06.11.2023 Views

Lupus ACR 2023 Brochure LF

  • No tags were found...

Create successful ePaper yourself

Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.

<strong>ACR</strong> <strong>2023</strong><br />

Congress Preview<br />

Chair’s Introduction<br />

Dear Colleagues,<br />

Welcome to the <strong>Lupus</strong> Forum <strong>ACR</strong> <strong>2023</strong> Highlights <strong>Brochure</strong>, providing you with all you need to know about the lupus<br />

content at this year’s Convergence, including the Scientific Sessions, Posters, Abstracts, and Industry Symposiums.<br />

I’ve selected my Chair’s picks of the key content – I hope you find them useful.<br />

There’s plenty of great lupus content on Sunday, including the poster session, SLE – Treatment Poster I. In this session we<br />

see the reporting of post-hoc analyses of treatment responses by SF-36 in the anifrolumab Phase 3 long-term extension<br />

trial (0582), and the impact of belimumab on steroid use and disease activity from OBSErve (0587). Also within this session<br />

is a poster comparing IgA2 anti-dsDNA antibodies and clinical outcome in trials of belimumab after rituximab (0589),<br />

further data from the investigation into CAR T cell therapy in SLE (0607), and data on the efficacy of cenerimod in patients<br />

with high IFN-1 gene expression signature (0608). We then have three posters from <strong>Lupus</strong> Forum Steering Committee<br />

member, Richard Furie, on renal involvement in anifrolumab-treated SLE patients (0595), SRI-4 and BICLA responses from<br />

the Phase 2 trial of deucravacitinib (0596), and efficacy of anifrolumab assessed by improvements in SLEDAI-2K (0597).<br />

One final pick on Sunday comes in the Abstract Session, SLE – Treatment I: Renal, a post-hoc analysis of the Phase 2<br />

trial of lupus nephritis patients treated with obinutuzumab (0784).<br />

On Monday I would draw your attention to Pediatric Rheumatology – Clinical Poster II: Connective Tissue Disease,<br />

and a poster on belimumab safety in paediatric patients (1257) offering new data for this patient group. SLE – Treatment<br />

Poster II sees data on the year 5 follow up of belimumab safety (1499) and LLDAS achievement in patients receiving<br />

deucravacitinib (1501).<br />

Tuesday features my last three Chair’s picks. SLE – Treatment Poster III includes post-hoc analysis of belimumab efficacy<br />

by race and ethnicity (2347), while the abstract session, SLE – Treatment II: Nonrenal sees Phase 2 data on emerging<br />

treatments, ianalumab in SLE (2487), and CLASI achievement with deucravacitinib in patients with CLE (2489).<br />

We add new content to the <strong>Lupus</strong> Forum regularly, with monthly summaries of key publications, podcasts, and congress<br />

materials such as these. You can register for updates at lupus-forum.com or keep up to date by following us on Twitter<br />

@<strong>Lupus</strong>Forum and on LinkedIn by searching “<strong>Lupus</strong> Forum”.<br />

I hope you find our selection of highlights useful and that you enjoy the meeting in San Diego!<br />

Ed Vital<br />

Chair of the <strong>Lupus</strong> Forum Steering Committee; Associate Professor, University of Leeds<br />

Developed under<br />

the auspices of<br />

Supported with educational grants from<br />

Sponsorship<br />

received from


Key: CP Chair’s pick Abstract session Poster session<br />

Scientific session<br />

Key <strong>Lupus</strong> Content<br />

Sunday, 12 November <strong>2023</strong><br />

09:00–<br />

10:00<br />

09:00–<br />

10:00<br />

09:00–<br />

11:00<br />

0006<br />

09:00–<br />

11:00<br />

0014<br />

09:00–<br />

11:00<br />

0178<br />

09:00–<br />

11:00<br />

0543<br />

0560<br />

09:00–<br />

11:00<br />

0582<br />

<strong>Lupus</strong> Prevention and Disease-Modifying<br />

Anti-<strong>Lupus</strong> Drugs (DMALDs), Are We There Yet?<br />

Anca Askanase, Maria Dall’Era, David Karp<br />

Under Pressure: Updates in <strong>Lupus</strong> Nephritis<br />

Simone Appenzeller, Hermine Brunner,<br />

Mark Mitsnefes<br />

B Cell Biology & Targets in Autoimmune<br />

& Inflammatory Disease Poster<br />

Preclinical Characterization of a Novel anti-CD40<br />

Antagonist Antibody-glucocorticoid Conjugate<br />

with Superior Preclinical Efficacy and Favorable<br />

Safety Profile<br />

Wenming Ren<br />

Genetics, Genomics & Proteomics Poster<br />

The 330 Genetic Risk Loci of Systemic <strong>Lupus</strong><br />

Erythematosus (SLE) Now Known Are Consonant<br />

with Multiple Causal Mechanisms Involving<br />

Epstein-Barr Virus (EBV)-Encoded Transcription<br />

Co-factors (TFs) in EBV-Infected B Cells<br />

Viktoryia Laurynenka<br />

Healthcare Disparities in Rheumatology<br />

Poster 1: <strong>Lupus</strong><br />

Traditional and <strong>Lupus</strong>-Specific Risk Factors<br />

for Cardiovascular Events Among Patients with<br />

Systemic <strong>Lupus</strong> Erythematosus<br />

Saloni Patolia<br />

SLE – Diagnosis, Manifestations,<br />

& Outcomes Poster I<br />

Sensitivity of the 2019 European Alliance of<br />

Associations for Rheumatology/American College<br />

of Rheumatology Classification Criteria for<br />

Systemic <strong>Lupus</strong> Erythematosus in a Populationbased<br />

Cohort; A Study Set in Norway 2000–2015<br />

Hilde Haukeland<br />

Genetic Determinants of <strong>Lupus</strong> Nephritis and<br />

Kidney Function in Systemic <strong>Lupus</strong> Erythematosus<br />

Linda Hiraki<br />

SLE – Treatment Poster I<br />

Evaluation of Anifrolumab Treatment<br />

Responses by the Short Form 36 Health<br />

Survey Version 2 in SLE: A Post Hoc<br />

Analysis of the Placebo-Controlled Phase 3<br />

Long-Term Extension Trial<br />

Vibeke Strand<br />

CP<br />

0583<br />

0584<br />

0587<br />

0588<br />

0589<br />

0590<br />

0591<br />

0592<br />

0593<br />

0594<br />

0595<br />

Therapeutic Potential of Imvotamab, a<br />

CD20-Targeted Bispecific IgM T Cell Engager,<br />

for the Treatment of Refractory Autoimmune<br />

Disease Patients<br />

Racquel Domingo-Gonzalez<br />

Targeting Key Components of SLE Pathogenesis<br />

with the Multifaceted Immunomodulatory<br />

Properties of Cenerimod, a Selective S1P1<br />

Receptor Modulator<br />

Marianne Martinic<br />

Impact of up to 24 Months Intravenous (IV) CP<br />

Belimumab (BEL) Treatment on Steroid Use<br />

and Disease Activity in Patients with SLE in<br />

Clinical Practice: Additional Post Hoc Pooled<br />

Analysis of Multicountry OBSErve Cohort Data<br />

Roger A Levy<br />

Long Term Safety and Predictors of Serious<br />

Infections Among Patients with Systemic <strong>Lupus</strong><br />

Erythematosus Treated with Rituximab: Audit from<br />

a Single Center Biologic Registry<br />

Augustine Jose<br />

A Comparative Evaluation of IgA2<br />

Anti-dsDNA Antibodies and Clinical<br />

Outcome in Two Clinical Trials of Belimumab<br />

After Rituximab in SLE<br />

Muhammad RA Shipa<br />

Comparing Safety and Efficacy of Sodium-Glucose<br />

Co-Transporter 2 Inhibitors versus Dipeptidyl<br />

Peptidase 4 Inhibitors in Patients with Systemic<br />

<strong>Lupus</strong> Erythematosus and Comorbid Type 2<br />

Diabetes Mellitus<br />

Jui-En Lo<br />

Despite Dramatic Expansion of Approved Biologics<br />

in SLE, Unmet Needs Remain<br />

Ryan Rex<br />

Real-World Treatment Patterns in Patients with<br />

Systemic <strong>Lupus</strong> Erythematosus: An Analysis of<br />

the SLE Prospective Observational Cohort Study<br />

(SPOCS)<br />

Martin Aringer<br />

<strong>Lupus</strong> Nephritis of the Spanish National Registry<br />

of Belimumab in Patients with Systemic <strong>Lupus</strong><br />

Erythematosus<br />

Vicente Aldasoro<br />

Baseline Innate Immunity Transcriptional<br />

Signatures Act as Predictors of Response to<br />

Immunosuppressive and Biologic Treatments in<br />

Systemic <strong>Lupus</strong> Erythematosus While Disturbances<br />

Linked to p53-signaling Define “Resistant” Disease<br />

Panagiotis Garantziotis<br />

Renal Involvement in Patients with<br />

Systemic <strong>Lupus</strong> Erythematosus Treated<br />

with Anifrolumab Compared with Placebo<br />

over a 4-Year Period<br />

Richard A Furie<br />

CP<br />

CP


Key: CP Chair’s pick Abstract session Poster session<br />

Scientific session<br />

0596<br />

0597<br />

0598<br />

0599<br />

Deucravacitinib, an Oral, Selective,<br />

CP<br />

Allosteric Tyrosine Kinase 2 Inhibitor, in a<br />

Phase 2 Trial in Systemic <strong>Lupus</strong> Erythematosus<br />

(SLE): Achievement of Sustained SRI(4),<br />

BICLA and Dual Responses over 48 Weeks<br />

Richard A Furie<br />

Efficacy of Anifrolumab in Systemic<br />

CP<br />

<strong>Lupus</strong> Erythematosus by Overall and<br />

Organ-Specific SLEDAI-2K Improvements:<br />

Results from the Randomized, Placebo-<br />

Controlled Phase 3 Long-Term Extension Study<br />

Richard A Furie<br />

Litifilimab Modulates Type I IFN Biomarkers<br />

in Patients with SLE or CLE in the Phase 2<br />

LILAC Study<br />

Richard A Furie<br />

Targeted Inhibition of Cathepsins Limits the<br />

Intracellular Complement Activation in <strong>Lupus</strong><br />

Nephritis Podocytes<br />

Ana Kunzler<br />

0782<br />

0784<br />

16:00–<br />

17:30<br />

0847<br />

Comparison of Dual-immunosuppressive<br />

Therapy with a Voclosporin-based, Tripleimmunosuppressive<br />

Regimen for <strong>Lupus</strong> Nephritis<br />

in the ALMS and AURORA 1 Studies<br />

Maria Dall’Era<br />

Kidney-Related Outcomes and Steroid-<br />

Sparing Effects in Patients with Active<br />

<strong>Lupus</strong> Nephritis Treated with Obinutuzumab:<br />

A Post Hoc Analysis of a Phase 2 Trial<br />

Brad Rovin<br />

SLE – Diagnosis, Manifestations,<br />

& Outcomes I: Biomarkers<br />

Development of an IFN 5-Gene Signature Score<br />

to Identify IFN-high and IFN-low Subsets and as a<br />

Pharmacodynamic Biomarker for Deucravacitinib<br />

Treatment in a Phase 2 Trial in Patients with<br />

Systemic <strong>Lupus</strong> Erythematosus<br />

Chun Wu<br />

CP<br />

0600<br />

0604<br />

0606<br />

0607<br />

0608<br />

12:00–<br />

13:00<br />

14:00–<br />

15:30<br />

0781<br />

Identification of Subsets of SLE Patients<br />

Responsive to Baricitinib by Transcriptomic<br />

Analysis at Baseline<br />

Prathyusha Bachali<br />

Is Belimumab Dose Optimization Possible in<br />

Patients with Systemic <strong>Lupus</strong> Erythematosus?:<br />

Analysis of This Therapeutic Strategy in a Large<br />

Multicenter Cohort of Patients from Spanish<br />

Rheumatology Departments<br />

Irene Altabas Gonzalez<br />

Risk of Damage Progression with Belimumab<br />

versus Oral Immunosuppressant Use in Patients<br />

with Systemic <strong>Lupus</strong> Erythematosus<br />

April Jorge<br />

CAR T Cell Therapy Leads to Long-term<br />

Abrogation of Autoimmunity in SLE<br />

Patients While Vaccination Responses<br />

Are Maintained<br />

Georg Schett<br />

Efficacy of Cenerimod in Patients with<br />

High IFN-1 Gene Expression Signature and<br />

High Anti-dsDNA Antibody Levels: Post-hoc<br />

Analysis from a Phase 2 Study<br />

Anca Askanase<br />

Interventions to Increase Minority Participation in<br />

<strong>Lupus</strong> Clinical Trials<br />

Irene Blanco, Saira Sheikh<br />

SLE – Treatment I: Renal<br />

Low vs. High Initial Oral Glucocorticoid Dose for<br />

<strong>Lupus</strong> Nephritis Induction Treatment: A Pooled<br />

Analysis of Randomized Controlled Clinical Trials<br />

Amit Saxena<br />

CP<br />

CP<br />

Monday, 13 November <strong>2023</strong><br />

07:30–<br />

08:30<br />

09:00–<br />

11:00<br />

0928<br />

09:00–<br />

11:00<br />

1227<br />

1247<br />

09:00–<br />

11:00<br />

1489<br />

1490<br />

Meet the Panel: The Latest in <strong>Lupus</strong> Treatment<br />

Maria Dall’Era, Richard A Furie, Marta Mosca<br />

SLE – Etiology & Pathogenesis Poster<br />

Skewing of B Cell Receptor Repertoire in<br />

Unswitched Memory B Cells Is Associated with<br />

Disease Activity of Systemic <strong>Lupus</strong> Erythematosus<br />

and Targeted by Belimumab<br />

Keishi Fujio<br />

Pediatric Rheumatology – Clinical Poster II:<br />

Connective Tissue Disease<br />

Serious Infections Following Rituximab<br />

Administration in Children with Systemic<br />

<strong>Lupus</strong> Erythematosus<br />

Jordan Roberts<br />

Pharmacokinetic, Pharmacodynamic, and<br />

Safety Profile of Subcutaneous Belimumab<br />

in Pediatric Patients with Systemic <strong>Lupus</strong><br />

Erythematosus: Analysis of Data from a<br />

Multicenter, Open-Label Trial<br />

Hermine Brunner<br />

SLE – Treatment Poster II<br />

Treatment with Upadacitinib in Patients with<br />

Systemic <strong>Lupus</strong> Erythematosus Results in the<br />

Inhibition of B-Cell–related Biomarkers: Analysis<br />

of the M19-130 (SLEek) Phase 2 Study<br />

Marie-Claude Gaudreau<br />

Early Experience with SGLT2i in Systemic<br />

<strong>Lupus</strong> Erythematosus<br />

Michelle Petri<br />

CP


Key: CP Chair’s pick Abstract session Poster session<br />

Scientific session<br />

1492<br />

1493<br />

1494<br />

1495<br />

1496<br />

1498<br />

1499<br />

1500<br />

Pre-treatment Differentially Expressed<br />

Metagenes Characterize Systemic <strong>Lupus</strong><br />

Patients Who Subsequently Achieve Clinical<br />

Response to Belimumab<br />

Miles Smith<br />

Novel BCMA-CD19 Compound CAR-T (cCAR)<br />

Targets B Cells and Plasma Cells Achieving<br />

Immune Reset and Eliminates All Autoantibodies<br />

in Systemic <strong>Lupus</strong> Erythematosus (SLE) and <strong>Lupus</strong><br />

Nephritis (LN) Patients Resulting in Long-Term,<br />

Medication-Free Remission<br />

Greg Deener<br />

The Effect of Belimumab on Steroid Use in<br />

Patients with SLE: Results from a Retrospective<br />

Observational Study of Real-World Data from a<br />

US Rheumatology Provider Network<br />

Karen Worley<br />

Deep Serological Profiling of SLE Patients Treated<br />

with anti-CD19 CAR T Cells<br />

Samik Basu<br />

Clinical Safety and Efficacy Results from<br />

EQUALISE Type B: A Phase 1b Open-label Clinical<br />

Study of Itolizumab, a Novel anti-CD6 Therapy, in<br />

Subjects with Active Proliferative <strong>Lupus</strong> Nephritis<br />

Kenneth Kalunian<br />

First-in-Human Safety, Tolerability,<br />

Pharmacokinetics, and Pharmacodynamics<br />

Study of DS-7011a, an Anti-TLR7 Antagonistic<br />

Monoclonal Antibody for the Treatment of<br />

Systemic <strong>Lupus</strong> Erythematosus<br />

Giorgio Senaldi<br />

Year-5 Follow-up of Belimumab Safety CP<br />

(Mortality and Malignancies) in Patients with<br />

Systemic <strong>Lupus</strong> Erythematosus (SLE) Who<br />

Completed a Phase 4, 52-week, Randomized,<br />

Double-blind Placebo-controlled Safety Study<br />

Saira Sheikh<br />

Cumulative Infections by Week 52 Among<br />

Patients with SLE: A Summary of Data from<br />

Placebo-Controlled Belimumab Studies<br />

Saira Sheikh<br />

1504<br />

1505<br />

1507<br />

1508<br />

1511<br />

1512<br />

14:00–<br />

15:00<br />

16:00–<br />

17:30<br />

1694<br />

1696<br />

Characteristics and Prior Treatment Journey of<br />

Systemic <strong>Lupus</strong> Erythematosus (SLE) Patients<br />

Who Were Prescribed Anifrolumab – Observations<br />

from the American Rheumatology Network (ARN)<br />

in the U.S<br />

Vasileios Kyttaris<br />

Long-term Safety and Efficacy of Voclosporin in<br />

Black Patients with <strong>Lupus</strong> Nephritis: Results from<br />

the AURORA 1 and AURORA 2 Studies<br />

Gabriel Contreras<br />

Pharmacodynamic Changes in SLE Relevant Gene<br />

Expression Induced by Deucravacitinib in Patients<br />

Enrolled in the Phase 2 PAISLEY Trial<br />

Yanhua Hu<br />

Predicting in Virtual Patients the Efficacy of an<br />

Anti IFNa Mab in Cutaneous <strong>Lupus</strong> Erythematosus<br />

Philippe Moingeon<br />

B-Cell Recovery in a Randomized Controlled Trial<br />

of B-Cell Depletion with Obinutuzumab for the<br />

Treatment of Proliferative <strong>Lupus</strong> Nephritis<br />

Ed Vital<br />

Rituximab Objective Outcome Measures Trial in<br />

SLE (ROOTS): Randomised and Rescue Therapy<br />

Outcomes from a Randomised Controlled Trial<br />

Ed Vital<br />

Cutting Through the Brain Fog: Cognitive<br />

Dysfunction in <strong>Lupus</strong><br />

Ian Bruce, Carla Cuda, Meggan Mackay<br />

SLE – Diagnosis, Manifestations,<br />

& Outcomes II: Omics<br />

Transcriptomic Analysis of the Impact of<br />

Iberdomide on Patients with SLE<br />

Peter Lipsky<br />

Multi-Omic Profiling Reveals Immune Cell<br />

Priming Signature Linked to Systemic <strong>Lupus</strong><br />

Erythematosus Prognosis<br />

Sarfaraz Hasni<br />

1501<br />

<strong>Lupus</strong> Low Disease Activity State (LLDAS) CP<br />

Achievement with Deucravacitinib, an Oral,<br />

Selective, Allosteric Tyrosine Kinase 2 Inhibitor,<br />

in a Phase 2 Trial in SLE<br />

Eric Morand<br />

1502<br />

Introduction of Belimumab Within Five Years of<br />

the Onset of Systemic <strong>Lupus</strong> Erythematosus (SLE)<br />

Contributes to the Better Therapeutic Response;<br />

A Multi-center Retrospective Cohort Study<br />

Kanako Kojima<br />

1503<br />

Disease Course and Complement as Predictors<br />

of Response to Standard of Care Plus Placebo<br />

in Patients with SLE: A Post Hoc Analysis of<br />

Dapirolizumab Pegol and Epratuzumab Clinical<br />

Trial Data<br />

Joan Merrill


Key: CP Chair’s pick Abstract session Poster session<br />

Scientific session<br />

Tuesday, 14 November <strong>2023</strong><br />

09:00–<br />

10:00<br />

<strong>Lupus</strong> in Africa<br />

Ida Dey, Hakeem Olaosebikan, Kate Webb<br />

2333<br />

Dapirolizumab Pegol Impacts Important<br />

Immunologic Pathways in SLE: Pharmacodynamic<br />

Analysis of B Cell and Type I Interferon Pathways<br />

from a Phase 2b Trial<br />

Ioana Cutcutache<br />

09:00-<br />

11:00<br />

2024<br />

09:00–<br />

11:00<br />

2264<br />

2277<br />

Patient Outcomes, Preferences,<br />

& Attitudes Poster III<br />

Patient-Reported Outcomes in Patients with <strong>Lupus</strong><br />

Nephritis: A Post Hoc Analysis of Control Arm<br />

Data from Two Completed Phase III Randomized<br />

Clinical Trials<br />

Lisa Lindsay<br />

SLE – Diagnosis, Manifestations,<br />

& Outcomes Poster III<br />

Proposal for Defining Moderate and Severe<br />

Activity States in Systemic <strong>Lupus</strong> Erythematosus.<br />

Impact on Flares and Other Outcomes<br />

Ivonne Lourdes Mamani Velarde<br />

Patients with Systemic <strong>Lupus</strong> Erythematosus:<br />

A Comparative Study Between Two Large,<br />

Multi-centric, Spanish and Argentinian Registers,<br />

Focused on Outcomes Differences<br />

Iñigo Rúa-Figueroa<br />

2334<br />

2336<br />

2337<br />

2338<br />

Remission Attainment in Patients with Systemic<br />

<strong>Lupus</strong> Erythematosus Treated with Anifrolumab<br />

Compared with Placebo over a 4-Year Period<br />

Ronald van Vollenhoven<br />

Identification of Urine Metabolites Linked<br />

to Disease Activity That Are Modulated by<br />

Anifrolumab in a Phase 2 LN Trial Using<br />

Untargeted Metabolomics Analysis<br />

David Jayne<br />

Safety and Tolerability of NIM-1324, an Oral,<br />

Once-daily LANCL2 Agonist, in a Randomized,<br />

Double-Blind, Placebo-Controlled Phase 1 Study<br />

in Normal Healthy Volunteers<br />

Andrew Leber<br />

Results of Single-Arm, Phase 1b Study of<br />

Anti-C1q Treatment (ANX009) Show That the<br />

Classical Pathway Is a Key Driver of Complement<br />

Activation and Consumption in Patients with<br />

Active <strong>Lupus</strong> Nephritis<br />

Maria Dall’Era<br />

2296<br />

2297<br />

2306<br />

Association Between EQ-5D-5L and SLEDAI<br />

Scores in Patients with Systemic <strong>Lupus</strong><br />

Erythematosus in the United States and Europe:<br />

A Real-world Survey<br />

Ebuwa Igho-Osagie<br />

Interferon-α as a Biomarker to Predict Flares in<br />

<strong>Lupus</strong> Nephritis<br />

Laura Patricia Whittall Garcia<br />

Changes in Rheumatology Disease Measures<br />

After Initiation of Belimumab Treatment in Patients<br />

with Systemic <strong>Lupus</strong> Erythematosus<br />

Bernard Rubin<br />

2341<br />

2342<br />

2344<br />

Spanish National Registry of Belimumab in<br />

Patients with Systemic <strong>Lupus</strong> Erythematosus<br />

Vicente Aldasoro<br />

Modulation of B Cell and Interferon Pathways<br />

by Ianalumab in Patients with Systemic <strong>Lupus</strong><br />

Erythematosus: Findings from a Phase 2 Clinical Trial<br />

Thomas Dörner<br />

Telitacicept versus Belimumab for Patients<br />

with Active Systemic <strong>Lupus</strong> Erythematosus:<br />

A Retrospective, Multicenter, Real-world<br />

Observational Study<br />

Huizhi Jin<br />

09:00–<br />

11:00<br />

2326<br />

2328<br />

2331<br />

2332<br />

SLE – Treatment Poster III<br />

Efficacy and Safety of Voclosporin in Patients<br />

with Proteinuria > 2 G/g<br />

Emily Littlejohn<br />

Deucravacitinib, an Oral, Allosteric, Tyrosine<br />

Kinase 2 (TYK2) Inhibitor, in Patients with Active<br />

Systemic <strong>Lupus</strong> Erythematosus: Patient-Reported<br />

Outcomes in a Phase 2 Trial<br />

Marta Mosca<br />

Molecular Predictors of Treatment Response<br />

in Two Trials of Abatacept in Systemic <strong>Lupus</strong><br />

Erythematosus<br />

Kevin Thomas<br />

Dapirolizumab Pegol Efficacy by Subgroups in<br />

Patients with SLE: A Post Hoc Analysis of Phase<br />

2b Clinical Trial Data<br />

Anca Askanase<br />

2345<br />

2346<br />

2347<br />

2348<br />

Paired Kidney Biopsies from the AURORA 2 Study<br />

of Voclosporin in Active <strong>Lupus</strong> Nephritis<br />

Samir Parikh<br />

SLE Medication Usage and Organ Damage<br />

Among Adult SLE Patients with SLE Treated<br />

with Belimumab (BEL): Pooled Data from Three<br />

Open-Label Extension Studies over 11+ Years<br />

Zahi Touma<br />

Efficacy of Belimumab in Patients with<br />

Systemic <strong>Lupus</strong> Erythematosus by Race<br />

and Ethnicity: A Large Post Hoc Integrated<br />

Analysis of Five Clinical Trials<br />

Saira Sheikh<br />

Incidence of Infections Among Adult Patients<br />

with SLE Treated with Belimumab (BEL):<br />

Pooled Data from Three Open-Label Extension<br />

Studies over 11+ Years<br />

Jinoos Yazdany<br />

CP


Key: CP Chair’s pick Abstract session Poster session<br />

Scientific session<br />

2349<br />

2350<br />

2351<br />

11:00–<br />

12:00<br />

14:00–<br />

15:30<br />

2485<br />

2487<br />

2488<br />

2489<br />

2490<br />

Selection of the Dose for Subcutaneous<br />

Administration to Non-Japanese Subjects and<br />

Intravenous Administration to Japanese Subjects<br />

in the First-in-Human Study of DS-7011a, an<br />

Anti-TLR7 Monoclonal Antibody for the Treatment<br />

of Systemic <strong>Lupus</strong> Erythematosus<br />

Li Zhang<br />

Upregulation of Both APRIL and BAFF in Systemic<br />

<strong>Lupus</strong> Erythematosus Suggests Non-Redundant<br />

Roles, Further Revealed by Dual Inhibition with<br />

Povetacicept (ALPN-303; TACI vTD-Fc)<br />

Tiffany Blair<br />

Health Outcomes Among Patients (Pts) with SLE<br />

Initiating Belimumab (BEL) With and Without the<br />

Use of Immunosuppressants in the Previous 2 Years<br />

Karen Worley<br />

Advancing Non-Invasive Biomarkers in<br />

ANCA-Associated Vasculitis and <strong>Lupus</strong> Nephritis:<br />

A Translational State of the Art<br />

Salem Almaani, Andrea Fava, Brad Rovin<br />

SLE – Treatment II: Nonrenal<br />

Comparative Risk of Serious Psychiatric Events<br />

with Belimumab versus Oral Immunosuppressant<br />

Use in Patients with Systemic <strong>Lupus</strong> Erythematosus<br />

April Jorge<br />

Phase 2 Safety and Efficacy of Subcutaneous<br />

(s.c.) Dose Ianalumab (VAY736; Anti-BAFFR<br />

mAb) Administered Monthly over 28 Weeks in<br />

Patients with Systemic <strong>Lupus</strong> Erythematosus<br />

(SLE) of Moderate-to-Severe Activity<br />

Nan Shen<br />

Efficacy and Safety of ABBV-599 High Dose<br />

(Elsubrutinib 60 mg and Upadacitinib 30 mg)<br />

and Upadacitinib Monotherapy for the Treatment<br />

of Systemic <strong>Lupus</strong> Erythematosus: A Phase 2,<br />

Double-blind, Placebo-controlled Trial<br />

Joan Merrill<br />

Cutaneous <strong>Lupus</strong> Erythematosus Disease CP<br />

Area and Severity Index (CLASI) Achievement<br />

and Sustained Response with Deucravacitinib,<br />

an Oral, Selective, Allosteric Tyrosine Kinase 2<br />

Inhibitor, in a Phase 2 Trial in SLE<br />

Cristina Arriens<br />

Safety and Efficacy of Mycophenolate Mofetil<br />

in New-onset Systemic <strong>Lupus</strong> Erythematosus<br />

with High Titer of Anti-dsDNA Antibody and<br />

Without Major Organ Involvement: A Multicenter<br />

Randomized Controlled Trial<br />

Junna Ye<br />

CP<br />

14:00–<br />

15:00<br />

16:00–<br />

17:00<br />

16:00–<br />

17:30<br />

2551<br />

TeleRheumatology Research: Where We Are Today?<br />

Jeffrey Curtis, Leila Khalili, Daniel Solomon<br />

Personalized Nutrition for Patients with<br />

Rheumatic Diseases<br />

Danica Cowan, Hana Kahleova, Sarah Patterson<br />

SLE – Diagnosis, Manifestations,<br />

& Outcomes III: Disease Activity<br />

Remission and Low Disease Activity (LDA) in<br />

Patients with SLE Treated with Belimumab (BEL):<br />

Results from a Large Integrated Analysis<br />

Ioannis Parodis<br />

Wednesday, 15 November <strong>2023</strong><br />

08:00–<br />

09:00<br />

Heterogeneity in <strong>Lupus</strong>: Lessons from the<br />

Autoimmunity Centers of Excellence<br />

Marcus Clark, Virginia Pascual, Iñaki Sanz<br />

Industry Sessions<br />

Sunday, 12 November <strong>2023</strong><br />

18:00–<br />

20:00<br />

18:00–<br />

20:00<br />

Disease Modification: A Roadmap to Slowing<br />

Organ Damage Progression in Patients with SLE<br />

Angela Crowley, Ashira Blazer, Rajeev Ragahavn<br />

Novartis’ Commitment in Rheumatology<br />

Adam Winseck, Antton Egana, Kelly Montalto<br />

Monday, 13 November <strong>2023</strong><br />

18:00–<br />

20:00<br />

Expanding Horizons for SLE: An Innovative<br />

Therapy Option<br />

Michelle Petri, Richard Furie<br />

Tuesday, 14 November <strong>2023</strong><br />

11:30–<br />

12:15<br />

18:00–<br />

20:00<br />

A Rheumatologist and Nephrologist Discuss<br />

Kidney Preservation in <strong>Lupus</strong> Nephritis<br />

Sheetal Desai, Tina Kochar<br />

Exploring New Frontiers: CAR T Cell Therapy in<br />

Autoimmune Diseases<br />

James Chung, Peter Merkel, Georg Schett,<br />

Richard Furie, Brad Rovin, Amber Podoll, Peter Maag<br />

Developed under<br />

the auspices of<br />

Supported with educational grants from<br />

Sponsorship<br />

received from

Hooray! Your file is uploaded and ready to be published.

Saved successfully!

Ooh no, something went wrong!