BREAST CYTOPATHOLOGY

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20 2. Non-neoplastic and Proliferative LesionsFigure 2.1. Fibrocystic changes. A partially folded fragment of apocrinecells seen in a background of numerous foamy macrophagesand cystic debris. (Smear, Papanicolaou.)Figure 2.2. Fibrocystic changes. A flat monolayered fragment ofapocrine epithelium alongside a cluster of large foamy macrophages.(Smear, Papanicolaou.)
Fibrocystic Changes 21Figure 2.3. Fibrocystic changes. A large fragment of apocrine cellsarranged in a large monolayered fashion. Cells are large and polygonalwith large nuclei and prominent nucleoli with abundant granularcytoplasm. Apocrine epithelium is a fairly common finding in breastaspirates and, except for rare occasions, represents benign lesions.(Smear, Papanicolaou.)metaplasia (large polygonal cells, abundant cytoplasm thatis distinctly granular, well-defined cytoplasmic borders,often prominent nucleoli)• Mild anisonucleosis, slight nuclear overlap• Sometimes macrophages predominate, often with foamycytoplasm—”foamy macrophages”• Myoepithelial cells, fragments of stroma, adipose tissue• Background of cystic debris• Rarely, microcalcifications (calcified debris)Pitfalls and Differential Diagnosis• Atypical ductal hyperplasia• Fibroadenoma• Low-grade ductal carcinoma
Page 2 and 3: Breast Cytopathology
Page 4 and 5: Syed Z. Ali, MDDepartment of Pathol
Page 6 and 7: To my parentsGul Bano (late) and Ma
Page 8 and 9: viiiForewordthis volume to rejuvena
Page 10 and 11: xSeries Prefaceand form the framewo
Page 12 and 13: xiiPrefacecarefully selected high-r
Page 14 and 15: ContentsForeword by Dorothy L. Rose
Page 16 and 17: 2 1. Introduction and Technical Asp
Page 24 and 25: 10 1. Introduction and Technical As
Page 30 and 31: 2Non-neoplastic andProliferative Le
Page 32 and 33: 18 2. Non-neoplastic and Proliferat
Page 58 and 59: Figure 2.26. Lactational change. Hy
Page 72 and 73: 58 3. Benign and Borderline TumorsC
Page 74 and 75: 60 3. Benign and Borderline TumorsF
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70 3. Benign and Borderline TumorsF
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74 3. Benign and Borderline Tumors
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84 3. Benign and Borderline TumorsG
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86 4. Primary Malignant Tumors• M
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88 4. Primary Malignant TumorsFigur
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92 4. Primary Malignant TumorsHisto
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100 4. Primary Malignant TumorsFigu
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104 4. Primary Malignant Tumors•
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116 4. Primary Malignant TumorsPitf
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120 4. Primary Malignant TumorsInfl
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134 4. Primary Malignant TumorsClin
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136 4. Primary Malignant Tumorsdiag
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5Metastatic and SecondaryTumorsMeta
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140 5. Metastatic and Secondary Tum
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Figure 5.6. Metastatic small cell c
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BFigure 5.9. (B) Metastatic papilla
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154 6. Breast Ductal LavageTable 6.
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156 6. Breast Ductal LavageFigure 6
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162 6. Breast Ductal Lavagecarcinom
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164 6. Breast Ductal LavageKrishnam
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166 IndexApocrine carcinomain axill
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168 IndexDuctal carcinoma (cont.)fi
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170 IndexFine-needle aspiration, of
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172 IndexLung cancer, 138metastatic
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174 IndexPapilloma (cont.)invasive
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BREAST CYTOPATHOLOGY

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