- Page 5 and 6: FIF THEDITIONESSENTIALCELL BIOLOGYB
- Page 7 and 8: PREFACENobel Prize-winning physicis
- Page 9 and 10: PrefaceviiJulie Lively, Louisiana S
- Page 11 and 12: PrefaceixAnimations and VideosStrea
- Page 13 and 14: PrefacexiLIST OF CHAPTERS andSPECIA
- Page 15: List of Chapters and Special Featur
- Page 18 and 19: xviContentsCHAPTER 2Chemical Compon
- Page 20 and 21: xviiiContentsATP Hydrolysis Allows
- Page 22 and 23: xxContentsSpecific Enzymes Couple t
- Page 24 and 25: xxiiContentsCHAPTER 10Analyzing the
- Page 26 and 27: xxivContentsIon Channels Randomly S
- Page 28 and 29: xxviContentsCHAPTER 15Intracellular
- Page 30 and 31: xxviiiContentsCHAPTER 17Cytoskeleto
- Page 32 and 33: xxxContentsCONTROL OF CELL NUMBERS
- Page 34 and 35: xxxiiContentsCANCER 718Cancer Cells
- Page 36 and 37: 2 CHAPTER 1 Cells: The Fundamental
- Page 38 and 39: 4 CHAPTER 1 Cells: The Fundamental
- Page 40 and 41: 6 CHAPTER 1 Cells: The Fundamental
- Page 42 and 43: 8 CHAPTER 1 Cells: The Fundamental
- Page 44 and 45: 10 CHAPTER 1 Cells: The Fundamental
- Page 46 and 47: 12PANEL 1-1 MICROSCOPYCONVENTIONAL
- Page 48 and 49: 14 CHAPTER 1 Cells: The Fundamental
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18 CHAPTER 1 Cells: The Fundamental
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20 CHAPTER 1 Cells: The Fundamental
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22 CHAPTER 1 Cells: The Fundamental
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24 CHAPTER 1 Cells: The Fundamental
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26 CHAPTER 1 Cells: The Fundamental
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28 CHAPTER 1 Cells: The Fundamental
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30HOW WE KNOWLIFE’S COMMON MECHAN
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32 CHAPTER 1 Cells: The Fundamental
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34 CHAPTER 1 Cells: The Fundamental
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36 CHAPTER 1 Cells: The Fundamental
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38 CHAPTER 1 Cells: The Fundamental
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40 CHAPTER 2 Chemical Components of
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42 CHAPTER 2 Chemical Components of
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44 CHAPTER 2 Chemical Components of
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46 CHAPTER 2 Chemical Components of
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48 CHAPTER 2 Chemical Components of
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50 CHAPTER 2 Chemical Components of
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52 CHAPTER 2 Chemical Components of
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54 CHAPTER 2 Chemical Components of
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56 CHAPTER 2 Chemical Components of
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58 CHAPTER 2 Chemical Components of
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60HOW WE KNOWTHE DISCOVERY OF MACRO
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62 CHAPTER 2 Chemical Components of
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64 CHAPTER 2 Chemical Components of
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66PANEL 2-1 CHEMICAL BONDS AND GROU
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68PANEL 2-2 THE CHEMICAL PROPERTIES
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Panel 2.03a70PANEL 2-3 THE PRINCIPA
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72PANEL 2-4 AN OUTLINE OF SOME OF T
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74PANEL 2-5 FATTY ACIDS AND OTHER L
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Panel 2.06a76PANEL 2-6 THE 20 AMINO
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78PANEL 2-7 A SURVEY OF THE NUCLEOT
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80 CHAPTER 2 Chemical Components of
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82 CHAPTER 3 Energy, Catalysis, and
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84 CHAPTER 3 Energy, Catalysis, and
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86 CHAPTER 3 Energy, Catalysis, and
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88 CHAPTER 3 Energy, Catalysis, and
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90 CHAPTER 3 Energy, Catalysis, and
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92 CHAPTER 3 Energy, Catalysis, and
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94PANEL 3-1 FREE ENERGY AND BIOLOGI
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96 CHAPTER 3 Energy, Catalysis, and
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98 CHAPTER 3 Energy, Catalysis, and
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100 CHAPTER 3 Energy, Catalysis, an
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102HOW WE KNOW“HIGH-ENERGY” PHO
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104 CHAPTER 3 Energy, Catalysis, an
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106 CHAPTER 3 Energy, Catalysis, an
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108 CHAPTER 3 Energy, Catalysis, an
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110 CHAPTER 3 Energy, Catalysis, an
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112 CHAPTER 3 Energy, Catalysis, an
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114 CHAPTER 3 Energy, Catalysis, an
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CHAPTER FOUR4Protein Structure and
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The Shape and Structure of Proteins
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The Shape and Structure of Proteins
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The Shape and Structure of Proteins
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The Shape and Structure of Proteins
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The Shape and Structure of Proteins
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The Shape and Structure of Proteins
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The Shape and Structure of Proteins
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The Shape and Structure of Proteins
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The Shape and Structure of Proteins
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How Proteins Work137HOW PROTEINS WO
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How Proteins Work139antigenbindings
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How Proteins Work141USING ANTIBODIE
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How Proteins Work143rate of reactio
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How Proteins Work145enzyme activity
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How Proteins Work147SUBSTRATEThis s
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How Proteins Are Controlled149Anoth
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How Proteins Are Controlled151Feedb
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How Proteins Are Controlled153Figur
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How Proteins Are Controlled155Figur
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How Proteins Are Controlled157unstr
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How Proteins Are Studied159portions
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How Proteins Are Studied161Figure 4
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Essential Concepts163determines bot
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ECB5 Panel 4.03b/panel 4.03b165DIFF
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PANEL 4-5 PROTEIN SEPARATION BY ELE
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169CRYOELECTRON MICROSCOPYX-ray cry
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Questions171of the enzyme but canno
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CHAPTER FIVE5DNA and ChromosomesLif
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The Structure of DNA175DNA, after a
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The Structure of DNA1775′3′(A)H
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The Structure of Eukaryotic Chromos
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The Structure of Eukaryotic Chromos
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The Structure of Eukaryotic Chromos
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The Structure of Eukaryotic Chromos
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The Structure of Eukaryotic Chromos
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The Regulation of Chromosome Struct
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The Regulation of Chromosome Struct
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HOW WE KNOWGENES ARE MADE OF DNA193
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195Virus cocktailsThe debate was no
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Questions197QUESTION 5-10A compact
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CHAPTER SIX6DNA Replication and Rep
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DNA Replication201Figure 6-3 In eac
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DNA Replication203model, it occurre
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DNA Replication205replication origi
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DNA Replication207that is, the dire
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DNA Replication209(A)ACTUAL 5′-to
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DNA Replication2115′ phosphateAAT
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DNA Replication213TABLE 6-1 PROTEIN
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DNA Repair215of cell division, the
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DNA Repair217mutated sequenceold st
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DNA Repair219TOP STRANDREPLICATEDCO
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DNA Repair221the repair, a recombin
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DNA Repair223The many other cells i
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Questions225KEY TERMScancerDNA liga
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CHAPTER SEVEN7From DNA to Protein:H
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From DNA to RNA229(A)SUGAR DIFFEREN
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From DNA to RNA231DNA double helixr
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From DNA to RNA233Signals in the DN
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From DNA to RNA235Initiation of Euk
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From DNA to RNA237transcriptionstar
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From DNA to RNA2395′3′promoters
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From DNA to RNA2415′U1RNA portion
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From RNA to Protein243nuclearenvelo
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From RNA to Protein245codonsGCAGCCG
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From RNA to Protein2475’UUUUUUUUU
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From RNA to Protein249Specific Enzy
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From RNA to Protein251has a mass of
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From RNA to Protein253folded RNA. T
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From RNA to Protein255ribosome, the
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From RNA to Protein257degrade those
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RNA and the Origins of Life259as we
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RNA and the Origins of Life261TABLE
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Essential Concepts263• Eukaryotic
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Questions265QUESTION 7-16A. The ave
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268 CHAPTER 8 Control of Gene Expre
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270 CHAPTER 8 Control of Gene Expre
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272 CHAPTER 8 Control of Gene Expre
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274 CHAPTER 8 Control of Gene Expre
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276 CHAPTER 8 Control of Gene Expre
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278 CHAPTER 8 Control of Gene Expre
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280HOW WE KNOWGENE REGULATION—THE
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282 CHAPTER 8 Control of Gene Expre
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284 CHAPTER 8 Control of Gene Expre
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286 CHAPTER 8 Control of Gene Expre
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288 CHAPTER 8 Control of Gene Expre
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290 CHAPTER 8 Control of Gene Expre
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292 CHAPTER 8 Control of Gene Expre
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294 CHAPTER 8 Control of Gene Expre
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CHAPTER NINE9How Genes andGenomes E
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Generating Genetic Variation299ORIG
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Generating Genetic Variation301smal
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Generating Genetic Variation303perc
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Generating Genetic Variation305Figu
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Generating Genetic Variation307If t
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Reconstructing Life’s Family Tree
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Reconstructing Life’s Family Tree
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Reconstructing Life’s Family Tree
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Mobile Genetic Elements and Viruses
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Mobile Genetic Elements and Viruses
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Mobile Genetic Elements and Viruses
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Examining the Human Genome321The ta
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Examining the Human Genome323genesr
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Examining the Human Genome325portio
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Examining the Human Genome327region
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Questions329• The human genome co
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Questions331GeneAminoAcidsRates of
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334 CHAPTER 10 Analyzing the Struct
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336 CHAPTER 10 Analyzing the Struct
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338 CHAPTER 10 Analyzing the Struct
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340 CHAPTER 10 Analyzing the Struct
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342 CHAPTER 10 Analyzing the Struct
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344 CHAPTER 10 Analyzing the Struct
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346 CHAPTER 10 Analyzing the Struct
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348HOW WE KNOWSEQUENCING THE HUMAN
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350 CHAPTER 10 Analyzing the Struct
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352 CHAPTER 10 Analyzing the Struct
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354 CHAPTER 10 Analyzing the Struct
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356 CHAPTER 10 Analyzing the Struct
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358 CHAPTER 10 Analyzing the Struct
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360 CHAPTER 10 Analyzing the Struct
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362 CHAPTER 10 Analyzing the Struct
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364 CHAPTER 10 Analyzing the Struct
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366 CHAPTER 11 Membrane Structure1r
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368 CHAPTER 11 Membrane Structurepo
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ECB5 e11.11/11.11370 CHAPTER 11 Mem
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372 CHAPTER 11 Membrane Structurefl
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374 CHAPTER 11 Membrane Structureno
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376 CHAPTER 11 Membrane StructureMe
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378 CHAPTER 11 Membrane Structurehy
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380 CHAPTER 11 Membrane StructureFi
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382 CHAPTER 11 Membrane StructureFi
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384HOW WE KNOWMEASURING MEMBRANE FL
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386 CHAPTER 11 Membrane Structurene
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388 CHAPTER 11 Membrane Structureab
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390 CHAPTER 12 Transport Across Cel
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392 CHAPTER 12 Transport Across Cel
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394 CHAPTER 12 Transport Across Cel
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396 CHAPTER 12 Transport Across Cel
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398CYTOSOLCHAPTER 12 Transport Acro
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400 CHAPTER 12 Transport Across Cel
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402 CHAPTER 12 Transport Across Cel
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404 CHAPTER 12 Transport Across Cel
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406 CHAPTER 12 Transport Across Cel
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408 CHAPTER 12 Transport Across Cel
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410 CHAPTER 12 Transport Across Cel
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412HOW WE KNOWSQUID REVEAL SECRETS
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414 CHAPTER 12 Transport Across Cel
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416 CHAPTER 12 Transport Across Cel
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418 CHAPTER 12 Transport Across Cel
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420 CHAPTER 12 Transport Across Cel
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422 CHAPTER 12 Transport Across Cel
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424 CHAPTER 12 Transport Across Cel
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CHAPTER THIRTEEN13How Cells Obtain
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The Breakdown and Utilization of Su
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The Breakdown and Utilization of Su
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The Breakdown and Utilization of Su
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The Breakdown and Utilization of Su
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The Breakdown and Utilization of Su
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The Breakdown and Utilization of Su
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The Breakdown and Utilization of Su
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The Breakdown and Utilization of Su
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The Breakdown and Utilization of Su
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Regulation of Metabolism447REGULATI
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Regulation of Metabolism449Cells St
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Essential Concepts451fat dropletsta
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Questions453QUESTION 13-13An animal
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456 CHAPTER 14 Energy Generation in
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458 CHAPTER 14 Energy Generation in
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460 CHAPTER 14 Energy Generation in
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462 CHAPTER 14 Energy Generation in
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464 CHAPTER 14 Energy Generation in
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466 CHAPTER 14 Energy Generation in
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468 CHAPTER 14 Energy Generation in
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470 CHAPTER 14 Energy Generation in
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472PANEL 14-1 REDOX POTENTIALSHOW R
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474 CHAPTER 14 Energy Generation in
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476HOW WE KNOWHOW CHEMIOSMOTIC COUP
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478 CHAPTER 14 Energy Generation in
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480 CHAPTER 14 Energy Generation in
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482 CHAPTER 14 Energy Generation in
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484 CHAPTER 14 Energy Generation in
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486 CHAPTER 14 Energy Generation in
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488 CHAPTER 14 Energy Generation in
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490 CHAPTER 14 Energy Generation in
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492 CHAPTER 14 Energy Generation in
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494 CHAPTER 14 Energy Generation in
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496 CHAPTER 15 Intracellular Compar
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498 CHAPTER 15 Intracellular Compar
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500 CHAPTER 15 Intracellular Compar
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502 CHAPTER 15 Intracellular Compar
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504 CHAPTER 15 Intracellular Compar
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506 CHAPTER 15 Intracellular Compar
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508 CHAPTER 15 Intracellular Compar
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510 CHAPTER 15 Intracellular Compar
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512 CHAPTER 15 Intracellular Compar
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514 CHAPTER 15 Intracellular Compar
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516 CHAPTER 15 Intracellular Compar
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518 CHAPTER 15 Intracellular Compar
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520HOW WE KNOWTRACKING PROTEIN AND
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522 CHAPTER 15 Intracellular Compar
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524 CHAPTER 15 Intracellular Compar
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526 CHAPTER 15 Intracellular Compar
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528 CHAPTER 15 Intracellular Compar
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530 CHAPTER 15 Intracellular Compar
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CHAPTER SIXTEEN16Cell SignalingIndi
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General Principles of Cell Signalin
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General Principles of Cell Signalin
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General Principles of Cell Signalin
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General Principles of Cell Signalin
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General Principles of Cell Signalin
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G-Protein-Coupled Receptors545Where
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G-Protein-Coupled Receptors547targe
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G-Protein-Coupled Receptors549Figur
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G-Protein-Coupled Receptors551epine
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G-Protein-Coupled Receptors553signa
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G-Protein-Coupled Receptors555(A)sm
- Page 591 and 592:
Enzyme-Coupled Receptors557Figure 1
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Enzyme-Coupled Receptors559interact
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Enzyme-Coupled Receptors561survival
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HOW WE KNOWUNTANGLING CELL SIGNALIN
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Enzyme-Coupled Receptors565unspecif
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Enzyme-Coupled Receptors567hormone
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Essential Concepts569signal Aplasma
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Questions571KEY TERMSadaptation GTP
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CHAPTER SEVENTEEN17CytoskeletonThe
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Intermediate Filaments575INTERMEDIA
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Intermediate Filaments577Intermedia
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Intermediate Filaments579Figure 17-
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Microtubules581αtubulin dimer(= mi
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Microtubules583nucleuscentrosomegro
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Microtubules585nerve cell body--mic
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Microtubules587minusendtailglobular
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Microtubules589Figure 17-22 Kinesin
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Microtubules591Figures 17-26 Flagel
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Actin Filaments593(A) (B) (C) (D) (
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Actin Filaments595keeps the actin m
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Actin Filaments597CONTRACTIONactin
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Actin Filaments599(A)UNSTIMULATED C
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Muscle Contraction601plus endminus
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Muscle Contraction603minusendmyosin
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Muscle Contraction605(A)actin10 nmt
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Questions607• In skeletal muscle
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CHAPTER EIGHTEEN18The Cell-Division
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Overview of the Cell Cycle611TABLE
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The Cell-Cycle Control System613ens
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HOW WE KNOWDISCOVERY OF CYCLINS AND
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The Cell-Cycle Control System617S c
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The Cell-Cycle Control System619Cdk
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G 1 Phase621CYTOSOLNUCLEUSactive Rb
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S Phase623S PHASEBefore a cell divi
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M Phase625Figure 18−17 Activated
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Mitosis627responsible for separatin
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Mitosis629MITOSIS3METAPHASEspindle
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Mitosis631Figure 18−22 A bipolar
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Mitosis633Figure 18−26). Although
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Mitosis635(A)ANAPHASE A CHROMOSOMES
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Cytokinesis637a fine glass needle)
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Control of Cell Numbers and Cell Si
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Control of Cell Numbers and Cell Si
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Control of Cell Numbers and Cell Si
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Control of Cell Numbers and Cell Si
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Essential Concepts647• When the n
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Questions649help determine the leng
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652 CHAPTER 19 Sexual Reproduction
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654 CHAPTER 19 Sexual Reproduction
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656 CHAPTER 19 Sexual Reproduction
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658 CHAPTER 19 Sexual Reproduction
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660 CHAPTER 19 Sexual Reproduction
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662 CHAPTER 19 Sexual Reproduction
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664 CHAPTER 19 Sexual Reproduction
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666 CHAPTER 19 Sexual Reproduction
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668 CHAPTER 19 Sexual Reproduction
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670 CHAPTER 19 Sexual Reproduction
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672 CHAPTER 19 Sexual Reproduction
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674 CHAPTER 19 Sexual Reproduction
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676 CHAPTER 19 Sexual Reproduction
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678 CHAPTER 19 Sexual Reproduction
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680 CHAPTER 19 Sexual Reproduction
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682 CHAPTER 19 Sexual Reproduction
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684HOW WE KNOWUSING SNPs TO GET A H
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686 CHAPTER 19 Sexual Reproduction
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688 CHAPTER 19 Sexual Reproduction
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690 CHAPTER 19 Sexual Reproduction
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692 CHAPTER 20 Cell Communities: Ti
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694 CHAPTER 20 Cell Communities: Ti
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696 CHAPTER 20 Cell Communities: Ti
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698 CHAPTER 20 Cell Communities: Ti
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700 CHAPTER 20 Cell Communities: Ti
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702 CHAPTER 20 Cell Communities: Ti
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704 CHAPTER 20 Cell Communities: Ti
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706 CHAPTER 20 Cell Communities: Ti
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708 CHAPTER 20 Cell Communities: Ti
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710 CHAPTER 20 Cell Communities: Ti
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712 CHAPTER 20 Cell Communities: Ti
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714 CHAPTER 20 Cell Communities: Ti
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716 CHAPTER 20 Cell Communities: Ti
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718 CHAPTER 20 Cell Communities: Ti
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720 CHAPTER 20 Cell Communities: Ti
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722 CHAPTER 20 Cell Communities: Ti
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724 CHAPTER 20 Cell Communities: Ti
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726 CHAPTER 20 Cell Communities: Ti
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728 CHAPTER 20 Cell Communities: Ti
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730HOW WE KNOWMAKING SENSE OF THE G
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732 CHAPTER 20 Cell Communities: Ti
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734 CHAPTER 20 Cell Communities: Ti
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A:2 Answersnondestructive and passe
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A:4 AnswersD. Carbon-14 has two add
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A:6 AnswersANSWER 2-19 Noncovalent
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A:8 Answerscase, higher-order struc
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A:10 AnswersFigure A4−4ANSWER 4-5
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A:12 Answerswhich it would normally
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A:14 Answersthe sugar-phosphate bac
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A:16 AnswersC. True. With proofread
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A:18 Answersuse of the word dogma,
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A:20 Answerscells, and reactions th
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A:22 AnswersANSWER 8-7 The affinity
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A:24 Answersthe second intron is no
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A:26 Answerslonger products that ev
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A:28 AnswersInternal hydrogen bonds
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A:30 Answersside of the membrane (i
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A:32 Answersin a membrane. A voltag
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A:34 Answerswhere most of the energ
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A:36 Answersthe Fe ions so that the
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A:38 Answersthis mixture, so that e
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A:40 Answersco-packaged in the ER w
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A:42 Answers3. The response to a si
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A:44 Answerstubulin subunits in adj
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A:46 Answersthe microtubule will al
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A:48 AnswersANSWER 18-13A. Radiatio
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A:50 AnswersANSWER 18-24 Antibodies
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A:52 Answersin the frequency of a d
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A:54 Answerseyed fly and a white-ey
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A:56 Answerscells, thereby increasi
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G:2 GlossaryantibodyProtein produce
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G:4 GlossarycholesterolShort, rigid
- Page 830 and 831:
G:6 Glossaryelectrochemical gradien
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G:8 Glossarymolecule is translated
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G:10 Glossaryiron-sulfur centerTigh
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G:12 GlossaryN-terminusThe end of a
- Page 838 and 839:
G:14 Glossarycore of a protein mole
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G:16 Glossaryfrom a DNA template us
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G:18 GlossarytubulinProtein from wh
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I:2 Indexamino acid sequences/seque
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I:4 Indexcancers 718-729anticancer
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I:6 Indexchromosomes (continued)mit
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I:8 IndexDNA methylation 287DNA-onl
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I:10 Indexfetal hemoglobin 305fibro
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I:12 Indexheart muscleacetylcholine
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I:14 Indexlysosomesdigestion in 527
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I:16 Indexnerve cells (neurons) (co
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I:18 Indexpolyacrylamide-gel electr
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I:20 IndexrRNAs (ribosomal RNAs) 16
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I:22 Indextranscription regulators/