BREAST CYTOPATHOLOGY

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80 3. Benign and Borderline Tumors• Rarely epithelial fragments have an outer layer ofcells with clear vacuolated cytoplasm. However, epithelialmyoepithelialdistinction is rarely appreciated within thesame fragment.• Background naked bipolar nuclei and metachromatic fibromyxoidstroma are present (some resemblance to salivarygland–type tumors).• Stroma may have “collagenous spherulosislike” appearance.• Rarely, apocrine cells and foamy macrophages are present.• The tubular variant may show pseudopapillary cores withcells arranged around branching vessels.Pitfalls and Differential Diagnosis• Biphasic breast tumors (fibroadenoma and others)• Low-grade ductal carcinoma• Mesenchymal neoplasms (of the spindle cell variant)Figure 3.24. Adenomyoepithelioma. Loosely cohesive fragment ofductal epithelium surrounding fibrous and myxomatous corescharacterize this lesion. (Smear, Papanicolaou.)
Adenomyoepithelioma 81Figure 3.25. Adenomyoepithelioma. Fragment of focally atypicalepithelium with somewhat enlarged crowded nuclei and focaltubular/glandular architecture (6 o’clock). The cytoplasm is pale toclear with well-defined borders. (Smear, Papanicolaou.).Figure 3.26. Adenomyoepithelioma. Higher magnification ofsomewhat pleomorphic epithelial/myoepithelial cells with thecharacteristic “soap bubble” cytoplasmic artifact is depicted. Thecells are seen in close association with bright magenta-coloredstromal material. (Smear, Papanicolaou.)
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Breast Cytopathology
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Syed Z. Ali, MDDepartment of Pathol
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To my parentsGul Bano (late) and Ma
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viiiForewordthis volume to rejuvena
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xSeries Prefaceand form the framewo
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xiiPrefacecarefully selected high-r
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ContentsForeword by Dorothy L. Rose
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2 1. Introduction and Technical Asp
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10 1. Introduction and Technical As
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2Non-neoplastic andProliferative Le
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18 2. Non-neoplastic and Proliferat
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Page 100 and 101: 86 4. Primary Malignant Tumors• M
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130 4. Primary Malignant TumorsPitf
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132 4. Primary Malignant TumorsFigu
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134 4. Primary Malignant TumorsClin
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136 4. Primary Malignant Tumorsdiag
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5Metastatic and SecondaryTumorsMeta
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140 5. Metastatic and Secondary Tum
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Figure 5.6. Metastatic small cell c
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BFigure 5.9. (B) Metastatic papilla
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154 6. Breast Ductal LavageTable 6.
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156 6. Breast Ductal LavageFigure 6
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162 6. Breast Ductal Lavagecarcinom
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164 6. Breast Ductal LavageKrishnam
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166 IndexApocrine carcinomain axill
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168 IndexDuctal carcinoma (cont.)fi
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170 IndexFine-needle aspiration, of
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172 IndexLung cancer, 138metastatic
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174 IndexPapilloma (cont.)invasive
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BREAST CYTOPATHOLOGY

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