CSF ACR 2023 PsA Highlights
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<strong>ACR</strong> <strong>2023</strong><br />
Congress Preview<br />
Psoriatic Arthritis<br />
Faculty Introduction<br />
Dear Colleagues,<br />
Welcome to this year’s selection of <strong>ACR</strong> abstracts on <strong>PsA</strong> and my ‘<strong>Highlights</strong>’. We have selected 26 abstracts that cover<br />
a range of key topics in the management of psoriatic arthritis that I believe will be of particular interest to you.<br />
Sunday’s poster session features comprehensive data from phase 2 and phase 3 trials of bimekizumab (0511 and 0527)<br />
and deucravacitinib (0485, 0508, and 0509). These studies, authored by Elaine Husni, Lihi Eder, and Philip Mease, provide<br />
insights into the efficacy, safety, and tolerability of these treatments. As part of an abstract session, Alan Kivitz (0776) will<br />
also discuss the efficacy and safety of secukinumab as a treatment for <strong>PsA</strong>.<br />
Launching into Monday, you’ll be met with another poster session with a focus on the treatment of spondylarthritis,<br />
including psoriatic arthritis, with posters from a variety of esteemed authors. Here you’ll find 16 of our recommended<br />
posters, with data from studies such as the phase 3 COSMOS study (1428) and the KEE<strong>PsA</strong>KE 1 and 2 trials (1434<br />
and 1435). Later that day the poster Prediction of Low Disease Activity in Patients with Ankylosing Spondylitis Treated<br />
with Secukinumab in Real World – Data from a German Observational Study by Uta Kiltz (1390) will also be presented.<br />
In addition, two abstracts by Philip Mease on the efficacy of Izokibep and the results from the FOREMOST study will be<br />
presented (1688 and 1691) that we recommend looking out for.<br />
On Tuesday, three more posters of note will be presented; Bimekizumab Treatment in Patients with Active <strong>PsA</strong> and Prior<br />
Inadequate Response to TNF Inhibitors: Sustained Efficacy and Safety Results from a Phase 3 Study and Its Open-Label<br />
Extension up to 1 Year by Laura Coates (2230), Four-year Secukinumab Treatment Outcomes in Axial Spondyloarthritis<br />
and Psoriatic Arthritis Patients Treated in Routine Care: Results from the EuroSpA Collaboration by Marion Pons (2199)<br />
and Direct and Indirect Effects of Upadacitinib or Adalimumab on Pain in Psoriatic Arthritis: Results from a Randomized<br />
Phase 3 Study by Peter Taylor (2251).<br />
On the Wednesday, we conclude the congress with a scientific session, a final poster presentation, and late-breaking<br />
abstracts. These sessions promise exciting updates on <strong>PsA</strong> therapy. You can find more details in this brochure.<br />
As always, thank you for your continued support. We hope you have a fantastic time and thank you for being a part<br />
of <strong>ACR</strong> <strong>2023</strong>!<br />
Kind regards<br />
Professor Laura Coates<br />
PS. Make sure you get all the insights from this <strong>ACR</strong> by downloading our other highlights brochures, and if you want to<br />
see the top picks for Lupus head on over to www.lupus-forum.com where you’ll find the top <strong>ACR</strong> picks and their top<br />
abstracts in the field of lupus therapeutics.<br />
Register for FREE content at<br />
www.cytokinesignalling.com<br />
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Cytokine Signalling Forum<br />
SPONSORSHIP AND UNRESTRICTED<br />
EDUCATIONAL GRANTS FROM<br />
DEVELOPED UNDER<br />
THE AUSPICES OF THE
KEY:<br />
H<br />
<strong>Highlights</strong><br />
ABSTRACT SESSION<br />
POSTER SESSION<br />
SCIENTIFIC SESSION<br />
Key Presentations<br />
Sunday, 12 November <strong>2023</strong><br />
09:00–<br />
11:00<br />
0338<br />
09:00–<br />
11:00<br />
0452<br />
09:00–<br />
11:00<br />
0485<br />
0498<br />
0499<br />
0508<br />
0509<br />
PATIENT OUTCOMES, PREFERENCES, &<br />
ATTITUDES POSTER I<br />
Comparative Disease Burden in Patients with Rheumatoid<br />
Arthritis, Psoriatic Arthritis or Ankylosing Spondylitis: Data<br />
from COVAD Patient-reported E-survey<br />
Diego Benavent<br />
RA – TREATMENTS POSTER I<br />
Real Life Safety and Survival of Targeted Therapies in<br />
Arthritis Patients over Age of 65<br />
Elena Grau Garcia<br />
SPONDYLOARTHRITIS INCLUDING PSORIATIC<br />
ARTHRITIS – DIAGNOSIS, MANIFESTATIONS,<br />
& OUTCOMES POSTER I: PSA<br />
Sex and Treatment-associated Outcomes in Patients<br />
with Active Psoriatic Arthritis Treated with Deucravacitinib,<br />
an Oral, Selective, Allosteric Tyrosine Kinase 2 Inhibitor,<br />
in a Phase 2 Trial<br />
Lihi Eder<br />
Biological Therapies for Psoriasis and Psoriatic Arthritiseffects<br />
on Future Risk Development of Major Adverse<br />
Cardiovascular Events (MACE)<br />
Howard Amital<br />
Durability of Response Among Patients with Psoriatic<br />
Arthritis (<strong>PsA</strong>) Using Biological or Targeted Synthetic<br />
Disease-Modifying Antirheumatic Drugs in the CorEvitas<br />
<strong>PsA</strong>/Spondyloarthritis Registry<br />
Robert Low<br />
Assessment of Pain Outcomes in a Phase 2 Trial<br />
of a Selective, Allosteric Tyrosine Kinase 2 Inhibitor,<br />
Deucravacitinib, in Patients with Active <strong>PsA</strong><br />
Philip J. Mease<br />
Assessment of Direct and Indirect Impact on<br />
Pain and Fatigue Outcomes in a Phase 2 Clinical<br />
Trial of Deucravacitinib, a Selective, Allosteric<br />
Tyrosine Kinase 2 Inhibitor, in Patients with<br />
Active <strong>PsA</strong>: A Mediation Analysis<br />
Philip J. Mease<br />
H<br />
H<br />
09:00–<br />
11:00<br />
0511<br />
0524<br />
0527<br />
14:00–<br />
15:30<br />
0739<br />
0775<br />
0776<br />
0779<br />
0780<br />
16:00–<br />
17:00<br />
12S155<br />
SPONDYLOARTHRITIS INCLUDING PSORIATIC<br />
ARTHRITIS – TREATMENT: AXSPA POSTER I<br />
Long-term Safety and Tolerability of Bimekizumab<br />
in Patients with Axial Spondyloarthritis and Psoriatic<br />
Arthritis: Results from Pooled Phase 2b/3 Studies<br />
Philip J. Mease<br />
Efficacy of Certolizumab Pegol in Preventing Anterior<br />
Uveitis Flares Compared with Standard Non-Biologic<br />
Treatment: A Matched Control Study in High-Risk<br />
Patients with Axial Spondyloarthritis<br />
Nigil Haroon<br />
Bimekizumab Treatment Impact on Pain and<br />
Fatigue in Patients with Active Psoriatic Arthritis<br />
Who Were Biologic DMARD Naïve or Had Inadequate<br />
Response or Intolerance to TNF-α Inhibitors: 1-Year<br />
Results from Two Phase 3 Studies<br />
M. Elaine Husni<br />
SPONDYLOARTHRITIS INCLUDING PSORIATIC<br />
ARTHRITIS – TREATMENT I: PSA<br />
Major Adverse Cardiovascular Event and Venous<br />
Thromboembolism Risk Comparing Advanced Therapies<br />
Among Individuals with Axial Spondylarthritis and<br />
Psoriatic Arthritis<br />
Sali Merjanah<br />
Effectiveness of Dose Reduction and Withdrawal Strategies of<br />
TNF Inhibitors in Psoriatic Arthritis and Axial Spondyloarthritis:<br />
Long Term Extension of the DRESS-PS Study<br />
Amy Peeters<br />
Efficacy and Safety of Intravenous Secukinumab<br />
for the Treatment of Active Psoriatic Arthritis:<br />
16- and 52-Week Results from a Randomized,<br />
Double-Blind, Phase 3 Study<br />
Alan Kivitz<br />
Influence of Sex on the Persistence of Different Classes<br />
of Targeted Therapies for Psoriatic Arthritis: A Cohort Study<br />
of 14,778 Patients from the French Health Insurance<br />
Database (SNDS)<br />
Laura Pina Vegas<br />
Assessing Differential Effects of DMARDs on Psoriasis<br />
Area and Severity Index and Patient Global Assessment<br />
in Subgroups of Patients with Active <strong>PsA</strong> Treated over<br />
52-weeks with Secukinumab in a Non-Interventional Trial<br />
(AQUILA) Using a Multistage Clustering Approach<br />
Michaela Koehm<br />
EPIDEMIOLOGY, HEALTH POLICY AND OUTCOMES<br />
Chairs: Kristi Kuhn, Michael Weisman<br />
FDA Update on Safety Issues in the Treatment of<br />
Rheumatic Diseases<br />
Eric Gapud, Nadia Habal, Anil Rajpal<br />
H<br />
H<br />
H
KEY:<br />
H<br />
<strong>Highlights</strong><br />
ABSTRACT SESSION<br />
POSTER SESSION<br />
SCIENTIFIC SESSION<br />
Monday, 13 November <strong>2023</strong><br />
09:00–<br />
11:00<br />
1041<br />
09:00–<br />
11:00<br />
1132<br />
09:00–<br />
11:00<br />
1210<br />
09:00–<br />
11:00<br />
1390<br />
1394<br />
09:00–<br />
11:00<br />
1412<br />
1413<br />
1414<br />
IMAGING OF RHEUMATIC DISEASES POSTER I<br />
Efficacy of Apremilast on Peripheral and Axial Inflammation<br />
in Patients with Psoriatic Arthritis Based on Whole-Body<br />
Magnetic Resonance Imaging<br />
Mikkel Østergaard<br />
MISCELLANEOUS RHEUMATIC &<br />
INFLAMMATORY DISEASES POSTER II<br />
Preclinical Profiles of FZ007-119, a Highly Potent and<br />
Selective Tyk2 Inhibitor, for the Treatment of Immune<br />
Mediated Inflammatory Disease<br />
Shiqun Zhang<br />
PATIENT OUTCOMES, PREFERENCES, &<br />
ATTITUDES POSTER II<br />
Assessing Patient-Reported Drug Efficacy and Adherence<br />
Among IL-23 Inhibitors for Psoriasis and Psoriatic Arthritis<br />
Fahad Ahmed<br />
SPONDYLOARTHRITIS INCLUDING PSORIATIC<br />
ARTHRITIS – DIAGNOSIS, MANIFESTATIONS,<br />
& OUTCOMES POSTER II: IMAGING & AS<br />
Prediction of Low Disease Activity in Patients<br />
with Ankylosing Spondylitis Treated with<br />
Secukinumab in Real World – Data from a<br />
German Observational Study<br />
Uta Kiltz<br />
Comorbidities, Not Long-Term Use of Nonsteroidal<br />
Anti-Inflammatory Drugs, May Be Associated with Chronic<br />
Kidney Disease in Patients with Ankylosing Spondylitis:<br />
A Nationwide Population-Based Study<br />
Bon San Koo<br />
SPONDYLOARTHRITIS INCLUDING PSORIATIC<br />
ARTHRITIS – TREATMENT POSTER II: SPA<br />
Improvements in Patient-Reported Outcomes H<br />
Through 6 Months of Guselkumab Treatment in<br />
Patients with Active Psoriatic Arthritis: Real World Data<br />
from the CorEvitas Psoriatic Arthritis/Spondyloarthritis<br />
(<strong>PsA</strong>/SpA) Registry<br />
Philip J. Mease<br />
Effect of Apremilast Treatment on the Domains of<br />
MDA-Joints in Patients with Early Oligoarticular Psoriatic<br />
Arthritis: 16-Week Results from FOREMOST<br />
Philip J. Mease<br />
Effects of Apremilast on Changes in Cardiometabolic<br />
Parameters by Diabetes and Obesity Status in Patients<br />
with Psoriatic Arthritis<br />
Philip J. Mease<br />
H<br />
1415<br />
1417<br />
1418<br />
1419<br />
1420<br />
1421<br />
1422<br />
1423<br />
1424<br />
1425<br />
1426<br />
Bimekizumab Treatment Impact on Work Productivity<br />
in Biologic DMARD-Naïve and TNFi-IR Patients with<br />
Active Psoriatic Arthritis: Results up to 1 Year from Two<br />
Phase 3 Studies<br />
Philip J. Mease<br />
Do Long-term Patient-reported Outcomes<br />
H<br />
Improve Similarly in Psoriatic Arthritis and Axial<br />
Spondyloarthritis Patients Treated with Secukinumab?<br />
Results from the EuroSpA Collaboration<br />
Marion Pons<br />
Efficacy of the Oral, Selective, Allosteric Tyrosine H<br />
Kinase 2 Inhibitor, Deucravacitinib, on Psoriasis in<br />
Patients with Active <strong>PsA</strong>: Results from a Phase 2 Trial<br />
Alice B. Gottlieb<br />
Impact of Psoriatic Arthritis Manifestations on<br />
Perception of Pain Improvement: Pooled Analysis<br />
of Two Phase 3, Randomized, DoubleBlind,<br />
Placebo-Controlled Studies with Guselkumab<br />
Peter Nash<br />
Changes in Serum Cytokines and Collagen Proteins<br />
Correlate with Durability of Guselkumab Efficacy and<br />
Continued Disease Improvement Through 2 Years in<br />
Patients with Active Psoriatic Arthritis<br />
Stefan Siebert<br />
Domains Impacting Minimal Disease Activity<br />
Non-Achievement in Patients with Psoriatic Arthritis<br />
and Inadequate Response to TNF Inhibitors Receiving<br />
Guselkumab (COSMOS)<br />
Laura Coates<br />
Long-Term Safety of Risankizumab in Patients<br />
with Psoriatic Disease: Integrated Analysis of<br />
Psoriasis and Psoriatic Arthritis Clinical Trial Data<br />
Laura Coates<br />
Impact of Upadacitinib on Enthesitis and Dactylitis<br />
by Location in Patients with Psoriatic Arthritis and<br />
an Inadequate Response to Biologic DMARDs from<br />
the SELECT-<strong>PsA</strong> 2 Trial<br />
Laura Coates<br />
Early Fatigue Improvement with Guselkumab Associates<br />
with Longer Term Disease Control in Patients with Active<br />
Psoriatic Arthritis Reporting Substantial Fatigue: Post Hoc<br />
Analyses of a Sub-Population of a Phase 3, Randomized,<br />
Controlled Trial of Guselkumab in Biologic-Naïve Patients<br />
Dafna Gladman<br />
Efficacy and Safety of Tofacitinib in an<br />
Open-Label, Long-Term Extension Study in<br />
Patients with Psoriatic Arthritis Who Received<br />
Adalimumab or Tofacitinib in a Phase 3 Randomized<br />
Controlled Study: A Post Hoc Analysis<br />
Dafna Gladman<br />
Distinct Treatment Response Trajectories in Patients with<br />
Psoriatic Arthritis Receiving Tofacitinib<br />
Dafna Gladman<br />
H<br />
H<br />
H<br />
H
KEY:<br />
H<br />
<strong>Highlights</strong><br />
ABSTRACT SESSION<br />
POSTER SESSION<br />
SCIENTIFIC SESSION<br />
1427<br />
Efficacy of Upadacitinib in Patients with Psoriatic Arthritis<br />
Stratified by Involvement of Weight-bearing Joint Regions:<br />
A Post Hoc Subgroup Analysis of the Phase 3, Randomized,<br />
SELECT-<strong>PsA</strong> 1 and SELECT-<strong>PsA</strong> 2 Trials<br />
Kristi Mizelle<br />
1439<br />
Better Drug Retention on anti-IL17A Compared to<br />
Anti-TNF Therapy Despite Its Inferior Effect on Composite<br />
Joint Indexes and Quality of Life in Patients with<br />
<strong>PsA</strong>–analysis from the Czech Biologics Registry ATTRA<br />
Jakub Zavada<br />
1428<br />
1429<br />
Guselkumab Provides Clinically Meaningful<br />
Improvents in Patient Reported Outcomes in<br />
Patients with Active Psoriatic Arthritis Who Are<br />
Inadequate Responders to Tumour Necrosis Factor<br />
Inhibitors: Results Through One Year of a Phase 3b,<br />
Randomized, Controlled Study (COSMOS)<br />
Laure Gossec<br />
Longitudinal Evaluation of the Novel Psoriatic Arthritis<br />
5-Thermometer Scale (<strong>PsA</strong>-5Ts) Domains During Treatment<br />
with Guselkumab: Pooled Analysis of Three Phase 3,<br />
Randomized, Double-blind, Placebo-Controlled Studies<br />
Carlo Selmi<br />
H<br />
1440<br />
16:00–<br />
17:30<br />
1687<br />
Removal of Methotrexate in Patients with Active Psoriatic<br />
Arthritis with Newly Induced Ustekinumab Treatment Leads<br />
to a Delayed Response in DAPSA and DAS28 Within the<br />
First 16 Weeks<br />
Michaela Koehm<br />
SPONDYLOARTHRITIS INCLUDING PSORIATIC<br />
ARTHRITIS – TREATMENT II: PSA<br />
Sex of the Patient Affects Response to Advanced<br />
Therapies in Psoriatic Arthritis: Meta-analysis of Data from<br />
Randomized Controlled Trials<br />
Lihi Eder<br />
1431<br />
Izokibep, a Unique IL-17A Inhibitor, Improves<br />
Patient-Reported Outcomes in Patients with<br />
Active Psoriatic Arthritis up to Week 46 – Phase 2<br />
RCT Results<br />
Peter C. Taylor<br />
H<br />
1688<br />
Izokibep Demonstrates Major Disease Control<br />
on <strong>ACR</strong>70, PASI100 and Enthesitis Resolution<br />
in Patients with Active Psoriatic Arthritis Treated<br />
Through 46 Weeks<br />
Philip J. Mease<br />
H<br />
1433<br />
1434<br />
1435<br />
Bimekizumab Impact on Core Group for Research H<br />
and Assessment of Psoriasis and Psoriatic Arthritis<br />
(GRAPPA) Domains for Patients with Psoriatic Arthritis:<br />
52-Week Results from Four Phase 3 Studies<br />
Joseph Merola<br />
Long-Term Efficacy and Safety of Risankizumab<br />
for Active Psoriatic Arthritis: 148-Week Results<br />
from the KEE<strong>PsA</strong>KE 2 Trial<br />
Andrew Östör<br />
Long-Term Efficacy and Safety of Risankizumab H<br />
for CsDMARD-IR Patients with Active Psoriatic<br />
Arthritis: 148-Week Results from the KEE<strong>PsA</strong>KE 1 Trial<br />
Lars Erik<br />
H<br />
1690<br />
1691<br />
1692<br />
Apremilast Reduces Inflammation as Measured by MRI of<br />
the Hand in Patients with Psoriatic Arthritis: Primary Results<br />
from the Phase 4 MOSAIC Study<br />
Mikkel Østergaard<br />
16-Week Results from FOREMOST, a Placebo-<br />
Controlled Study Involving Oligoarticular Psoriatic<br />
Arthritis Treated with Apremilast<br />
Philip J. Mease<br />
Insights on the Use of JAK-inhibitors in Patients with<br />
Psoriatic Arthritis in an International Collaboration of<br />
Registers (the “JAK-pot” Study)<br />
Romain Aymon<br />
H<br />
1436<br />
Secukinumab Demonstrates a Consistent Safety<br />
Profile in Patients with Psoriasis, Psoriatic<br />
Arthritis and Axial Spondyloarthritis: Updated<br />
Pooled Safety Analysis from Clinical Trials<br />
Atul Deodhar<br />
H<br />
1437<br />
Bimekizumab Maintained Efficacy Responses<br />
Through 52 Weeks in Biologic Disease-Modifying<br />
Antirheumatic Drug-Naïve Patients with Psoriatic<br />
Arthritis Who Were Responders at Week 16:<br />
Results from a Phase 3, Active-Reference Study<br />
William R. Tillett<br />
H<br />
1438<br />
Efficacy of Guselkumab in Early-Onset and<br />
Late-Onset Psoriatic Arthritis: Post Hoc Pooled<br />
Analyses of Two Phase 3 Randomized Controlled<br />
Trials in Patients with Active <strong>PsA</strong><br />
Enrique Soriano<br />
H
KEY:<br />
H<br />
<strong>Highlights</strong><br />
ABSTRACT SESSION<br />
POSTER SESSION<br />
SCIENTIFIC SESSION<br />
Tuesday, 14 November <strong>2023</strong><br />
09:00–<br />
11:00<br />
1891<br />
09:00–<br />
11:00<br />
0265<br />
1920<br />
09:00–<br />
11:00<br />
2145<br />
2146<br />
09:00–<br />
11:00<br />
2199<br />
09:00–<br />
11:00<br />
2227<br />
2228<br />
2229<br />
IMAGING OF RHEUMATIC DISEASES POSTER II<br />
Effect of Apremilast on Disease Interception in Patients with<br />
Psoriasis at Increased Risk of Developing <strong>PsA</strong> – Results of<br />
the Prospective Interventional Epos Trial<br />
David Simon<br />
MISCELLANEOUS RHEUMATIC &<br />
INFLAMMATORY DISEASES POSTER III<br />
Differential and Combinatorial Mechanism of Action of<br />
Golimumab and Guselkumab in Ulcerative Colitis Induction<br />
Therapy: IL-23 Blockade Drives Restoration of Normal<br />
Epithelium and Mucosal Healing<br />
Dennis McGonagle<br />
A Phase Ib/II Randomized, Double-blind, Placebo-controlled<br />
Study of Novel anti-IL-17A Monoclonal Antibody JS005 in<br />
Patients with Moderate to Severe Psoriasis<br />
Zhanglei Mu<br />
RA – TREATMENTS POSTER III<br />
Patterns of Use, Effectiveness, Persistence and Cardiovascular<br />
Risk in Patients with Rheumatic Diseases Treated with<br />
Upadacitinib in a Real-world Setting. UPAREAL Study<br />
Alicia Garcia Dorta<br />
After JAK Inhibitor Failure, “Switching” or “Cycling”?<br />
Pablo Francisco Muñoz Martínez<br />
SPONDYLOARTHRITIS INCLUDING PSORIATIC<br />
ARTHRITIS – DIAGNOSIS, MANIFESTATIONS,<br />
& OUTCOMES POSTER III: SPA<br />
Four-year Secukinumab Treatment Outcomes<br />
in Axial Spondyloarthritis and Psoriatic Arthritis<br />
Patients Treated in Routine Care: Results from<br />
the EuroSpA Collaboration<br />
Marion Pons<br />
SPONDYLOARTHRITIS INCLUDING PSORIATIC<br />
ARTHRITIS – TREATMENT: SPA POSTER III<br />
The Impact of Smoking Status on One Year Secukinumab<br />
Retention Rate in 1,684 Patients with <strong>PsA</strong>: Real-World<br />
Results from the EuroSpA Collaboration<br />
Zohra Faizy Ahmadzay<br />
Early Improvement in 3 Visual Analogue Scale (3VAS)/4VAS<br />
Predicts Reduced Rates of Radiographic Change in<br />
Bio-naive Active Psoriatic Arthritis Patients Receiving<br />
Guselkumab Treatment<br />
William R. Tillett/Laura Coates<br />
Individual Entheseal Points Have Differential Frequency<br />
of Involvement and Impact on Patient Reported<br />
Outcomes in Patients with Active Psoriatic Arthritis:<br />
Pooled Analysis of Two Phase 3, Randomized,<br />
Double-Blind, Placebo-Controlled Studies<br />
Laura Coates<br />
H<br />
2230<br />
2231<br />
2232<br />
2233<br />
2236<br />
2237<br />
2238<br />
2239<br />
2240<br />
2241<br />
2242<br />
2243<br />
2244<br />
Bimekizumab Treatment in Patients with Active<br />
<strong>PsA</strong> and Prior Inadequate Response to TNF Inhibitors:<br />
Sustained Efficacy and Safety Results from a Phase 3<br />
Study and Its Open-Label Extension up to 1 Year<br />
Laura Coates<br />
Ixekizumab Significantly Improves Nail Disease and<br />
Adjacent Joint Tenderness and Swelling in Psoriatic Arthritis<br />
Dennis McGonagle<br />
Guselkumab, an IL-23p19 Subunit–specific Monoclonal<br />
Antibody, Is Able to Bind CD64+ Myeloid Cells, Potently<br />
Neutralize IL-23 Produced from the Cells, and Mediate<br />
Internalization of IL-23<br />
Dennis McGonagle<br />
Neutrophil Levels Associate with Early Improvement in Spinal<br />
Pain and Week 24 Multi-Domain Disease Control During<br />
Guselkumab Treatment in Active Psoriatic Arthritis: Post Hoc<br />
Pooled Analyses of Two Phase 3 Randomized Controlled Trials<br />
Thomas Macleod<br />
Guselkumab Provides Rapid Clinically Meaningful<br />
Improvements in Clinical and Patient Reported Outcomes<br />
and Sustained Disease Control of Psoriatic Arthritis<br />
Jeffrey R. Curtis<br />
Upadacitinib in Refractory Psoriatic Arthritis.<br />
Multicenter Study of 134 Patients in Clinical Practice<br />
Eva Galindez-Agirregoikoa<br />
Longitudinal Effect of Guselkumab on Biomarkers<br />
of Inflammation and Cardiovascular Risk in Bionaive<br />
Patients with Active Psoriatic Arthritis and High Systemic<br />
Inflammatory Burden: Post-hoc Analysis of a Phase 3,<br />
Randomized, Double-blind, Placebo-Controlled Study<br />
Arthur Kavanaugh<br />
Achievement of Disease Control in <strong>PsA</strong> Patients Treated<br />
with Upadacitinib at Week 152: Post Hoc Analysis of the<br />
Long-term Extensions of Two Phase 3 Trials<br />
Arthur Kavanaugh<br />
Persistence to Therapy Among Patients with Psoriatic Arthritis<br />
Treated with IL-17A or TNFα Inhibitors (IL-17Ai or TNFi)<br />
Aisha Vadhariya/Sarah Ross<br />
Guselkumab Efficacy in Active Psoriatic Arthritis Patients with<br />
or Without Hyperuricemia: Post-hoc Analysis of Two Phase 3,<br />
Randomized, Doubleblind, Placebo-Controlled Studies<br />
Renaud Felten<br />
Irrespective of the Number of Erosions at Baseline,<br />
Patients with Psoriatic Arthritis Treated with Ixekizumab<br />
Show Improved Clinical Outcomes<br />
M. Elaine Husni<br />
Ultrasound Enthesitis Responsiveness versus Clinical Enthesitis<br />
Responsiveness: Week 52 Results of an Exploratory Analysis<br />
from a Phase 3b Study in Patients with Psoriatic Arthritis<br />
Maria Antonietta D’Agostino<br />
Switching Between Biologics and Targeted Synthetic<br />
Therapies Due to Inefficacy in Psoriatic Arthritis<br />
Dalifer Freites Núñez<br />
H
KEY:<br />
H<br />
<strong>Highlights</strong><br />
ABSTRACT SESSION<br />
POSTER SESSION<br />
SCIENTIFIC SESSION<br />
2245<br />
2246<br />
2249<br />
2250<br />
2251<br />
2252<br />
2253<br />
2254<br />
16:00–<br />
17:30<br />
2505<br />
Drug Survival of Risankizumab vs Other Biologics After<br />
13 Months of Treatment Among Patients with <strong>PsA</strong> in the<br />
Multicountry Postmarketing Observational VALUE Study<br />
Lars Erik<br />
Real-World Switching and Discontinuation Patterns for<br />
Biologic Disease-Modifying Antirheumatic Drugs in Patients<br />
with Active Psoriatic Arthritis in Japan<br />
Lars Erik<br />
Bimekizumab-Treated Patients with Active <strong>PsA</strong> Showed<br />
Sustained Improvement in Disease Symptoms Assessed<br />
by the <strong>PsA</strong> Impact of Disease (<strong>PsA</strong>ID)-12 Questionnaire:<br />
1-Year Results Reported from Two Phase 3 Studies<br />
Dafna Gladman<br />
Bimekizumab Impact on Health-Related Quality of Life and<br />
Physical Function in Patients with Active Psoriatic Arthritis<br />
Who Were Biologic DMARD Naïve or Had Inadequate<br />
Response or Intolerance to TNF-α Inhibitors: 1-Year Results<br />
from Two Phase 3, Randomized Studies<br />
Dafna Gladman<br />
Direct and Indirect Effects of Upadacitinib<br />
or Adalimumab on Pain in Psoriatic Arthritis:<br />
Results from a Randomized Phase 3 Study<br />
Peter C. Taylor<br />
Bimekizumab Maintained Efficacy Responses Through<br />
52 Weeks in Patients with Psoriatic Arthritis and<br />
Inadequate Response or Intolerance to TNF-α Inhibitors<br />
Who Were Responders at Week 16: Results from a<br />
Phase 3, Randomized Study<br />
William R. Tillett<br />
Deucravacitinib, an Oral, Allosteric, Selective Tyrosine<br />
Kinase 2 Inhibitor, in Patients with Plaque Psoriasis Who<br />
Screened Positive for Psoriatic Arthritis in POETYK PSO-1<br />
and POETYK PSO-2: Effect on Joint Pain and Peripheral<br />
Joint Disease vs Placebo and Apremilast<br />
Joseph Merola<br />
The Effects of Interleukin 17 Inhibitors on Major Adverse<br />
Cardiovascular Events in Patients Naïve to Biologic Agents<br />
with Psoriasis or Psoriatic Arthritis: A Systematic Review<br />
and Meta-Analysis of Randomized Controlled Trials<br />
Ruoning Ni<br />
CYTOKINES & CELL TRAFFICKING<br />
Discovery of First-in-Class IRAK4 Scaffolding Inhibitors for<br />
the Treatment of Inflammatory Disorders<br />
Kate Byth<br />
H<br />
Wednesday, 15 November <strong>2023</strong><br />
09:00–<br />
10:30<br />
2566<br />
9:15–<br />
10:15<br />
15W112<br />
EPIDEMIOLOGY & PUBLIC HEALTH III<br />
Comparisons of the Risk of Serious Infections Associated<br />
with the Different Classes of Targeted Therapies Used in<br />
Psoriatic Arthritis Patients: A Nationwide Cohort Study from<br />
the French Health Insurance Database<br />
Léa Bastard<br />
SPONDYLOARTHRITIS (SPA) INCLUDING<br />
PSORIATIC ARTHRITIS (PSA)<br />
Chairs: M. Elaine Husni<br />
Getting Skin and Joint in the Game: Key Players in the<br />
Psoriatic Arthritis Microenvironment<br />
Ursula Fearon, Christopher Ritchlin, Jose Scher<br />
Satellite Symposia<br />
SUNDAY, 12 NOVEMBER <strong>2023</strong><br />
11:30–<br />
12:15<br />
18:00–<br />
20:00<br />
18:00–<br />
20:00<br />
18:00–<br />
20:00<br />
Treating Patients with <strong>PsA</strong> and AS Today & Tomorrow<br />
Sponsor: Eli Lilly Chair: Ara Dikranian<br />
Novartis’ Commitment in Rheumatology<br />
Sponsor: Novartis Chairs: Adam Winseck, Antton Egana,<br />
Kelly Montalto<br />
The IL-17 Story: All in the Family<br />
Sponsor: UCB, Inc Chair: Dirk Elewaut<br />
Reaching Beneath the Surface: Exploring treatment that<br />
addresses multiple domains with a well-documented safety<br />
profile for adult patients with active <strong>PsA</strong><br />
Sponsor: AbbVie Chair: Alan Epstein<br />
MONDAY, 13 NOVEMBER <strong>2023</strong><br />
18:00–<br />
20:00<br />
Navigating the Complexities of Individualized Treatment in<br />
Psoriatic Arthritis and Axial Spondyloarthritis<br />
Sponsor: Eli Lilly Chairs: Arthur Kavanaugh,<br />
Catherine Bakewell,<br />
Atul Deodhar, Alexis Ogdie<br />
TUESDAY, 14 NOVEMBER <strong>2023</strong><br />
18:00–<br />
20:00<br />
Raising the Bar: Optimizing Outcomes with IL-23/IL-17<br />
Inhibitors in Spondyloarthritis<br />
Sponsor: UCB Chairs: Lianne S. Gensler,<br />
Ana-Maria Orbai,<br />
Victoria Navarro-Compán<br />
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