Volume 54Number 8Cranial growth centers 579Fig. 15. The outlines of the three mandibles shown in Fig. 14 superimposed on the condyle.Compare the apparent growth direction as viewed from the temporomandibular joint with theactual one shown in Fig. 14. The discrepancy between the findings cannot be explained by theconcept of the eondylar cartilage having a pushing and directing force,point toward its subordinate role as a site of growth, not as a growth center, inthe growth of the mandible.CONCLUSIONSThe foregoing discussion of the available information concerning the growthof the craniofaeial skeleton has led to the conclusion that most of the areaswhich have been labeled growth centers in the past either do not qualify as suchor have not been studied sufficiently for the claim to be proved beyond doubt.If these sutures and cartilages do, indeed, lack independent growth-promotingpotential, what are the factors responsible for the craniofacial skeleton?Several students of craniofacial growth have proposed essentially similarconcepts regarding it. Van der Klaauw3g viewed the skull as composed of morethan thirty relatively independent functional units, each governed by its ownfunctional growth director, as it were. Scott16 divided the craniofacial skeletoninto eight different regions, each having its own growth pattern, related to thedifferent organs they house or support. The latest theory is presented by Mos+~,~~* s8who maintains that the growth of the craniofacial skeleton is under the influenceof the “functional matrix,” by which he means all the soft tissues (even emptyspaces) within which the bony structures are embedded.
Thcrc is, as TW have seen, much c~vitlence, both clinical and experimental,that can be used to support these theories.“’ SO. li5f RS, w The t hcorics, howr’vt~r’, arcnot explicit enough, it seems, and they ha\e not, been prowd beyond an?- doubt.Nerertheless, they appear valuable as stimuli and as l\orking hppothwrs forfurther research in the field. Rincc so many observations apptlar Incompatiblewith older views, we should keep an opw mind and look I’or c~xplanations andtheories that would be in agreement with all the known facts.The author’s own research reported here has been supported by grants from The SigridJuselius Foundation, Helsinki, Finland, and from the National Inst,itutes of Dcmtal Research(Dl434, DE-01793) and of Child Health am1 Human Development (HI)-001 771, UnitedStates Public Health Service.REFERENCES1. Andersen, H.: Histochemistry and Development of the Human Shoulder and AcromioclavicularJoints With Particular Refcrenre to the Early Development of the Clavicle,Aeta Anat. 55: 124-165, 1963.2. Applrbaum, E.: Integration of Anatomic and Cephalometric Studies of Growth of theHead, A&f. J. ORTHOIMZNTIC~ 39: 6’12-622, 1953.3. Bvis, V.: The Significance of the Angle of the Mandible: An Experimental and ComparativeStudy, Am. J. Phys. Anthrop. 19: 55-61, 1961.4. Baer, M. J.: Patterns of Growth of the Skull as Revcalod by Vital Staining, Hurrmn Biol.26: 80-126, 1954.5. Balinsky, B. I.: An Introduction to Embryology, Philadelphia, 1960, W. B. Saunders Co.6. Baume, L. J.: The Postnatal Growth Activity of the Nasal Cartilage Septum, Helvet.odont. acta 5: 9-13, 1961.7. Baume, L. J. : Principles of Cephalofacial Development Revealed by Experiment,al Biology,AM. J. ORTIIOD~NTICS 47: 881-901, 1961.8. Baume, L. J., and Derichsweiler, H.: Is the Condylar Growth Center Responsive toOrthodontic Treatment B Oral Surg., Oral Med. & Oral Path. 14: 347-362, 1961.9. Bjark, A. : Cranial Base Development, AM. J. ORTHODONTICS 41: 198-225, 1955.10. Bjb;rk, A.: Variations in the Growth Pattern of the Human Mandible: LongitudinalRadiographic Study by the Implant Method, J. D. Res. 42: 400-411, 1963.11. Bjb;rk, A.: Sutural Growth of the Upper Face Studied by the Implant Method, Actaodont. scandinav. 24: 109-127, 1966.12. Blackwood, H. J. J.: Growth of the Mandibular Condyle of the Rat Studied WithTritiated Thymidinc, Arch. Oral Biol. 11: 493-500, 1966.13. Blount, W. B., and Clarke, G. R,.: Control of Bone Growth by Epiphyseal Stapling, J.Bone & Joint Surg. 31A: 464-478, 1949.14. Brash, J. C., McKeag, H. T. il., and Scott, J. H.: The Aetiology of Irregularity andMalocclusion of the Teeth, ed. 2, London, 1956, The Dental Board of the United Kingdom.15. Breitner, C.: Bone Changes Resulting From Experimental Orthodontic Treatment, AM. .J.ORTHODONTICS &ORAL 9~~~26: 521-547, 1940.16. Breitner, C.: Further Investigations of Bone Changes Resulting Fro’m ExperimentalOrthodontic Treatment, AM. J. ORTHODO~ICS & ORAL SURG. 27: 605-632, 1941.17. Coulombre, A. J., and Crelin, E. 8.: The Role of the Developing Eye in the Morphogenesisof the Avian Skull, Am. J. Phys. Anthrop. 16: 25.37, 1958.18. Das, A., Meyer, J., and Sicher, H.: X-ray and Alizarin Studies on the Effect of BilateralCondylectomy in the Rat, Angle Orthodontist 3.5: 138.148, 1965.19. BuBrul, E. L., and Laskin, D. M.: Prcadaptivo Potentialities of the Mammalian Skull :An Experiment in Growth and Form, Am. J. Anat. 109: 117-132, 1961.20. Enlow, D. H., and Harris, D. B.: A Study of the Postnatal Growth of the HumanMandible, AM. J. ORTHODONTICS 50: 25-50, 1964.