33 Special Types of Invasive Breast Carcinoma: Diagnostic Criteria ...

cystic hypersecretory duct carcinoma of the breast: pathology, therapy, and
follow-up of 39 patients. Cancer 1988;61:1611-1620.
37. Colandrea JM, Shmookler BM, O'Dowd GJ, Cohen MH. Cystic
hypersecretory duct carcinoma of the breast. Report of a case with fineneedle
aspiration. Arch Pathol Lab Med 1988;112:560-3.
38. Rosen PP, Scott M. Cystic hypersecretory duct carcinoma of the breast. Am
J Surg Pathol 1984;8:31-41.
39. Ranade A, Batra R et all. Clinicopathological evalution of 100 cases of
mucnious carcinoma of breast with emphasis on axillary staging and special
referece to a micropapillary pattern. J Clin Pathol 2010;63: 1043-1047.
40. Yu J, Bhargava R, Dabbs DJ. Invasive lobular carcinoma with extracellular
mucin production and HER-2 overexpression: a case report and further case
studies. Diagn Pathol. 2010 Jun 15;5:36.
41. Rosen P. Rosen’s Breast Pathology. 2009: 515-533.
Case 5:
History: 29 year old female with a breast lump who was felt by patient.
Mammogram found a 2 cm suspicious mass under the nipple
Submitted diagnosis: Invasive secretory carcinoma (well-differentiated invasive
breast carcinoma, overall mBR grade 1; nuclear grade 2, tubule grade 2,
mitotic grade 1).
SECRETORY CARCINOMA
Background: A rare tumor, with a frequency of less than 0.15% of all breat
carcinoma. The tumor is located near the areola in about ½ of cases. Although initially
described in young patients and called juvenile carcinoma, secretory carcinoma may
not only be found in children under 10 years of age, but also in adults as old as 73
years of age (1-6). Indeed, the majority of cases in later studies have been reported in
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