BREAST CYTOPATHOLOGY

Figure 3.18. Intraductal papilloma. Two enlarged fragments of
hyperchromatic crowded epithelium appear cytologically atypical.
However, a closer look shows the presence of myoepithelial cells
and a total lack of singly dispersed atypical epithelial cells. Papillomas
may harbor significant epithelial atypia, and one needs to have
a significantly higher threshold for interpretation of malignancy in
such settings. (Smear, Papanicolaou.)
Figure 3.19. Intraductal papilloma. Higher magnification shows the
degree of epithelial atypia in such lesions. The nuclei are enlarged
and pleomorphic. However, there were no individually dispersed
epithelial cells in the smear background. (Smear, Diff-Quik.)