Feng, Xiaodong_ Xie, Hong-Guang - Applying pharmacogenomics in therapeutics-CRC Press (2016)

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(a)(b)2p23 regionTelomereSHGC-565760ALKSHGC-104192Centromere3’ 5’~300 kb~442 kbLSI ALK Dual Color, Break ApartRearrangement Probe(c)(d)FIGURE 5.2 FISH results for HER2 (a and b) and ALK (c and d). (a) Control with normalcells (arrows) with two copies of centromere signals (green) and two copies of HER2 signals(red) for chromosome 17; (b) a patient with abnormal cells (arrows), two copies of centromeresignals (green), and amplified HER2 signals (red). (c) LSI ALK Dual Color Break Apartprobe (Abbott Molecular; www.abbottmolecular.com). (d) FISH results for ALK rearrangement.Arrow: abnormal cells with one fusion signal, separate one red and one green signalindicating ALK rearrangement.
BIOMEDICAL SCIENCEApplying Pharmacogenomicsin TherapeuticsRecent advances in high-throughput gene sequencing and other omicsbiotechnologies have served as a springboard for the field of pharmacogenomics.Pharmacogenomics is now generally accepted as the major determinant ofvariable drug safety, efficacy, and cost-effectiveness. Therefore, widespread useof pharmacogenomics for patient care has become a critical requirement. Thereis an unprecedented urgency for aspiring and practicing clinicians to becometrained on how to interpret data from pharmacogenomic testing in preparationfor the future of healthcare—i.e., personalized medicine.Applying Pharmacogenomics in Therapeutics provides timely coverageof the principles, practice, and potential of pharmacogenomics andpersonalized medicine. Comprised of chapters contributed by well-establishedpharmacologists and scientists from US and Chinese academia and industry,this authoritative text:• Demonstrates how to apply the principles of pharmacogenomics andits biotechnologies in patient care• Depicts the use of genetic biomarkers in drug discovery and development,laboratory medicine, and clinical services• Describes the practice of pharmacogenomics in the treatment of cancers,cardiovascular diseases, neurologic and psychiatric disorders,and pulmonary diseases• Discusses the merging of pharmacogenomics and alternative medicine,as well as the integration of pharmacogenomics into pharmacoeconomicsEach chapter begins with the key concepts, followed by in-depth explorationsof case reports or critical evaluations of genetic variants/biomarkers, andconcludes with questions for self-examination.K18948an informa businesswww.crcpress.com6000 Broken Sound Parkway, NWSuite 300, Boca Raton, FL 33487711 Third AvenueNew York, NY 100172 Park Square, Milton ParkAbingdon, Oxon OX14 4RN, UKwww.crcpress.com
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DedicationWe dedicate this book to
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viiiContentsChapter 10 Pharmacogeno
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EditorsXiaodong Feng, PhD, PharmD,
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ContributorsWeiguo Chen, PhDDepartm
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1Concepts inPharmacogenomics andPer
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Concepts in Pharmacogenomics and Pe
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Feng, Xiaodong_ Xie, Hong-Guang - Applying pharmacogenomics in therapeutics-CRC Press (2016)

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