33 Special Types of Invasive Breast Carcinoma: Diagnostic Criteria ...

Osseous Differentiation (Osteosarcoma)
Dx:
Carcinosarcoma
with
OOsseous Differentiation
Diff ti ti
(Osteogenic Sarcoma)
Prognosis of Metaplastic Carcinoma
Rayson, et al. (Mayo Clinic). Annals of Oncology 10:413-419, 1999.
• 3-year DFS was 40%.
• 3-year OS was 71%.
• 87% of MBC patients were node negative.
• 10 chemo regimens used for metastatic disease - one partial
response.
• NNo responses tto tamoxifen t if in i 4 patients ti t with ith metastatic t t ti disease. di
• Median survival after development of metastases was 8 mos.
• Conclusions: Despite presenting more commonly as nodenegative
disease, DFS and OS in MBC is decreased compared
to typical adeno-carcinomas. Systemic therapy also appears to
be less effective.
• 5-year OS for matrix-producing carcinoma roughly 68%.
• 5-year OS for invasive breast carcinoma (all types) roughly 75%
10/8/2011
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