The overview of Leptin replacement therapy

THE OVERVIEW OF
LEPTIN REPLACEMENT
THERAPY

Leptin is a hormone that controls obesity and
related health issues in human bodies. Scientists,
for so many years, are engaged to discover how to
use the leptin hormone to treat obesity.

Hundreds of renowned names are included in the list – for
example, Tuncay Delibasi – the famous Turkish professor
and a medical person who is doing his best to develop the
advanced structure of leptin replacement therapy for
obesity.

When leptin sends neurotransmitter signals
to the brain in the hypothalamus sector, it
tells the person to stop eating to maintain
his/her desired BMI (Body Mass Index).
Scientists have observed that laboratory mice
have got polymorphism in their leptin gene.
Such mutations in the gene prevent
manufacturing the required leptin protein.

Due to the less leptin appearance, the lab mice have
developed morbidity obesity. The other strain has the
polymorphism or mutation in the gene encoding for LEPR
(leptin receptor). In such cases, the brain or hypothalamus is
not capable of receiving leptin signals. Therefore, signal
disruption happens and it causes mutations of polymorphism
in their leptin receptors and lab mice become obese.

A comparative study
has shown the
involvements of lean
and obese individuals
as per their leptin
hormone levels. These
types of comparative
studies have developed
the chances of leptin
replacement to treat
obesity. This is a
medical treatment that
controls leptin
expression levels in
obese people and helps
them to control obesity.
LEPTIN THERAPY

Leptin therapy is used to
reverse endocrine and
metabolic alterations that are
associated with leptin
deficiency. Less number of T-
cells, defective T-cells and CD4
cause leptin deficiency. Leptin
therapy can reverse these
reductions. Tuncay Delibasi
has discovered in his latest
research that leptin
replacement therapy is very
useful for patients who are
suffering from congenital
leptin deficiency.

Leptin also is
being used to
treat energy
loss such as
anorexia
nervosa.
Scientists
have found
that immune
function gets
changed
during leptin
replacement.