33 Special Types of Invasive Breast Carcinoma: Diagnostic Criteria ...
33 Special Types of Invasive Breast Carcinoma: Diagnostic Criteria ... 33 Special Types of Invasive Breast Carcinoma: Diagnostic Criteria ...
E-cadherin IHC CASE F E-cadherin IHC 10/8/2011 28
Literature Summary: Correlation of E-cadherin Expression as a Prognostic Factor • 5 papers report lack of expression as a predictor of poor outcome. • 7 papers report no significance. • 4 papers report expression as a predictor of poor outcome prognosticator. E-cadherin status in breast cancer correlates with histologic type but does not correlate with established prognostic parameters. Am J Clin Pathol (United States), Mar 2006, 125(3) p377-85 - “Statistically a correlation of EC loss with a positive diagnosis of ILC was found but there was no correlation with any prognostic tumor variables.” - “EC is helpful in classifying cases with indeterminate histologic features. EC loss is uncommon in non-lobular carcinomas with no correlation to currently established prognostic variables.” Location of our sign-out microscopes in surgical pathology In San Diego 10/8/2011 29
- Page 1 and 2: 33 Special Types of Invasive Breast
- Page 3 and 4: Special Types of Invasive Breast Ca
- Page 5 and 6: INVASIVE BREAST CARCINOMAS CONSIDER
- Page 7 and 8: ER Neg. PR Neg. HER2 Neg. CK 5/6 Po
- Page 9 and 10: Triple-negative Breast Carcinomas
- Page 11 and 12: E-cadherin E-cadherin EGFR ++ ER ne
- Page 13 and 14: ER/PR Positive HER2 Negative INVASI
- Page 15 and 16: Tubulolobular Signet-ring Histiocyt
- Page 17 and 18: Illustrative Example: 61 y/o female
- Page 19 and 20: E-Cadherin ER PR 10/8/2011 17
- Page 21 and 22: LCIS vs DCIS • Patients with lobu
- Page 23 and 24: Examples of E-cadherin staining in
- Page 25 and 26: Classic Low-grade DCIS - E-cadherin
- Page 27 and 28: E-cadherin IHC CASE D 10/8/2011 25
- Page 29: E-cadherin IHC CASE E 10/8/2011 27
- Page 33 and 34: 10/8/2011 31
- Page 35 and 36: CD10 SMA MIB-1 10/8/2011 33
- Page 37 and 38: Carter et al. Cancer 1977 & 1983
- Page 39 and 40: Differential Diagnosis: 1. Invasive
- Page 41 and 42: 10/8/2011 39
- Page 43 and 44: SYNAPTOPHYSIN SMA 10/8/2011 41
- Page 45 and 46: Nassar et al. (AJSP 2006;30:501-7.)
- Page 47 and 48: Special Types of Invasive Breast Ca
- Page 49 and 50: Tubular carcinoma • It has been d
- Page 51 and 52: Tubular carcinoma Histopathology
- Page 53 and 54: Flat Epithelial Atypia When should
- Page 55 and 56: Microglandular adenosis + reticulin
- Page 57 and 58: mitosis ductal ductal, NST tubular
- Page 59 and 60: Treatment • Breast conservation t
- Page 61 and 62: Cribriform carcinoma Histopathology
- Page 63 and 64: Cribriform carcinoma Prognosis •
- Page 65 and 66: Cribriform Carcinoma Pearls of Path
- Page 67 and 68: Clinicopathological features Mucino
- Page 69 and 70: Case 4 Mucinous carcinoma Mixed muc
- Page 71 and 72: Treatment • Breast conservation a
- Page 73 and 74: Incipient mucocele-like lesion Cyst
- Page 75 and 76: 10/8/2011 73
- Page 77 and 78: 10/8/2011 75
- Page 79 and 80: SMA Dx: Spindle-cell Breast Carcino
Literature Summary:<br />
Correlation <strong>of</strong> E-cadherin<br />
Expression as a Prognostic Factor<br />
• 5 papers report lack <strong>of</strong> expression as a<br />
predictor <strong>of</strong> poor outcome.<br />
• 7 papers report no significance.<br />
• 4 papers report expression as a predictor <strong>of</strong><br />
poor outcome prognosticator.<br />
E-cadherin status in breast cancer correlates<br />
with histologic type but does not correlate with<br />
established prognostic parameters.<br />
Am J Clin Pathol (United States), Mar 2006, 125(3) p377-85<br />
- “Statistically a correlation <strong>of</strong> EC loss with a positive<br />
diagnosis <strong>of</strong> ILC was found but there was no<br />
correlation with any prognostic tumor variables.”<br />
- “EC is helpful in classifying cases with indeterminate<br />
histologic features. EC loss is uncommon in<br />
non-lobular carcinomas with no correlation to<br />
currently established prognostic variables.”<br />
Location <strong>of</strong> our sign-out<br />
microscopes in surgical pathology<br />
In San Diego<br />
10/8/2011<br />
29
Change language