BREAST CYTOPATHOLOGY

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32 2. Non-neoplastic and Proliferative Lesions• Aggregates of distended macrophages, with refractilecytoplasmic globules• Inflammatory cells, multinucleated giant cells• Degenerated, often vacuolated, adipocytesPitfalls and Differential Diagnosis• Fat necrosis• Ductal carcinoma• LipomaFat Necrosis/Organizing HematomaClinical Features• Trauma-induced inflammatory conditions• History of trauma may or may not be available• Mammographically, fat necrosis with subsequent calcificationmay also mimic a neoplastic process• May result in a firm, irregular, fixed, and painfulbreast mass• Mimics breast cancer not only clinically and radiologicallybut also cytopathologically• May create diagnostic problems if the history of injury isremote or is not recalled by the patientCytomorphologic Characteristics(Figures 2.12 to 2.17)• Scant cellularity (rarely smears appear hypercellular due toabundance of inflammatory cells, histiocytes, and endothelialproliferation)• Abundant foamy or hemosiderin-containing macrophages,lymphocytes, plasma cells, fibroblasts, and fragments offibrous tissue and newly formed vessels• Degenerated/necrotic fat cells/vacuoles, often with calcifieddebris and dirty granular background, lipophages• Occasional multinucleated foreign body–type giant cells
Fat Necrosis/Organizing Hematoma 33Figure 2.12. Fat necrosis. Degenerated fat, histiocytes, and multinucleatedforeign body–type giant cells. (Smear, Papanicolaou.)Figure 2.13. Fat necrosis. Hypercellular smear depicting degeneratedfat, chronic inflammatory cells, and multinucleated histiocytes.Abundant fine capillary vessels represent formation of granulationtissue. (Smear, Papanicolaou.)
Page 2 and 3: Breast Cytopathology
Page 4 and 5: Syed Z. Ali, MDDepartment of Pathol
Page 6 and 7: To my parentsGul Bano (late) and Ma
Page 8 and 9: viiiForewordthis volume to rejuvena
Page 10 and 11: xSeries Prefaceand form the framewo
Page 12 and 13: xiiPrefacecarefully selected high-r
Page 14 and 15: ContentsForeword by Dorothy L. Rose
Page 16 and 17: 2 1. Introduction and Technical Asp
Page 24 and 25: 10 1. Introduction and Technical As
Page 30 and 31: 2Non-neoplastic andProliferative Le
Page 32 and 33: 18 2. Non-neoplastic and Proliferat
Page 58 and 59: Figure 2.26. Lactational change. Hy
Page 72 and 73: 58 3. Benign and Borderline TumorsC
Page 74 and 75: 60 3. Benign and Borderline TumorsF
Page 82 and 83: 68 3. Benign and Borderline Tumors
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82 3. Benign and Borderline TumorsF
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84 3. Benign and Borderline TumorsG
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86 4. Primary Malignant Tumors• M
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88 4. Primary Malignant TumorsFigur
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92 4. Primary Malignant TumorsHisto
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100 4. Primary Malignant TumorsFigu
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104 4. Primary Malignant Tumors•
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116 4. Primary Malignant TumorsPitf
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120 4. Primary Malignant TumorsInfl
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134 4. Primary Malignant TumorsClin
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136 4. Primary Malignant Tumorsdiag
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5Metastatic and SecondaryTumorsMeta
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140 5. Metastatic and Secondary Tum
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Figure 5.6. Metastatic small cell c
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BFigure 5.9. (B) Metastatic papilla
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154 6. Breast Ductal LavageTable 6.
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156 6. Breast Ductal LavageFigure 6
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162 6. Breast Ductal Lavagecarcinom
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164 6. Breast Ductal LavageKrishnam
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166 IndexApocrine carcinomain axill
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168 IndexDuctal carcinoma (cont.)fi
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170 IndexFine-needle aspiration, of
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172 IndexLung cancer, 138metastatic
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174 IndexPapilloma (cont.)invasive
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BREAST CYTOPATHOLOGY

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