Feng, Xiaodong_ Xie, Hong-Guang - Applying pharmacogenomics in therapeutics-CRC Press (2016)

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Concepts in
Pharmacogenomics and
Personalized Medicine
Kelly C. Lee, Joseph D. Ma, and Grace M. Kuo
CONTENTS
Key Concepts..............................................................................................................2
Introduction.................................................................................................................2
Definitions..............................................................................................................3
Efficacy: Omeprazole..................................................................................................4
Clinical Case..........................................................................................................4
Background............................................................................................................4
Gene/Allele of Interest and Functional Effect.......................................................4
Clinical Relevance..................................................................................................5
Testing Availability and Recommendations...........................................................8
Efficacy: Trastuzumab................................................................................................8
Clinical Case..........................................................................................................8
Background............................................................................................................8
Gene/Allele of Interest and Functional Effect.......................................................9
Clinical Relevance..................................................................................................9
Testing Availability and Recommendations......................................................... 10
Toxicity: Abacavir..................................................................................................... 10
Clinical Case........................................................................................................ 10
Background.......................................................................................................... 10
Gene/Allele of Interest and Functional Effect..................................................... 11
Clinical Relevance................................................................................................ 11
Testing Availability and Recommendations......................................................... 11
Toxicity: Carbamazepine.......................................................................................... 12
Clinical Case........................................................................................................ 12
Background.......................................................................................................... 12
Gene/Allele of Interest and Functional Effect..................................................... 13
Clinical Relevance................................................................................................ 13
Test Availability and Recommendations.............................................................. 15
Toxicity: Codeine...................................................................................................... 15
Clinical Case........................................................................................................ 15
Background.......................................................................................................... 15
Gene/Allele of Interest and Functional Effect..................................................... 15
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