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33 Special Types of Invasive Breast Carcinoma: Diagnostic Criteria ...

33 Special Types of Invasive Breast Carcinoma: Diagnostic Criteria ...

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Spindle-cell <strong>Carcinoma</strong> <strong>of</strong> the <strong>Breast</strong><br />

(Metaplastic <strong>Carcinoma</strong> Variant)<br />

• Most metaplastic carcinomas are high-grade.<br />

• BUT, spindle-cell ca can be deceptively benign.<br />

• Misdiagnosed g as nodular fasciitis, , fibromatosis, ,<br />

granulation tissue, or squamous metaplasia.<br />

• Also can be misclassified as sarcoma.<br />

• YET, these spindle-cell cas can show aggressive<br />

behavior like infiltrating duct carcinomas (NST).<br />

• 5-year survival for spindle-cell ca reported at 64%.<br />

Dx:<br />

High-grade<br />

SSarcomatoid t id<br />

<strong>Carcinoma</strong><br />

Illustrative<br />

Case<br />

10/8/2011<br />

83

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