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CSF ACR 2023 PsA Highlights

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<strong>ACR</strong> <strong>2023</strong><br />

Congress Preview<br />

Psoriatic Arthritis<br />

Faculty Introduction<br />

Dear Colleagues,<br />

Welcome to this year’s selection of <strong>ACR</strong> abstracts on <strong>PsA</strong> and my ‘<strong>Highlights</strong>’. We have selected 26 abstracts that cover<br />

a range of key topics in the management of psoriatic arthritis that I believe will be of particular interest to you.<br />

Sunday’s poster session features comprehensive data from phase 2 and phase 3 trials of bimekizumab (0511 and 0527)<br />

and deucravacitinib (0485, 0508, and 0509). These studies, authored by Elaine Husni, Lihi Eder, and Philip Mease, provide<br />

insights into the efficacy, safety, and tolerability of these treatments. As part of an abstract session, Alan Kivitz (0776) will<br />

also discuss the efficacy and safety of secukinumab as a treatment for <strong>PsA</strong>.<br />

Launching into Monday, you’ll be met with another poster session with a focus on the treatment of spondylarthritis,<br />

including psoriatic arthritis, with posters from a variety of esteemed authors. Here you’ll find 16 of our recommended<br />

posters, with data from studies such as the phase 3 COSMOS study (1428) and the KEE<strong>PsA</strong>KE 1 and 2 trials (1434<br />

and 1435). Later that day the poster Prediction of Low Disease Activity in Patients with Ankylosing Spondylitis Treated<br />

with Secukinumab in Real World – Data from a German Observational Study by Uta Kiltz (1390) will also be presented.<br />

In addition, two abstracts by Philip Mease on the efficacy of Izokibep and the results from the FOREMOST study will be<br />

presented (1688 and 1691) that we recommend looking out for.<br />

On Tuesday, three more posters of note will be presented; Bimekizumab Treatment in Patients with Active <strong>PsA</strong> and Prior<br />

Inadequate Response to TNF Inhibitors: Sustained Efficacy and Safety Results from a Phase 3 Study and Its Open-Label<br />

Extension up to 1 Year by Laura Coates (2230), Four-year Secukinumab Treatment Outcomes in Axial Spondyloarthritis<br />

and Psoriatic Arthritis Patients Treated in Routine Care: Results from the EuroSpA Collaboration by Marion Pons (2199)<br />

and Direct and Indirect Effects of Upadacitinib or Adalimumab on Pain in Psoriatic Arthritis: Results from a Randomized<br />

Phase 3 Study by Peter Taylor (2251).<br />

On the Wednesday, we conclude the congress with a scientific session, a final poster presentation, and late-breaking<br />

abstracts. These sessions promise exciting updates on <strong>PsA</strong> therapy. You can find more details in this brochure.<br />

As always, thank you for your continued support. We hope you have a fantastic time and thank you for being a part<br />

of <strong>ACR</strong> <strong>2023</strong>!<br />

Kind regards<br />

Professor Laura Coates<br />

PS. Make sure you get all the insights from this <strong>ACR</strong> by downloading our other highlights brochures, and if you want to<br />

see the top picks for Lupus head on over to www.lupus-forum.com where you’ll find the top <strong>ACR</strong> picks and their top<br />

abstracts in the field of lupus therapeutics.<br />

Register for FREE content at<br />

www.cytokinesignalling.com<br />

Follow us at:<br />

Cytokine Signalling Forum<br />

SPONSORSHIP AND UNRESTRICTED<br />

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THE AUSPICES OF THE


KEY:<br />

H<br />

<strong>Highlights</strong><br />

ABSTRACT SESSION<br />

POSTER SESSION<br />

SCIENTIFIC SESSION<br />

Key Presentations<br />

Sunday, 12 November <strong>2023</strong><br />

09:00–<br />

11:00<br />

0338<br />

09:00–<br />

11:00<br />

0452<br />

09:00–<br />

11:00<br />

0485<br />

0498<br />

0499<br />

0508<br />

0509<br />

PATIENT OUTCOMES, PREFERENCES, &<br />

ATTITUDES POSTER I<br />

Comparative Disease Burden in Patients with Rheumatoid<br />

Arthritis, Psoriatic Arthritis or Ankylosing Spondylitis: Data<br />

from COVAD Patient-reported E-survey<br />

Diego Benavent<br />

RA – TREATMENTS POSTER I<br />

Real Life Safety and Survival of Targeted Therapies in<br />

Arthritis Patients over Age of 65<br />

Elena Grau Garcia<br />

SPONDYLOARTHRITIS INCLUDING PSORIATIC<br />

ARTHRITIS – DIAGNOSIS, MANIFESTATIONS,<br />

& OUTCOMES POSTER I: PSA<br />

Sex and Treatment-associated Outcomes in Patients<br />

with Active Psoriatic Arthritis Treated with Deucravacitinib,<br />

an Oral, Selective, Allosteric Tyrosine Kinase 2 Inhibitor,<br />

in a Phase 2 Trial<br />

Lihi Eder<br />

Biological Therapies for Psoriasis and Psoriatic Arthritiseffects<br />

on Future Risk Development of Major Adverse<br />

Cardiovascular Events (MACE)<br />

Howard Amital<br />

Durability of Response Among Patients with Psoriatic<br />

Arthritis (<strong>PsA</strong>) Using Biological or Targeted Synthetic<br />

Disease-Modifying Antirheumatic Drugs in the CorEvitas<br />

<strong>PsA</strong>/Spondyloarthritis Registry<br />

Robert Low<br />

Assessment of Pain Outcomes in a Phase 2 Trial<br />

of a Selective, Allosteric Tyrosine Kinase 2 Inhibitor,<br />

Deucravacitinib, in Patients with Active <strong>PsA</strong><br />

Philip J. Mease<br />

Assessment of Direct and Indirect Impact on<br />

Pain and Fatigue Outcomes in a Phase 2 Clinical<br />

Trial of Deucravacitinib, a Selective, Allosteric<br />

Tyrosine Kinase 2 Inhibitor, in Patients with<br />

Active <strong>PsA</strong>: A Mediation Analysis<br />

Philip J. Mease<br />

H<br />

H<br />

09:00–<br />

11:00<br />

0511<br />

0524<br />

0527<br />

14:00–<br />

15:30<br />

0739<br />

0775<br />

0776<br />

0779<br />

0780<br />

16:00–<br />

17:00<br />

12S155<br />

SPONDYLOARTHRITIS INCLUDING PSORIATIC<br />

ARTHRITIS – TREATMENT: AXSPA POSTER I<br />

Long-term Safety and Tolerability of Bimekizumab<br />

in Patients with Axial Spondyloarthritis and Psoriatic<br />

Arthritis: Results from Pooled Phase 2b/3 Studies<br />

Philip J. Mease<br />

Efficacy of Certolizumab Pegol in Preventing Anterior<br />

Uveitis Flares Compared with Standard Non-Biologic<br />

Treatment: A Matched Control Study in High-Risk<br />

Patients with Axial Spondyloarthritis<br />

Nigil Haroon<br />

Bimekizumab Treatment Impact on Pain and<br />

Fatigue in Patients with Active Psoriatic Arthritis<br />

Who Were Biologic DMARD Naïve or Had Inadequate<br />

Response or Intolerance to TNF-α Inhibitors: 1-Year<br />

Results from Two Phase 3 Studies<br />

M. Elaine Husni<br />

SPONDYLOARTHRITIS INCLUDING PSORIATIC<br />

ARTHRITIS – TREATMENT I: PSA<br />

Major Adverse Cardiovascular Event and Venous<br />

Thromboembolism Risk Comparing Advanced Therapies<br />

Among Individuals with Axial Spondylarthritis and<br />

Psoriatic Arthritis<br />

Sali Merjanah<br />

Effectiveness of Dose Reduction and Withdrawal Strategies of<br />

TNF Inhibitors in Psoriatic Arthritis and Axial Spondyloarthritis:<br />

Long Term Extension of the DRESS-PS Study<br />

Amy Peeters<br />

Efficacy and Safety of Intravenous Secukinumab<br />

for the Treatment of Active Psoriatic Arthritis:<br />

16- and 52-Week Results from a Randomized,<br />

Double-Blind, Phase 3 Study<br />

Alan Kivitz<br />

Influence of Sex on the Persistence of Different Classes<br />

of Targeted Therapies for Psoriatic Arthritis: A Cohort Study<br />

of 14,778 Patients from the French Health Insurance<br />

Database (SNDS)<br />

Laura Pina Vegas<br />

Assessing Differential Effects of DMARDs on Psoriasis<br />

Area and Severity Index and Patient Global Assessment<br />

in Subgroups of Patients with Active <strong>PsA</strong> Treated over<br />

52-weeks with Secukinumab in a Non-Interventional Trial<br />

(AQUILA) Using a Multistage Clustering Approach<br />

Michaela Koehm<br />

EPIDEMIOLOGY, HEALTH POLICY AND OUTCOMES<br />

Chairs: Kristi Kuhn, Michael Weisman<br />

FDA Update on Safety Issues in the Treatment of<br />

Rheumatic Diseases<br />

Eric Gapud, Nadia Habal, Anil Rajpal<br />

H<br />

H<br />

H


KEY:<br />

H<br />

<strong>Highlights</strong><br />

ABSTRACT SESSION<br />

POSTER SESSION<br />

SCIENTIFIC SESSION<br />

Monday, 13 November <strong>2023</strong><br />

09:00–<br />

11:00<br />

1041<br />

09:00–<br />

11:00<br />

1132<br />

09:00–<br />

11:00<br />

1210<br />

09:00–<br />

11:00<br />

1390<br />

1394<br />

09:00–<br />

11:00<br />

1412<br />

1413<br />

1414<br />

IMAGING OF RHEUMATIC DISEASES POSTER I<br />

Efficacy of Apremilast on Peripheral and Axial Inflammation<br />

in Patients with Psoriatic Arthritis Based on Whole-Body<br />

Magnetic Resonance Imaging<br />

Mikkel Østergaard<br />

MISCELLANEOUS RHEUMATIC &<br />

INFLAMMATORY DISEASES POSTER II<br />

Preclinical Profiles of FZ007-119, a Highly Potent and<br />

Selective Tyk2 Inhibitor, for the Treatment of Immune<br />

Mediated Inflammatory Disease<br />

Shiqun Zhang<br />

PATIENT OUTCOMES, PREFERENCES, &<br />

ATTITUDES POSTER II<br />

Assessing Patient-Reported Drug Efficacy and Adherence<br />

Among IL-23 Inhibitors for Psoriasis and Psoriatic Arthritis<br />

Fahad Ahmed<br />

SPONDYLOARTHRITIS INCLUDING PSORIATIC<br />

ARTHRITIS – DIAGNOSIS, MANIFESTATIONS,<br />

& OUTCOMES POSTER II: IMAGING & AS<br />

Prediction of Low Disease Activity in Patients<br />

with Ankylosing Spondylitis Treated with<br />

Secukinumab in Real World – Data from a<br />

German Observational Study<br />

Uta Kiltz<br />

Comorbidities, Not Long-Term Use of Nonsteroidal<br />

Anti-Inflammatory Drugs, May Be Associated with Chronic<br />

Kidney Disease in Patients with Ankylosing Spondylitis:<br />

A Nationwide Population-Based Study<br />

Bon San Koo<br />

SPONDYLOARTHRITIS INCLUDING PSORIATIC<br />

ARTHRITIS – TREATMENT POSTER II: SPA<br />

Improvements in Patient-Reported Outcomes H<br />

Through 6 Months of Guselkumab Treatment in<br />

Patients with Active Psoriatic Arthritis: Real World Data<br />

from the CorEvitas Psoriatic Arthritis/Spondyloarthritis<br />

(<strong>PsA</strong>/SpA) Registry<br />

Philip J. Mease<br />

Effect of Apremilast Treatment on the Domains of<br />

MDA-Joints in Patients with Early Oligoarticular Psoriatic<br />

Arthritis: 16-Week Results from FOREMOST<br />

Philip J. Mease<br />

Effects of Apremilast on Changes in Cardiometabolic<br />

Parameters by Diabetes and Obesity Status in Patients<br />

with Psoriatic Arthritis<br />

Philip J. Mease<br />

H<br />

1415<br />

1417<br />

1418<br />

1419<br />

1420<br />

1421<br />

1422<br />

1423<br />

1424<br />

1425<br />

1426<br />

Bimekizumab Treatment Impact on Work Productivity<br />

in Biologic DMARD-Naïve and TNFi-IR Patients with<br />

Active Psoriatic Arthritis: Results up to 1 Year from Two<br />

Phase 3 Studies<br />

Philip J. Mease<br />

Do Long-term Patient-reported Outcomes<br />

H<br />

Improve Similarly in Psoriatic Arthritis and Axial<br />

Spondyloarthritis Patients Treated with Secukinumab?<br />

Results from the EuroSpA Collaboration<br />

Marion Pons<br />

Efficacy of the Oral, Selective, Allosteric Tyrosine H<br />

Kinase 2 Inhibitor, Deucravacitinib, on Psoriasis in<br />

Patients with Active <strong>PsA</strong>: Results from a Phase 2 Trial<br />

Alice B. Gottlieb<br />

Impact of Psoriatic Arthritis Manifestations on<br />

Perception of Pain Improvement: Pooled Analysis<br />

of Two Phase 3, Randomized, DoubleBlind,<br />

Placebo-Controlled Studies with Guselkumab<br />

Peter Nash<br />

Changes in Serum Cytokines and Collagen Proteins<br />

Correlate with Durability of Guselkumab Efficacy and<br />

Continued Disease Improvement Through 2 Years in<br />

Patients with Active Psoriatic Arthritis<br />

Stefan Siebert<br />

Domains Impacting Minimal Disease Activity<br />

Non-Achievement in Patients with Psoriatic Arthritis<br />

and Inadequate Response to TNF Inhibitors Receiving<br />

Guselkumab (COSMOS)<br />

Laura Coates<br />

Long-Term Safety of Risankizumab in Patients<br />

with Psoriatic Disease: Integrated Analysis of<br />

Psoriasis and Psoriatic Arthritis Clinical Trial Data<br />

Laura Coates<br />

Impact of Upadacitinib on Enthesitis and Dactylitis<br />

by Location in Patients with Psoriatic Arthritis and<br />

an Inadequate Response to Biologic DMARDs from<br />

the SELECT-<strong>PsA</strong> 2 Trial<br />

Laura Coates<br />

Early Fatigue Improvement with Guselkumab Associates<br />

with Longer Term Disease Control in Patients with Active<br />

Psoriatic Arthritis Reporting Substantial Fatigue: Post Hoc<br />

Analyses of a Sub-Population of a Phase 3, Randomized,<br />

Controlled Trial of Guselkumab in Biologic-Naïve Patients<br />

Dafna Gladman<br />

Efficacy and Safety of Tofacitinib in an<br />

Open-Label, Long-Term Extension Study in<br />

Patients with Psoriatic Arthritis Who Received<br />

Adalimumab or Tofacitinib in a Phase 3 Randomized<br />

Controlled Study: A Post Hoc Analysis<br />

Dafna Gladman<br />

Distinct Treatment Response Trajectories in Patients with<br />

Psoriatic Arthritis Receiving Tofacitinib<br />

Dafna Gladman<br />

H<br />

H<br />

H<br />

H


KEY:<br />

H<br />

<strong>Highlights</strong><br />

ABSTRACT SESSION<br />

POSTER SESSION<br />

SCIENTIFIC SESSION<br />

1427<br />

Efficacy of Upadacitinib in Patients with Psoriatic Arthritis<br />

Stratified by Involvement of Weight-bearing Joint Regions:<br />

A Post Hoc Subgroup Analysis of the Phase 3, Randomized,<br />

SELECT-<strong>PsA</strong> 1 and SELECT-<strong>PsA</strong> 2 Trials<br />

Kristi Mizelle<br />

1439<br />

Better Drug Retention on anti-IL17A Compared to<br />

Anti-TNF Therapy Despite Its Inferior Effect on Composite<br />

Joint Indexes and Quality of Life in Patients with<br />

<strong>PsA</strong>–analysis from the Czech Biologics Registry ATTRA<br />

Jakub Zavada<br />

1428<br />

1429<br />

Guselkumab Provides Clinically Meaningful<br />

Improvents in Patient Reported Outcomes in<br />

Patients with Active Psoriatic Arthritis Who Are<br />

Inadequate Responders to Tumour Necrosis Factor<br />

Inhibitors: Results Through One Year of a Phase 3b,<br />

Randomized, Controlled Study (COSMOS)<br />

Laure Gossec<br />

Longitudinal Evaluation of the Novel Psoriatic Arthritis<br />

5-Thermometer Scale (<strong>PsA</strong>-5Ts) Domains During Treatment<br />

with Guselkumab: Pooled Analysis of Three Phase 3,<br />

Randomized, Double-blind, Placebo-Controlled Studies<br />

Carlo Selmi<br />

H<br />

1440<br />

16:00–<br />

17:30<br />

1687<br />

Removal of Methotrexate in Patients with Active Psoriatic<br />

Arthritis with Newly Induced Ustekinumab Treatment Leads<br />

to a Delayed Response in DAPSA and DAS28 Within the<br />

First 16 Weeks<br />

Michaela Koehm<br />

SPONDYLOARTHRITIS INCLUDING PSORIATIC<br />

ARTHRITIS – TREATMENT II: PSA<br />

Sex of the Patient Affects Response to Advanced<br />

Therapies in Psoriatic Arthritis: Meta-analysis of Data from<br />

Randomized Controlled Trials<br />

Lihi Eder<br />

1431<br />

Izokibep, a Unique IL-17A Inhibitor, Improves<br />

Patient-Reported Outcomes in Patients with<br />

Active Psoriatic Arthritis up to Week 46 – Phase 2<br />

RCT Results<br />

Peter C. Taylor<br />

H<br />

1688<br />

Izokibep Demonstrates Major Disease Control<br />

on <strong>ACR</strong>70, PASI100 and Enthesitis Resolution<br />

in Patients with Active Psoriatic Arthritis Treated<br />

Through 46 Weeks<br />

Philip J. Mease<br />

H<br />

1433<br />

1434<br />

1435<br />

Bimekizumab Impact on Core Group for Research H<br />

and Assessment of Psoriasis and Psoriatic Arthritis<br />

(GRAPPA) Domains for Patients with Psoriatic Arthritis:<br />

52-Week Results from Four Phase 3 Studies<br />

Joseph Merola<br />

Long-Term Efficacy and Safety of Risankizumab<br />

for Active Psoriatic Arthritis: 148-Week Results<br />

from the KEE<strong>PsA</strong>KE 2 Trial<br />

Andrew Östör<br />

Long-Term Efficacy and Safety of Risankizumab H<br />

for CsDMARD-IR Patients with Active Psoriatic<br />

Arthritis: 148-Week Results from the KEE<strong>PsA</strong>KE 1 Trial<br />

Lars Erik<br />

H<br />

1690<br />

1691<br />

1692<br />

Apremilast Reduces Inflammation as Measured by MRI of<br />

the Hand in Patients with Psoriatic Arthritis: Primary Results<br />

from the Phase 4 MOSAIC Study<br />

Mikkel Østergaard<br />

16-Week Results from FOREMOST, a Placebo-<br />

Controlled Study Involving Oligoarticular Psoriatic<br />

Arthritis Treated with Apremilast<br />

Philip J. Mease<br />

Insights on the Use of JAK-inhibitors in Patients with<br />

Psoriatic Arthritis in an International Collaboration of<br />

Registers (the “JAK-pot” Study)<br />

Romain Aymon<br />

H<br />

1436<br />

Secukinumab Demonstrates a Consistent Safety<br />

Profile in Patients with Psoriasis, Psoriatic<br />

Arthritis and Axial Spondyloarthritis: Updated<br />

Pooled Safety Analysis from Clinical Trials<br />

Atul Deodhar<br />

H<br />

1437<br />

Bimekizumab Maintained Efficacy Responses<br />

Through 52 Weeks in Biologic Disease-Modifying<br />

Antirheumatic Drug-Naïve Patients with Psoriatic<br />

Arthritis Who Were Responders at Week 16:<br />

Results from a Phase 3, Active-Reference Study<br />

William R. Tillett<br />

H<br />

1438<br />

Efficacy of Guselkumab in Early-Onset and<br />

Late-Onset Psoriatic Arthritis: Post Hoc Pooled<br />

Analyses of Two Phase 3 Randomized Controlled<br />

Trials in Patients with Active <strong>PsA</strong><br />

Enrique Soriano<br />

H


KEY:<br />

H<br />

<strong>Highlights</strong><br />

ABSTRACT SESSION<br />

POSTER SESSION<br />

SCIENTIFIC SESSION<br />

Tuesday, 14 November <strong>2023</strong><br />

09:00–<br />

11:00<br />

1891<br />

09:00–<br />

11:00<br />

0265<br />

1920<br />

09:00–<br />

11:00<br />

2145<br />

2146<br />

09:00–<br />

11:00<br />

2199<br />

09:00–<br />

11:00<br />

2227<br />

2228<br />

2229<br />

IMAGING OF RHEUMATIC DISEASES POSTER II<br />

Effect of Apremilast on Disease Interception in Patients with<br />

Psoriasis at Increased Risk of Developing <strong>PsA</strong> – Results of<br />

the Prospective Interventional Epos Trial<br />

David Simon<br />

MISCELLANEOUS RHEUMATIC &<br />

INFLAMMATORY DISEASES POSTER III<br />

Differential and Combinatorial Mechanism of Action of<br />

Golimumab and Guselkumab in Ulcerative Colitis Induction<br />

Therapy: IL-23 Blockade Drives Restoration of Normal<br />

Epithelium and Mucosal Healing<br />

Dennis McGonagle<br />

A Phase Ib/II Randomized, Double-blind, Placebo-controlled<br />

Study of Novel anti-IL-17A Monoclonal Antibody JS005 in<br />

Patients with Moderate to Severe Psoriasis<br />

Zhanglei Mu<br />

RA – TREATMENTS POSTER III<br />

Patterns of Use, Effectiveness, Persistence and Cardiovascular<br />

Risk in Patients with Rheumatic Diseases Treated with<br />

Upadacitinib in a Real-world Setting. UPAREAL Study<br />

Alicia Garcia Dorta<br />

After JAK Inhibitor Failure, “Switching” or “Cycling”?<br />

Pablo Francisco Muñoz Martínez<br />

SPONDYLOARTHRITIS INCLUDING PSORIATIC<br />

ARTHRITIS – DIAGNOSIS, MANIFESTATIONS,<br />

& OUTCOMES POSTER III: SPA<br />

Four-year Secukinumab Treatment Outcomes<br />

in Axial Spondyloarthritis and Psoriatic Arthritis<br />

Patients Treated in Routine Care: Results from<br />

the EuroSpA Collaboration<br />

Marion Pons<br />

SPONDYLOARTHRITIS INCLUDING PSORIATIC<br />

ARTHRITIS – TREATMENT: SPA POSTER III<br />

The Impact of Smoking Status on One Year Secukinumab<br />

Retention Rate in 1,684 Patients with <strong>PsA</strong>: Real-World<br />

Results from the EuroSpA Collaboration<br />

Zohra Faizy Ahmadzay<br />

Early Improvement in 3 Visual Analogue Scale (3VAS)/4VAS<br />

Predicts Reduced Rates of Radiographic Change in<br />

Bio-naive Active Psoriatic Arthritis Patients Receiving<br />

Guselkumab Treatment<br />

William R. Tillett/Laura Coates<br />

Individual Entheseal Points Have Differential Frequency<br />

of Involvement and Impact on Patient Reported<br />

Outcomes in Patients with Active Psoriatic Arthritis:<br />

Pooled Analysis of Two Phase 3, Randomized,<br />

Double-Blind, Placebo-Controlled Studies<br />

Laura Coates<br />

H<br />

2230<br />

2231<br />

2232<br />

2233<br />

2236<br />

2237<br />

2238<br />

2239<br />

2240<br />

2241<br />

2242<br />

2243<br />

2244<br />

Bimekizumab Treatment in Patients with Active<br />

<strong>PsA</strong> and Prior Inadequate Response to TNF Inhibitors:<br />

Sustained Efficacy and Safety Results from a Phase 3<br />

Study and Its Open-Label Extension up to 1 Year<br />

Laura Coates<br />

Ixekizumab Significantly Improves Nail Disease and<br />

Adjacent Joint Tenderness and Swelling in Psoriatic Arthritis<br />

Dennis McGonagle<br />

Guselkumab, an IL-23p19 Subunit–specific Monoclonal<br />

Antibody, Is Able to Bind CD64+ Myeloid Cells, Potently<br />

Neutralize IL-23 Produced from the Cells, and Mediate<br />

Internalization of IL-23<br />

Dennis McGonagle<br />

Neutrophil Levels Associate with Early Improvement in Spinal<br />

Pain and Week 24 Multi-Domain Disease Control During<br />

Guselkumab Treatment in Active Psoriatic Arthritis: Post Hoc<br />

Pooled Analyses of Two Phase 3 Randomized Controlled Trials<br />

Thomas Macleod<br />

Guselkumab Provides Rapid Clinically Meaningful<br />

Improvements in Clinical and Patient Reported Outcomes<br />

and Sustained Disease Control of Psoriatic Arthritis<br />

Jeffrey R. Curtis<br />

Upadacitinib in Refractory Psoriatic Arthritis.<br />

Multicenter Study of 134 Patients in Clinical Practice<br />

Eva Galindez-Agirregoikoa<br />

Longitudinal Effect of Guselkumab on Biomarkers<br />

of Inflammation and Cardiovascular Risk in Bionaive<br />

Patients with Active Psoriatic Arthritis and High Systemic<br />

Inflammatory Burden: Post-hoc Analysis of a Phase 3,<br />

Randomized, Double-blind, Placebo-Controlled Study<br />

Arthur Kavanaugh<br />

Achievement of Disease Control in <strong>PsA</strong> Patients Treated<br />

with Upadacitinib at Week 152: Post Hoc Analysis of the<br />

Long-term Extensions of Two Phase 3 Trials<br />

Arthur Kavanaugh<br />

Persistence to Therapy Among Patients with Psoriatic Arthritis<br />

Treated with IL-17A or TNFα Inhibitors (IL-17Ai or TNFi)<br />

Aisha Vadhariya/Sarah Ross<br />

Guselkumab Efficacy in Active Psoriatic Arthritis Patients with<br />

or Without Hyperuricemia: Post-hoc Analysis of Two Phase 3,<br />

Randomized, Doubleblind, Placebo-Controlled Studies<br />

Renaud Felten<br />

Irrespective of the Number of Erosions at Baseline,<br />

Patients with Psoriatic Arthritis Treated with Ixekizumab<br />

Show Improved Clinical Outcomes<br />

M. Elaine Husni<br />

Ultrasound Enthesitis Responsiveness versus Clinical Enthesitis<br />

Responsiveness: Week 52 Results of an Exploratory Analysis<br />

from a Phase 3b Study in Patients with Psoriatic Arthritis<br />

Maria Antonietta D’Agostino<br />

Switching Between Biologics and Targeted Synthetic<br />

Therapies Due to Inefficacy in Psoriatic Arthritis<br />

Dalifer Freites Núñez<br />

H


KEY:<br />

H<br />

<strong>Highlights</strong><br />

ABSTRACT SESSION<br />

POSTER SESSION<br />

SCIENTIFIC SESSION<br />

2245<br />

2246<br />

2249<br />

2250<br />

2251<br />

2252<br />

2253<br />

2254<br />

16:00–<br />

17:30<br />

2505<br />

Drug Survival of Risankizumab vs Other Biologics After<br />

13 Months of Treatment Among Patients with <strong>PsA</strong> in the<br />

Multicountry Postmarketing Observational VALUE Study<br />

Lars Erik<br />

Real-World Switching and Discontinuation Patterns for<br />

Biologic Disease-Modifying Antirheumatic Drugs in Patients<br />

with Active Psoriatic Arthritis in Japan<br />

Lars Erik<br />

Bimekizumab-Treated Patients with Active <strong>PsA</strong> Showed<br />

Sustained Improvement in Disease Symptoms Assessed<br />

by the <strong>PsA</strong> Impact of Disease (<strong>PsA</strong>ID)-12 Questionnaire:<br />

1-Year Results Reported from Two Phase 3 Studies<br />

Dafna Gladman<br />

Bimekizumab Impact on Health-Related Quality of Life and<br />

Physical Function in Patients with Active Psoriatic Arthritis<br />

Who Were Biologic DMARD Naïve or Had Inadequate<br />

Response or Intolerance to TNF-α Inhibitors: 1-Year Results<br />

from Two Phase 3, Randomized Studies<br />

Dafna Gladman<br />

Direct and Indirect Effects of Upadacitinib<br />

or Adalimumab on Pain in Psoriatic Arthritis:<br />

Results from a Randomized Phase 3 Study<br />

Peter C. Taylor<br />

Bimekizumab Maintained Efficacy Responses Through<br />

52 Weeks in Patients with Psoriatic Arthritis and<br />

Inadequate Response or Intolerance to TNF-α Inhibitors<br />

Who Were Responders at Week 16: Results from a<br />

Phase 3, Randomized Study<br />

William R. Tillett<br />

Deucravacitinib, an Oral, Allosteric, Selective Tyrosine<br />

Kinase 2 Inhibitor, in Patients with Plaque Psoriasis Who<br />

Screened Positive for Psoriatic Arthritis in POETYK PSO-1<br />

and POETYK PSO-2: Effect on Joint Pain and Peripheral<br />

Joint Disease vs Placebo and Apremilast<br />

Joseph Merola<br />

The Effects of Interleukin 17 Inhibitors on Major Adverse<br />

Cardiovascular Events in Patients Naïve to Biologic Agents<br />

with Psoriasis or Psoriatic Arthritis: A Systematic Review<br />

and Meta-Analysis of Randomized Controlled Trials<br />

Ruoning Ni<br />

CYTOKINES & CELL TRAFFICKING<br />

Discovery of First-in-Class IRAK4 Scaffolding Inhibitors for<br />

the Treatment of Inflammatory Disorders<br />

Kate Byth<br />

H<br />

Wednesday, 15 November <strong>2023</strong><br />

09:00–<br />

10:30<br />

2566<br />

9:15–<br />

10:15<br />

15W112<br />

EPIDEMIOLOGY & PUBLIC HEALTH III<br />

Comparisons of the Risk of Serious Infections Associated<br />

with the Different Classes of Targeted Therapies Used in<br />

Psoriatic Arthritis Patients: A Nationwide Cohort Study from<br />

the French Health Insurance Database<br />

Léa Bastard<br />

SPONDYLOARTHRITIS (SPA) INCLUDING<br />

PSORIATIC ARTHRITIS (PSA)<br />

Chairs: M. Elaine Husni<br />

Getting Skin and Joint in the Game: Key Players in the<br />

Psoriatic Arthritis Microenvironment<br />

Ursula Fearon, Christopher Ritchlin, Jose Scher<br />

Satellite Symposia<br />

SUNDAY, 12 NOVEMBER <strong>2023</strong><br />

11:30–<br />

12:15<br />

18:00–<br />

20:00<br />

18:00–<br />

20:00<br />

18:00–<br />

20:00<br />

Treating Patients with <strong>PsA</strong> and AS Today & Tomorrow<br />

Sponsor: Eli Lilly Chair: Ara Dikranian<br />

Novartis’ Commitment in Rheumatology<br />

Sponsor: Novartis Chairs: Adam Winseck, Antton Egana,<br />

Kelly Montalto<br />

The IL-17 Story: All in the Family<br />

Sponsor: UCB, Inc Chair: Dirk Elewaut<br />

Reaching Beneath the Surface: Exploring treatment that<br />

addresses multiple domains with a well-documented safety<br />

profile for adult patients with active <strong>PsA</strong><br />

Sponsor: AbbVie Chair: Alan Epstein<br />

MONDAY, 13 NOVEMBER <strong>2023</strong><br />

18:00–<br />

20:00<br />

Navigating the Complexities of Individualized Treatment in<br />

Psoriatic Arthritis and Axial Spondyloarthritis<br />

Sponsor: Eli Lilly Chairs: Arthur Kavanaugh,<br />

Catherine Bakewell,<br />

Atul Deodhar, Alexis Ogdie<br />

TUESDAY, 14 NOVEMBER <strong>2023</strong><br />

18:00–<br />

20:00<br />

Raising the Bar: Optimizing Outcomes with IL-23/IL-17<br />

Inhibitors in Spondyloarthritis<br />

Sponsor: UCB Chairs: Lianne S. Gensler,<br />

Ana-Maria Orbai,<br />

Victoria Navarro-Compán<br />

Register for FREE content at<br />

www.cytokinesignalling.com<br />

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Cytokine Signalling Forum<br />

SPONSORSHIP AND UNRESTRICTED<br />

EDUCATIONAL GRANTS FROM<br />

DEVELOPED UNDER<br />

THE AUSPICES OF THE

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