Feng, Xiaodong_ Xie, Hong-Guang - Applying pharmacogenomics in therapeutics-CRC Press (2016)

6 Applying Pharmacogenomics in Therapeutics
TABLE 1.1
Summary of Dual and Triple Therapy with Omeprazole and Reported H. pylori Cure Rates Based
on CYP2C19 Genotype
H. pylori Cure Rates
(Cured Patients/Total Number of Patients)
Drug Regimen a Hom EMs b Het EMs c PMs d
Regimen 1 28.6%
(8/28)
Regimen 2 73.9%
(17/23)
Regimen 3 33%
(3/9)
Regimen 4 43%
(3/7)
Regimen 5 81%
(13/16)
Regimen 6 76.2%
(16/21)
Regimen 7 72.7%
(64/88)
Regimen 8 68.9%
(31/45)
Regimen 9 73.3%
(22/30)
60%
(15/25)
68.8%
(33/48)
30%
(3/10)
58.3%
(7/12)
94.7%
(18/19)
88.9%
(24/27)
92.1%
(117/127)
84.4%
(27/32)
86.1%
(31/36)
100%
(9/9)
83.3%
(15/18)
100%
(2/2)
100%
(2/2)
100%
(9/9)
90%
(9/10)
97.8%
(45/46)
91.3%
(21/23)
85%
(17/20)
Hom EMs vs.
PMs
Hom EMs vs.
Het EMs
Het EMs vs.
PMs Reference
p < 0.05 p < 0.001 p < 0.05 17
NS NS NS 35
NS e 26
NS e 26
NS e 26
NS NS NS 36
p < 0.001 p < 0.001 NS 30
p = 0.023 f 6
NS NS NS 34
(Continued)