33 Special Types of Invasive Breast Carcinoma: Diagnostic Criteria ...

10-YEAR SURVIVAL BY INVASIVE TUMOR TYPE
AND MODIFIED BLOOM-RICHARDSON GRADE (mBR)
(Periera et al. Histopathol 1995;27:219-226)
Type (~100% total): Overall Grade 1 Grade 2 Grade 3
Ductal (NST) (50%) 46 76 55 39
Lobular (Classic) (6%) 53 71 55 38
Mixed Ductal + Lobular (5%) 41 88 52 31
Tubular (2.4%) 90 90 none none
Tubulo-lobular (1%) 91 91 none none
Mixed Tubular + Ductal (15%) 64 86 63 18
Mucinous (1%) 81 86 75 none
Mixed Ductal+Special type (2.5%) 64 81 59 55
Medullary (3%) 51 none none 51
Atypical Medullary (5%) 63 none none 63
Invasive Papillary (0.3%) 60 to few to few to few
Invasive Cribriform (0.8%) 90 90 none none
Solid Lobular (1.4%) 33 none 63 18
Alveolar Lobular (0.6%) 77 none 77 none
Mixed Lobular (6.4%) 48 71 52 43
NOTE: (Ellis et al. [8] and Periera et al. [6] criteria): Tubular = > 90% classic lowgrade
tubular carcinoma. Mixed tubular = stellate mass with peripheral infiltrating
border showing ductal (NST) carcinoma + some central areas showing classical
tubular carcinoma. Cribriform = > 90% invasive cribriform pattern of small regular
cells or > 50% classic cribriform, if remainder classic tubular carcinoma. Mucinous =
small islands (10-20 cells) of uniform small cells in lakes of extracellular mucin; any
amount of invasive ductal (NST) carcinoma places the lesion in the mixed ductal +
mucinous type. Mixed ductal + special types or lobular = a special type or lobular
tumor that also contains ductal (NST) carcinoma amounting to10-90% of the total
invasive tumor. Medullary = must show all of the following features: 1) sheets of
large bizarre carcinoma cells forming syncytial network, 2) moderate to large numbers
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