Feng, Xiaodong_ Xie, Hong-Guang - Applying pharmacogenomics in therapeutics-CRC Press (2016)

9 Applying
Pharmacogenomics
in the Therapeutics
of Pulmonary Diseases
Wei Zhang and Jason X.-J. Yuan
CONTENTS
Key Concepts.......................................................................................................... 221
Introduction.............................................................................................................222
General Pharmacogenetic and Pharmacogenomic Approaches..............................223
Applying Pharmacogenomics to Pulmonary Disorders..........................................224
Chronic Obstructive Pulmonary Disease...........................................................224
Brief Background..........................................................................................224
Therapy for COPD........................................................................................225
Genetics and Pharmacogenetics of COPD....................................................226
Asthma...............................................................................................................227
Brief Background..........................................................................................227
Therapy for Asthma.......................................................................................228
Genetics and Pharmacogenetics of Asthma..................................................229
Pulmonary Hypertension....................................................................................230
Brief Background..........................................................................................230
Therapy for Pulmonary Hypertension........................................................... 231
Genetics and Pharmacogenetics of Pulmonary Hypertension....................... 232
Conclusions............................................................................................................. 233
Thoughts for Further Consideration........................................................................ 233
Study Questions......................................................................................................234
References...............................................................................................................234
KEY CONCEPTS
• Pharmacogenetic and pharmacogenomic studies aim to elucidate genetic
determinants for drug response, a complex phenotype.
• Responses to therapeutics may be affected by various genetic and nongenetic
factors.
• Several pulmonary disorders, such as chronic obstructive pulmonary
disease (COPD), asthma, and pulmonary hypertension, have been under
221