BREAST CYTOPATHOLOGY
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18 2. Non-neoplastic and Proliferative Lesions
• Anucleated squamous cells, parakeratotic cells, and keratinous
material
• Ductal epithelium with varying degrees of reactive atypia
• Granulation tissue
• Foamy histiocytes, cholesterol crystals
Pitfalls and Differential Diagnosis
• Duct ectasia
• Ductal carcinoma with squamous differentiation, metastatic
squamous cell carcinoma, and metaplastic carcinoma
Granulomatous Mastitis
Clinical Features
• Characterized by the presence of granulomatous reaction
and giant cell formation
• An inflammatory lesion of either unknown etiology or the
result of tuberculosis, fungal infection, epidermal inclusion
cyst, or foreign body reaction such as suture and leakage
from silicone implants
Cytomorphologic Characteristics
• Variable cellularity (usually high)
• Epithelioid histiocytes, singly and in loose clusters
• Mixed inflammatory cells, cellular debris
• Few to abundant foreign body–type giant cells
• Ductal epithelial fragments often with significant reactive
atypia
Pitfalls and Differential Diagnosis
• Duct ectasia
• Low-grade ductal carcinoma