Oscillations, Waves, and Interactions - GWDG

Applied physics at the “Dritte” 15
permanent damage to the cell, a process called sonoporation. Molecular uptake
is a precondition for many biological and medical applications. In order to gain
deeper insights in both mechanisms, tissue injury and sonoporation, the interactions
of cavitation bubbles with cells and boundaries have been studied [180,181].
The need for an objective assessment of voice quality after curative minimalinvasive
laser resection of laryngeal carcinomas led to an intensive cooperation with
the department of phoniatrics and pedriatric audiology of our university [182,183].
Acoustical analyses for the description of pathologic voices and for the documentation
of progress in voice rehabilitation measures were developed [31].
In 2000 a biophysics group was established at the Dritte. Headed by Manfred
Radmacher this group was concerned with mechanical properties of biomaterial and
imaging of biological samples using atomic force microscopy [184,185].
In 2006 Christoph Schmidt was appointed professor for biophysics at the institute.
The general theme relating his research projects is the study of dynamic
physical properties of complex biological macromolecules and their assemblies up
to the level of cells [186–188]. These projects involve a) biological motor proteins
in single-molecule experiments with the goal of understanding the physical principles
of biological force generation in a multitude of active transport processes, b)
the dynamics of DNA enzymes in order to understand the still incompletely known
highly complex mechanical tasks in replication, transcription and packing, and c)
the collective dynamics of systems ranging from synthetic colloids to whole cells. In
particular, networks of semiflexible proteins are studied, in vitro and also in living
cells, with so-called microrheology techniques in order to understand the functional
principles of the cytoskeleton, which play crucial roles in processes such as cell division,
cell locomotion, or cell growth, as well as mechano-sensing and signalling.
Future work is indicated in the article by Christoph Schmidt and Stefan Lakämper
in this book [189].
References
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in Bonn’, Acustica 9, 465 (1959).
[2] W. Junius, ‘Raumakustische Untersuchungen mit neueren Meßverfahren in der Liederhalle
Stuttgart’, Acustica 9, 289 (1959).
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Plenarsaals des Baden-Württembergischen Landtages in Stuttgart’, Acustica 12, 55
(1962).
[4] E. Meyer and K. H. Kuttruff, ‘Zur Raumakustik einer großen Festhalle (Erfahrungen
mit einer elektroakustischen Nachhallanlage)’, Acustica 14, 138 (1964).
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[6] G. R. Schodder, F. K. Schröder, and R. Thiele, ‘Verbesserung der Hörsamkeit eines
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[7] E. Meyer and R. Thiele, ‘Raumakustische Untersuchungen in zahlreichen Konzertsälen
und Rundfunkstudios unter Anwendung neuerer Meßverfahren’, Acustica 6, 425
(1956).
[8] E. Meyer, ‘Definition and Diffusion in Rooms’, J. Acoust. Soc. Am. 26, 630 (1954).