33 Special Types of Invasive Breast Carcinoma: Diagnostic Criteria ...
33 Special Types of Invasive Breast Carcinoma: Diagnostic Criteria ... 33 Special Types of Invasive Breast Carcinoma: Diagnostic Criteria ...
Breast Synoptic Report • -Invasive tumor type: tubular • -Invasive tumor size: 1.1 cm • -Invasive tumor grade (modified Bloom-Richardson): 1 • -Nuclear grade: 1 • -Mitotic grade & mf count: 1 • -Tubule/papilla formation: 1 • -Total mBR score: 3 • -Lymphatic-vascular invasion: absent • -Blood vascular invasion: absent • -Resection margins for invasive tumor: widely clear • -Duct carcinoma in situ type: solid and cribriform • -Duct carcinoma in situ size: 0.3 cm around the invasive tumor • -Duct carcinoma in situ grade: low grade • -Microcalcifications: present • -Resection margins for carcinoma in situ: widely clear [> 1cm] • -Lymph nodes positive /total lymph nodes sampled: negative (0/3) • -AJCC/UICC stage: pT1cN0 • -Her2/neu status: negative • -Hormone receptor status (ER/PR): positive (3+, 100%) • -Additional comments: biopsy site changes present Cribriform carcinoma • Special type of well differentiated breast carcinoma (mBR I) • It should be recognized as distinct entity • EExcellent ll t prognosis i • Morphologically similar to cribriform DCIS • Often mixed with
Cribriform carcinoma Histopathology • Pure form shows >90% of cribriform architecture • Invasive irregular cribriform growth of tumor cells • Similar to low grade cribriform DCIS • Desmoplastic stroma • Tumor cells have low grade nuclei • Rare or no mitosis • Mucin positive secretion • Often mixed with
- Page 9 and 10: Triple-negative Breast Carcinomas
- Page 11 and 12: E-cadherin E-cadherin EGFR ++ ER ne
- Page 13 and 14: ER/PR Positive HER2 Negative INVASI
- Page 15 and 16: Tubulolobular Signet-ring Histiocyt
- Page 17 and 18: Illustrative Example: 61 y/o female
- Page 19 and 20: E-Cadherin ER PR 10/8/2011 17
- Page 21 and 22: LCIS vs DCIS • Patients with lobu
- Page 23 and 24: Examples of E-cadherin staining in
- Page 25 and 26: Classic Low-grade DCIS - E-cadherin
- Page 27 and 28: E-cadherin IHC CASE D 10/8/2011 25
- Page 29 and 30: E-cadherin IHC CASE E 10/8/2011 27
- Page 31 and 32: Literature Summary: Correlation of
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- Page 35 and 36: CD10 SMA MIB-1 10/8/2011 33
- Page 37 and 38: Carter et al. Cancer 1977 & 1983
- Page 39 and 40: Differential Diagnosis: 1. Invasive
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- Page 43 and 44: SYNAPTOPHYSIN SMA 10/8/2011 41
- Page 45 and 46: Nassar et al. (AJSP 2006;30:501-7.)
- Page 47 and 48: Special Types of Invasive Breast Ca
- Page 49 and 50: Tubular carcinoma • It has been d
- Page 51 and 52: Tubular carcinoma Histopathology
- Page 53 and 54: Flat Epithelial Atypia When should
- Page 55 and 56: Microglandular adenosis + reticulin
- Page 57 and 58: mitosis ductal ductal, NST tubular
- Page 59: Treatment • Breast conservation t
- Page 63 and 64: Cribriform carcinoma Prognosis •
- Page 65 and 66: Cribriform Carcinoma Pearls of Path
- Page 67 and 68: Clinicopathological features Mucino
- Page 69 and 70: Case 4 Mucinous carcinoma Mixed muc
- Page 71 and 72: Treatment • Breast conservation a
- Page 73 and 74: Incipient mucocele-like lesion Cyst
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- Page 79 and 80: SMA Dx: Spindle-cell Breast Carcino
- Page 81 and 82: Dx: Pure Squamous Carcinoma 10/8/20
- Page 83 and 84: Osseous Differentiation (Osteosarco
- Page 85 and 86: Spindle-cell Carcinoma of the Breas
- Page 87 and 88: Phyllodes y Tumors Phyllodes Tumor
- Page 89 and 90: Diagnosis: Benign g (Low-grade) Phy
- Page 91 and 92: Diagnosis: Malignant (High-grade) P
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- Page 97 and 98: Illustrative Case 10/8/2011 95
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- Page 101 and 102: Dx: Mixed Spindle-cell & Cl Classic
- Page 103 and 104: Dx: Adenomyoepithelioma, Epithelioi
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- Page 109 and 110: Case 1 • 40 year old female • B
<strong>Breast</strong> Synoptic Report<br />
• -<strong>Invasive</strong> tumor type: tubular<br />
• -<strong>Invasive</strong> tumor size: 1.1 cm<br />
• -<strong>Invasive</strong> tumor grade (modified Bloom-Richardson): 1<br />
• -Nuclear grade: 1<br />
• -Mitotic grade & mf count: 1<br />
• -Tubule/papilla formation: 1<br />
• -Total mBR score: 3<br />
• -Lymphatic-vascular invasion: absent<br />
• -Blood vascular invasion: absent<br />
• -Resection margins for invasive tumor: widely clear<br />
• -Duct carcinoma in situ type: solid and cribriform<br />
• -Duct carcinoma in situ size: 0.3 cm around the invasive tumor<br />
• -Duct carcinoma in situ grade: low grade<br />
• -Microcalcifications: present<br />
• -Resection margins for carcinoma in situ: widely clear [> 1cm]<br />
• -Lymph nodes positive /total lymph nodes sampled: negative (0/3)<br />
• -AJCC/UICC stage: pT1cN0<br />
• -Her2/neu status: negative<br />
• -Hormone receptor status (ER/PR): positive (3+, 100%)<br />
• -Additional comments: biopsy site changes present<br />
Cribriform carcinoma<br />
• <strong>Special</strong> type <strong>of</strong> well differentiated breast<br />
carcinoma (mBR I)<br />
• It should be recognized as distinct entity<br />
• EExcellent ll t prognosis i<br />
• Morphologically similar to cribriform DCIS<br />
• Often mixed with
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