Feng, Xiaodong_ Xie, Hong-Guang - Applying pharmacogenomics in therapeutics-CRC Press (2016)

BIOMEDICAL SCIENCE
Applying Pharmacogenomics
in Therapeutics
Recent advances in high-throughput gene sequencing and other omics
biotechnologies have served as a springboard for the field of pharmacogenomics.
Pharmacogenomics is now generally accepted as the major determinant of
variable drug safety, efficacy, and cost-effectiveness. Therefore, widespread use
of pharmacogenomics for patient care has become a critical requirement. There
is an unprecedented urgency for aspiring and practicing clinicians to become
trained on how to interpret data from pharmacogenomic testing in preparation
for the future of healthcare—i.e., personalized medicine.
Applying Pharmacogenomics in Therapeutics provides timely coverage
of the principles, practice, and potential of pharmacogenomics and
personalized medicine. Comprised of chapters contributed by well-established
pharmacologists and scientists from US and Chinese academia and industry,
this authoritative text:
• Demonstrates how to apply the principles of pharmacogenomics and
its biotechnologies in patient care
• Depicts the use of genetic biomarkers in drug discovery and development,
laboratory medicine, and clinical services
• Describes the practice of pharmacogenomics in the treatment of cancers,
cardiovascular diseases, neurologic and psychiatric disorders,
and pulmonary diseases
• Discusses the merging of pharmacogenomics and alternative medicine,
as well as the integration of pharmacogenomics into pharmacoeconomics
Each chapter begins with the key concepts, followed by in-depth explorations
of case reports or critical evaluations of genetic variants/biomarkers, and
concludes with questions for self-examination.
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