scientific evidence that Palatinose can 

help maintain thermoregulation during exercise 3 – an interesting 

benefit considering that athletes have to cope with ever-increasing 

Fig. 3: Palatinose is suitable for a wide range of food and drink 

applications, including sports beverages. Photo © : shutterstock/Ukrolenochka 

temperatures in summertime. Tests with an 

isomaltulose-electrolyte-drink during exercise 

demonstrated that it was just as good as 

an electrolyte drink with sucrose in regulating 

the body temperature and even showed a 

beneficial effect on hydration as more fluid 

was stored in the body and less urine was 

excreted. 4,5 

Isomalt as a tooth-friendly sugar 

replacer 

Isomalt is another low-glycaemic carb which 

BENEO derives from sugar beet. It is the only 

sugar replacer made from this plant, but 

with half as many calories as sucrose and 

an almost negligible effect on blood sugar 

and insulin levels. Isomalt is well-suited for 

the confectionery segment, as it has a sugarlike, 

mild taste that enhances subtle flavours 

but has no aftertaste or cooling effect associated 

with some sweeteners. The mild 

sweetness leads to a more intense aroma. 

Isomalt provides bulk and texture, too, and 

can replace conventional sugar in the same 

proportion in numerous applications within 

the confectionery and bakery segments. In 

products such as cookies, cakes, chews and 

jellies, Isomalt contributes to a good texture. 

It also supports the whiteness in coatings. 



In the field of sugar replacers, Isomalt offers 

another important feature: It is tooth-friendly, 

as demonstrated by an official EU health 

claim. Studies have shown that the sugar 

substitute does not nourish caries bacteria 

and reduces the development of plaque. 

These properties qualify Isomalt for use in 

tooth-friendly versions of chewing gums, 

candies and other confectionery – and 

contribute to their popularity: Isomalt is the 

most widely used sugar replacer in sugarfree 

hard candies worldwide. 

Putting it into practice 

While a healthier product is appealing to 

many consumers, it will only succeed on 

the market if it delivers the right indulgence. 

Reducing or replacing conventional sugar 

should therefore involve sensorial and technological 

considerations. By removing sugar, 

product qualities such as bulk, mouthfeel 

and texture can be negatively impacted. 

Ingredients must therefore be added back in 

to create a pleasing product for consumers. 

To ensure that the end product tastes as good as usual, but is healthier 

than before, specialists at the BENEO-Technology Center conduct 

regular recipe trials that also undergo stringent sensorial evaluation, 

to guarantee that they will deliver in terms of taste and texture. Reformulating 

products in order to lower their sugar content or focus on 

a low-glycaemic effect, requires the close collaboration of manufacturers 

and functional ingredients experts. 

References 

1 

https://www.who.int/news/item/15-05-2023-who-advises-not-to-use-non-sugar-sweeteners-for-weight-control-in-newly-released-guideline 

2 

International Diabetes Federation, Diabetes Atlas 9th Edition (2019) 

3 

Otsuka et al. (2021) Int J Environ Res Public Health 18(11). https://pubmed.ncbi.nlm.nih. 

gov/34072006/ 

4 

Takada et al (2022) Eur J Appl Physiol 22(12):2615-2626. doi: 10.1007/s00421-022- 

05044-9 

5 

Amano et al. (2022) Physiol Behav. 249:113770. https://doi.org/10.1016/j.physbeh.2022.113770 


Klaudia Volmer, Product Manager 

Functional Carbohydrates 

BENEO GmbH 

Phone: +49 621 421-150 

contact@beneo.com 

www.beneo.com


Photo © : GoodMills Innovation 

Spermidine science: unlocking the secrets 

to healthy ageing 

Katharina Ursula Haack 

A growing body of scientific evidence is driving interest in spermidine 

as an active ingredient for inclusion in healthy ageing 

products. Max Weber, Category Manager Baking, Snacks & 

Special Ingredients at GoodMills Innovation GmbH, summarises 

the science behind this remarkable compound and examines 

the opportunities for incorporating it into marketable food, 

beverage and supplement concepts. 

In recent years, healthy ageing has become one of the most dynamic 

areas of health science, with researchers working to discover new 

insights that can help people to live longer and healthier. For example, 

researchers are currently investigating telomere length, DNA damage 

and inflammation as biomarkers of ageing in order to better understand 

the ageing process and develop healthy ageing interventions. 

Cell renewal science 

One of the biggest breakthroughs in age related health science in 

recent history has been Yoshinori Ohsumi’s research into the mechanisms 

behind autophagy. 

The word autophagy originates from the 

Greek words auto and phagein, (meaning 

‘self eating’). This concept emerged during 

the 1960s, when researchers first observed 

that a cell could recycle its contents. 

Difficulties in studying the phenomenon 

meant that little was known until Ohsumi, of 

the Tokyo Institute of Technology, focused his 

efforts on this process. Ohsumi’s research 

led to a new paradigm in autophagy science 

and in 2016 he was awarded the Nobel Prize 

in Physiology or Medicine for his discoveries 

of mechanisms for autophagy. 

Via these mechanisms, damaged organelles 

(subcellular structures that perform specific 

tasks in the cell) are recycled and used in 

the biosynthesis of new cell generation, thus 

promoting sustained cell health. 



Thanks to the research carried out by 

Ohsumi and others, the scientific community 

now has a better understanding of how 

autophagy controls important physiological 

functions where cellular components need 

to be degraded and recycled. 

Autophagy and ageing 

Scientists also established that autophagy 

is an important process for healthy ageing. 

Defects in the autophagy process have been 

associated with immunity loss, cognitive loss 

and ageing. Autophagy is thought to protect 

against diseases and slow down the ageing 

process. 

The next challenge was working out what 

interventions could promote autophagy 

activity. This is where spermidine - a polyamine 

that that occurs naturally in all living 

organisms, including plants, foodstuffs, 

mammals and men - comes into play. 

Through its interactions with cell metabolism, 

spermidine has been characterised by scientists as a natural 

autophagy inducer, and, in this capacity, has been shown to act as 

an ‘anti-ageing agent’. 

Spermidine under investigation 

Today, there is a robust and ever-expanding body of research 

pertaining to spermidine’s role in many of the molecular mechanisms 

involved in ageing. To date over 13,000 studies have been carried out 

on spermidine, of which approximately 70 are human clinical trials. 

Photo © : GoodMills Innovation


Photo © : GoodMills Innovation 

About 100 scientific laboratories are currently investigating spermidine 

and its effects. Having established its anti-ageing functionality, 

research is now evolving to explore the mechanisms responsible, 

as well as spermidine’s role in specific health areas, such as heart 

disease, cancer, immunity, dementia and longevity. 

High spermidine levels for a longer life 

One of the most interesting findings was the discovery in 2012 that 

the endogenous spermidine level decreases with age, especially after 

60, but that very old people, over 90, have very high levels 1 . This 

might seem paradoxical but actually makes perfect sense - those with 

high spermidine levels live longer. 

Another more recent study involving 829 participants aged 45-84 

found that a spermidine-rich diet can add five years onto a person’s 

lifespan 2 . The researchers said the study provided the first evidence 

of an association between nutrition rich in spermidine and increased 

survival in humans. 

“If confirmed in future intervention trials, our study may have implications 

for health education at a population level advocating high spermidine 

content as a novel feature of a healthy diet,” the researchers 

wrote in The American Journal of Clinical Nutrition. 

Lifespan and healthspan: 

protecting cognitive performance 

But a long lifespan is just one dimension of healthy ageing - quality of 

life is as important as quantity. To this end, spermidine also appears 

to have positive effects on age-related neurological disorders and 

cognitive impairment. 

The Vienna Dementia Study in 2021 3 was a major milestone in 

establishing a clear correlation between intake of spermidine and 

the improvement of cognitive performance in seniors with no or 

mild dementia. 85 seniors from six nursing homes participated in 

the multi-centre, double-blind study, which showed improved cognitive 

performance after just three months of spermidine supplementation. 

This corroborated findings that spermidine supplementation 

increases memory performance in a similar 

study carried out at Charité in 2018 4 . 

Meeting demand for anti-ageing solutions 

As global populations grow older, and the 

prospect of living into their eighties or nineties 

becomes a realistic expectation for many 

people, demand for nutritional solutions that 

can help support long, healthy, active lifestyles 

is poised to surge in the next few years. 

A recent market intelligence report predicted 

a CAGR (Compound Annual Growth Rate) of 

5.23 % for anti-ageing supplements globally 

between 2023 and 2028. 

As one of the most researched active 

compounds, spermidine is likely to play a 

starring role in the healthy ageing revolution. 

However, this is dependent on food, 

beverage and supplement manufacturers 

having an application-ready source of spermidine 

at their disposal. 

In order to satisfy changing consumer 

pre ferences, it is also important that spermidine 

is available in plant-based, veganfriendly 

formats. The same report highlights 

plant-based supplements as a significant 

growth opportunity in this space as 

consumers seek natural, sustainable and 

additive-free products. 

Natural extraction 

SpermidineEvo ® delivers on both fronts. It 

is sourced from wheat germ, which has the 

highest spermidine concentration of any 

plant-based foodstuff - higher than soybeans, 

buckwheat and rice. The wheat germ is 

well protected inside the wheat kernel and 

accounts for approximately 2.5-3.5 % of 

the total kernel. GoodMills has optimised 

the milling process to separate the germ, 

bran and other grain components. A gentle 

thermal treatment improves the stability of 

the wheat germ. This is followed by a milling 

process to produce a fine powder with an 

aromatic, nutty taste. This highly concentrated 

form of wheat germ has a tightly 

controlled spermidine content - up to five 

times as much as conventional wheat germs. 



2 g of SpermidineEvo ® provides a 1 mg dose 

of spermidine. 

The ingredient also contains other valuable 

vitamins and minerals, including vitamin E, 

which has long been considered a key antiaging 

ingredient owing to its proven ability to 

protect cells against oxidative damage. 

Importantly, SpermidineEvo ® is not classed 

as a Novel Food, which means no regulatory 

approval is needed to incorporate it 

into foods and beverages destined for sale 

in the EU. 

Psychographic segmentation 

Whilst finding the right ingredients is a challenge 

for product developers, for marketers, 

the challenge is figuring out what kinds 

of healthy ageing products will capture 

consumer interest and imagination. 

Market research shows that healthy ageing 

is a very relevant topic for all age groups, not 

just seniors. That is why GoodMills Innovation 

is advising customers to use a psychographic 

segmentation approach when it 

comes to finding the right audience for their 

products. 

Lifestyle consumers, for example, seem 

to be a natural target, as maintaining their 

physical and cognitive health as they age is 

of high importance to them and they have 

the spending power to put it into practice. 

When targeting a more mature audience, 

brands should also take account of the fact 

that ‘old’ people don’t want to view themselves 

as ‘old’. Therefore, products need 

to be geared towards age-neutral audiences 

and focus on aspirational values, with 

preventative health and positive ageing at 

the forefront of communication. 

Keeping products age-neutral also means 

that brands are likely to attract a broader 

audience. In Innova’s 2021 Health & Nutrition 

Survey, 66 % of consumers globally 

said that healthy ageing was very/extremely 

important to them. That represents a large 

potential market. 

Whilst seniors are the most obvious target for healthy-ageing products, 

younger consumers are increasingly switched on to the idea 

of taking proactive action to slow the ageing process. According to 

the same Innova survey, almost 50 % of Generation Z consumers 

reported taking steps to age healthily from the age of 20. 

A powerful product development tool 

Consumers want to live longer and better, and nutrition is one of the 

most promising strategies for promoting healthy ageing. Spermidine’s 

role in maintaining physical and cognitive health through its ability to 

influence autophagy is well documented, making it a prime candidate 

for the job. Providing the crucial link between academic research and 

real world product development, SpermidineEvo ® enables manufacturers 

to develop powerful products that harness spermidine science 

and market demand for healthy ageing solutions. 

References 

1 

Pucciarelli S, Moreschini B, Micozzi D, De Fronzo GS, Carpi FM, Polzonetti V, Vincenzetti S, 

Mignini F, Napolioni V. Spermidine and spermine are enriched in whole blood of nona/centenarians. 

Rejuvenation Res. 2012 Dec;15(6):590-5. doi: 10.1089/rej.2012.1349. Epub 2012 

Nov 16. PMID: 22950434. 

2 

Kiechl S, Pechlaner R, Willeit P, Notdurfter M, Paulweber B, Willeit K, Werner P, Ruckenstuhl 

C, Iglseder B, Weger S, Mairhofer B, Gartner M, Kedenko L, Chmelikova M, Stekovic 

S, Stuppner H, Oberhollenzer F, Kroemer G, Mayr M, Eisenberg T, Tilg H, Madeo F, Willeit J. 

Higher spermidine intake is linked to lower mortality: a prospective population-based study. 

Am J Clin Nutr. 2018 Aug 1;108(2):371-380. doi: 10.1093/ajcn/nqy102. PMID: 29955838. 

3 

Pekar T, Bruckner K, Pauschenwein-Frantsich S, Gschaider A, Oppliger M, Willesberger J, 

Ungersbäck P, Wendzel A, Kremer A, Flak W, Wantke F, Jarisch R. The positive effect of spermidine 

in older adults suffering from dementia : First results of a 3-month trial. Wien Klin 

Wochenschr. 2021 May;133(9-10):484-491. doi: 10.1007/s00508-020-01758-y. Epub 2020 

Nov 19. PMID: 33211152; PMCID: PMC8116233. 

4 

Wirth M, Benson G, Schwarz C, Köbe T, Grittner U, Schmitz D, Sigrist SJ, Bohlken J, Stekovic 

S, Madeo F, Flöel A. The effect of spermidine on memory performance in older adults at risk 

for dementia: A randomized controlled trial. Cortex. 2018 Dec;109:181-188. doi: 10.1016/j. 

cortex.2018.09.014. Epub 2018 Oct 4. PMID: 30388439. 

5 

https://www.marknteladvisors.com/research-library/anti-aging-supplements-market.html 


Katharina Ursula Haack, 

Head of Marketing Communications, 

GoodMills Innovation GmbH 

Trettaustr. 35 

21107 Hamburg, Germany 

Katharina.Haack@goodmillsinnovation.com 

www.goodmillsinnovation.com 


45


Photo © : GELITA 

Equipping the body to push harder for longer 

GELITA introduces the first protein ingredient targeted at endurance sports 

Oliver Wolf 

Whether it’s a marathon, a triathlon, a team event like football 

or a high intensity gym-based workout, sports that test 

endurance may differ in specifics, but they share a common 

denominator: they place extreme demands on the body over 

a sustained period of time. 

Traditionally, because endurance sports rely heavily on aerobic 

metabolism, nutrition products aimed at participants have been rich 

in carbohydrate, which is sometimes referred to as ‘the master fuel’. 

However, carbohydrates are not the whole story. Endurance performance 

also requires protein, and a new product from collagen manufacturer 

GELITA aims to fill a gap in the market with a specific type of 

protein with particular benefits in this respect. 

A growing market 

Consumer interest in endurance activities is growing, and online platforms 

and Apps encouraging people to come together in events and 

track their individual progress are booming. 

Strava, said to be the world’s largest sports 

community, recently published a review of 

data from its 100 million-plus members, 

which showed that the number of runners 

who completed a marathon in 2022 was 

almost twice as high as in 2021 (1). And 

when events booking platform Let’s Do This 

secured $60 million in new funding last year, 

co-founder Sam Brown said: “The global 

sports endurance market is worth an estimated 

$18 billion… we know this is only set 

to grow.” 

In terms of sports nutrition products, analysts 

at Future Market Insights (FMI), valued the 

global market at around USD 30.6 billion in 

2022. By 2032, FMI expects it to have more 

than doubled in value, to be worth around 

USD 64 billion. 



North America leads the way in consumption 

of sports nutrition products, with the 

UK, Germany and France the next biggest 

markets, and Asia-Pacific predicted to be 

the fastest growing region over the next 10 

years (2). 

“Consumers are treating their bodies like 

an ecosystem and seeking solutions that 

complement their personal health and 

evolving needs,” says FMI. “Consumer 

needs have become more diverse and 

sophisticated and are defining premium 

growth categories.” 

Products targeting endurance sports look 

likely to be one of these premium growth 

categories – not only because more people 

are taking part, but also because participants 

often have high levels of disposable 

income. In an article entitled ‘Why 

rich people love triathlons’, for instance, 

personal trainer Alexander Cortes says: 

“Endurance sports are very popular in the 

highest income brackets… It’s a mixture 

of psychology, social status signaling and 

prestige, and environmental luxury.” (3) 

Already, the market offers endurance 

sports participants an abundance of carbohydrate-rich 

foods and drinks that supply 

an instant boost of energy. But until now, 

there hasn’t been a targeted protein solution 

that offers long-lasting, foundational 

benefits that can help them to push harder 

and perform better in a sustained way. 

Protein for endurance 

Adequate protein intake is essential for performance. Proteins are 

vital building blocks for the structure and metabolism of muscle, 

bone and connective tissue. Proteins and amino acids also play a 

key role in cellular metabolism, hormone balance, immunity, coagulation 

and energy metabolism. 

In terms of sports nutrition, proteins are often reported to have 

positive effects on muscle protein synthesis, muscle mass, muscle 

strength, improvement of body composition, prevention of catabolic 

state, immune competence and optimal regeneration in the 

post-exercise phase (4). 

GELITA’s new product, PeptENDURE ® , harnesses the benefits of 

a specific set of Bioactive Collagen Peptides (BCP ® ) with a unique 

ability to provide long-term adaptation benefits for endurance athletes 

in particular. 

What is PeptENDURE ® ? 

PeptENDURE ® is composed of functional short chain amino acids 

produced by simple hydrolysis of natural collagen protein. But rather 

than simply building muscle like a traditional protein supplement, it 

delivers foundational changes. 

PeptENDURE ® has been shown in two studies and in practice to 

improve energy metabolism, endurance and cardiovascular fitness 

so that athletes find it easier to push harder and perform better. 

“PeptENDURE ® isn’t just another ‘quick fix’ product – it is something 

different that allows athletes to see long-term performance benefits,” 

says Martin Walter, Category Manager Healthy Aging & Sports Nutrition 

at GELITA. “Our research suggests that PeptENDURE ® promotes 

adaptative changes in the mitochondria. This is supported by two 

placebo controlled clinical trials, where results were impressive.” 

PROBIOTICS 

INFANT QUALITY 

SAME BENEFITS AS USING 

FRESH YOGURT 

PRESENCE OF LIVING BACTERIA 

CONTRIBUTES TO INNER 

WELL-BEING 

IMPROVEMENT OF 

LACTOSE DIGESTION 

INDUSTRIAL TOOL THAT PRODUCES 

INFANT FORMULA 

HIGHLY CONTROLLED 

ENVIRONMENT 

SOURCE OF PROTEINS & CALCIUM 

Food ingredients 

 

28-30 november 2023 

Frankfurt (Germany) 


47


In the first trial, young, active women took either a daily dose of 

PeptENDURE ® or placebo for 12 weeks, alongside concurrent resistance 

and endurance training three times a week. At the end of 12 

weeks, both groups completed a one-hour running time trial. The 

results showed that the PeptENDURE ® group ran significantly further 

than the placebo group (+331 m) and also had a significant increase 

Fig. 1: After 12 weeks in the women’s study, the PeptENDURE ® group was 

not only faster than baseline, but also ran 331m more than the placebo 

group in a one-hour time trial. 

in fat-free mass. There were also visible 

improvements such as improved aerobic 

metabolism, improved heart rate and higher 

individual anaerobic thresholds (5). 

In the second trial, the same study design 

followed young, active men. Participants 

took either a daily dose of PeptENDURE ® or 

a placebo for 12 weeks, alongside concurrent 

resistance and endurance training three 

times a week. At the end of the 12 weeks, the 

PeptENDURE ® group ran significantly further 

(+662 m) in the one-hour time trial than the 

placebo group. In addition, the fat mass of 

the intervention group decreased and the 

lactate threshold improved significantly, indicating 

increased fat metabolism (6). 

“Overall, the trials showed that participants 

who took PeptENDURE ® were able to run 14 

percent faster compared to baseline, which 

could be the difference between finishing 

fifth in a race and finishing first,” says Martin 

Walter. 

Characteristics and applications 

Fig. 2: The men who took PeptENDURE ® for 12 weeks were faster than at 

baseline and ran significantly more in one hour (662m) than those who took 

placebo. 

Like all GELITA BCP ® , PeptENDURE ® is a 

pure white, neutral-tasting powder. It comes 

in agglomerated form for dust-free handling, 

combines well with other micronutrients such 

Due to its excellent solubility, PeptENDURE ® is perfectly suited for ready-to-drink products. (Photo © : GELITA) 



as vitamins and minerals and has excellent 

bioavailability. Recommended intake is 15 g 

daily for at least three months. 

GELITA expects powder supplements to be 

the core application format for PeptENDURE ® 

as it dissolves quickly and easily in water and 

other drinks. There’s no need for a blender or 

other complicated routine – users simply stir 

and go. The powder can also be mixed with 

other foods, such as yogurt, for example, for 

breakfast in the morning with cereals. 

Being 100 percent natural and free from 

E-numbers, PeptENDURE ® is ideal for clean 

label products, and it can be customised 

with different flavors and levels of sweetness. 

PeptENDURE ® also works well in ready-todrink 

concepts, gels and nutrition bars. 

GELITA is a leader in collagen peptide 

science and has many years of experience 

in sports nutrition. “Safety is always 

our top priority with all of our products, and 

PeptENDURE ® is no different,” says Martin 

Walter. “Its safety has been well documented 

in human and animal studies. It is non-allergenic, 

non-GMO, gluten-free, GRAS and 

accepted by the World Anti-Doping Agency, 

so athletes can consume it with confidence.” 

Positioning and potential 

PeptENDURE ® can be used as an everyday training partner for athletes in all 

endurance sports, from long-distance running, cycling and triathlon to team 

sports and high-intensity gym-based activities.(Photo © : GELITA) 

running and triathlon to team sports and high-intensity gym-based 

activities. This makes it appealing for a wide range of consumers and 

brings manufacturers many benefits, including the ability to expand 

their sports nutrition portfolio with high value products. 

GELITA’s technical application service team supports manufacturers 

and supplement brands regarding product applications, regulatory 

or technical issues. GELITA can also offer support with marketing 

advice. 

As PeptENDURE ® is different to other sports 

nutrition ingredients, it can be seen as an 

‘add on’ product for athletes, rather than an 

alternative. It could, for instance, be positioned 

as a ‘Daily Adaptation’ product that 

forms part of an endurance-based training 

program. 

PeptENDURE ® can also be positioned as part 

of a ‘Competition Bundle’, where products 

are collated for consumers looking to 

embrace a period of training ahead of a 

new goal, or as a ‘Training Partner’ offering 

holistic support that equips users to take on 

any challenge. 

Unlike anything else on the market, 

PeptENDURE ® has the potential to become 

the everyday training partner for participants 

in all endurance sports – from long-distance 

References 

(1) Strava, Year in Sport 2022. https://www.strava.com/yis-community-2022 [Last 

accessed 10.10.2023] 

(2) Future Market Insights ‘Capitalizing on the trends shaping the sports nutrition market: 

2023 and beyond!’ Presented at Vitafoods Europe 2022. https-//www.futuremarketinsights. 

com/blogs/sports-nutrition-market-2023.pdf [Last accessed: 11.10.2023]. 

(3) https://cortes.site/why-rich-people-love-triathlons/ [Last accessed 12.10.23] 

(4) Koenig et al. (2020): Proteins in sports nutrition. Position of the working group sports 

nutrition of the German Nutrition Society (DGE). Ernahrungs Umschau 2020; 67(7): 132–9. 

DOI: 10.4455/eu.2020.039 

(5) Jendricke et al. (2020): Influence of Specific Collagen Peptides and Concurrent Training 

on Cardiometabolic Parameters and Performance Indices in Women: A Randomized 

Controlled Trial. Front Nutr. 2020 Nov 19;7:580918. doi: 10.3389/fnut.2020.580918. 

(6) Jerger et al. (in preparation) 


Oliver Wolf 

Marketing EMEIA, 

Business Unit Nutrition & Health Ingredients 

GELITA AG 

Oliver.Wolf@gelita.com 

www.gelita.com 


49

Obituary 

Au Revoir Edouard 

We mourn the loss of our friend and partner - Edouard Costemend 

Photo © : Adobe Stock/AlenKadr 

For decades Edouard has been the representative of Wellness Foods 

& Supplements and other journals of the Dr. Harnisch publishing 

house in France. 

Born in Lille in 1937, married to Marie-Christine since 1977, he had 

two children, Benjamin and Constance. In 2022 he became the 

happy grandfather of his first grandchild. 

He had been taught the German language and culture by his father, a 

medical doctor. His first internship took him to Leica in Wetzlar, where 

he developed his passion for Leica and photography. 

For 28 years he worked for Gustav Elm, an advertising agency in 

Paris, which represented, among others, the magazine DER SPIEGEL 

in France. Since 1993 he has been working independently with 

his company AD PRESSE International, since 2000 exclusively for 

Dr. Harnisch Verlag. His son Benjamin has meanwhile succeeded 

him as area representative for France. 

In addition to his professional activities, Edouard Costemend was an 

umpire at the French Open Tennis Championships at Roland Garros. 

Furthermore, he was characterized by lively cultural and political 

interests. 

Edouard Costemend was a noble, impressive man; he was trusted 

and held in high esteem everywhere. His integrity was a benchmark 

for all his colleagues. At the same time Edouard could be very funny 

and had a warm sense of humor. He was a wonderful host whenever 

we met in Paris and he loved showing the team different special 

places, away from the more tourist areas. 

Edouard Costemend (*1937-2023) 

We lose a valued friend and good partner 

and will miss him greatly. 

Our sympathy goes to his family, 

Marie-Christine, Benjamin and Constance. 

Benno Keller, Publisher 

Silke Watkins, Editor-in-Chief 

Impressum 

ISSN 2364-8104 

Wellness Foods & Supplements | No. 3/2023 

Publishing Company 

Dr Harnisch Publications 

Dr Claus-Jörg Harnisch, Benno Keller 

Eschenstr. 25 | D-90441 Nuremberg | Germany 

Phone: +49 (0)911 2018-0 

Fax: +49 (0)911 2018-100 

wfs@harnisch.com | www.harnisch.com 

Editor-in-Chief Silke Watkins 

Publisher Benno Keller 

Editorial team Sebastian Martinek, 

Ian Healey 

Media Representatives 

France 

Benjamin Costemend, benjamin.costemend@gmail.com 

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Benno Keller, keller@harnisch.com 

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North America 

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International Magazine September 2022 ISSN 2628-5851 

Technology & Marketing 

Technology & Marketing 3/22 

Ingredients: Plant-Based Food, Black Soldier Flies, Fibers and Cellulose, Grain Acceptability 

Processing: Wet Petfood Processing, Quality Control, Heat Exchangers, Mixing 

Packaging: Pouches and Alutrays, No Waste, Weighing Investment 

Free trial issue at food@harnisch.com 

The magazine PetFood PRO has grown out of a conviction 

and wish to underline the high level of quality and care in the 

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will endeavour to present this in an informative way, through a 

reader-friendly style and with a marketing perspective. 

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