BREAST CYTOPATHOLOGY

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36 2. Non-neoplastic and Proliferative Lesions• “Chicken-wire” or arborizing capillaries, often with proliferatingfibroblasts• Epithelioid histiocytes can be overinterpreted as malignantepithelial cells; and/or ductal epithelial fragments presentin the smear are overcalled because of the significant reactiveatypia present• Reactive epithelial atypia associated with fat necrosis hasresulted in false-positive diagnoses of cancerPitfalls and Differential Diagnosis• Ductal carcinomaMucocelelike LesionClinical Features• Rare lesion often quite small, usually a diagnosticproblem on FNA (differentiation from mucinouscarcinoma)• Often associated with fibrocystic changes and is thought tooriginate from ruptured mucinous cyst into breast stromaltissuesCytomorphologic Characteristics(Figures 2.18 and 2.19)• Smears with scant cellularity• Small epithelial fragments, monomorphic, lack ofatypia• Abundant background mucin• Muciphages, in varying numbers• Occasional bare myoepithelial nucleiPitfalls and Differential Diagnosis• Colloid carcinoma
Mucocelelike Lesion 37Figure 2.18. Mucocele. Thick, abundant mucinous background containingrare macrophages. These lesions are devoid of ductal epithelium,a helpful finding to distinguish them from well-differentiatedmucinous carcinoma. (Smear, Diff-Quik.)Figure 2.19. Mucocele. Higher magnification shows numerousmucin-containing macrophages in a thick mucinous background.(Smear, Diff Quik.)
Page 2 and 3: Breast Cytopathology
Page 4 and 5: Syed Z. Ali, MDDepartment of Pathol
Page 6 and 7: To my parentsGul Bano (late) and Ma
Page 8 and 9: viiiForewordthis volume to rejuvena
Page 10 and 11: xSeries Prefaceand form the framewo
Page 12 and 13: xiiPrefacecarefully selected high-r
Page 14 and 15: ContentsForeword by Dorothy L. Rose
Page 16 and 17: 2 1. Introduction and Technical Asp
Page 24 and 25: 10 1. Introduction and Technical As
Page 30 and 31: 2Non-neoplastic andProliferative Le
Page 32 and 33: 18 2. Non-neoplastic and Proliferat
Page 58 and 59: Figure 2.26. Lactational change. Hy
Page 72 and 73: 58 3. Benign and Borderline TumorsC
Page 74 and 75: 60 3. Benign and Borderline TumorsF
Page 82 and 83: 68 3. Benign and Borderline Tumors
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86 4. Primary Malignant Tumors• M
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88 4. Primary Malignant TumorsFigur
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92 4. Primary Malignant TumorsHisto
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100 4. Primary Malignant TumorsFigu
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104 4. Primary Malignant Tumors•
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116 4. Primary Malignant TumorsPitf
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120 4. Primary Malignant TumorsInfl
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134 4. Primary Malignant TumorsClin
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136 4. Primary Malignant Tumorsdiag
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5Metastatic and SecondaryTumorsMeta
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140 5. Metastatic and Secondary Tum
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Figure 5.6. Metastatic small cell c
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BFigure 5.9. (B) Metastatic papilla
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154 6. Breast Ductal LavageTable 6.
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156 6. Breast Ductal LavageFigure 6
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162 6. Breast Ductal Lavagecarcinom
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164 6. Breast Ductal LavageKrishnam
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166 IndexApocrine carcinomain axill
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168 IndexDuctal carcinoma (cont.)fi
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170 IndexFine-needle aspiration, of
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172 IndexLung cancer, 138metastatic
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174 IndexPapilloma (cont.)invasive
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BREAST CYTOPATHOLOGY

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