Feng, Xiaodong_ Xie, Hong-Guang - Applying pharmacogenomics in therapeutics-CRC Press (2016)

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xivJianbo J. Song, PhD, FACMGAmbry GeneticsAliso Viejo, CaliforniaKaiser Permanente Northern CaliforniaRegional Genetics LaboratoriesSan Jose, CaliforniaRuth Vinall, PhDDepartment of Pharmaceuticaland Biomedical SciencesCalifornia Northstate UniversityCollege of PharmacyElk Grove, CaliforniaTibebe Woldemariam, PhDDepartment of Biomedicaland Pharmaceutical SciencesCalifornia Northstate UniversityCollege of PharmacyElk Grove, CaliforniaHong-Guang Xie, MD, PhDGeneral Clinical Research CenterNanjing First HospitalNanjing Medical UniversityNanjing, ChinaJason X.-J. Yuan, MD, PhDDivision of Translationaland Regenerative MedicineDepartment of MedicineCollege of MedicineThe University of ArizonaTucson, ArizonaContributorsWei Zhang, PhD (Chapters 3 and 9)Department of Preventive MedicineNorthwestern University FeinbergSchool of MedicineChicago, IllinoisWei Zhang, PhD (Chapter 10)Department of Clinical PharmacologyXiangya HospitalCentral South UniversityChangsha, ChinaHong-Hao Zhou, MDDepartment of Clinical PharmacologyXiangya HospitalCentral South UniversityChangsha, China
1Concepts inPharmacogenomics andPersonalized MedicineKelly C. Lee, Joseph D. Ma, and Grace M. KuoCONTENTSKey Concepts..............................................................................................................2Introduction.................................................................................................................2Definitions..............................................................................................................3Efficacy: Omeprazole..................................................................................................4Clinical Case..........................................................................................................4Background............................................................................................................4Gene/Allele of Interest and Functional Effect.......................................................4Clinical Relevance..................................................................................................5Testing Availability and Recommendations...........................................................8Efficacy: Trastuzumab................................................................................................8Clinical Case..........................................................................................................8Background............................................................................................................8Gene/Allele of Interest and Functional Effect.......................................................9Clinical Relevance..................................................................................................9Testing Availability and Recommendations......................................................... 10Toxicity: Abacavir..................................................................................................... 10Clinical Case........................................................................................................ 10Background.......................................................................................................... 10Gene/Allele of Interest and Functional Effect..................................................... 11Clinical Relevance................................................................................................ 11Testing Availability and Recommendations......................................................... 11Toxicity: Carbamazepine.......................................................................................... 12Clinical Case........................................................................................................ 12Background.......................................................................................................... 12Gene/Allele of Interest and Functional Effect..................................................... 13Clinical Relevance................................................................................................ 13Test Availability and Recommendations.............................................................. 15Toxicity: Codeine...................................................................................................... 15Clinical Case........................................................................................................ 15Background.......................................................................................................... 15Gene/Allele of Interest and Functional Effect..................................................... 151
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11 PharmacoeconogenomicsA Good Marr
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Pharmacoeconomics of Pharmacogenomi
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BIOMEDICAL SCIENCEApplying Pharmaco
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Feng, Xiaodong_ Xie, Hong-Guang - Applying pharmacogenomics in therapeutics-CRC Press (2016)

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