BREAST CYTOPATHOLOGY

24 2. Non-neoplastic and Proliferative Lesions
Figure 2.6. Atypical ductal hyperplasia. At higher magnification,
this case illustrates markedly enlarged and hyperchromatic nuclei
imparting a crowded look to the cellular fragment. The fragment
still depicts a cohesive architecture with lack of individually dispersed
epithelial cells. Although the cytologic features are worrisome,
the follow-up revealed multifocal atypical ductal hyperplasia.
(Smear, Papanicolaou.)
Figure 2.7. Atypical ductal hyperplasia. Cellular fragment displaying
more pleomorphism with enlarged crowded nuclei and the
beginning of a three-dimensional architecture. The cells are loosely
cohesive at the fragment edges. (Smear, Papanicolaou.)